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Soaring global inflation. Rising fuel prices. A deadlocked Congress unable to tackle sweeping gun safety legislation. President Biden and his aides are frustrated by a cascade of challenges — and the window for a political revival is closing. Jonathan Lemire reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Gulf Coast's long reign as a hub for oil and gas production could help it secure a lead role in generating energy from wind and green hydrogen, but it will face some big obstacles. Kelsey Tamborrino reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

The 5-4 decision blocking Texas’ social media law was closer than expected, and Justice Samuel Alito’s dissent suggests conservative judges may be shifting on the free speech rights of tech platforms. Brendan Bordelon reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

A pair of federal programs compensating people who suffer injuries from vaccines and pandemic treatments are now facing so many claims that thousands of people may not receive payment for their injuries any time soon. Covid has only made it more complicated. Lauren Gardner reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Even by the cash-flush standards of modern politics, Rick Caruso’s run for mayor of Los Angeles has been a shock-and-awe campaign of financial bombardment. Elena Schneider reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

As the White House this month weighed how hard to engage Amazon founder Jeff Bezos over his criticism of its economic policies, it brought back senior advisor Anita Dunn, whose former firm does work for Amazon. Hailey Fuchs reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

A new investigation from Politico’s E&E News has pulled back the curtain on FEMA’s unfair flood grant programs, which for years have favored wealthy and white areas. Tom Frank reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Governments warn against panicking, but they are planning for the worst outcome. Carmen Paun reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Due to a combination of Food and Drug Administration regulations and trade policy, 98% of the infant formula consumed in the United States is made here. But the current nationwide shortage of infant formula is proving a cautionary tale. Doug Palmer reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

What’s next for Georgia Gov. Brian Kemp? Will the national fight over abortion lead to Rep. Henry Cuellar’s (D-Texas) defeat in the primary? Scott Bland shares his burning questions ahead of tonight's primaries. Learn more about your ad choices. Visit megaphone.fm/adchoices

Senate Minority Leader Mitch McConnell is determined to stamp out an isolationist, pro-Trump wing of his party that has pushed back on $40 billion in aid to Ukraine — and U.S. support more broadly. Andrew Desiderio reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Vice President has cast more tie-breaking votes than all but two predecessors. It’s starting to frustrate some staff. Eugene Daniels reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Legalizing weed isn’t the top priority for most voters, but Pennsylvania Lt. Gov. John Fetterman — who clinched the Dem nom for Senate — is betting that it could help draw people to the polls. Natalie Fertig reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

When friends and family got sick last year, people across Ghana scrambled to get shots. But there weren’t enough. Now, many say they don’t want the jab. Local volunteers are struggling to change their minds. Erin Banco reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today, primary voters in North Carolina's 11th Congressional District will decide whether their representative has become more trouble than he's worth. Once a rising conservative star, Cawthorn is now mired in controversy, facing the very real possibility his electoral career might end as quickly as it began. Michael Kruse reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

A growing number of U.S. lawmakers are pressing the Biden administration to establish a humanitarian corridor in the Black Sea, to help transport millions of tons of grain from Ukraine to the world food supply. But doing so is complicated — and could provoke retaliation from Russia. Meredith Lee reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

President Joe Biden and Democrats have pushed through billions of dollars in new funding for rural development. But now comes the hard part — working through a federal bureaucracy that makes it almost impossible for local leaders in the smallest, poorest areas to figure out how to get the money. Ximena Bustillo reports on a new system that hopes to solve the problem. Learn more about your ad choices. Visit megaphone.fm/adchoices

Blue-state governors and lawmakers from California to New York are vowing to turn their states into sanctuaries for people seeking abortions. Plus, the years-long push for over-the-counter birth control is ramping up inside the FDA in the wake of a potential Supreme Court decision rolling back abortion rights. Lauren Gardner reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

The debate over Bitcoin and other cryptocurrencies took on a new dimension last month when Fidelity Investments, one of the world’s largest asset managers, announced that it would soon allow participants in its 401(k) plans to invest some of their retirement savings in Bitcoin. Last Wednesday, that led Sens. Elizabeth Warren, D-Mass., and Tina Smith, D-Minn., to send Fidelity a letter challenging the decision. Ben Schreckinger reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

A bitter GOP primary in West Virginia has turned into one of the most hard-fought Republican primaries of the midterms, testing everything from Trump’s influence and the potency of ideological purity to small government to whether a GOP congressman can sell his primary voters on the merits of a bipartisan compromise in a hyper-polarized climate. Ally Mutnick reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Last week, speculation spread that the U.S. provided intelligence to Ukraine that helped target Russian generals and Russia’s Moskva warship. Alex Ward explains why these leaks created such a firestorm. Learn more about your ad choices. Visit megaphone.fm/adchoices

Presenting Playbook Deep Dive: This week on Playbook Deep Dive, POLITICO’s Peter Canellos talks with our own Josh Gerstein, who broke this week’s massive news that the Supreme Court’s conservative majority has drafted an opinion to overturn Roe v. Wade. Peter and Josh nerd out on everything from the history of the court, to potential implications of the draft opinion — both for the country and the judiciary itself. Peter Canellos is POLITICO's managing editor for enterprise.Josh Gerstein is POLITICO's senior legal affairs reporter.Kara Tabor is a producer for POLITICO audio.Brook Hayes is a producer for POLITICO audio.Adam Allington is senior producer for POLITICO audio.Jenny Ament is executive producer for POLITICO audio. Learn more about your ad choices. Visit megaphone.fm/adchoices

Clinical trials have long been plagued by inefficiency, lack of diversity and the inability to leverage data. The pandemic increased the need to modernize trials, which pushed many trials to lean on technology to conduct trials remotely. Ben Leonard explains why money is pouring into the space and why many clinical trials are still stuck in the previous century. Learn more about your ad choices. Visit megaphone.fm/adchoices

According to an initial draft majority opinion written by Justice Samuel Alito circulated inside the court and obtained by POLITICO, the Supreme Court has voted to strike down the landmark Roe v. Wade decision, kicking abortion policy to the states. Michigan Gov. Gretchen Whitmer filed a lawsuit last month challenging her state’s 1931 law banning abortion, which would go into effect when Roe is struck down. Alice Miranda Ollstein reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Biden administration is scrambling to counter China’s new security pact with the Solomon Islands and a possible military base in the South Pacific nation. Phelim Kine reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Months before two infants died and another was hospitalized from bacterial infections, a whistleblower alerted senior FDA officials to what he said were "lax practices, including regulatory violations" at an Abbott Nutrition infant formula plant last October. But it was still months before the FDA investigated and formula was recalled. Helena Bottemiller-Evich reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Presenting Playbook Deep Dive: The White House Correspondents’ Dinner is back for the first time since 2019. Journalists, A-list celebrities and Washington’s power players will pack the cavernous ballroom at the Washington Hilton. That means brunch is back too. On this week’s episode, Playbook co-author Ryan Lizza gets a tour from Tammy Haddad at the site of her annual garden brunch, one of the most sought after invites of the weekend. Plus, insights from comedian and WHCD alum Elayne Boosler and Ed Solomon of Anthony's Tuxedos in Georgetown. Learn more about your ad choices. Visit megaphone.fm/adchoices

The FDA may propose a rule banning menthol cigarettes as early as today, a decision 10 years in the making. Katherine Foley reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

The world’s richest man has a lot of experience getting his way in Washington. But doing it as Twitter's owner may be different. Rebecca Kern reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Federal regulators are just beginning to tackle a technical flaw that threatens to hold back the United States’ next giant leap in communications: Many of our radios suck. John Hendel reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

An alleged human trafficking ring in Georgia highlights many of the loopholes found in the H-2A agricultural visa program, renewing calls for an overhaul. Ximena Bustillo reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

This week Playbook co-author Ryan Lizza is in Arizona to dig into a few big plotlines ahead of this year’s elections. Trump narrowly lost the state in 2020, Senator Mark Kelly – the Democratic incumbent – is one of the most vulnerable senators up for reelection this year and strategists are already looking at the 2024 Senate election to see who will run against Kyrsten Sinema. On this week’s Playbook Deep Dive Episode, Ryan joins Rep. Ruben Gallego for a long dinner and a few drinks. They discuss Gallego’s fraught history with Sinema, a potential campaign against her in 2024, the political environment in Arizona ahead of midterms and his deployment in the Iraq war. Ryan Lizza is a Playbook co-author for POLITICO.Rep. Ruben Gallego is the congressman for Arizona's 7th district.Kara Tabor is a producer for POLITICO audio.Carlos Prieto is a producer for POLITICO audio.Brook Hayes is senior producer for POLITICO audio.Jenny Ament is executive producer for POLITICO audio. Learn more about your ad choices. Visit megaphone.fm/adchoices

Learn more about your ad choices. Visit megaphone.fm/adchoices

Russia’s ambassador to the United States can’t get meetings with senior officials at the White House or the State Department. He can’t convince U.S. lawmakers to see him, and it's rare to find an American think tanker who’s willing to admit to having any contact with the envoy. Senior foreign affairs correspondent Nahal Toosi discusses her conversation with Russia’s ambassador to the U.S. and D.C.'s loneliest man, Anatoly Antonov. Learn more about your ad choices. Visit megaphone.fm/adchoices

We're six and a half months out from the the midterms, and to keep track of the almost 500 seats up for grabs, POLITICO has launched an election forecaster. Steve Shepard, the man behind the tracker, breaks down his 2022 election predictions and which races to keep an eye on. Learn more about your ad choices. Visit megaphone.fm/adchoices

A newly drawn House district offered the prospect of electing Oregon’s first Latina to Congress. Then a top super PAC unexpectedly swooped in. Sabrina Rodriguez reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Gentrification has dramatically transformed Washington, D.C. — as a result, the city now has a smaller Black population. That decline mirrors a nationwide trend, nine of the 10 cities with the largest Black populations have also seen decreases in Black residents. Delece Smith-Barrow reports on the latest installment of The Recast’s Next Great Migration series: Washington, D.C. Read the full piece here. Read other Next Great Migration work at politico.com/greatmigration Learn more about your ad choices. Visit megaphone.fm/adchoices

Insulin is what economists would call a super inelastic product — no matter what the cost is, people will pay for it because it's a life-saving medication. Two bills currently in Congress hope to drive down costs. Katherine Foley reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

American consumers are seeing food prices rise at the fastest rate since 1981. Supply chain snarls, labor shortages and climate challenges — plus the conflict in Ukraine — share the blame. Steven Overly reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

As political pressure grows to crack down on Russian oligarchs, U.S. policymakers are taking a deeper look at an industry that has long avoided anti-money-laundering rules: real estate. POLITICO's Katy O'Donnell discusses the push in Congress to close foreign money loopholes. Learn more about your ad choices. Visit megaphone.fm/adchoices

A POLITICO investigation based on more than 50 interviews finds the FDA is failing to meet American consumers' expectations on food safety and nutrition. POLITICO's Helena Bottemiller Evich reports on the agency's structural flaws and the risks posed to Americans. Learn more about your ad choices. Visit megaphone.fm/adchoices

Trained by the U.S. Army, a group of trailblazing Afghan women became a formidable military force during the war in Afghanistan. They now live scattered around the U.S., stuck in immigration limbo. Amanda Ripley reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Federal protections for state and territorial cannabis markets don't apply to Native American tribes. Natalie Fertig reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

On Monday, the U.N. offered a familiarly stark report card on the world’s progress on cutting emissions from the IPCC, which has been monitoring climate change since 1988. Despite the panel's regular reports about the consequences of burning fossil fuels, between 1990 and 2019 global emissions rose 54 percent and they are still rising. POLITICO's Karl Mathiesen reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Amazon has been pushing into health care for years, starting with wearable health devices and pharmacy services. But the nationwide expansion of its “Amazon Care” service is its biggest move in the rapidly growing telehealth industry, which could grow to a $20 billion sector over the next five years. Emily Birnbaum reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

In a copy of a Zoom recording provided to POLITICO, New York City Mayor Eric Adams instructed administration staff that every single communication from a city agency, down to notices about cherry blossoms in bloom, must be approved by City Hall — warning that anyone violating his “discipline of message” would be fired. Julia Marsh reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

A raft of punishing sanctions sent Russia’s currency crashing after its invasion of Ukraine. A month later, the ruble has staged a dramatic recovery — putting pressure on the Biden administration and allies to deploy even tougher measures. But officials say the ruble's recovery is not necessarily a sign of improvement in the Russian economy or Putin’s position. Kate Davidson reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

POLITICO reporter Rachael Levy broke the story that some hospitals have been asking patients to remove their N95 masks — even though they offer better protection. Rachael’s reporting changed a national policy in a matter of days — but the question remains why policymakers in the US are behind on mask guidance. Rachael Levy reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Florida’s fight over contentious LGBTQ legislation — the "Parental Rights in Education Bill," dubbed the “Don’t Say Gay” bill by opponents — had its genesis nearly two years ago, not in the halls of the state Legislature but in a September conversation between a Tallahassee mother and her 13-year-old teen. Gary Fineout reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

On Monday, President Joe Biden released his administration’s new budget proposal. It includes increases in domestic investments and a big boost in military funding. To pay for it, Biden proposed increasing taxes on corporations and the rich — including a new minimum tax on Americans with incomes of $100 million or more. Brian Faler reports. Learn more about your ad choices. Visit megaphone.fm/adchoices