Multiple Myeloma | Oncology Today with Dr Neil Love: Emerging Role of CELMoDs (Cereblon E3 Ligase Modulators) and Other Novel Approaches to Targeting Protein Degradation Pathways in Multiple Myeloma (Companion Faculty Lecture)
Research To Practice | Oncology Videos · Dr. Neil Love
September 28, 202334m 25s
Audio is streamed directly from the publisher (traffic.libsyn.com) as published in their RSS feed. Play Podcasts does not host this file. Rights-holders can request removal through the copyright & takedown page.
Show Notes
Featuring a slide presentation and related discussion from Dr Paul G Richardson, including the following topics:
- Biologic rationale for targeting protein degradation pathways as a therapeutic approach in multiple myeloma (MM); mechanism of action of CELMoDs (0:00)
- Published efficacy and safety findings with iberdomide-containing combination regimens from the Phase I/II CC-220-MM-001 study (6:30)
- Emerging data with mezigdomide/dexamethasone for relapsed/refractory MM (13:22)
- Early results with and ongoing investigations of mezigdomide/dexamethasone in combination with a proteasome inhibitor (29:54)