Testosterone Therapy 101: Risks, Benefits & Types of TRT ft. Dr. Mohit Khera
Dr. Mohit Khera, leading urologist and sexual health researcher, joins Dr. Rena Malik to unpack the worldwide decline in testosterone, the importance of symptoms over lab numbers, and why free testosterone matters most. They explore various testosterone therapies, their impact on fertility, and the value of semen analysis as a health indicator. The episode also covers how lifestyle factors, estrogen, and mental health intersect with testosterone; clarifies myths about risks; and reviews regenerative treatments for erectile dysfunction, such as hyperbaric oxygen, shockwave therapy, PRP, and Botox.
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Show Notes
Dr. Mohit Khera, renowned urologist, researcher, and expert in male and female sexual health, joins Dr. Rena Malik to discuss the global decline in testosterone, why symptoms matter more than blood test reference numbers, and the crucial role of free testosterone. They dive into types of testosterone replacement therapies—including injectables, gels, orals, and pellets—their risks, benefits, and considerations around fertility. The conversation also covers how semen analysis serves as a window into overall health, the influence of lifestyle changes (like weight loss, sleep, and stress management) on hormone levels, and the relationship between testosterone, cardiovascular health, depression, and prostate cancer. Dr. Khera and Dr. Malik explore regenerative therapies for erectile dysfunction, including hyperbaric oxygen, shockwave therapy, stem cells, PRP, and Botox, and discuss lesser-known issues such as post-finasteride syndrome and the status of sexual health in women.
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▶️Chapters:
00:00:00 – Introduction
00:02:10 – The Testosterone Decline
00:06:07 – Free vs. Total Testosterone
00:11:32 – TRT Options
00:14:19 – Oral Testosterone & Fertility
00:17:26 – Protecting Fertility on TRT
00:20:38 – Recovery After TRT
00:29:10 – The Power of Estrogen
00:38:48 – Boosting Testosterone Naturally
00:42:31 – Stress & Operator Syndrome
00:50:12 – ED & Shockwave Therapy
00:55:13 – Regenerative Therapies
01:36:24 – Closing Thoughts
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DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death.
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