RealPharma: Conversations with Pharma Pathfinders

🧠 Episode Summary What if we’ve been thinking about cancer all wrong? In this deeply personal and paradigm-shifting episode of RealPharma, hosts Dr. Na-Ri Oh and Ian Wendt sit down with Dr. Christopher Gregg—neuroscientist, entrepreneur, and stage 4 cancer patient—to explore a bold new vision for cancer care. Dr. Gregg shares how his own diagnosis sparked a radical rethink of oncology: moving away from the “war on cancer” mindset toward managing it as a chronic, controllable condition. Drawing inspiration from agriculture, AI, and evolutionary biology, he introduces the concept of “algorithms as drugs”—dynamic, data-driven treatment strategies designed to outmaneuver resistance. This conversation blends cutting-edge science with raw human experience, offering a hopeful and pragmatic roadmap for the future of precision medicine. 🔑 Key Topics Covered Why curing cancer may not always be the best goal—and what to aim for instead The concept of adaptive therapy and managing cancer like a chronic disease What elephants, farmers, and pests can teach us about treatment resistance The limitations of today’s drug development and clinical trial systems “Algorithms as drugs” and the future of programmable medicine How AI, smartphones, and behavioral data can unlock scalable precision care The role of value-based care models in accelerating innovation Dr. Gregg’s personal journey living 7+ years with stage 4 cancer Building Storyline Health, Primordial AI, and Uncharted Health The importance of patient agency—and the risks of unguided experimentation 🚀 Why This Episode Matters Cancer care is at an inflection point. While billions are spent developing new drugs, Dr. Gregg argues that the real breakthrough may come from how we use the drugs we already have. By combining AI, real-time patient data, and systems thinking, this approach could dramatically extend lives, reduce costs, and make care more human-centered. 🔗 Learn More Explore Dr. Gregg’s free masterclass: Uncharted Health Follow developments from Storyline Health and Primordial AI Stay tuned for upcoming clinical applications of algorithm-driven care 🎧 About the Guest Dr. Christopher Gregg is a Professor of Neurobiology and Human Genetics at the University of Utah, a leading researcher in genomics and brain science, and a biotech entrepreneur. His work spans neuroscience, AI, and precision medicine—and is deeply informed by his personal experience living with metastatic cancer.

The Opioid Reckoning (Part 2): Litigation, Accountability, and the Fight for Justice with Paul T. Farrell Jr. In Part 2 of our deep dive into the opioid crisis, hosts Dr. Na-Ri Oh and Ian Wendt continue their conversation with Paul T. Farrell Jr., the West Virginia attorney who helped lead the historic national opioid litigation. This episode moves beyond the legal strategy discussed in Part 1 and explores the human toll, the documentary that captured the battle, the controversial trial outcome, and the surprising legal reversal years later. It’s a story of perseverance, public health accountability, and the long arc of justice. 🎬 From Courtroom to Documentary Paul shares the unexpected origin story behind the PBS documentary The Bitter Pill, directed by Clay Tweel. What began as a filmmaker casually attending a hearing soon turned into a seven-year chronicle of the opioid litigation, capturing the rise of a local lawsuit in Huntington, West Virginia into a nationwide legal movement. The documentary highlights not only the legal fight but also the devastating real-world impact of the opioid epidemic on families, healthcare workers, and communities. ⚖️ The Trial That Shook the Case A major focus of the episode is the Cabell County trial, the first major test of the legal strategy that ultimately helped drive national settlements. Paul explains how: The case became the bellwether trial for thousands of similar lawsuits. A national settlement framework complicated the ability to settle locally. The federal judge ultimately ruled against the plaintiffs on legal grounds—even as similar arguments succeeded in other jurisdictions. For Paul and his team, the ruling felt like a devastating setback after years of work. 💰 The $50 Billion National Settlement Despite the loss in the bellwether trial, the broader litigation resulted in nearly $50 billion in settlements with pharmaceutical manufacturers, distributors, and pharmacies. Paul explains the goals behind the settlement: Transparency around how opioid pills were distributed across the U.S. Accountability for the systemic failures that fueled the epidemic Funding for opioid abatement programs, rather than compensation for individual claims In West Virginia, settlement funds were allocated through a unique structure that created the West Virginia First Foundation, a statewide public-private trust designed to ensure funds are used specifically to combat addiction and support recovery programs. 🔄 A Stunning Legal Reversal The documentary originally ends on a bleak note after the Cabell County loss. But the story didn’t end there. In October 2025, the Fourth Circuit Court of Appeals reversed the trial court’s decision, reopening the case and giving Cabell County another opportunity to argue its claims. For Paul, the decision brought a sense of vindication after years of uncertainty and reignited the fight for accountability. 🧠 Has the System Changed? The episode closes with a broader discussion about whether the opioid crisis could happen again. Paul reflects on changes across the healthcare ecosystem: Greater scrutiny and transparency in medical research and publishing Stronger safeguards for pharmacists and prescription monitoring Increased attention to controlled substance distribution practices But he also warns that the incentives in healthcare and pharmaceuticals remain powerful—and vigilance will be essential. 💡 Final Reflections When asked what sustains him through years of litigation, setbacks, and public scrutiny, Paul points to faith, community, and the people who show up along the journey at the right moments. It’s a fitting close to a story that began with one lawsuit in a small Appalachian city—and grew into one of the largest public health litigations in U.S. history. 🎧 In This Episode The origin and filming of The Bitter Pill documentary Inside the Cabell County bellwether trial Why the national opioid settlement unfolded the way it did The structure and purpose of opioid abatement funding The 2025 appellate reversal that revived the case Whether the healthcare system has truly changed 👥 Guest Paul T. Farrell Jr. Attorney and lead counsel in the Cabell County opioid litigation, which helped catalyze the nationwide opioid settlements.

The Opioid Reckoning (Part 1): Paul Farrell Jr. on Litigation, Accountability, and the System That Failed West Virginia has had the highest drug overdose death rate in the United States for over a decade. In a state with fewer than 2 million people, 780 million prescription opioids were distributed in just six years. For Paul Farrell Jr., a Huntington, West Virginia native and mass tort attorney, those numbers weren’t abstract statistics. They were neighbors. Friends. Family members. In Part 1 of this two-part episode, hosts Na-Ri Oh and Ian Wendt sit down with Paul to unpack how the largest civil litigation in American history — the opioid multidistrict litigation (MDL 2804) — came together, and how it reshaped the conversation around corporate accountability in the pharmaceutical supply chain. This is not just a legal story. It’s a story about systems failure — across manufacturers, distributors, regulators, policymakers, and healthcare stakeholders — and what happens when transparency finally forces a reckoning. In This Episode Growing up in Huntington, WV as the opioid crisis escalated The investigative journalism that exposed 780 million pills — and the moment Paul decided to act What “public nuisance” law is — and why it became the legal breakthrough strategy The role of distributors as the “choke point” in the opioid supply chain How 3,000+ cases consolidated into the largest MDL in U.S. history Why abatement — not just financial damages — became central to the settlement strategy Internal company communications that revealed troubling attitudes toward affected communities The intersection of regulation, enforcement, and corporate responsibility How transparency and subpoena power changed the trajectory of the crisis Why This Conversation Matters For those working in pharma, healthcare, commercialization, policy, compliance, or distribution, this episode challenges us to examine difficult questions: Where does responsibility truly lie in a complex healthcare ecosystem? What happens when financial incentives distort oversight? And how do we prevent the next Pandora’s box from opening? This episode sets the foundation for a deeper conversation about accountability, culture, regulation, and reform. Coming Next Week: Part 2 There was simply too much to cover in one episode. In Part 2, we’ll explore: The evolution of the litigation and key tipping points The role of state attorneys general and settlement frameworks The ongoing PBM litigation The documentary The Bitter Pill And what lasting change should look like for the industry Make sure to subscribe so you don’t miss it.

Ending the Diagnostic Odyssey: Rare Disease, Employers & Reimagining Health Plans Hosts: Na-Ri Oh & Ian Wendt Guest: Joshua Resnikoff, Founder & CEO, Sunstone Health Episode Overview What if the biggest innovation in rare disease wasn’t a new drug—but a new way to navigate the system? In this episode, Na-Ri and Ian sit down with Joshua Resnikoff, biomedical engineer turned founder of Sunstone Health, to explore how employers can fundamentally rethink healthcare spending—while dramatically improving outcomes for families facing rare diseases. Josh’s journey into healthcare reform wasn’t academic—it was personal. After years navigating the healthcare system to diagnose his son’s rare periodic fever syndrome, Josh experienced firsthand the emotional, financial, and systemic toll of what’s known as the diagnostic odyssey. That experience sparked a mission: compress a seven-year diagnostic journey into just 12 weeks. This conversation dives into rare disease, employer-sponsored health plans, insurance mechanics, and why aligning incentives might be the key to transforming care. 🔬 From Scientist to System Builder Josh’s background as a biomedical engineer at Harvard’s Wyss Institute The rare disease journey that reshaped his career Why getting a diagnosis—even without treatment—changes everything The emotional and economic cost of delayed diagnosis 🧬 The 7-Year Diagnostic Odyssey On average, it takes: 7 years from first symptom to effective treatment for rare disease patients Countless ER visits, specialist referrals, medication trials, and escalating costs Significant emotional strain—rare disease families face dramatically higher stress and divorce rates Sunstone’s model reduces that timeline to approximately 12 weeks using: Whole genome sequencing AI-powered clinical interpretation Expert clinician review (human-in-the-loop model) Direct coordination with local care teams The result? Earlier intervention. Reduced healthcare utilization. Better outcomes. 💼 Why Employers Are the Key Josh explains why self-funded employers—not traditional commercial insurers—are uniquely positioned to drive change. Key insights: ~2/3 of Americans receive insurance through employers Many large employers are self-funded, meaning they pay claims directly Employers think in long-term employee retention (not 12-month insurance cycles) Better healthcare = healthier employees = higher retention & productivity Sunstone’s innovative model: No per-employee-per-month subscription fees Employers only pay when a family receives actionable results High ROI through reduced ER visits, unnecessary treatments, and delayed care 🛡 Insurance 101 (Made Understandable) The episode breaks down: Fully insured vs. self-funded plans Third-party administrators (TPAs) Stop-loss / reinsurance How high-cost cases (like $2M gene therapies) are financially managed The takeaway: When diagnoses happen earlier, total system costs often decrease—even when advanced therapies are involved. 🤝 Mission-Driven Innovation A powerful theme throughout the conversation: Many leaders in the rare disease ecosystem—including Josh—entered the field because of their own children. That lived experience shapes: Sunstone’s patient-first data ownership model Continuous reanalysis of patient data Clinical trial matching Ethical alignment with families As Josh says: “Even if this whole thing went belly up, we will have helped hundreds of families—and I’d feel good about that for the rest of my life.” 🚀 Recent Milestones Successfully raised Series A funding 800+ community investors via WeFunder Integration with Broad Clinical Labs Expanded epilepsy and autism-focused programs Rapidly growing employer pipeline 🔗 Learn More 🌐 Sunstone Health: https://sunstonehealth.com 💼 Connect with Josh on LinkedIn

🎙️ Beyond Survival: Why Empathy Is the Missing Prescription in Pharma Episode Summary: In this no-holds-barred conversation, Na-Ri Oh and Ian Wendt sit down with Matthew Zachary—brain cancer survivor, founder of Stupid Cancer, host of Out of Patients, and a relentless disruptor in patient advocacy. At 21, Matthew was diagnosed with brain cancer and faced a life-altering decision: take chemotherapy and lose his identity as a musician, or reject treatment and risk everything. That decision became the first of many moments where he saw the cracks in the healthcare system—specifically, the glaring absence of empathy. Now, nearly three decades later, Matthew shares how his experience transformed into a mission to fix what’s broken: in pharma, in media, in patient engagement—and in how we talk about what matters most. This isn’t your typical Pharma Podcast. It’s a masterclass in calling out BS, rethinking metrics that matter, and re-centering real human lives in healthcare strategy. What You’ll Hear in This Episode: 🎹 The life-defining decision Matthew made at 21—and why he turned down chemo 💊 How a lack of empathy almost cost him everything 🧠 The problem with patient engagement that’s all talk and no trust 🎤 The rise of Stupid Cancer and the “Howard Stern of Healthcare” era 📺 Why DTC ads may be a $28 billion distraction 🧵 The missing link between pharma marketers and patient communities 🔥 How compliance is killing creativity—and what to do about it 🗳️ Why Matthew is building a voter movement out of patient voices Memorable Quote: “If there is no empathy, there is no conversation.” – Matthew Zachary Mentioned in the Episode: Stupid Cancer Out of Patients Podcast Matthew’s upcoming book: We the Patients: How to Understand, Navigate, and Survive America’s Healthcare Nightmare WeThePatients.org Guest: Matthew Zachary (@MatthewZachary) Let me know if you'd like a shorter version for Spotify/Apple Podcast platforms or suggested social media captions to promote the episode.

🎙️ Real Pharma – Episode Title: Breaking the Silence: Why Pharma Needs to Speak Up Hosts: Na-Ri Oh & Ian Wendt Guest: Brian Reid, Founder & Principal at Reid Strategic 🔍 Episode Summary: In this episode of Real Pharma, Na-Ri and Ian sit down with Brian Reid—a healthcare communicator, strategist, and former journalist who's worked across government, pharma, and media—to explore a provocative question: Why is the pharmaceutical industry so quiet when it comes to telling its own story? Together, they unpack the communication failures shaping drug pricing, PBMs, the Inflation Reduction Act (IRA), biosimilars, and the broader healthcare system. Brian argues that the problem isn’t a lack of data or platforms—it’s a lack of courage, clarity, and commitment to narrative. From the importance of speaking up in a noisy media environment to the myth of reputational risk, this conversation is a must-listen for anyone in life sciences, policy, or healthcare storytelling. 🧠 What You’ll Learn: Why pharma’s “default to silence” is damaging public trust—and what the industry can do instead The communications trap around complex topics like PBMs, pricing, and benefit design How public perception problems could have been avoided with smarter storytelling (hello, Hep C) Why simplicity is power—and how “pharm-to-table” and Mark Cuban are reframing the narrative The case for overcommunication in the face of misinformation and AI-driven “slop” Why the Medicare Prescription Payment Plan was a missed communication opportunity—and how to fix it 🔊 Quotable Moments: “We're in a 30-year experiment of what happens when pharma steps back from the policy debate—and the results are in.” – Brian Reid “I just want pharma to beat Bigfoot in public trust. That’s my goal.” – Brian Reid “When in doubt, just shout. Say something. Do something.” – Na-Ri Oh “It’s not always about having the perfect message—it’s about showing up and making the case.” – Ian Wendt 🧭 Resources Mentioned: Cost Curve – Brian Reid’s daily newsletter on healthcare policy: ReidStrategic.com KFF’s piece on complexity as a barrier to affordability Examples from Mark Cuban’s Cost Plus Drugs and Eli Lilly CEO Dave Ricks’ public podcast appearances 👥 Connect with Brian Reid: 💼 Website: ReidStrategic.com 📬 Newsletter: Cost Curve 💬 LinkedIn: Brian Reid

Episode Title: Formulation as Strategy: Why CDMOs Matter More Than Ever Guest: Elizabeth Hickman, President & CEO, Austin Pharmaceutics Episode Overview In this episode of RealPharma, hosts Nari Oh and Ian Wendt sit down with Elizabeth Hickman, President and CEO of Austin Pharmaceutics, to unpack one of the most critical—and often misunderstood—elements of drug development: formulation and the evolving role of CDMOs. As drug molecules become more complex and solubility challenges grow, CDMOs are no longer just manufacturing vendors. They are strategic partners helping biotech and pharma companies bridge the gap between discovery and commercialization. Elizabeth shares her journey from commercial pharma leadership to running a science-driven CDMO, and explains why formulation decisions made early can determine whether a promising molecule ever reaches patients. 🔍 Key Topics Covered The expanding role of CDMOs Why CDMOs are shifting from executional partners to strategic extensions of pharma and biotech teams. Why formulation is make-or-break How solubility and bioavailability challenges derail up to 80% of modern drug candidates—and why these issues must be addressed early. From “undruggable” to developable How AI-driven discovery and structure-based drug design are unlocking new targets while creating new development hurdles. Inside Austin Pharmaceuticals’ approach A look at Austin’s proprietary Kinetisol® technology and how amorphous solid dispersion can improve bioavailability, scalability, manufacturability, and sustainability. Small biotech vs. big pharma dynamics What early-stage companies should look for in a CDMO partner—and the most common mistakes teams make when selecting one. Patient impact starts with formulation How pill burden, dosing frequency, and manufacturability directly affect adherence, cost, and competitiveness. The future of CDMOs Reshoring, cost pressures, AI adoption, and the growing need for talent with both scientific depth and entrepreneurial mindset. 💡 Memorable Takeaways “Formulation is where promising molecules either become viable drugs—or stall out.” Solving in-vivo performance alone isn’t enough; scalability and manufacturability must be designed in from day one. The best CDMO relationships are built on transparency, urgency, and shared long-term vision. Advanced formulation isn’t just a technical advantage—it’s a competitive and economic one. 👤 About the Guest Elizabeth Hickman is President and CEO of Austin Pharmaceutics, a U.S.-based early-phase CDMO specializing in formulation development for challenging small-molecule drugs. With a background spanning commercial strategy, drug launches, and executive leadership, Elizabeth brings a sponsor-centric mindset to CDMO partnerships—helping clients accelerate innovation while reducing risk.

🎧 Hosts: Na-Ri Oh & Ian Wendt 🎓 Special Guests: Emma Cousin (PhD Candidate, Choice Institute – UW), Amos Fung (RealPharma Intern & Student Pharmacist) 🔍 Episode Summary: In this thought-provoking episode, hosts Na-Ri Oh and Ian Wendt sit down with Emma Cousin, a PhD candidate at the Choice Institute, University of Washington, to unpack the real-world implications of the Inflation Reduction Act (IRA)—particularly the Medicare Drug Price Negotiation Program. Joining them is Amos Fung, a RealPharma intern who brings a front-line pharmacy perspective to the policy conversation. Together, they discuss: 📜 A primer on the IRA’s healthcare provisions—what it is, how it came to be, and why it matters now. 💊 How CMS selects drugs for Medicare negotiation and whether this process constitutes true “negotiation.” 👩‍⚕️ The ripple effects on pharmacists, pharmacies, and patient care. 💸 The looming concerns around cashflow, operational readiness, and access as the 2026 implementation date approaches. 🧠 How researchers like Emma are modeling long-term effects—and what metrics we’ll need to track to assess the IRA’s success. 🔄 Unintended consequences and who might be left behind—especially independent pharmacies and vulnerable communities. 📈 A candid discussion on myths around drug pricing and why “good intentions” in policy still need strong evidence and thoughtful execution. 🎯 Key Takeaways: The IRA marks the first time Medicare can directly negotiate drug prices—albeit in a tightly structured format that raises questions about the fairness of “negotiation.” Pharmacies face operational and financial strain, particularly smaller or independent ones, due to rebate lags and implementation complexities. Patients will benefit from caps on out-of-pocket costs, but awareness and education are lacking—many don’t realize what the law offers. Stakeholders like pharmacists, researchers, and policy influencers need better communication and clearer technical standards from CMS. Evidence-based policy should be the north star for drug pricing reforms, but real-world implementation remains messy and evolving. 🧠 Resources & Mentions: Brian Reid & Adam Fein – Top newsletters to follow for updates on drug pricing policy. CMS Guidance Documents – Frequently updated, but often inaccessible to non-policy experts. National Pharmaceutical Council, Milliman, Portal (Harvard) – Organizations doing forward-looking modeling and policy impact research.

Reinventing Cell Therapy with Acoustics, Microfluidics & High-Throughput Engineering In this episode, hosts Na-Ri Oh and Ian Wendt sit down with Dr. Andrew Gray — immune cell engineer, biotech founder, venture capitalist, and CEO of CellEcho — to explore how a new acoustic-powered gene-delivery platform may redefine the boundaries of cell therapy. The conversation spans the current state of the cell therapy landscape, the persistent barriers to scalability, and why CellEcho’s ASOP platform (Acoustically Stabilized Oscillatory Pockets) could unlock a new era of faster, cheaper, and more effective cell engineering. 🔬 Episode Highlights 1. The State of Cell Therapy: Breakthroughs & Bottlenecks Despite scientific success, many pharma companies are exiting cell therapy due to cost, complexity, and manufacturing burdens. Conversely, major players like BMS continue doubling down, acquiring companies such as Orbital Therapeutics. Autologous therapies remain logistically overwhelming and expensive—often ~$400k per dose. 2. Why Cell Therapy Is So Hard to Scale “Vein-to-vein” timelines are still measured in weeks, not days. Manufacturing is bespoke: each patient’s cells must be extracted, engineered, expanded, frozen, shipped, and reinfused. Viral vectors and current non-viral delivery methods introduce cost, complexity, and biological limits. 3. The Next Frontier: In Vivo, Allogeneic & Beyond Allogeneic CAR-Ts remain challenging due to immune rejection and complex engineering. In vivo CAR-T offers promise but is limited by the small genetic “payload capacity” of lipid nanoparticles. Solid tumors remain particularly difficult: only ~9% response rates in some indications. 4. Introducing CellEcho & the ASOP Platform CellEcho’s technology emerged from UC Irvine’s microfluidics program. By applying precision acoustic energy, the platform can: Hold cells in place using thousands of stable micro-eddies Open controlled, programmable “portals” in cell membranes Sequentially deliver multiple genetic payloads with high efficiency Achieve 1 billion cells/hour processing rates Reduce dose production costs by ~100× Enable high-throughput engineering, not just manufacturing This unlocks the ability to test dozens to hundreds of engineered CAR-T variants in days—rather than the years needed today. One academic lab spent 6 years evaluating 11 CAR-T variants. CellEcho tested 8 variants in under 48 hours — and aims for 100+ per week. 5. From Better Manufacturing to Better Medicines While CellEcho originally targeted faster manufacturing, Andrew shares that the bigger opportunity is designing entirely better therapies, not simply making today’s ones faster. This includes: Engineering CAR-Ts with multiple CAR constructs Arming cells with resistance to tumor suppression signals Precise control over expression levels (avoiding under- or over-expression) Unlocking new indications: autoimmunity, neurodegeneration, regenerative medicine 6. Personal Motivation & Mission Andrew shares how his mother's struggle with myasthenia gravis sparked his lifelong journey in immunology. His 20-year career investigating immune evasion, Tregs, and tumor microenvironments culminated in his conviction that next-generation cell engineering is essential. 7. What’s Next for CellEcho Currently initiating pre-seed fundraising Supported by multiple federal grants (including NSF SBIR) Expanding early partnerships with Stanford, Mass General Brigham, and industry collaborators Building a fully automated, AI-augmented cell therapy design platform Dual strategy: Cell-therapy-development-as-a-service Proprietary therapeutic pipeline in select indications 💡 Key Takeaways Cell therapy works — but not broadly or efficiently enough. Engineering complexity, not biology alone, is the rate-limiting step. Acoustic microfluidics enables a scalable, programmable, non-viral way to engineer living cells. High-throughput screening for cell therapies could transform discovery the way combinatorial chemistry transformed small molecules. The real revolution isn’t just faster production — it’s better, more sophisticated therapies. 🔗 Learn More About CellEcho Visit: https://cellechobio.com Contact: Via the Info link on the website (messages route directly to Dr. Gray).

👩‍🔬👨‍⚕️ Hosts: Na-Ri Oh & Ian Wendt 🎧 Guest: Dr. Ron Shigeta – Biotech visionary, co-founder of IndieBio, and food innovation expert. 🧬 Episode Summary: In this deeply insightful and refreshingly candid episode, Ian and Nari welcome back biotech veteran Dr. Ron Shigeta to explore the evolving landscape where food, health, and biotech collide. From the collapse of the lab-grown meat hype cycle to the challenges of democratizing access to functional food, Ron brings hard truths, historical context, and cautious optimism to the table. As the U.S. federal government embraces its Make America Healthy Again (MAHA) agenda—reforming food policy to prioritize public health—the conversation asks: 👉 Can we finally treat food as medicine, and make it scalable, credible, and affordable? 👉 What went wrong with cultured meat—and what comes next? 👉 Why does Ron really hate the term “food tech”? If you’ve ever wondered whether the future of wellness lies in your fridge, your pharmacy, or your feed, this one’s for you. 🔑 Key Topics Covered: MAHA & Food Policy Shifts: What the government’s new approach to food says about public health—and why it matters. Cultured Meat's Cautionary Tale: Why the dream of lab-grown meat stumbled—and how the next wave of companies might succeed. Ultra-Processed vs. Ultra-Useful: A frank conversation on consumer trust, marketing blunders, and what “processed” really means. Food as Preventative Medicine: From diabetes to GLP-1s to micronutrients—why we’re ignoring the obvious. Pharma’s Cost Spiral & Innovation Trap: $2M gene therapies, $500K cancer cures, and why food might be the only scalable solution left. The Neuroscience of Eating: Food isn’t just fuel—it’s identity, emotion, and the deepest form of human behavior. Why “Food Tech” is Bad Branding: Ron’s passionate take on why the tech world misunderstands how people eat. 🧠 Memorable Quotes: “Technology for the public will always win—because once people use it, they can’t let it go.” – Ron Shigeta “We’ve invented healthcare Americans can’t afford.” – Ron Shigeta “Nobody buys food because it’s high-tech. Nobody. That’s not how trust is built.” – Ron Shigeta 📚 Mentioned in This Episode: MAHA (Make America Healthy Again) policy initiative GLP-1s and the rise of preventative obesity drugs Blue zones and the elusive science of longevity Golden rice and biotech’s public trust problem OneSkin and peptide-based functional cosmetics Ron’s upcoming book on food, neuroscience, and the future of health

🎙 Episode Title: From Job Search to Power Move: How Top Talent’s Playing 2025 🧠 Guests: Kristiaan Rawlings, Executive Director at EPM Scientific 🎧 Hosts: Na-Ri Oh & Ian Wendt Episode Summary Layoffs. AI. Resume black holes. The biopharma hiring market feels noisy—and not in a good way. But beneath the doomscrolling, there’s a more nuanced story unfolding. In this episode, Kristiaan Rawlings returns to RealPharma to deliver a data-backed pulse check on the state of hiring across the industry. Drawing from hundreds of hours of direct conversations with execs, talent leaders, and hiring managers, Kristiaan unpacks: 📈 Which therapy areas and functions are hiring (and which are not) 🧠 How AI is actually being used in recruitment—and where it falls short 👀 Why 70% of senior roles are now confidential 🤝 The traits that are getting candidates hired in 2025 💸 Sign-on bonuses: who’s getting them, how to ask, and what to watch out for Whether you're job hunting, hiring, or just trying to read the market right—this conversation brings the clarity. Resources & Links 🔗 Connect with Kristiaan Rawlings on LinkedIn 🌐 Explore non-confidential roles at EPM Scientific

Where Policy Meets the Pharmacy Counter Featuring Congressman Jake Auchincloss Episode Summary In this episode of RealPharma, hosts Na-Ri Oh and Ian Wendt sit down with Congressman Jake Auchincloss (MA-04) to dissect the tangled web of policy, profit, and politics driving America’s drug pricing system. From pharmacy benefit managers (PBMs) to the politics of tariffs, this discussion explores the push for transparency, fair competition, and sustainable reform in healthcare. Auchincloss, a Marine veteran and member of the House Energy and Commerce Committee, brings a rare combination of policy depth and industry fluency. Together, they unpack how entrenched middlemen have distorted the system—and what bipartisan solutions could finally restore balance between innovation and access. What You’ll Learn: Why PBM reform has momentum but keeps stalling in Congress How the Pharmacists Fight Back Act could level the playing field for independent pharmacies The purpose of the Patients Before Monopolies Act and how it targets vertical integration Auchincloss’s vision for a “biotech social contract” that links innovation, IP protection, and insurance design The real story behind drug import tariffs and the risks of chaotic trade policy How U.S. innovation compares to China’s rapidly advancing biotech ecosystem The importance of aligning drug pricing reform with patient access and national competitiveness Memorable Moments: “PBMs deserve to be bulldozed for their behavior over the last two decades.” “There’s no moral hazard in getting sick—no one fakes chemotherapy to get free drugs.” “The most expensive thing in the world is what hasn’t been invented yet.” Why It Matters: As drug costs rise and innovation races ahead, the U.S. faces a defining choice: will healthcare policy reward breakthroughs or bureaucracy? Congressman Auchincloss argues that reform is not just about prices—it’s about preserving America’s leadership in biomedical innovation while ensuring patients can actually access the medicines that save lives. Guest: Congressman Jake Auchincloss U.S. Representative for Massachusetts’ 4th District Member, House Committee on Energy and Commerce Hosts: Na-Ri Oh & Ian Wendt

Episode Title: “Conversations, Not Campaigns: The Art of Authentic Engagement in Healthcare” 🗣️ Episode Summary In this episode, hosts Dr. Na-Ri Oh and Ian Wendt sit down with Colin Hung — healthcare technologist, marketing strategist, and co-founder of the long-running #HCLDR (Healthcare Leadership) Twitter community. Colin shares his journey from biomedical engineering to becoming one of the most respected community builders in digital health. Together, they explore what authentic engagement really looks like in the healthcare and pharma industries — from how companies can move beyond broadcasting to truly listening, to how AI can support rather than replace human connection in patient advocacy. 🧭 Key Themes & Takeaways From Engineer to Connector: How Colin’s early career in biomedical engineering shaped his systems-thinking approach to digital health. Building #HCLDR: The story behind one of the most influential online healthcare communities — what made it work, and how it evolved over 13 years. Conversation > Communication: Why genuine listening and empathy are more powerful than any marketing message in healthcare engagement. Pharma’s Challenge: How manufacturers can engage meaningfully online despite regulatory constraints — and why showing up as people first matters most. AI in Healthcare: The promise and pitfalls of AI in patient engagement — and how to use it responsibly to empower, not replace, the human touch. The Future of Digital Communities: What comes next for online healthcare engagement now that #HCLDR has passed the torch to new community creators. 👥 Guest Bio: Colin Hung Colin Hung is a healthcare technologist, community strategist, and co-founder of the #HCLDR community. With more than 25 years in health IT, Colin has been a driving force in bringing together patients, clinicians, and innovators to discuss the future of care. He’s also a writer, speaker, and advocate for inclusive, patient-centered technology. 🔗 Connect with Colin: LinkedIn: https://www.linkedin.com/in/colinhung/ Twitter (X): https://twitter.com/Colin_Hung 🏷️ Organizations, Movements & Mentions #HCLDR (Healthcare Leadership) — A global online healthcare leadership community founded in 2012 that brought together patients, providers, and industry leaders for weekly discussions on improving healthcare. 🔗 https://hcldr.wordpress.com 🔗 https://twitter.com/search?q=%23HCLDR 🎧 Listen & Subscribe Find The RealPharma Podcast on: Spotify Apple Podcasts Google Podcasts

🎙️ Episode Title: Building the Highway for AI in Pharma: A Conversation with Ilya Burkov 📍 Episode Summary In this episode of RealPharma, hosts Na-Ri Oh and Ian Wendt sit down with Dr. Ilya Burkov, Head of AI Cloud at Nebius, to explore the critical infrastructure enabling the AI revolution in drug development. While the headlines often focus on the promise of AI, Ilya brings us backstage—where the real acceleration happens. From GPU scalability and regulatory compliance to synthetic data and digital twins, this conversation unpacks how the roads, bridges, and power lines of cloud infrastructure are shaping the future of biopharma R&D. Whether you're a biotech founder, pharma executive, or AI enthusiast, this episode offers a 360° view into the unseen tech powering the next generation of therapies. 🧠 What You’ll Learn Why AI needs more than just models—it needs muscle. The role of GPUs-as-a-service in reducing drug discovery timelines How infrastructure and compliance go hand in hand in regulated industries Why digital twins and synthetic control arms could be the future of clinical trials Challenges biotech startups face—and how AI-first models could level the playing field The ethical promise of fully virtual drug pipelines 🧭 Key Quote “Think of AI in pharma as the car. What we’re building is the highway—bridges, power, road signs—so researchers can just drive.” — Dr. Ilya Burkov 🧰 Resources & Mentions Ilya Burkov on LinkedIn Nebius AI Cloud FDA Digital Health Initiatives 👥 About the Guest Dr. Ilya Burkov is Head of AI Cloud at Nebius, where he leads teams building cloud platforms purpose-built for AI workloads in life sciences. With a background in large-scale computing and a deep understanding of compliance in regulated industries, Ilya bridges the gap between bleeding-edge technology and real-world healthcare impact. 🎧 Listen & Subscribe Find RealPharma on your favorite podcast platform: Apple Podcasts | Spotify | Amazon Music 👉 Don’t forget to rate and review the show—it helps others discover the future of pharma!

🎙️ Episode Title: Inside the CMC Black Box: A Deep Dive with Reza Oliyai 🧾 Show Notes: What exactly is CMC — and why is it behind more FDA rejections than any other category? In this episode of RealPharma, hosts Na-Ri Oh and Ian Wendt sit down with Dr. Reza Oliyai, former SVP of Pharmaceutical & Biologics Operations at Gilead Sciences, and now Founder & CEO of Oliyai Consulting, to demystify the world of Chemistry, Manufacturing, and Controls (CMC). With over three decades of experience and a role in advancing 200+ drug candidates and 27 product launches, Reza offers a front-row seat to what goes wrong — and right — in the drug development journey. 🔍 In this episode, we explore: What CMC really means — and why the "controls" part is most overlooked Why 74% of FDA complete response letters involve CMC issues The pitfalls of the “Phase 1 mentality” in late-stage development AI in CMC: helpful tool or overhyped distraction? How to evaluate CDMO partners (and why big pharma’s pick might be your wrong fit) The evolving geopolitical landscape and its impact on global manufacturing What startups, investors, and boards need to understand about CMC before it’s too late Career advice: what it takes to lead in this increasingly complex field 🧠 Key Quote: “CMC is a black box to most executives. That’s a problem. Because it’s also the number one reason drugs get delayed.” — Dr. Reza Oliyai Whether you're in manufacturing, regulatory, executive leadership, or just trying to understand what actually gets a drug to market — this episode is a must-listen. 🔗 Resources & Mentions: Oliyai Consulting Reza Oliyai on LinkedIn FDA’s recent publication of Complete Response Letters 👤 About Our Guest: Dr. Reza Oliyai is a globally recognized leader in pharmaceutical operations, with deep expertise across small molecules, biologics, ADCs, peptides, siRNA, and more. After 28 years at Gilead Sciences, he now advises over 100 organizations worldwide through his firm, Oliyai Consulting.

In this episode of RealPharma, Ian Wendt and Na-Ri Oh sit down with Dara Katcher Levy, a regulatory attorney at Hyman, Phelps & McNamara, P.C.—widely regarded as one of the nation’s top firms in food and drug law. Dara brings decades of expertise in promotional review, labeling negotiations, and post-market compliance, helping life sciences companies navigate the complex world of FDA regulations. Together, they unpack the most pressing regulatory questions facing biopharma in 2025: DTC Advertising Under Fire: Why the U.S. remains one of only two countries allowing direct-to-consumer (DTC) prescription drug ads, and the political push to restrict them. AI in Pharma Marketing: How AI is being adopted to streamline promotional reviews, where it adds efficiency, and where compliance risks still demand human oversight. FDA Enforcement Trends: Why the Office of Prescription Drug Promotion (OPDP) has shifted its focus from celebrity DTC ads (think Serena Williams and Brittany Mahomes) to healthcare professional materials, and what that means for manufacturers. Telehealth & Influencers: The murky legal ground when platforms like Hims & Hers Health, Inc. or paid content creators promote prescription drugs. Should they be held to the same standards as manufacturers? First Amendment vs. FDA: A deep dive into recent enforcement controversies—like the warning letter to Sprout Pharmaceuticals over its CEO’s personal Instagram post—and whether FDA is overreaching in regulating speech. Dara also shares how she advises clients to balance responsible communication with compliance, and why she believes patients benefit from more information, not less, so long as it’s presented transparently and fairly. Resources & References Hyman, Phelps & McNamara, P.C. – Dara’s firm, specializing in FDA law. FDA OPDP Enforcement Letters Database – Track recent untitled and warning letters. Food, Drug, and Cosmetic Act (FDCA) – The foundation of FDA authority. FDORA (Food and Drug Omnibus Reform Act of 2022) – Recent legislation impacting drug development and promotion. Addyi (flibanserin) – Sprout Pharmaceuticals – Case study mentioned in FDA’s 2024 enforcement actions.

Episode Title: From Rock Star to Rare Disease Revolutionary: Casey McPherson’s Fight for His Daughter’s Life In this deeply personal and inspiring conversation, hosts Na-Ri Oh and Ian Wendt sit down with Casey McPherson, founder and CEO of AlphaRose Therapeutics—and acclaimed recording artist—to explore how one father’s determination to save his daughter’s life is shaking up the rare disease drug development model. Casey shares his journey from fronting rock bands to founding a biotech company, sparked by his daughter Rose’s diagnosis with an ultra-rare genetic disorder. He discusses why the current rare disease model is broken, how Alpha Rose is reimagining the path from diagnosis to treatment, and the emotional and ethical complexities of innovating in this space. What You’ll Learn in This Episode: How Casey’s music career prepared him to run a biotech startup. Why rare disease families face a “diagnostic odyssey” and what needs to change. The gap between available technology and systemic barriers to treatment. How AlphaRose Therapeutics is creating scalable models for ultra-rare diseases. The promise—and challenges—of engaging with regulators like the FDA in new ways. Why the Leonard Cohen classic Hallelujah has become a personal anthem for Casey. Links & Resources: AlphaRose Therapeutics StartEngine – Invest in Alpha Rose (crowdfunding equity round open until August) Leonard Cohen – Hallelujah (Jeff Buckley cover) People Magazine feature on Casey McPherson Follow Casey on Instagram

Episode Title: Behind the PBM Curtain: Antonio Ciaccia Exposes the Game Show Notes: In this compelling episode of Real Pharma, hosts Na-Ri Oh and Ian Wendt welcome back Antonio Ciaccia, CEO of 46brooklyn Research and President of 3 Axis Advisors, for a hard-hitting discussion on the power and pitfalls of pharmacy benefit managers (PBMs). PBMs remain one of the most opaque and influential forces in healthcare—shaping drug prices, patient access, and payer negotiations—often under the guise of cost savings. Antonio, widely recognized as one of the most outspoken voices for transparency in the pharmaceutical supply chain, takes us deep inside the systemic problems that have led to distorted pricing models, misaligned incentives, and challenges for manufacturers, payers, and patients alike. Key Topics Covered: The Gross-to-Net Bubble: How rebates, discounts, and government distortions drive higher list prices and undermine value-based formulary design. PBM Consolidation & Vertical Integration: The impact of PBMs owning wholesalers, specialty pharmacies, and even repackaging themselves as drug companies. The 340B Program & Market Distortions: Why hospitals and covered entities are often incentivized to favor higher-priced drugs over clinically superior, cost-effective alternatives. Policy and Reform: What’s being done at the state and federal levels, including the FTC investigations, Medicaid reforms, and disruptive models like Mark Cuban’s Cost Plus Drugs. Burn It Down or Fix It? Antonio’s candid take on whether incremental improvements can save the current system or if structural overhaul is the only way forward. What Manufacturers Should Know: Strategies for navigating PBM-driven formularies, access barriers, and rebate-driven contracting. Antonio also shares actionable insights for payers, manufacturers, and policymakers on how to realign incentives and reduce inefficiencies that inflate costs without adding value. Why Listen: If you work in pharma, healthcare policy, or benefit design—or simply want to understand why your medications cost what they do—this conversation is a must-listen. Antonio’s expertise cuts through industry jargon and exposes the real forces driving the drug pricing crisis. Resources & Links: 46brooklyn Research – Data-driven analysis on drug pricing. 3 Axis Advisors – Market intelligence and consulting on drug pricing and PBMs. Related Episodes: 340B or Bust: Is This Program Failing the Sick

🎙️ 340B or Bust: Is This Program Failing the Sick? This week on Real Pharma, hosts Dr. Na-Ri Oh and Ian Wendt dive into the tangled world of 340B with returning guest William “Bill” Sarraille—one of the most respected voices in healthcare law, an active patient advocate, and a rare disease patient himself. The 340B Drug Pricing Program was intended to help vulnerable patients by requiring drug manufacturers to provide discounted medications to covered entities. But as Bill puts it, has the program strayed too far from its patient-first mission? With explosive growth, patchwork state laws, opaque data, and billions on the line, is it still doing what it was designed to do—or are the sick paying the ultimate price? 🔍 In this episode, we explore: ✅ How 340B ballooned from a modest program to a behemoth that may soon outpace Medicare Part D ✅ Why transparency remains elusive—and who’s resisting it ✅ The uncomfortable reality: charity care rates at major hospitals vs. billions in 340B profits ✅ The looming risks to rare disease innovation and patient access ✅ Bill’s insider perspective on why patients often aren’t seeing the savings ✅ What changes might be coming from state houses, courts, and possibly Washington Bill also shares candid insights from his own journey as a rare disease patient—and why that makes him both more hopeful and more skeptical than ever. 💡 Links & Resources Mentioned Bill Sarraille on LinkedIn: https://www.linkedin.com/in/william-sarraille-634a8827/ ADAP Advocacy Association: https://www.adapadvocacy.org/ 340B Report (for policy resources & updates): https://340breport.com/

Episode Title: Paging Dr. ChaptGPT with Bryce Sady AI Adoption in Healthcare: Navigating the Present and Shaping the Future with Bryce Sady Episode Description: On today's insightful episode of RealPharma, hosts Dr. Na-Ri Oh and Ian Wendt sit down with Bryce Sady, Vice President of Product Development at PSL Group's Medical Education and Communications Division, a veteran innovator at the intersection of healthcare data, education, and AI. Together, they dive into the fascinating landscape of artificial intelligence in healthcare and pharmaceuticals. From practical applications, barriers, and regulatory hurdles, to how clinicians and pharma professionals are integrating AI into their workflows, Bryce sheds light on current adoption rates and trends across the healthcare ecosystem. Key Highlights: How healthcare professionals' AI adoption rates compare to the general public (hint: it might surprise you!) The real-world, practical AI use-cases currently shaping clinician workflows. Challenges and opportunities around integrating AI into heavily regulated environments. Insights on clinician education and how platforms like PSL Group’s "Doogle" are changing the landscape. Predictions for near-term trends in AI, including the pivotal roles of ambient scribes and patient communication tools. Ethical considerations and liability discussions as AI becomes essential in clinical decision-making. Bryce also shares his personal inspirations drawn from Tracy Kidder's powerful book, Mountains Beyond Mountains, reflecting on the importance of patient-centered perseverance in healthcare innovation. Who should listen? Healthcare professionals, medical educators, pharma marketers, digital health innovators, and anyone curious about the rapidly evolving role of AI in healthcare. Contact Bryce Sady on LinkedIn: https://www.linkedin.com/in/brycesady Companies and Resources mentioned: DougallGPT: https://dougallgpt.com/ Instar Research: https://www.instarresearch.com/ PeerDirect: https://peerdirect.com/ Tracey Kidder, Mountains Beyond Mountains. (2003) https://a.co/d/9mDpHgR How the U.S. Public and AI Experts View Artificial Intelligence. Apr 3, 2025. https://www.pewresearch.org/internet/2025/04/03/artificial-intelligence-in-daily-life-views-and-experiences/ The state of AI: How organizations are rewiring to capture value. Mar 12, 2025. https://www.mckinsey.com/capabilities/quantumblack/our-insights/the-state-of-ai Physician sentiments around the use of AI in heathcare: motivations, opportunities, risks, and use cases. February 2025. https://www.ama-assn.org/system/files/physician-ai-sentiment-report.pdf The Healthcare AI Adoption Index. Apr 18, 2025. https://www.bain.com/insights/the-healthcare-ai-adoption-index

Episode Title: “Hiring Heat Check: What’s Hot in Biotech + Pharma Talent in Mid-2025” 🎙️ Hosts: Ian Wendt & Na-Ri Oh 🎧 Guest: Kristiaan Rawlings, Executive Recruiter at EPM Scientific Episode Overview: This week, fan favorite Kristiaan Rawlings returns to RealPharma to give us the raw and real insights on pharma and biotech hiring trends as we hit the midpoint of 2025. From compensation curves and BD boom times to the rise of GLP-1s and the return of oncology, this episode is your ultimate pulse check on where hiring is headed—and how to stand out in a crowded field. Key Topics Covered: 🔹 BD & Search/Eval Roles in Overdrive Why demand is surging—and why having both scientific chops and business fluency makes you the unicorn every company wants. 🔹 Therapy Area Hot List Immunology, inflammation, liver disease (MASH), GLP-1s, and yes—oncology is back, baby. 🔹 Career Advice for Every Archetype Whether you’re a lifer from Big Pharma or a job-hopper with a story to tell, Kristiaan offers smart, tactical advice on how to pitch your value. 🔹 Hiring Manager Intel From pre-reads to leave-behinds to storytelling frameworks like STAR, we cover tools that actually make you memorable in interviews. 🔹 Sales Teams = Prizefighters? Kristiaan breaks down why commercial ops teams are like a boxer’s entourage—and why the whole team needs to hit harder in 2025. 🔹 Show Me the Money Real talk on compensation ranges from Director to SVP (spoiler: the market’s healthy), plus trends in title inflation/deflation. Mentioned in This Episode: Sadhna Bokhiria's salary benchmark post: Kiria Research LinkedIn Post on Pharma Salary Trends EPM Scientific (Kristiaan’s firm): https://www.epmscientific.com Connect with Kristiaan Rawlings: 📩 Kristiaan on LinkedIn 🧪 Check out openings at EPM Scientific: https://www.epmscientific.com/jobs Episode Highlights: “A 16-year tenure at one company? That’s a marriage. But now you’re dating again—and you need to know your story.” — Kristiaan Rawlings 📢 Subscribe to RealPharma Available on Spotify, Apple Podcasts, and wherever you get your dose of biopharma brilliance. 💬 Liked this episode? Let us know what roles or trends you'd like us to cover next time!

🎙 Episode Title: The Future of Biotech Guest: Andrew Craig, Founder of Plain English Finance | Author of Our Future is Biotech 📌 Episode Summary In this bold and wide-ranging conversation, Ian Wendt and Na-Ri Oh sit down with Andrew Craig—British investor, entrepreneur, and author—to explore how biotechnology is poised to shape the next century in the same way physics and computing shaped the last. Craig draws on his decades of experience as a London and New York investment banker and as a former partner at WG Partners, where he advised more than 60 biotech companies and worked on marquee deals like the $7.6B sale of Nordia Bank and IPOs for brands like EasyJet and Burberry. But his latest passion lies at the intersection of finance and innovation: making the case that our future is biotech—without a question mark. 🔍 Topics Covered Why biology will define the 21st century: Andrew outlines the structural and technological reasons biotech is primed for exponential impact. CRISPR, AI, and the "exponential stack": How data storage, ML, and sequencing speed make today's breakthroughs possible. Fixing Europe's biotech lag: The cultural, capital, and regulatory headwinds slowing biotech innovation in the UK and EU. Rebuilding trust in pharma: Why good actors in drug development don’t get headlines—and how that hurts innovation. From Oxford Biomedica to DNA-based storage: Vivid examples of tech cost reductions and where we're headed next. The case for optimism: How to resist the press's negative bias and invest in human progress—literally. 📚 Resources & Links 📘 Andrew’s latest book: Our Future is Biotech on Amazon 📕 His first bestseller: How to Own the World on Amazon 🌐 Plain English Finance: www.plainenglishfinance.com 🔗 Connect with Andrew on LinkedIn: linkedin.com/in/andrewcraigpef 🧠 Memorable Quotes “The last century was about physics and tech. The next one will be about biology—and by extension, biotech.” “If success begets success, then a crop of billion-dollar biotech companies in Europe can kickstart a self-sustaining cycle of innovation and investment.” “People forget that the smartphone they hold was a $100 million science project in the 1990s. Biotech is heading the same direction.” “We need to fight the narrative that pharma is inherently bad. There are good actors, and we must do a better job telling those stories.” 📈 Key Takeaway Biotech isn't just a sector—it's a structural solution to some of humanity’s greatest problems. From disease treatment to environmental restoration, the converging forces of AI, genetics, and biological engineering make this the most consequential time in science since the industrial revolution.

🎙 Episode Title: Rooted in Results: The Future of Functional Medicine with Dr. Erica Armstrong 🧬 Episode Summary In this episode, Dr. Na-Ri Oh and Ian Wendt sit down with Dr. Erica Armstrong, board-certified family medicine physician and founder of Root Functional Medicine, to explore the promise, challenges, and evolution of functional medicine. Dr. Armstrong discusses how Root’s systems-based, data-driven approach is helping patients uncover the root causes of chronic disease, improve outcomes, and reduce reliance on pharmaceuticals—all while scaling care with smart tech and telehealth. Whether you're in biotech, med affairs, or digital health, this conversation offers an eye-opening look into how patient-centric, preventative medicine could transform our approach to chronic disease—and what pharma can learn from it. 🧪 What You'll Learn: Why traditional medicine may be great at managing symptoms—but not always solving problems How functional medicine complements pharmaceuticals and improves adherence The biomarkers we’re missing (hello, fasting insulin!) Why nutrition might be the most under-prescribed medicine How Root Functional Medicine is scaling personalized care without sacrificing quality The role of AI, telehealth, and tech platforms in building the future of functional medicine 🧵 Resources & Links Mentioned: 🔹 Guest Bio & Links Dr. Erica Armstrong, MD, IFMCP Founder, Root Functional Medicine LinkedIn: Dr. Erica Armstrong Website: rootfunctionalmedicine.com Instagram: @rootfunctionalmedicine 📘 Publications & Tools The PCOS Thyroid Connection by Dr. Erica Armstrong Available on Amazon Root’s Blog & White Papers ➤ rootfunctionalmedicine.com/blog ➤ White paper on Autoimmune Conditions: Read here 💊 Related Guests Mentioned Dr. Grace Magedman — Leadership & functional medicine coach LinkedIn: Dr. Grace Magedman 💡 Topics Mentioned Institute for Functional Medicine (IFM) training: functionalmedicine.org GLP-1s and functional complements to pharmaceutical therapies Personalized lab testing and the Root Cause Panel 📱 Follow the Hosts Nari Oh – LinkedIn Ian Wendt – LinkedIn 🧠 Favorite Quotes 🗣 "Functional medicine is not more expensive than missed work, missed vacations, or endless procedures with no answers." – Dr. Erica Armstrong 🧪 "We start with conventionally trained MDs and pair them with dietitians to make the magic happen." 🧠 "Balanced blood sugar—protein, fat, and fiber—is the one thing I tell everyone to start with."

🎙️ RealPharma Podcast Episode Title: Cracking the Code on Patient Engagement: Conversational AI with Dan Fox 🗓️ Release Date: May 5, 2025 🎧 Hosts: Dr. Na-Ri Oh & Ian Wendt 🎤 Guest: Dan Fox, Managing Director of Healthcare at Drips Episode Summary: In this eye-opening episode, we welcome Dan Fox, a trailblazer in AI-powered patient communication, to explore how proactive outreach and conversational AI are reshaping healthcare engagement. As the Managing Director of Healthcare at Drips, Dan shares how his team is using SMS-based AI to boost patient adherence, improve outcomes, and build trust—even in the face of complex compliance and tech fluency challenges. From personalized text reminders that get 60–80% response rates to thoughtful strategies for integrating AI without sacrificing patient experience, Dan takes us deep into what’s working (and what’s not) in healthcare communication today. Plus, he shares what excites him most about the future—including AI therapists, ambient scribes, and closing the tech adoption gap in health systems. 🔑 Key Topics Covered: Why “attention” is the biggest communication challenge in healthcare How AI-driven SMS is outperforming traditional channels like email and mail Real-world outcomes: 4.1% improvement in national medication adherence rates Navigating regulatory complexity with Drips' proprietary “rules engine” Why many healthcare orgs use “compliance” as a crutch against innovation Texting seniors? Yes—it works (and they even say “thank you, sweetie” ❤️) The future of AI in healthcare: from virtual triage to AI therapists 🧠 Notable Quotes: “We’re not using generative AI in our consumer outreach—because every single word needs to be approved. But we use AI to scale natural conversations.” – Dan Fox “Trust is everything. We use personalization and omnichannel context to build it—one message at a time.” – Dan Fox “We don’t want PHI. We just want to start the right conversation.” – Dan Fox 📘 Resources Mentioned: Drips.com – Learn more about their AI-powered engagement solutions CMS Star Ratings: Why medication adherence matters Companies like RxAnte mentioned for rules-based healthcare targeting 📩 Connect with Dan Fox: Website: drips.com LinkedIn: https://www.linkedin.com/in/dsweeneyfox/ Role: Healthcare Strategy Lead 🎧 How to Listen: Available wherever you get your podcasts—Spotify, Apple Podcasts, Amazon Music, and more.

In this powerful and deeply human episode of RealPharma, we’re joined by Grace Magedman, PharmD—former Chief Pharmacy Officer at Children’s Hospital of Orange County, functional medicine practitioner, and founder of The Magidman Group. Grace takes us inside her 20+ years of hospital pharmacy leadership, where she navigated high-stakes medication decisions, complex implementation of rare disease therapies, and the ethical strain of resource constraints. But her most transformative leadership moment came not in the boardroom—but in her own experience of burnout. Now a certified high-performance coach, Grace shares how she rebuilt from the inside out, creating the Functional Resilience Framework—a science-based system that blends neuroscience, functional medicine, and leadership development to help others sustain performance without sacrificing purpose. Whether you’re in pharma, hospital leadership, or simply navigating the demands of high-impact work, Grace’s insights offer a roadmap to lead with clarity, energy, and longevity. 📌 Resources & Links:Learn more about Grace’s work: magedmangroup.com Connect with Grace on LinkedIn: linkedin.com/in/magedman/ Interested in the Functional Resilience Framework? Contact Grace directly for coaching or workshops.

In this second part of our deep dive into hematology and oncology, we welcome back Dr. Yaming Wang, founder of Alphabet Health LTD and an expert in molecular oncology, pharmaceutical strategy, and medical education. Building on our previous discussion, we explore cutting-edge advancements in cancer diagnostics and therapies, including the promise and limitations of liquid biopsies, the evolution of immunotherapy, and the expanding role of CAR-T and antibody-drug conjugates. But innovation alone isn’t enough—how do we ensure these breakthroughs reach the patients who need them most? We tackle the challenges of healthcare communication, provider education, and patient access, examining how AI, public health initiatives, and systemic change can bridge the gap between scientific progress and real-world impact. Join hosts Dr. Na-Ri Oh and Ian Wendt for an engaging and thought-provoking conversation that not only highlights the science behind cancer treatment but also the urgent need to make these life-saving therapies more widely accessible. Don't miss this critical discussion on the future of oncology!

🎙 RealPharma Podcast – Oncology Part 1: Understanding the Cancer Universe with Dr. Yaming Wang Cancer is one of the most complex and pressing challenges in modern medicine. But how much do we really understand about it? In this first episode of our two-part oncology deep dive, we sit down with Dr. Yaming Wang, founder of Alphabet Health, to break down the fundamentals of oncology and hematology. From the earliest discoveries in cancer research to today’s cutting-edge targeted therapies and immunotherapy, Dr. Wang shares his expertise on the science behind cancer, why it remains such a difficult disease to treat, and the role of communication in bridging the gap between innovation and patient care. 🔬 Topics we cover in this episode: ✔ The difference between solid tumors and blood cancers ✔ Why cancer is like its own universe in medicine ✔ How early detection and screening can make a difference ✔ The evolution of chemotherapy, targeted therapies, and immunotherapy ✔ Why science alone isn’t enough—effective communication is key Whether you're a biotech professional, healthcare communicator, or just curious about the latest in oncology, this episode is packed with insights you won’t want to miss. Resources: Dr. Yaming Wang on LinkedIn Alphabet Health LTD General Cancer Information & Education:🔹 National Cancer Institute (NCI) – Comprehensive cancer research and education 👉 https://www.cancer.gov 🔹 American Cancer Society (ACS) – Trusted resource for cancer prevention, diagnosis, and treatment 👉 https://www.cancer.org 🔹 World Health Organization (WHO) – Cancer Fact Sheet – Global insights on cancer trends and impact 👉 https://www.who.int/news-room/fact-sheets/detail/cancer Oncology Research & Innovations:🔹 American Society of Clinical Oncology (ASCO) – Latest breakthroughs in cancer treatment and clinical trials 👉 https://www.asco.org 🔹 National Comprehensive Cancer Network (NCCN) – Guidelines for cancer treatment and best practices 👉 https://www.nccn.org 🔹 ClinicalTrials.gov – Find ongoing cancer clinical trials worldwide 👉 https://clinicaltrials.gov Cancer Screening & Prevention:🔹 CDC Cancer Prevention & Screening Guidelines – Know the recommended screening tests 👉 https://www.cdc.gov/cancer/dcpc/prevention/index.htm 🔹 Prevent Cancer Foundation – Focus on early detection and prevention strategies 👉 https://www.preventcancer.org Emerging Technologies & Future of Cancer Care:🔹 Caris Life Sciences – Liquid Biopsy & Precision Oncology 👉 https://www.carislifesciences.com 🔹 National Cancer Institute – Immunotherapy Research 👉 https://www.cancer.gov/research/areas/treatment/immunotherapy 🔹 AI in Oncology: How Artificial Intelligence is Changing Cancer Detection (Article from Nature) 👉 https://www.nature.com/articles/d41586-020-00847-2 #RealPharmaPodcast #Oncology #CancerResearch #Biotech #Pharma #MedicalInnovation #Immunotherapy #Healthcare

In this episode of Real Pharma, hosts Na-Ri Oh and Ian Wendt engage with Joshua Kettner, co-founder of DreamBody Clinic, to explore the intricacies of stem cell therapy. They discuss the clinic's unique approach to regenerative medicine, the science behind mesenchymal stem cells, and the various applications and limitations of this therapy. The conversation also delves into the regulatory challenges faced in the US and how these impact the availability of such treatments. Kettner shares personal anecdotes and insights from his experience in the field, providing a comprehensive overview of the current landscape of stem cell therapy. In this conversation, Joshua Ketner discusses the complexities of stem cell therapy, including FDA regulations, economic challenges, and the importance of donor vetting. He highlights the risks and efficacy of treatments, the growing interest in longevity and anti-aging, and the vision behind his clinic's approach to regenerative medicine. The discussion emphasizes the need for better accessibility to these treatments for patients in need. Resources: Deam Body Clinic The Ultimate Guide to Stem Cell Therapy Stem Cell Research Learning Center Stem cells: What they are and what they do

In this riveting episode of RealPharma, hosts Na-Ri Oh and Ian Wendt sit down with the renowned ethnopharmacologist, Dennis McKenna, to explore the profound intersection of nature, science, and healing. From Dennis’s storied journey into the world of plant medicines to the evolving landscape of psychedelic therapies, this conversation is as thought-provoking as it is inspiring. Key Topics Discussed: 🌿 Dennis’s Journey: How an early fascination with psychedelics and traditional practices shaped his career in ethnopharmacology. 🌌 Modern Psychedelic Science: The exciting potential of compounds like Ibogaine and psilocybin for treating addiction, PTSD, and neurodegenerative disorders. 🌍 Ethical Dimensions: The importance of honoring indigenous knowledge and the call for reciprocity in drug development. 🔬 Challenges in Biopharma: Why current regulatory frameworks struggle with psychedelics and how innovation can bridge the gap. 🎤 McKenna Academy's Mission: Insights into biodiversity preservation, education, and the Academy’s role in advancing plant medicine research. Notable Moments: Dennis recounts the inspiration behind his 50-year journey in ethnopharmacology. A deep dive into the “set and setting” principle and its importance for both traditional and modern psychedelic practices. Discussion on how biopharma can balance commercialization with ethical responsibilities toward indigenous communities. Insights into the upcoming COCA Summit and its aim to shift perceptions and regulations around this misunderstood plant. Resources: Dennis McKenna on LinkedIn Dennis McKenna on Wikipedia McKenna Academy of Natural Philosophy Wisdom of the Leaf Coca Summit Dennis McKenna books Lykos path to MDMA approval

Year-End Wrap-Up with Kristiaan RawlingsIn this episode of the Real Pharma Podcast, hosts Ian Wendt and Na-Ri Oh welcome back frequent guest Kristiaan Rawlings, a seasoned commercial pharmaceutical recruiter, for a year-end reflection on the pharmaceutical job market in 2024 and a look ahead to 2025. The discussion highlights key trends, challenges, and opportunities for candidates and employers alike. Key Highlights:Job Market Trends Executive Presence Hot Therapeutic Areas Advice for Candidates Employer Insights Looking to 2025 Resources: Kristiaan Rawlings on LinkedIn EPM Scientific Biospace: Top 12 Companies Hiring in Biopharma

In this episode of the Real Pharma Podcast, hosts Ian Wendt and Dr. Na-Ri Oh and guest Jason Scharf delve into the evolving landscape of TechBio, exploring its definition, the rise of bio innovation, and the challenges and opportunities it presents. They discuss the shift from traditional drug development methods to innovative approaches driven by technology, the importance of adapting business models in the pharmaceutical industry, and the need for a balanced regulatory framework that fosters innovation while ensuring safety. Jason shares insights on the future of drug development, the role of big pharma, and the necessity for a collaborative ecosystem to drive progress in healthcare. In this conversation, Jason Scharf discusses the evolving landscape of the TechBio sector, particularly in Austin, Texas. He highlights the intersection of science and policy, the growth of Austin as a tech bio hub, and the dynamics of the local ecosystem. Scharf emphasizes the importance of innovation, investment philosophy, and the future trends shaping the industry. He also shares personal insights on entrepreneurship and the significance of understanding one's skills and passions in driving change. Resources: Jason Scharf on LinkedIn Jason Scharf on X (Twitter) Austin Next Podcast

In this conversation, Roger Estafanos discusses the evolving field of radiopharmaceuticals, highlighting their transformative impact on cancer treatment and patient care. He explains the targeted nature of these therapies, the importance of personalized medicine, and the challenges faced in regulatory processes and patient safety. The discussion also covers the role of different radioisotopes, the complexities of supply chain management, and the need for improved access to these innovative treatments. The conversation delves into the complexities and advancements in the field of radiopharmaceuticals, focusing on logistics, future opportunities, investment landscapes, commercialization challenges, talent acquisition, and technological innovations. The speakers emphasize the importance of optimizing supply chains, the potential for expanding applications beyond oncology, and the role of AI in enhancing imaging processes. They also discuss the need for education among healthcare providers and patients, as well as the personal motivations driving their work in this evolving field. Resources: Roger Estafanos on LinkedIn **Society of Nuclear Medicine and Molecular Imaging (SNMMI)** Comprehensive resource on the use of radiopharmaceuticals in imaging and therapy: [https://www.snmmi.org] **Theragnostics Explained** An introduction to theragnostic approaches combining diagnostics and therapy: [https://www.cancer.gov/about-cancer/treatment/types/theragnostic] **U.S. Nuclear Regulatory Commission (NRC)** Guidelines for handling, licensing, and safe administration of radiopharmaceuticals: [https://www.nrc.gov] **FDA Guidance on Radiopharmaceuticals** Regulatory pathways and guidelines for the development of radiopharmaceuticals: [https://www.fda.gov] **Patient Advocacy in Radiopharmaceuticals** Information for patients and caregivers about radiopharmaceutical therapies: [https://www.patientadvocate.org] **Radiopharmaceutical Treatment Education** Tips and safety guidelines for patients undergoing radiopharmaceutical treatments: [https://www.cancer.net] **AI in Radiopharmaceutical Imaging** How AI is transforming diagnostic imaging and patient care: [https://www.auntminnie.com] **Global Radiopharmaceutical Market Reports** Market trends, forecasts, and analysis: [https://www.globenewswire.com]

In this conversation, Aaron Burnett, from Wheelhouse DMG, discusses the rapid evolution of digital marketing in the healthcare sector, emphasizing the importance of data strategy and compliance with regulations like HIPAA. He highlights the shift from third-party data reliance to first-party data utilization, which enhances marketing effectiveness and patient engagement. The discussion also covers the need for collaboration among marketing, compliance, and IT teams to develop effective data strategies and the role of customer data platforms in personalizing healthcare marketing efforts. In this conversation, the speakers delve into the complexities of data privacy, patient consent, and the ethical implications of using AI in healthcare. They discuss the transformative role of AI and machine learning in digital health, emphasizing the importance of first-party data and the need for compelling content. The conversation also touches on marketing strategies in a digital landscape, the evolution of media mix modeling, and the tools that enhance digital marketing efforts. Finally, the discussion concludes with an inspiring anecdote about unconventional thinking and the pursuit of personal fulfillment. Resources: Aaron Burnett on LinkedIn Wheelhouse DMG Digital Marketing 2024: The Complete Guide For Beginners

In this latest episode of RealPharma, we’re diving back into the fascinating world of AI in pharma, breaking down all the insights from our conversation with the brilliant Andree Bates! If you missed it or want to catch the highlights, this episode serves up a concise, punchy summary covering everything from predictive analytics to patient outcomes and beyond. But there's a twist. Our hosts, this time, bring a unique, fresh perspective to the conversation—you might notice something different about how they tackle the topic. Stick around until the end, and you’ll find out what makes this episode truly special. Curious? You won’t want to miss this one. Tune in, share your thoughts, and see if you can guess what’s up! Resources Andree Bates on LinkedIn Eularis AI in biopharma research: A time to focus and scale AI in Biopharma: Use Cases and Considerations Artificial intelligence and its expanding role across the biopharma landscape

In this episode, Dr. Na-Ri Oh and Ian Wendt sit down with Philip Vyt, a renowned expert in omnichannel strategy and founder of Shyft, a consultancy specializing in omnichannel approaches for biopharma. They delve into the key concepts behind omnichannel and its distinction from multichannel, emphasizing the centrality of healthcare professionals (HCPs) in engagement strategies. Philip breaks down the importance of personalized content delivery and the role of interconnected channels in creating a 360-degree view of HCP interactions. He also shares practical advice for biopharma companies—both large and small—on building effective omnichannel campaigns, starting with "minimal viable campaigns" to learn by doing. The conversation explores the challenges companies face, such as managing content supply chains and the integration of technology, while highlighting the significant investments needed in marketing technology (MarTech) for a truly effective omnichannel approach. Philip also discusses the differences between the U.S. and European markets in terms of data privacy and consent, as well as the evolving role of AI and automation in real-time engagement with HCPs. Throughout, Philip provides actionable insights on how companies can avoid common pitfalls, emphasizing a focus on execution and the importance of aligning marketing with commercial excellence. Listeners will gain a deeper understanding of what it takes to implement a successful omnichannel strategy and why it’s a journey that requires commitment, adaptation, and collaboration across teams. Resources: Philip Vyt on LinkedIn

In this episode, Dr. Na-Ri and Ian Wendt welcome back Kristiaan Rawlings, from EPM Scientific to discuss the latest trends in pharma and biotech hiring. They explore the key drivers of hiring, the impact of AI and advanced analytics, and the evolving expectations of candidates. Kristiaan emphasizes the importance of change agents in the industry and shares insights on the optimistic outlook for small biotechs and oncology. The conversation also touches on strategies for candidates to navigate career transitions and for companies to attract top talent in a competitive market. Resources: Kristiaan Rawlings on LinkedIn EPM Scientific BioSpace 2024 Employment Outlook BioSpace Complete Guide to the Biopharma Job Search BioSpace 2024 Job Search Toolkit

In this episode, Ian Wendt and Dr. Na-Ri Oh interview Michael C. Barnes, Chairman of the Center for US Policy, about the US opioid crisis. They discuss the evolution of US policy on opioids, the impact of the crisis on different communities, the role of legislation and harm reduction, the accountability of the pharmaceutical industry, barriers to accessing treatment, and the importance of advocacy in addressing stigma. The conversation explores various themes related to the substance use disorder crisis, including the lack of parity in insurance plans, the role of prescribers, the need for treatment and support, the potential for decriminalization, the economic impact of substance use disorders, and the US-centric nature of the problem. The guests discuss the importance of addressing substance use disorder as a health condition and providing therapeutic responses and harm reduction services. They also highlight the need for policies that focus on prevention, access to treatment, and economic opportunities for individuals in recovery. The conversation emphasizes the complexity of the issue and the need for comprehensive solutions. Resources: Michael Barnes on LinkedIn Center for US Policy NOPE Task Force Recovery Friendly Workplace Institute Pain News Network

Danny McBryan, an executive leader in the pharmaceutical industry, discusses the evolving role of medical affairs in healthcare. He highlights the importance of medical affairs in conveying the science of pharmaceutical companies and translating complex data into a meaningful narrative for healthcare providers, payers, patients, and policymakers. McBryan emphasizes the need for medical affairs to be seen as a strategic partner rather than a support function and advocates for closer collaboration between medical affairs, health economics, and outcomes research (HEOR) to demonstrate the value of drugs and address unmet needs. He also discusses the impact of digital transformation on medical affairs, including wearables, therapeutic digital solutions, social media, data analysis, and real-world evidence. McBryan envisions a future where medical affairs plays a more strategic role, engages with patients, and contributes to drug discovery and development. RESOURCES Danny MCBryan on LinkedIn Medical Affairs Professional Society The Future of Medical Affairs 2030

In this episode, Na-Ri and Ian interview Stacey Tinianov, an independent patient advocate and founder of Advocates for Collaborative Education. They discuss the importance of patient advocacy, the role of digital health, and the future of patient engagement. Stacey shares her personal journey into patient advocacy and highlights the gaps in knowledge and understanding she experienced as a breast cancer survivor. She emphasizes the need for human-centered design in healthcare, where patients are at the center of the design, development, and deployment of programs and technologies. Stacey also discusses the impact of digital platforms on patient engagement and the importance of building relationships and engaging with patients beyond a transactional level. Patient advocacy is a multifaceted field that encompasses various areas, including clinical trial advocacy, research advocacy, and policy advocacy. The future of patient advocacy lies in the expansion of voices and the focus on improving quality of life and survivorship. Advocates play a crucial role in shaping clinical trials, ensuring patient-reported outcomes are considered, and driving policy changes. The ultimate goal is to achieve true partnerships between advocacy and industry, as well as the decentralization of clinical trials. Patient advocates can effectively communicate by understanding their motivation and goals and tailoring their language to resonate with different stakeholders. The consequences of not getting patient advocacy right include a regression to the frustrating relationship patients had with pharmaceutical companies in the past. However, progress has been made, and patient advocacy has the potential to drive positive change in healthcare. Resources: Stacey Tinianov on LinkedIn Rabble Health Advocates for Collaborative Education International Cancer Advocacy Network Patient Advocate Foundation

Summary Dr. Andrée Bates, a pioneering force in the realm of artificial intelligence within the pharmaceutical industry, shares insights on the evolving role of AI in pharma, the future of healthcare innovation, and her advocacy for women in leadership. She discusses the early days of AI in pharma, the challenges faced, and the evolution of AI terminology. Dr. Bates also explores the application of AI in commercial insights and analytics, market access, drug discovery, and clinical trials. The conversation covers a wide range of topics related to the application of AI in the biopharma industry, including the use of synthetic data, digital twins, regulatory and medical affairs, market access, precision doctor targeting, and ethical implications. Dr. Andree Bates shares insights on the impact of AI on drug discovery, clinical trials, and patient care, as well as the potential for AI to revolutionize the industry. Resources Andree Bates on LinkedIn Eularis AI in biopharma research: A time to focus and scale AI in Biopharma: Use Cases and Considerations Artificial intelligence and its expanding role across the biopharma landscape

Summary In this episode, Dr. Na-Ri Oh and Ian Wendt discuss Pharmacy Benefit Managers (PBMs) and their impact on drug pricing and patient access to medications. They are joined by Antonio Ciaccia, CEO of 46 Brooklyn Research and president of 3 Access Advisors, which provides insights into the role of PBMs in the drug supply chain. The conversation highlights the consolidation of power among the top three PBMs, their anti-competitive behaviors, and the need for increased scrutiny and regulatory measures. The discussion also explores the distorted incentive structures that favor high-cost drugs over lower-cost alternatives, leading to higher drug costs and limited access for patients. The conversation explores the impact of pharmacy benefit managers (PBMs) on drug costs and access to medications. The report states that PBMs control about 70% of all specialty drug revenue, leading to the closure of independent retail pharmacies in rural areas. The conversation emphasizes the need for transparency and accountability in the PBM industry. It also discusses the potential solutions, including market-based approaches and policy changes, to address the inefficiencies and anti-competitive behaviors of PBMs. Resources Antonio Ciaccia on LinkedIn Antonio Ciaccia on Twitter/X 3 Axis Advisors 46 Brooklyn Research FTC Interim Report on PBMs

In this episode, Dr. Na-Ri Oh and Ian Wendt discuss the 340B drug pricing program with guest William Sarraille, a healthcare law expert. They explore the origins of the program and its intended purpose. However, the program has grown exponentially and is now the second largest drug program in the country. Bill raises concerns about the lack of transparency and accountability in the program, as well as the impact on patients. He argues that the program should focus on delivering value to patients and ensuring that they benefit from the discounts. The conversation delves into the complexities and challenges of the 340B program, highlighting issues such as the patient definition, transparency, contract pharmacies, and the allocation of funds. The discussion considers the need for a more comprehensive and transparent system that ensures the benefits of the program flow to the patients. They also explore the possibility of implementing a claims data process that provides faster payment and greater certainty for both manufacturers and 340B entities. The conversation concludes with a reflection on the importance of leadership and collaboration in finding solutions to the program's problems. Resources: William Sarraille on LinkedIn HRSA 340B Information American Hospital Information (AHA) Fact Sheet 340BHealth.org

Summary Dr. Ron Shigeta, a pioneer in the biotech startup ecosystem, shares his insights and experiences in this episode. He discusses the success of IndieBio, a biotech accelerator that demonstrated the potential of modest investments in fueling biotech innovations. Dr. Shigeta also highlights the importance of timing, luck, and having a clear vision in the biotech industry. He explains the differences between synthetic biology and pharma startups and the challenges and opportunities they present. Additionally, he discusses the factors he considers when evaluating startup opportunities and the mindset of successful entrepreneurs. Finally, he shares his perspective on managing risk in biotech startups and the personal transition of becoming a startup CEO. In this conversation, Ron Shigeta discusses the landscape of venture capital funds and startup incubators, highlighting the importance of fund size and check-writing capabilities. He also explains his attraction to the food industry and the deep structural biology of food. The convergence of food and biotech is explored, with a focus on consumer applications and health-related applications. Ron shares different strategies for innovation and offers advice for aspiring entrepreneurs. He discusses promising areas for transformational impact, including the golden age of biology and the future of food and sustainability. Chapters 00:00 Introduction to Dr. Ron Shigeta 01:31 Dr. Shigeta's transition from scientist to biotech startup figure 05:19 The impact of IndieBio's small investment model 08:43 The economics of biotech startups 09:57 Different pathways in biotech: synthetic biology vs. pharma 13:42 Factors in evaluating startup opportunities 14:09 The mindset of successful entrepreneurs 19:35 The importance of company vision and team dynamics 22:23 Managing risk in biotech startups 27:28 The personal transition of becoming a startup CEO 31:23 The risk tolerance of entrepreneurs 32:36 Venture Capital Funds and Startup Incubators 37:15 The Attraction of the Food Industry 42:30 Convergence of Food and Biotech 46:12 Innovation in Biotech and Pharma 49:37 Different Strategies for Innovation 51:42 Advice for Aspiring Entrepreneurs 53:47 Promising Areas for Transformational Impact 01:01:26 The Golden Age of Biology 01:04:51 The Impact of Whole Foods Conference 01:08:49 The Future of Food and Sustainability Resources: Ron Shigeta on LinkedIn Ron Shigeta on X (Twitter) iAccelerate

In this enlightening episode of the RealPharma Podcast, hosts Ian Wendt and Dr. Nari Oh sit down with Dr. Steven King, a luminary in the field of ethnobotanical research and sustainable pharmaceutical development. Dr. King, currently serving as the Chief Sustainable Supply, Ethnobotanical Research, and IP Officer at Jaguar Health, shares his remarkable journey from a young adventurer in the Amazon rainforest to a pioneering figure in the integration of traditional botanical knowledge with modern medicine. Join us as we delve into the fascinating world of ethnobotany, exploring how Dr. King's lifelong passion for plant-based healing has led to groundbreaking developments in the pharmaceutical industry. Discover the story behind the Croton lechleri tree, popularly known as the Dragon's Blood tree, and how its unique properties have been harnessed to create an FDA-approved medication derived from this Amazonian marvel. Dr. King offers insights into his early experiences living with indigenous communities in South America, learning about their traditional uses of plants for medicine, and the ethical considerations involved in bringing these ancient practices into the global market. We discuss the importance of sustainability and respectful collaboration with local communities, emphasizing the crucial balance between conservation and commerce. This episode also touches on the broader implications of Dr. King’s work, from his contributions to the Healing Forest Conservatory to the role of bioethics in the commercialization of traditional knowledge. As the conversation unfolds, we explore the exciting future of plant-based therapeutics and the potential for ethnobotanical research to address some of the most pressing health challenges of our time. Tune in for a captivating discussion that spans decades of exploration, scientific discovery, and cultural exchange, highlighting how ancient wisdom can inform and transform modern healthcare. Chapters 00:00 Introduction to Ethnobotany 02:04 Biocultural Diversity and Pharmaceutical Development 13:20 The Croton lechleri Tree and its Medicinal Uses 15:59 Ethnobotanical Research vs. Traditional Drug Development 21:39 Intellectual Property and Benefit-Sharing 24:27 Ethical and Sustainable Practices in Working with Indigenous Communities 28:27 Respecting Indigenous Knowledge and Rights in Plant-Based Medicine Development 34:03 The Financial Benefits of Commercializing Plant-Based Drugs for Indigenous Communities 36:23 The Potential Therapeutic Applications of Psychedelic Research Resources: Dr. Steven King - LinkedIn One River: Explorations and Discoveries in the Amazon Rain Forest Plants, People, and Culture: The Science of Ethnobotany

Command the Room: Dr. Laura Sicola's Strategies for Executive Communication Excellence Hosts: Dr. Na-Ri Oh and Ian Wendt In this episode of the Real Pharma Podcast, we delve into the intricacies of effective executive communication with Dr. Laura Sicola, a renowned expert in leadership communication and cognitive linguistics. Dr. Sicola has spent over two decades transforming top-level executives into confident, inspiring leaders. Her unique approach, grounded in cognitive linguistics, empowers professionals to communicate their passion and expertise effectively, ensuring they get the buy-in they need for the results they want. Join us as we explore these topics and more, providing valuable insights for pharma professionals and anyone looking to enhance their executive communication skills. Dr. Sicola's expertise offers a roadmap to becoming a more effective and inspiring leader. Chapters 00:00:00 - Introduction to WIFM: What's In It For Me? 00:00:34 - Real Pharma Podcast Introduction 00:01:02 - Introducing Dr. Laura Sicola 00:02:37 - Welcome and TEDx Talk Discussion 00:03:51 - Defining Linguistics 00:04:41 - Importance of How You Say It 00:05:52 - The Myth of Content vs. Delivery 00:07:01 - The Linguistic Glass Ceiling 00:09:06 - Transitioning from Technical Expertise to Leadership 00:11:04 - Your Work Speaks for Itself, But Not for You 00:12:24 - Developing Leadership Skills 00:13:07 - The Challenge of Self-Awareness 00:15:33 - Recording Yourself for Self-Diagnosis 00:17:16 - Impact of COVID on Communication 00:18:48 - Basic Skills for Effective Communication 00:20:14 - Executive Presentations: What's In It For Them? 00:23:05 - Seeking Constructive Feedback 00:25:27 - Common Reasons for Seeking Coaching 00:27:05 - The Expert's Curse 00:29:37 - The Gift of Clear Feedback 00:30:39 - Proactively Seeking Feedback 00:32:14 - Questions to Ask for Constructive Feedback 00:35:01 - The Importance of Diverse Feedback 00:36:20 - Communicating Complex Data Effectively 00:37:04 - The Role of Slide Design in Communication 00:40:13 - The Value of Interpretation and Insights 00:41:17 - Two Versions of PowerPoint: Pre-Read and Presentation 00:43:08 - The $200 is $200 Rule Resources Find Dr. Laura Sicola on: LinkedIn Twitter laurasicola.com Speaking To Influence TEDx Talk

Summary Ilisa Bernstein, a senior Vice President at the American Pharmacists Association, discusses the history and current landscape of drug importation policies with a focus on Florida's program. Safety concerns, supply chain issues, and intellectual property rights are key considerations. The impact on the Canadian drug supply and the transparency of imported drugs for consumers are also discussed. Manufacturer concerns regarding rebates and discounts, as well as potential oversupply and export restrictions, are highlighted. The conversation explores the complexities and concerns surrounding drug importation programs. It discusses the mechanisms that manufacturers may use to control drug importation, such as restricting volume or increasing prices. The potential impact on the drug supply in Canada and the need for policies to protect it are also examined. The logistical challenges at the border and the vulnerabilities in the drug supply chain are highlighted. The importance of maintaining patient confidence in drug quality and the risks associated with personal drug importation are discussed. The conversation concludes by considering alternative solutions to lower drug prices and the inspiration drawn from historical figures. Chapters 00:00 Introduction of Ilisa Bernstein 01:19 Background on Drug Importation 08:21 Safety Concerns 10:04 Supply Chain and Drug Source 14:58 Transparency and IP Issues 20:57 Consumer Transparency and NDC Numbers 21:10 Intellectual Property Concerns 22:59 Challenges and Points of Contention 25:12 Manufacturer Concerns: Rebates and Discounts 28:06 Oversupply and Export Restrictions 29:09 Mechanisms to Control Drug Importation 30:39 Policies to Protect Drug Supply in Canada 31:12 Logistical Challenges at the Border 33:07 Vulnerabilities in the Drug Supply Chain 35:03 Maintaining Patient Confidence in Drug Quality 36:31 Risks Before the Border 38:01 Complexities and Concerns for Community Pharmacists 41:31 The Future of Drug Importation Programs 44:00 The Motivation Behind Drug Importation Programs 46:01 Exploring Other Solutions to Lower Drug Prices 48:19 The Illegality of Personal Drug Importation 49:05 Balancing Cost Savings and Patient Safety 50:02 Inspiration from Historical Figures Resources: Ilisa Bernstein American Pharmacists Association The Partnership for Safe Medicines

Summary In this episode, Kristiaan Rawlings discusses the 2024-2025 Commercial Market Update and Salary Guide produced by EPM Scientific. The life sciences sector remains resilient due to aging populations, scientific advances, and robust investment. Hiring practices and compensation are influenced by these factors across the Americas, Europe, and APAC regions. The hiring focus has shifted from life-threatening diseases to more common health issues, such as dermatology and respiratory diseases. The most in-demand roles include marketing, commercial operations (salesforce effectiveness, commercial analytics, and training), and sales. Market access roles have seen less demand. Despite the availability of talent, salaries have remained high or even increased. In this conversation, Kristiaan Rawlings discusses the current trends in the life sciences job market, specifically in the commercial operations field. He explains the increase in demand for talent, the impact of title deflation, and the rise in salaries. He also highlights the regional differences in job opportunities, with a shift towards the East Coast of the United States. Additionally, he touches on the importance of executive presence and the return of in-person networking events. Overall, the conversation provides valuable insights into the evolving landscape of the life sciences job market. Chapters 00:00 High Demand for Marketing Roles 04:26 Focus on Core Areas with Existing Blockbuster Products 05:53 Sought-After Skills for Commercial Operations and Product Launches 13:54 Challenges with LinkedIn Applications and Fake Job Postings 24:25 Selective Market Based on Therapy Area and Experience 24:51 The Three Pillars of Focus: Salesforce Effectiveness, Commercial Analytics, and Training 25:21 High Demand for Talent in Incentive Compensation, Analytics, and Competitive Intelligence 26:17 Sales Roles in High Demand During Product Launches 26:46 Quiet Market in the Field of Market Access 27:14 Salaries Holding Strong or Increasing Despite High Supply of Talent 32:30 Geography Becoming Less of a Factor in Salary and Opportunity 41:08 High Demand for Medical Affairs and Health Economics 44:01 The Importance of Executive Presence and Networking for Career Success Resources Kristiaan Rawlings - LinkedIn 2024/2025 EPM Commercial Update and Salary Guide

Summary In this episode, hosts Ian Wendt and Dr. Na-Ri Oh , and guest Kira Dineen discuss the intersection of genomics and healthcare. They explore the concept of personalized medicine and how advancements in genomics are revolutionizing healthcare. Kira shares her personal journey and the inspiration behind her DNA Today podcast. The conversation delves into the technology behind personalized medicine and the challenges of building comprehensive genetic databases. The ethical considerations of genomics, including access to information and the potential misuse of genetic data, are also explored. The episode concludes with a discussion on the need for ethical frameworks to keep pace with technological advancements in genomics. The conversation explores the controversial topic of gene editing, particularly the use of CRISPR technology. The hosts discuss the ethical considerations and the choice of genetic targets for editing. They also touch on the accessibility and long-term consequences of CRISPR. The conversation then shifts to the cost of treatment and the role of genetic testing in drug development. The potential of AI in genetic research is explored, as well as the future of personalized medicine. The episode concludes with a discussion on professional motivation and the importance of networking. Chapters 00:00 Introduction to Kira Dineen and the Intersection of Genomics and Healthcare 02:07 Genomics and Personalized Medicine 04:13 Kira Dineen's Personal Journey and the DNA Today Podcast 08:08 The Trend Towards Personalized Medicine in Biopharma 10:11 The Technology Behind Personalized Medicine 12:39 Building Databases and Overcoming Barriers 15:18 Ethical Considerations in Genomics 20:39 Ethics and the Use of Genetic Information 24:06 Ethics Keeping Pace with Technological Advances 25:44 Managing Ethical Considerations in Genetic Research 27:21 Controversial Gene Editing 28:18 Choosing Genetic Targets 29:10 Ethical Considerations 29:44 Accessibility of CRISPR 30:13 Long-Term Consequences of CRISPR 32:51 Healthcare Equity and Cost of Treatment 34:25 Cost of Genomic Sequencing 35:22 Genetic Testing and Drug Development 38:13 Role of Genetic Testing in Clinical Trials 42:20 AI in Genetic Research 46:34 Future of Personalized Medicine 49:56 Professional Motivation and Networking Resources: Kira Dineen, MS, LCGC, CG(ASCP)CM (LInkedIn, Twitter) DNAtoday.com Breath from Salt (DNA Today author interview Episode #147) Maury Povich interview on DNA Today Patient Empowerment Program: A Rare Disease Podcast

Dive into the high-stakes world of Venture Capital in biopharma with Jim Trenkle! Have you ever wondered what it takes to turn groundbreaking scientific discoveries into life-saving treatments? What role do venture capitalists play in this thrilling journey from the lab to the clinic? This episode peels back the curtain on the biopharma venture capital scene, revealing the risks, rewards, and radical innovations driving the future of healthcare. Join hosts Dr. Na-Ri Oh and Ian Wendt as they explore with Jim the secrets of successful biopharma investments, the challenges of navigating the complex landscape of medical research funding, and the thrilling potential of the next big breakthroughs. Don't miss this conversation that could change the way you see medicine and innovation. In this episode, Jim Trenkle, a partner at Nova Holdings, shares insights on venture capital in the biopharma industry. He explains the different stages of investment, from seed rounds to IPOs, and the role of venture capitalists in providing capital and expertise. Jim discusses the current state of raising capital for biotech startups, including the impact of interest rates and market conditions. He also highlights the challenges and evaluation criteria in biotech VC, emphasizing the importance of a well-thought-out plan and addressing unmet needs. Jim Trenkle also discusses his own career path and the importance of finding work that has a deeper impact. He shares his journey from being a medicinal chemist to venture capital, highlighting the value of lifelong learning and broadening one's impact. Trenkle also discusses the challenges and skills required in venture capital, emphasizing the need for humility and the ability to make decisions that have a real impact. He reflects on the lessons learned from the Theranos scandal and the role of venture capitalists in evaluating companies. Trenkle explores the reasons behind company closures and failures in the biopharma industry and the potential for innovation and technological advances to shape the future of venture capital. He concludes with advice on career growth and the importance of following one's passion. Chapters 00:00 Introduction of Jim Trankel 01:01 Understanding Venture Capital in BioPharma 07:59 The Current State of Raising Capital for Biotech Startups 11:23 The Landscape of Biotech Funding 16:25 Challenges and Evaluation in Biotech VC 23:16 What Does Good Look Like and Pitfalls to Avoid 31:19 Jim Trankel's Career Path 31:59 Career Path and Impact 35:19 Challenges and Skills in Venture 37:05 Evaluating Companies and Capital Allocators 38:23 Lessons from Theranos 46:01 Company Closures and Failures 52:42 The Future of VC in Biopharma 58:32 Advice and Mentors Resources Jim Trenkle, PhD (LinkedIn) Novo Holdings 1. **2024 US Venture Capital Outlook | PitchBook**: Provides predictions for the US VC ecosystem in 2024, including insights on unicorn companies and valuation trends 2. **2024 Venture Capital Trends: Opportunities and Challenges - Founders Network**: Discusses the shift towards startups demonstrating strong fundamentals and a clear path to profitability 3. **2024 Outlook: Private Equity & Venture Capital - Cambridge Associates**: Highlights the expected increase in capital flows to private European turnaround and value strategies 4. **5 Trends to Watch: 2024 Venture Capital | Greenberg Traurig LLP**: Governance issues and IPO momentum are among the trends highlighted for VC in 2024 5. **Global Venture Capital Outlook: The Latest Trends | Bain & Company**: Covers a broad range of industries and the impact on venture capital funding 6. **4 Important Venture Capital Trends (2024-2026) | Exploding Topics**: Explores equity crowdfunding platforms like WeFunder and StartEngine, highlighting their growth and impact on the startup funding landscape 7. **Venture capital market to seek new floor in 2024 | EY - US**: Provides insights into the economic headwinds impacting investor appetite and the outlook for the VC market in 2024 8. **5 Venture Capital Trends to Watch in 2024 | Coresignal**: Discusses portfolio diversification and the role of cryptocurrency in VC trends 9. **Top 4 Trends in Venture Capital for 2024 | Allvue Systems**: Highlights the opportunities in the European VC market and the ongoing interest in AI and biotech startups 10. **2024 Trends in Venture Capital | Deloitte US**: Offers a perspective on the state of the IPO market, with AI as a potential catalyst for change