![PubReading [140] - Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis - R. D’Agata, M. Giuffrida and G. Spoto](https://media.rss.com/pub-reading/20220604_120651_b1eb6c62ae4201ef92e04bdcecbaf143.jpg)
PubReading [140] - Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis - R. D’Agata, M. Giuffrida and G. Spoto
PubReading · Mando Mourad
Audio is streamed directly from the publisher (content.rss.com) as published in their RSS feed. Play Podcasts does not host this file. Rights-holders can request removal through the copyright & takedown page.
Show Notes
The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the basis of innovative cancer detection methods based on liquid biopsy. Such methods are expected to provide new opportunities for a better understanding of cancer disease at the molecular level, thus contributing to improved patient outcomes. Advanced biosensors can advance possibilities for cancer-related nucleic acid biomarkers detection. In this context, peptide nucleic acids (PNAs) play an important role in the fabrication of highly sensitive biosensors. This review provides an overview of recently described PNA-based biosensors for cancer biomarker detection. One of the most striking features of the described detection approaches is represented by the possibility to detect target nucleic acids at the ultra-low concentration with the capability to identify single-base mutations.
doi: 10.3390/molecules22111951 - 2017