PNAS Science Sessions

"The implications of human metabolic network topology for disease comorbidity"

"MicroRNA-directed transcriptional gene silencing in mammalian cells"

"Fluid helium at conditions of giant planetary interiors"

Randy Schekman, the PNAS Editor-in-Chief, discusses the selection process and history of the Cozzarelli Prize. The Cozzarelli Prize is given annually to six outstanding PNAS articles, each representing one of the major disciplines of the National Academy of Sciences.

Fred Gage is a professor in the Laboratory of Genetics at the Salk Institute in La Jolla, CA. In this podcast, Dr. Gage talks about the subtleties involved as researchers explore how to use stem cells to treat conditions such as Parkinson's disease.

Thomas Wellems is the head of the Malaria and Vector Research Unit at the National Institutes of Health. In this episode, he discusses the advances made in the fight against malaria and the problems that still remain.

Bruce Alberts is the former President of the National Academy of Sciences and the current editor-in-chief of Science. In this podcast, Dr. Alberts talks about how he generates ideas for editorials, how Science approaches issues of scientific misconduct, and his opinion on the proliferation of journals worldwide.

PNAS is one of the world's most-cited multidisciplinary scientific journals and has been published by the National Academies since 1915. This podcast, part of the Sounds of Science produced by the National Academies, looks at the history and future of this publication with Ken Fulton, publisher of PNAS.

Pamela J. Fraker was elected to the National Academy of Sciences in 2007. She is known for her investigations of the impact of nutritional deficiencies, particularly of zinc, on immune defense. Her work provided evidence that deficiency in protein--calories causes a decline in antibody and cell mediated responses, which leads to higher rates of infection, poor wound healing, and other adverse impacts in the malnourished and those with chronic disease.

Ran Nathan organized the Movement Ecology Special Feature for PNAS. He is an associate professor and the chair of the department of Evolution, Systematics, and Ecology at the Hebrew University of Jerusalem, in Jerusalem, Israel.

Elected to the National Academy of Sciences in 1990 for her work in the field of Plant Biology, Nina Fedoroff is a pioneer in the molecular aspects of plant transposable elements. Building upon the work of Barbara McClintock, she elucidated the sequence of some of these elements, demonstrated their utility for gene cloning and was instrumental in converting the study of plant transposable elements into one accessible by molecular techniques.

Richard T. Durrett was elected to the National Academy of Sciences in 2007 for his work in applied mathematical sciences. Durrett's research in probability theory concerns problems that arise from ecology and genetics. He has developed mathematical models to study the evolution of microsatellites, impacts of selective sweeps on genetic variation, genome rearrangement, gene duplication, and gene regulation.

C. Owen Lovejoy was elected to the National Academy of Sciences in 2007 for his work in the field of anthropology. Lovejoy overturned traditional models of human origins by integrating biomechanics into biological anthropology, demonstrating that the earliest hominids walked on two legs. He developed novel methods for quantifying sexual dimorphism and revealing the demographics of prehistoric humans.

Albert Libchaber was elected to the National Academy of Sciences in 2007 for his work in physics. Libchaber has made lasting and fundamental contributions to experimental chaos dynamics and its application to biological physics, from elucidating the forces at work when a fish swims through water to defining the minimal conditions necessary for artificial life.

John G. Hildebrand was elected to the National Academy of Sciences in 2007. His work on the functional organization, physiology, and development of the central olfactory system of insects has made him a pioneer in analyzing neural mechanisms underlying chemosensory control of mating behavior and insect--plant interactions. This work has application in disruption of insect mating behavior and herbivory, with practical benefit to human health and welfare.

Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.

Targeted delivery of proteins across the blood--brain barrier.

Müller cells are living optical fibers in the vertebrate retina.

Savanna chimpanzees use tools to harvest the underground storage organs of plants.

Faceting ionic shells into icosahedra via electrostatics.

Incorporating plant functional diversity effects in ecosystem service assessments