138. Back to Basics - Adjuvant CDK4/6 inhibitors in Early Breast Cancer
Oncology for the Inquisitive Mind · Michael Fernando and Josh Hurwitz
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Show Notes
Early Breast Cancer had one of its defining moments in the 1990s, when five years of adjuvant tamoxifen reduced the recurrence risk of invasive breast cancer by 49%! These days, those types of improvements are much harder to substantiate with the effect treatments currently on the market, but there is promise. This week, on our Back to Basics episode, Michael and Josh look at the role of abemaciclib and ribociclib in the adjuvant setting in patients with high-risk early breast cancer. Both of these drugs are CDK4/6 inhibitors and have been shows to be efficacious in the metastatic hormone receptor positive status breast cancer space.
This week we explore MONARCH-E and NATALEE and highlight the data and how it could impact CKD's role in this emerging landscape.
Studies discussed in the episode:
MONARCH-E
NATALEE
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Art courtesy of Taryn Silver
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