Neurology Minute

In part one of this series, Dr. Jeff Ratliff and Dr. Dara Albert discuss the themes or buckets that self-identified FND knowledge gaps fall into. Show citation: Miller R, Lidstone S, Perez DL, Albert DVF. Education Research: Targeting Self-Described Knowledge Gaps to Improve Functional Neurologic Disorder Education Among Clinicians. Neurol Educ. 2025;4(3):e200239. Published 2025 Sep 5. doi:10.1212/NE9.0000000000200239

In the December episode of the President's Spotlight, Dr. Jason Crowell speaks with Dr. Natalia Rost to provide an overview of the Academy's journey through 2025. Show reference: https://www.aan.com/about-the-aan/presidents-spotlight

In the fourth installment of our series on primary progressive aphasia (PPA), Dr. Rogan Magee discusses semantic variant PPA. Show citations: Grossman M, Seeley WW, Boxer AL, et al. Frontotemporal lobar degeneration. Nat Rev Dis Primers. 2023;9(1):40. Published 2023 Aug 10. doi:10.1038/s41572-023-00447-0 Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-1014. doi:10.1212/WNL.0b013e31821103e6 Santos-Santos MA, Rabinovici GD, Iaccarino L, et al. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018;75(3):342-352. doi:10.1001/jamaneurol.2017.4309 Mandelli ML, Lorca-Puls DL, Lukic S, et al. Network anatomy in logopenic variant of primary progressive aphasia. Hum Brain Mapp. 2023;44(11):4390-4406. doi:10.1002/hbm.26388 Putcha D, Erkkinen M, Daffner KR. Functional Neurocircuitry of Cognition and Cognitive Syndromes. In: Silbersweig DA, Safar LT, Daffner KR. eds. Neuropsychiatry and behavioral neurology: principles and practice. McGraw Hill; 2021. Accessed November 6, 2025. https://neurology.mhmedical.com/content.aspx?bookid=3007&sectionid=253215676 Montembeault M, Brambati SM, Gorno-Tempini ML, Migliaccio R. Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review. Front Neurol. 2018;9:692. Published 2018 Aug 21. doi:10.3389/fneur.2018.00692 Clark DG. Frontotemporal Dementia. Continuum (Minneap Minn). 2024;30(6):1642-1672. doi:10.1212/CON.0000000000001506

In the third installment of our series on primary progressive aphasia (PPA), Dr. Rogan Magee discusses nonfluent/agrammatic PPA. Show citations: Grossman M, Seeley WW, Boxer AL, et al. Frontotemporal lobar degeneration. Nat Rev Dis Primers. 2023;9(1):40. Published 2023 Aug 10. doi:10.1038/s41572-023-00447-0 Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-1014. doi:10.1212/WNL.0b013e31821103e6 Santos-Santos MA, Rabinovici GD, Iaccarino L, et al. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018;75(3):342-352. doi:10.1001/jamaneurol.2017.4309 Mandelli ML, Lorca-Puls DL, Lukic S, et al. Network anatomy in logopenic variant of primary progressive aphasia. Hum Brain Mapp. 2023;44(11):4390-4406. doi:10.1002/hbm.26388 Putcha D, Erkkinen M, Daffner KR. Functional Neurocircuitry of Cognition and Cognitive Syndromes. In: Silbersweig DA, Safar LT, Daffner KR. eds. Neuropsychiatry and behavioral neurology: principles and practice. McGraw Hill; 2021. Accessed November 6, 2025. https://neurology.mhmedical.com/content.aspx?bookid=3007&sectionid=253215676 Montembeault M, Brambati SM, Gorno-Tempini ML, Migliaccio R. Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review. Front Neurol. 2018;9:692. Published 2018 Aug 21. doi:10.3389/fneur.2018.00692 Clark DG. Frontotemporal Dementia. Continuum (Minneap Minn). 2024;30(6):1642-1672. doi:10.1212/CON.0000000000001506

Dr. Alex Menze and Professor Hakan Cetin discuss the need to reevaluate the approach to diagnosing and treating seronegative myasthenia gravis. Show citations: Krenn M, Wagner M, Schuller H, et al. Screening for Congenital Myasthenic Syndromes in Adults With Seronegative Myasthenia Gravis Using Next-Generation Sequencing. Neurology. 2025;105(8):e214177. doi:10.1212/WNL.0000000000214177

Dr. Gregg Day and Professor Jonathan Rohrer discuss the significance of studying individuals at risk of developing genetic frontotemporal dementia, focusing on how early cognitive changes before symptoms appear can inform research and future therapeutic trials. Show citation: Russell LL, Bouzigues A, Convery RS, et al. Executive Function Deficits in Genetic Frontotemporal Dementia: Results From the GENFI Study. Neurol Genet. 2025;11(4):e200248. Published 2025 Jul 21. doi:10.1212/NXG.0000000000200248

In the second installment of our series on primary progressive aphasia (PPA), Dr. Rogan Magee discusses logopenic PPA. Show citations: Grossman M, Seeley WW, Boxer AL, et al. Frontotemporal lobar degeneration. Nat Rev Dis Primers. 2023;9(1):40. Published 2023 Aug 10. doi:10.1038/s41572-023-00447-0 Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-1014. doi:10.1212/WNL.0b013e31821103e6 Santos-Santos MA, Rabinovici GD, Iaccarino L, et al. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018;75(3):342-352. doi:10.1001/jamaneurol.2017.4309 Mandelli ML, Lorca-Puls DL, Lukic S, et al. Network anatomy in logopenic variant of primary progressive aphasia. Hum Brain Mapp. 2023;44(11):4390-4406. doi:10.1002/hbm.26388 Putcha D, Erkkinen M, Daffner KR. Functional Neurocircuitry of Cognition and Cognitive Syndromes. In: Silbersweig DA, Safar LT, Daffner KR. eds. Neuropsychiatry and behavioral neurology: principles and practice. McGraw Hill; 2021. Accessed November 6, 2025. https://neurology.mhmedical.com/content.aspx?bookid=3007&sectionid=253215676 Montembeault M, Brambati SM, Gorno-Tempini ML, Migliaccio R. Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review. Front Neurol. 2018;9:692. Published 2018 Aug 21. doi:10.3389/fneur.2018.00692 Clark DG. Frontotemporal Dementia. Continuum (Minneap Minn). 2024;30(6):1642-1672. doi:10.1212/CON.0000000000001506

In the first part of this series, Dr. Rogan Magee provides an introduction to primary progressive aphasia (PPA) and explains its three subtypes. Show citations: Grossman M, Seeley WW, Boxer AL, et al. Frontotemporal lobar degeneration. Nat Rev Dis Primers. 2023;9(1):40. Published 2023 Aug 10. doi:10.1038/s41572-023-00447-0 Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-1014. doi:10.1212/WNL.0b013e31821103e6 Santos-Santos MA, Rabinovici GD, Iaccarino L, et al. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018;75(3):342-352. doi:10.1001/jamaneurol.2017.4309 Mandelli ML, Lorca-Puls DL, Lukic S, et al. Network anatomy in logopenic variant of primary progressive aphasia. Hum Brain Mapp. 2023;44(11):4390-4406. doi:10.1002/hbm.26388 Putcha D, Erkkinen M, Daffner KR. Functional Neurocircuitry of Cognition and Cognitive Syndromes. In: Silbersweig DA, Safar LT, Daffner KR. eds. Neuropsychiatry and behavioral neurology: principles and practice. McGraw Hill; 2021. Accessed November 6, 2025. https://neurology.mhmedical.com/content.aspx?bookid=3007&sectionid=253215676 Montembeault M, Brambati SM, Gorno-Tempini ML, Migliaccio R. Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review. Front Neurol. 2018;9:692. Published 2018 Aug 21. doi:10.3389/fneur.2018.00692 Clark DG. Frontotemporal Dementia. Continuum (Minneap Minn). 2024;30(6):1642-1672. doi:10.1212/CON.0000000000001506

In this episode of the Neurology Minute, Dr. Nara Miriam Michaelson delves into another women's history minute to discuss Sylvia Lawry.

Dr. Jason Crowell and Dr. YuHong Fu discuss the importance of differentiating between dementia with Lewy bodies and Parkinson disease dementia. Show citatiion: Fu Y, Halliday GM. Dementia with Lewy bodies and Parkinson disease dementia - the same or different and is it important?. Nat Rev Neurol. 2025;21(7):394-403. doi:10.1038/s41582-025-01090-x

Dr. Dan Ackerman and Dr. Isabel Hostettler discuss the diagnosis, risk factors, and prognosis of RCVS, highlighting the need to recognize symptoms and distinguish it from other causes of subarachnoid hemorrhage. Show reference: Hostettler IC, Ponciano A, Wilson D, et al. Outcomes After Reversible Cerebral Vasoconstriction Syndrome With Convexity Subarachnoid Hemorrhage: Individual Patient Data Analysis. Neurology. 2025;105(5):e213984. doi:10.1212/WNL.0000000000213984

In the November episode of the President's Spotlight, Dr. Jason Crowell talks with Dr. Natalia Rost about the Centers for Medicare & Medicaid Services final rule for how physicians are reimbursed in 2026. Show reference: https://www.aan.com/about-the-aan/presidents-spotlight

Dr. Aaron Zelikovich discusses a recent article on nipocalimab and its role in treating generalized myasthenia gravis. Show citations: Antozzi C, Vu T, Ramchandren S, et al. Safety and efficacy of nipocalimab in adults with generalised myasthenia gravis (Vivacity-MG3): a phase 3, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2025;24(2):105-116. doi:10.1016/S1474-4422(24)00498-8

Dr. Katherine Havard Coiro discusses the 2024 McDonald Criteria for Multiple Sclerosis and how to interpret cerebrospinal fluid. Show reference: Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Montalban, Xavier, et al. The Lancet Neurology, Volume 24, Issue 10, 850 - 865

In this episode of the Neurology Minute, Dr. Alison Christy delves into another women's history minute to discuss Marcelle Lapicque.

Dr. Alison Christy and Dr. Matthew Ryan Woodward discuss the complexities of status epilepticus, focusing on its definitions, the transition to refractory and super-refractory states, and the implications for treatment. Show citation: Woodward MR, Brown JP, Kittner SJ, et al. Super-Refractory Status Epilepticus Diagnosis, Management, and Prognostication: An International Survey Study. Neurol Clin Pract. 2025;15(5):e200520. doi:10.1212/CPJ.0000000000200520

In the second part of this two-part series, Dr. Bradley Ong explains the four clinical phases of a typical migraine attack. Show citation: Lipton RB, Stokes J, Evans CJ, et al. Characterizing the patient experience during the prodrome phase of migraine: A qualitative study of symptoms and their timing. Headache. 2025;65(8):1355-1368. doi:10.1111/head.15024

In part one of this two-part series, Dr. Bradley Ong discusses the prodrome phase of migraine and how it represents the earliest stage of the attack. Show citation: Lipton RB, Stokes J, Evans CJ, et al. Characterizing the patient experience during the prodrome phase of migraine: A qualitative study of symptoms and their timing. Headache. 2025;65(8):1355-1368. doi:10.1111/head.15024

In part two of this series, Dr. Stacey Clardy and Dr. Sandra Vukusic discuss gender disparities in the treatment of multiple sclerosis. Show citation: Gavoille A, Leray E, Marignier R, et al. Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis. Neurology. 105(4) e213907. doi:10.1212/WNL.0000000000213907

In part one of this two-part series, Dr. Stacey Clardy and Dr. Sandra Vukusic discuss what disease-modifying therapies can be safely continued and strategically timed when pregnancy is anticipated. Show citation: Gavoille A, Leray E, Marignier R, et al. Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis. Neurology. 105(4) e213907. doi:10.1212/WNL.0000000000213907

Dr. Alison Christy and Dr. Jennifer L. McGuire discuss neuroimaging findings linked to ICANS, exploring whether specific imaging patterns correlate with distinct neurologic symptoms. Show citation: McGuire JL, Pinto S, Erdogan EN, et al. Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies. Neurology. 2025;105(7):e214086. doi:10.1212/WNL.0000000000214086

Dr. Alison Christy and Dr. Jennifer L. McGuire discuss neuroimaging findings linked to ICANS, exploring whether specific imaging patterns correlate with distinct neurologic symptoms. Show citation: McGuire JL, Pinto S, Erdogan EN, et al. Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies. Neurology. 2025;105(7):e214086. doi:10.1212/WNL.0000000000214086

In the final episode of this three-part series, Dr. Jeff Lambe addresses practical considerations surrounding the inclusion of the optic nerve as a topography for demonstrating dissemination in space. Show citation: Montalban X, Lebrun-Frénay C, Oh J, et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. 2025;24(10):850-865. doi:10.1016/S1474-4422(25)00270-4

In part two of this three-part series, Dr. Jeff Lambe outlines how the optic nerve is being incorporated as one of five topographies used to demonstrate dissemination in space. Show citation: Montalban X, Lebrun-Frénay C, Oh J, et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. 2025;24(10):850-865. doi:10.1016/S1474-4422(25)00270-4

In part one of this three-part series, Dr. Jeff Lambe discusses the rationale for including the optic nerve in the 2024 revisions to the McDonald criteria. Show citation: Montalban X, Lebrun-Frénay C, Oh J, et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. 2025;24(10):850-865. doi:10.1016/S1474-4422(25)00270-4

Dr. Katie Krulisky and Dr. Stefano Meletti discuss the incidence and characteristics of postictal central apnea in focal seizures. Show citation: Meletti S, Burani M, Ballerini A, et al. Persistent Postictal Central Apnea in Focal Seizures: Incidence, Features, and Imaging Findings. Neurology. 2025;105(4):e213856. doi:10.1212/WNL.0000000000213856

Dr. Greg Cooper and Dr. Claudia Suemoto discuss the association between consumption of low- and no-calorie sweeteners and cognitive decline. Show citations: Gonçalves NG, Martinez-Steele E, Lotufo PA, et al. Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline: An 8-Year Prospective Study. Neurology. 2025;105(7):e214023. doi:10.1212/WNL.0000000000214023

Dr. Paul Crane discusses Oropouche virus and its neurologic complications.

In the second part of this two-part series, Dr. Kaitlyn Palmer explains how these biomarkers change our approach to diagnosing multiple sclerosis. Show reference: Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Montalban, Xavier, et al. The Lancet Neurology, Volume 24, Issue 10, 850 - 865

In part one of this two-part series, Dr. Kaitlyn Palmer discusses two new MRI biomarkers to increase diagnostic specificity for multiple sclerosis. Show reference: Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Montalban, Xavier, et al. The Lancet Neurology, Volume 24, Issue 10, 850 - 865

Dr. Katie Krulisky and Dr. Rosemary Dray-Spira discuss the trends in prenatal exposure to antiseizure medications over the past decade. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213933 Citation: Pouneh S, Jérôme D, Sara M, et al. Trends in Prenatal Exposure to Antiseizure Medications Over the Past Decade: A Nationwide Study. Neurology. 2025;105(4): e213933.

Dr. Greg Cooper and Dr. Jonathan Graff-Redford discuss the key takeaways from the recent Alzheimer's Association International Conference (AAIC).

Dr. Margarita Fedorova discusses whether living near a golf course impacts the risk of Parkinson disease. Show reference: Krzyzanowski B, Mullan AF, Dorsey ER, et al. Proximity to Golf Courses and Risk of Parkinson Disease. JAMA Netw Open. 2025;8(5):e259198. doi:10.1001/jamanetworkopen.2025.9198

In the second episode of this two-part series, Dr. Justin Abbatemarco and Dr. Jennifer E. Fugate discuss patient outcomes and how to manage these individuals both in the hospital and outside the hospital. Show reference: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00232-7/abstract

In the first episode of this two-part series, Dr. Justin Abbatemarco and Dr. Jennifer E. Fugate discuss posterior reversible encephalopathy syndrome (PRES), highlighting both typical and atypical MRI findings. Show reference: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00232-7/abstract

Dr. Gregg Day and Drs. Laura Baker and Melissa Yu discuss interventions that enhance or safeguard cognitive function in older adults at risk of cognitive decline and dementia. Show reference: https://jamanetwork.com/journals/jama/article-abstract/2837046

In the second part of this two-part series, Casey Kozak concludes the discussion about the TOAST criteria for classifying acute ischemic stroke.

In the first part of this two-part series, Casey Kozak discusses the TOAST criteria for classifying acute ischemic stroke. In this episode, she covers large artery atherosclerosis and small vessel disease.

In the final episode of this five-part series, Dr. Paul Crane concludes the measles series by discussing testing and prevention.

In the fourth episode of this five-part series, Dr. Paul Crane discusses subacute sclerosing panencephalitis, a serious complication of measles.

Dr. Jessica Ailani and Dr. Kathleen Digre discuss three key updates in the understanding and management of idiopathic intracranial hypertension. Show references: https://jamanetwork.com/journals/jamaneurology/article-abstract/2836065 https://www.neurology.org/doi/10.1212/WNL.0000000000009312

Dr. Andy Southerland and Dr. Amrou Sarraj examine whether general anesthesia (GA) compared with non-GA was associated with better functional outcomes in the SELECT2 trial. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213819

In the October episode of the President's Spotlight, Dr. Jason Crowell talks with Dr. Natalia Rost about the crucial role research plays in neurology for clinicians and scientists. Show reference: https://www.aan.com/about-the-aan/presidents-spotlight

In this episode, Dr. Andy Southerland discusses the Capitol Hill Report from October 6th, covering the government shutdown and its potential impact on you and your patients. Stay updated with what's happening on the hill by visiting aan.com/chr. Take a minute to email your members of Congress and ensure your voice is heard!

In the second episode of this two-part series, Dr. Kiran Thakur and Dr. Ava Easton discuss how to get involved in advocacy efforts and policy development related to encephalitis. Show reference: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00057-6/fulltext

In part one of this two-part series, Dr. Kiran Thakur and Dr. Ava Easton discuss the World Health Organization's technical brief on encephalitis. Show reference: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00057-6/fulltext

In the third episode of this five-part series, Dr. Paul Crane discusses measles inclusion body encephalitis.

In the third episode of this five-part series, Dr. Paul Crane discusses measles inclusion body encephalitis.

In the second part of this five-part series, Dr. Paul Crane discusses the early neurologic complications associated with measles.

In the first part of this five-part series, Dr. Paul Crane discusses the reemergence of measles and outlines steps to take if you suspect someone may have measles.