Desmoid Tumors | Oncology Today with Dr Neil Love: Management of Desmoid Tumors
Research To Practice | Oncology Videos · Dr. Neil Love
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Show Notes
Featuring perspectives from Dr Mrinal Gounder, including the following topics:
• Incidence and prevalence of desmoid tumors (00:00)
• Outcomes associated with historical management paradigms for desmoid tumors (17:15)
• Rationale for targeting the gamma secretase complex and Notch pathway as a therapeutic approach for desmoid tumors; mechanism of action of nirogacestat (20:56)
• Key efficacy outcomes from the Phase III DeFi trial evaluating the gamma secretase inhibitor nirogacestat versus placebo for progressing desmoid tumors (30:14)
• Spectrum and frequency of adverse events, including ovarian dysfunction, with nirogacestat (36:06)
CME information and select publications