Brain Metastases with HER2-Positive Breast Cancer — An Interview with Dr Sarah Sammons on Optimal Management Approaches
Research To Practice | Oncology Videos · Dr. Neil Love
August 26, 202545m 42s
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Show Notes
Featuring an interview with Dr Sarah Sammons, including the following topics:
- Development of brain metastases in patients with HER2-positive and HER2-negative breast cancer (0:00)
- Local therapy approaches for the treatment of brain metastases (8:23)
- Treatment options for patients with HER2-positive breast cancer and CNS-only disease progression (16:36)
- Clinical presentation of leptomeningeal disease; management of functional sequelae associated with brain metastases (19:07)
- Investigational agents for the treatment of brain metastases in HER2-positive breast cancer (25:01)
- Case: A 65-year-old woman with ER-negative, HER2-positive metastatic breast cancer (mBC) develops a single 6-mm brain metastasis after 4 years of maintenance trastuzumab/pertuzumab (27:38)
- Screening for brain metastases; radiation necrosis as a side effect of radiation therapy (31:00)
- Case: A 39-year-old woman with ER-negative, HER2-positive mBC develops 7 new brain metastases 6 months into treatment with a taxane, trastuzumab and pertuzumab (34:30)