Breast Cancer | Oncology Today with Dr Neil Love: Optimizing the Management of Metastatic BRCA-Negative, Triple-Negative Breast Cancer (Companion Faculty Lecture)
Research To Practice | Oncology Videos · Dr. Neil Love
September 25, 202427m 22s
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Show Notes
Featuring a slide presentation and related discussion from Dr Tiffany A Traina, including the following topics:
- Extended follow-up with pembrolizumab/chemotherapy for patients with previously untreated PD-L1-positive metastatic triple-negative breast cancer (mTNBC) (0:00)
- ASCENT trial: Survival advantage with sacituzumab govitecan versus physician's choice of chemotherapy for patients with relapsed/refractory TNBC (2:49)
- Treatment-associated side effects with sacituzumab govitecan (5:32)
- Activity of sacituzumab govitecan irrespective of TROP2 expression level and in patients with brain metastases (6:48)
- Ongoing Phase III studies evaluating sacituzumab govitecan in earlier lines of treatment (eg, ASCENT-03, ASCENT-04) (8:51)
- Efficacy and tolerability of trastuzumab deruxtecan in patients with HER2-low and HER2-ultralow metastatic breast cancer (10:26)
- Activity and ongoing investigations of other novel agents and strategies for mTNBC (20:05)