
No Priors: Artificial Intelligence | Technology | Startups
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to [email protected].
Conviction
Show overview
No Priors: Artificial Intelligence | Technology | Startups has been publishing since 2023, and across the 3 years since has built a catalogue of 175 episodes, alongside 1 trailer or bonus episode. That works out to roughly 110 hours of audio in total. Releases follow a weekly cadence, with the show now in its 3rd season.
Episodes typically run thirty-five to sixty minutes — most land between 32 min and 44 min — and the run-time is fairly consistent across the catalogue. It is catalogued as a EN-language Technology show.
The show is actively publishing — the most recent episode landed 5 days ago, with 30 episodes already out so far this year. Published by Conviction.
From the publisher
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to [email protected]. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Latest Episodes
View all 175 episodesFrom Restoring Sight to Reimagining the Brain, with Max Hodak
What Chess.com Teaches US About Superhuman Capabilities, with CEO Erik Allebest
Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad
Building an Autonomous Enterprise for Real-World Services with Netic Founder Melisa Tokmak
Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
Why Traditional Benchmarks Fail Modern AI Models with OpenAI Research Scientist Noam Brown
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip Bu Tan
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
The Rise of the Full-Stack Builder and Hyper-Leveraged Generalist with Microsoft CEO Satya Nadella
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
Scaling Global Organizations in the Age of AI with ServiceNow CEO Bill McDermott
The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire

AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
What happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic Labs, which is pioneering an AI foundation lab for atoms. Liam discusses how he pivoted from dark matter physics research to the front lines of artificial intelligence, including stints at Google Brain and working on ChatGPT at OpenAI. He talks about how Periodic is connecting massive language models to the physical world to overcome data bottlenecks in material science. Liam also shares how they use language models as an orchestration layer operating alongside specialized neural nets to run closed-loop physical experiments. They also explore the future of AGI and ASI, as well as the role of robotics in lab automation. Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @LiamFedus | @periodiclabs Chapters: 00:00 – Cold Open 00:05 – Liam Fedus Introduction 00:39 – Liam’s Background at Google Brain, OpenAI 05:14 – From ChatGPT to Materials and Atoms 06:34 – Training Data in the Physical World 09:52 – Generalization Across Domains 11:31 – Models as an Orchestration Layer 12:48 – Commercialization and Business Model 16:10 – How Periodic’s Success May Shape the Future 17:45 – Multidisciplinary Scaling 19:41 – Capital and Compute 21:12 – Hiring at Periodic 21:44 – Thoughts on AGI and ASI 23:30 – Timeline for Machine-Directed Self-Improvement 25:39 – Automation and Data Generation 27:59 – Why Liam is Excited About the Future of Robotics 29:25 – Conclusion