![PubReading [173] - CAR T cell immunotherapy for human cancer - C. June, M. Milone et al.](https://media.rss.com/pub-reading/20220604_120651_b1eb6c62ae4201ef92e04bdcecbaf143.jpg)
PubReading [173] - CAR T cell immunotherapy for human cancer - C. June, M. Milone et al.
PubReading · Mando Mourad
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Show Notes
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years.
DOI: 10.1126/science.aar6711 - 2018