Breast Cancer | Oncology Today with Dr Neil Love: Key Presentations on Breast Cancer from the 2022 ASCO Annual Meeting
Research To Practice | Oncology Videos · Dr. Neil Love
July 18, 202247m 57s
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Show Notes
Featuring an interview with Dr Angela DeMichele, including the following topics:
- Staining for HER2 expression and clinical relevance of HER2-0 breast cancer (0:00)
- Biology of HER2-mutated breast cancer; sequencing of sacituzumab govitecan and trastuzumab deruxtecan for estrogen receptor (ER)-negative breast cancer (4:21)
- Role of trastuzumab deruxtecan in HER2-low, ER-positive breast cancer; biologic rationale for targeting HER3 with patritumab deruxtecan (11:39)
- Ongoing clinical trials of tucatinib for HER2-positive locally advanced or metastatic breast cancer: HER2CLIMB-04 and HER2CLIMB-05 (17:16)
- Recent data with and biomarkers of response for sacituzumab govitecan for triple-negative breast cancer (TNBC); benefits of chemotherapy for disease with a BRCA mutation (22:22)
- Molecular alterations associated with PARP inhibitor response and potential implications for clinical practice (25:45)
- Current role of PARP inhibitors, immunotherapy, chemotherapy, and combination therapies for TNBC (28:57)
- Potential role of sacituzumab govitecan for ER-positive, HER2-negative breast cancer (33:54)
- Tolerability of capivasertib; using genomic testing to identify tumor subtypes less responsive to endocrine therapy (37:24)
- Using genomic risk scores to inform treatment for ER-positive, HER2-negative breast cancer that has spread to lymph nodes (43:04)