Chronic Lymphocytic Leukemia — An Interview with Dr Catherine C Coombs on Real-World Cases and Current Questions and Controversies Presented at Recent Conferences
Research To Practice | Oncology Videos · Dr. Neil Love
April 5, 202558m 13s
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Show Notes
Featuring an interview with Dr Catherine C Coombs, including the following topics:
- Case: A woman in her early 80s with dementia and newly diagnosed IGHV-mutated del(13q) chronic lymphocytic leukemia (CLL) receives initial treatment with zanubrutinib (0:00)
- Current and investigational initial therapy approaches for CLL (13:41)
- Case: A man in his late 40s under observation for asymptomatic CLL develops worsening symptoms and initiates treatment with venetoclax/obinutuzumab (28:15)
- Phase III AMPLIFY trial of fixed-duration acalabrutinib combined with venetoclax with or without obinutuzumab as first-line treatment for CLL (36:02)
- Other novel venetoclax combinations for the treatment of CLL (43:36)
- Case: A man in his mid 70s with multiregimen-refractory CLL receives pirtobrutinib (46:51)
- Personal perspectives on the activity and tolerability of pirtobrutinib; sequencing pirtobrutinib and chimeric antigen receptor T-cell therapy for patients with CLL (51:16)