Science & Medicine: UT Health researcher creates mice with fully functioning human immune systems

THX mice can be used to study anything that requires a vigorous human immune response, from cancer medications to vaccines and organ transplantation. The mice were created at UT Health San Antonio using human stem cells, but what makes them unique is they also received a dose of estrogen. This is the critical point, according to Dr. Paolo Casali, that leads to the development of a robust human immune system in THX mice.