Ep. 44 Testosterone Replacement Therapy: An Evolutionary Lens

Testosterone Replacement Therapy is gaining popularity with many advocates and detractors. Lucas and Brion explore the evolutionary basis for testosterone and how that can inform your choice on whether to get on TRT Notes: Testosterone prescribing in the United States, 2002-2016: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396809/ Danish Study on Lowering T levels: https://academic.oup.com/jcem/article/92/12/4696/2597312#52560365 The He Hormone, 2000 New York Times: https://www.nytimes.com/2000/04/02/magazine/the-he-hormone.html Testicle Shrinkage: https://www.thebodywellusa.com/will-taking-testosterone-make-testicles-shrink/ Testosterone Therapy and anabolic steroids: https://thinksteroids.com/steroid-profiles/testosterone/ TRT shuts down production of Pregnenolone and other upstream metabolites: https://www.sciencedirect.com/science/article/pii/0022473185902572?via%3Dihub Supplementing Pregnenolone: https://www.testosteronewisdom.com/pregnenolone-what-you-need-to-know-about-this-precursor-hormone/ Forum thread on suppression: https://www.excelmale.com/forum/threads/anabolic-steroids-and-trt-decrease-shbg-dhea-pregnenolone-and-progesterone-in-men.3990/ T Trials showing Plaque Build Up: https://www.npr.org/sections/health-shots/2017/02/21/515456194/does-testosterone-improve-older-mens-health-it-depends Evolutionary Psychology Wiki: https://en.wikipedia.org/wiki/Evolutionary_psychology More Boy Children After War: https://www.popsci.com/scitech/article/2008-12/why-does-war-breed-more-boys/ Ghengis Khan’s 16 Million Children: https://www.thevintagenews.com/2018/06/09/genghis-khan/ NY Times Is There Anything Good about Men: https://tierneylab.blogs.nytimes.com/2007/08/20/is-there-anything-good-about-men-and-other-tricky-questions/ Low Free Testosterone Predicts Mortality from Cardiovascular Disease: https://academic.oup.com/jcem/article/97/1/179/2833341 Benefits and Risks of TRT: https://www.excelmale.com/trt-benefits-vs-risks/ The Testosterone Scam the Kills Healthy Men: https://www.healthscamsexposed.com/2014/03/the-testosterone-scam-that-kills-healthy-men/ Testosterone linked to shorter male lifespan: https://www.news.com.au/lifestyle/health/testosterone-linked-to-shorter-male-lifespan/news-story/539c29145e7b98692c176e182ee4f777 Testosterone Levels Drop after having kids: https://www.medicalnewstoday.com/articles/234266.php#1 Low Testosterone and Suicide: https://www.ncbi.nlm.nih.gov/pubmed/23893672 Lower Testosterone causing suicide?: https://www.1st-man.com/low-testosterone-male-suicide/ Silent Epidemic of Male Suicide: https://www.bcmj.org/articles/silent-epidemic-male-suicide Music by Jenny Jahlee from Live at KBOO