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Trial of the Week: SPLIT

Trial of the Week: SPLIT

Anthony Hawkins, our fluid steward, joins the podcast to highlight findings from the landmark SPLIT trial, a study researching the ideal crystalloid in the critically ill.

Pharmacy to Dose: The Critical Care Podcast

October 20, 202345m 4s

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Show Notes

Trial of the Week: SPLIT

Special Guest: Anthony Hawkins, PharmD, FCCM, BCCCP


Anthony Hawkins joins me to highlight the “Effect of a Buffered Crystalloid Solution vs. Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial” published in JAMA. 

We compare the composition of different crystalloids, review pertinent trials published prior to this study, discuss the findings from the SPLIT RCT, what is the best primary outcome in these studies, research on the horizon, questions to be answered, and much more. 


Reference list: https://pharmacytodose.files.wordpress.com/2023/10/split-tow-references.pdf


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