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Gastroesophageal Cancers | Lunch with the Investigators: Gastroesophageal Cancers

Gastroesophageal Cancers | Lunch with the Investigators: Gastroesophageal Cancers

Research To Practice | Oncology Videos · Dr. Neil Love

July 13, 202359m 48s

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Show Notes

Featuring perspectives from Dr Yelena Y Janjigian, Dr Manish A Shah and Dr Harry H Yoon, including the following topics:

  • Integration of Immune Checkpoint Inhibitors into the Management of HER2-Negative Gastroesophageal (GE) Cancers
    • Introduction (0:00)
    • Adjuvant immunotherapy for GE cancers (1:54)
    • First-line anti-PD-1/PD-L1 antibody-based regimens for metastatic HER2-negative GE cancer (13:11)
    • Future role of novel immunotherapies/checkpoint inhibitors (20:57)
  • Optimal Management of HER2-Positive GE Cancers
    • Selection of first-line therapy for metastatic HER2-positive GE cancer (28:37)
    • Selection of second-line therapy for metastatic HER2-positive GE cancer (36:56)
  • Therapeutic Options for Relapsed/Refractory GE Cancers; Novel Investigational Approaches
    • Selection of second-line therapy for metastatic HER2-negative GE cancer (42:11)
    • Zolbetuximab/chemotherapy as first-line therapy for claudin 18.2-positive metastatic GE cancer (43:09)
    • Use of circulating tumor DNA assays for patients with GE cancers (53:37)

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