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Gorilla Mode Nitric Pre-Workout is the most potent and comprehensive stimulant free pre-workout on the market in ALL aspects. All angles of saturating the muscle with blood and hydration have been addressed in this formula and are quite literally maxed out. https://youtu.be/iFlmwQXBs6U Gorilla Mode Nitric Supplement Facts Per Full Daily Dose: L-Citrulline – 10,000 mg Creatine Monohydrate – 5000 mg Betaine Anhydrous – 4000 mg GlycerPump™ (65% Glycerol Powder) – 4000 mg Malic Acid – 3000 mg Agmatine Sulfate – 1500 mg Nitrosigine® (inositol-stabilized arginine silicate) – 1500 mg Sodium Nitrate – 1500 mg VasoDrive-AP® (isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) isolated from hydrolyzed milk casein) – 254 mg Gorilla Mode Nitric Vs. Other Pre-Workouts On The Market This is the most maxed out stimulant free pre-workout formula on the market in all aspects. It is also the most comprehensive formula that targets nitric oxide (NO), vasodilation and intracellular hyper-hydration from multiple angles, while maintaining top end dosages across all of those pathways. We completely saturate the traditional Arginine–eNOS–nitric oxide (NO) pathway with a massive 10 gram dose of L-Citrulline, 1.5 grams of Nitrosigine and 1.5 grams of Agmatine Sulfate. The often neglected nitrate–nitrite–nitric oxide (NO) pathway is also topped out with a 1500 mg dose of Sodium Nitrate. A high level of intracellular hyper-hydration is achieved with 5 grams of Creatine Monohydrate, 4 grams of Glycerpump and 4 grams of Betaine Anhydrous. We also addressed the enzyme angiotensin converting enzyme (ACE) with VasoDrive-AP®, which acts as an ACE inhibitor and significantly increases vasodilation. Finally, we have 3 grams of Malic Acid added in on top of the 10 grams of pure L-Citrulline to act as a Krebs cycle intermediary and counter lactic acid buildup during training. Some of these pathways are so maxed out that we could have easily just chosen one of them and sold the product for $39.99 and still had one of the most potent pre-workouts in the industry. Instead, I packed it all into one absurd product that clocks in with over 30 grams of efficacious active ingredients per full dose. It was incredibly expensive to create, but I am very happy with how it turned out, and I am not exaggerating when I say that this pre-workout is absolutely unmatched. Basically, I just included exactly what I would want to see in a stimulant free pre-workout, even at the obvious detriment of our margins. This product is even more potent than Gorilla Mode when it comes to pure pump and performance. The full daily dose is 2 scoops. Even a half dose (1 scoop) is still far more potent than the majority of other pre-workouts out there at their max dosages. This is another product I wanted to be head and shoulders, clear as day, superior to everything else in the industry. Just like in my description of how Gorilla Mode stacks up to other products in this industry, we can actually back up why our product is better than the rest. When (insert fitness influencer name here) launches their own supplement line, they will regurgitate the same story about how their products are effectively dosed, only use the highest quality ingredients, blah blah blah. They don't even know what they're selling half the time, let alone what combinations of ingredients work synergistically, or how to dose a product properly. They employ others to manufacture their products, or use a pre-made formula their manufacturer uses for every company where they just slap a different label on it and sell it for a huge margin. At the end of the day, most fitness influencers have no idea what goes into making an effective product. They don't know how their products work, they probably wouldn’t even use them if they didn’t sell them, they didn't formulate them, and they have to pay the overhead involved with having a team under them who is responsible for all of that. As you’ve already experienced with Gorilla Mode and Gorilla Mind Nootropics, it is me formulating the products, and they work because I actually put in them what I would want in a product and buy myself if I didn’t have a company. The same applies with Gorilla Mode Nitric. If I didn’t have this product, for an effective stim-free pre-workout I would probably be mixing up 6000-10,000 mg of L-Citrulline for vasodilation (with 6000 mg being the bare minimum of pure L-Citrulline, not Citrulline Malate, and would be dependent on my budget at the time), a saturation dose of Creatine Monohydrate (5000 mg), 3000-4000 mg of Glycerpump to hyper-hydrate the muscle with water, and maybe a quarter teaspoon of Himalayan Pink Salt. The fact that a significant amount of supplement companies will skimp out on Creatine Monohydrate and either not include it at all, or only include a subpar dosage, really sheds light on how scammy this industry can be. That is the cheapest ingredient they could easily dose properly, and even that they won't shell o

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Both Testosterone and anabolic androgenic steroids (AAS) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [R, R]. Secondary immunodeficiency, much more common than primary immunodeficiency (that is to say those caused by genetic defects affecting the cells of the immune system), is characterized by various factors that affect a normal immune system, including infectious, iatrogenic, metabolic and environmental factors. These immune deficiencies are manifested clinically with an increased frequency or unusual complications of common infections and occasionally with the onset of opportunistic pathogen infections. https://youtu.be/ceqSC6GYks4 Nandrolone And Anadrol Effects On The Immune System Nandrolone Decanoate and Anadrol directly induce the production of inflammatory cytokines Interleukin 1 Beta (IL-1β) and Tumor Necrosis Factor Alpha (TNF-α) in human peripheral blood leukocyte cultures [R]. Testosterone and DHEA had no direct cytokine inducing effect in the same model. Nandrolone Decanoate also inhibits interferon production in NDV-infected mouse L-929 and human WISH cells. Winstrol And Trenbolone Effects On The Immune System Winstrol and Trenbolone were found to be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner [R]. Testosterone, Teslac, Anavar And Winstrol Effects On The Immune System To evaluate how anabolic steroids affect the immune system, five commercially available steroids with various types of structural differences were studied in a rodent model [R]. Animals were divided into five groups and treated with Testosterone (group 1), Testosterone Propionate (Group 2), the steroidal aromatase inhibitor Testolactone (Teslac) (Group 3), Anavar (Group 4), and Winstrol (Group 5). Significant immunosuppression was observed with all groups. However, by day 10, the Teslac, Anavar and Winstrol treated group showed immunostimulation and actually exceeded baseline immunity while the Testosterone treated groups maintained immunosuppressed. To truly test the effects of endogenous androgens on the immune system a second experiment was then performed. Ten animals maintained in a similar manner to the initial experiment were either treated intact or were castrated and then treated for 8 days, with Anavar (1.1 mg/kg/day), Testosterone (1.1 mg/kg/day) or Anavar combined with physiologic amounts of Testosterone (15 μg/day). Anavar was selected because it has the greatest anabolic activity of all Testosterone analogues as compared to Testosterone (androgenic/anabolic activity = 1:13). In the intact animals after 8 days of treatment with Anavar, serum Testosterone levels were measured by radioimmunoassay on tail vein blood. Levels were either undetectable or very low, reflecting what would be significant HPTA suppression. Immune function (DCH responses) measured at the same time revealed a 41% increase over baseline. The Testosterone treated group experienced a 36% suppression of immune function. Further treatment for 8 days with Anavar combined with physiologic amounts of Testosterone eliminated the immune system enhancement provided by Anavar monotherapy and returned the DCH responses to levels that were not significantly different from baseline. The results were different in the castrated animals. Castration, resulted in an increase in immune (DCH) responses. The mean observed change was 90% greater than intact (pre-castration) baseline. That means that castrated rats had a 90% improvement above and beyond rats that weren’t castrated. Eight day administration of Anavar to these animals had an immunodepressive effect returning the DCH response to baseline. Eight day treatment with Anavar combined with physiologic doses of Testosterone produced an even greater suppression, 45% change from baseline. These observations indicate that immune alterations do occur with anabolic steroids which are immunosuppressive when the steroid nucleus is intact and immunostimulatory with nuclear alterations. How Steroids Influence Immune Function The hypothesis to explain the immune system responses to steroids is as follows. Exogenous androgenic anabolic steroids produce two effects on the immune system: (A) a direct early effect on immune function which is suppressive and, (B) an indirect delayed stimulatory effect mediated through the negative feedback on the pituitary. (B) results in inhibition of gonadal Testosterone through diminished LH release. A decrease in the synthesis of Testosterone results in low serum Testosterone level and immune stimulation. Castration, by abolishing the modulation of Testosterone secretion eliminates the effect of (B) but leaves (A) intact. In summation, the more suppressive a steroid is the more it can indirectly enhance immune function, simply by suppressing the endogenous production of Testosterone and its

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Arnold Schwarzenegger's steroid cycle from the golden era of bodybuilding is a topic that is often heavily debated. There's a lot of speculation around what kind of drug use the golden era bodybuilders deployed to get the physiques that are so sought after nowadays. While Arnold himself never detailed exactly what he took, we have a handful of credible sources of information that all seem to overlap in their descriptions of his steroid use. Despite this information being very accessible, it often goes overlooked because it is buried in the nooks and crannies of the internet. There is such an overwhelming amount of content on the internet now that this information has become increasingly more difficult to find over the years. While Arnold likely experimented a bit here and there, this article will detail what he built his physique on, and the staple anabolics he very likely used throughout his Mr. Olympia reign. https://youtu.be/Ap9I1ReF5KY Arnold Schwarzenegger Briefly Touches On His First Steroid Cycle In Arnold Schwarzenegger's autobiography "Total Recall - My Unbelievably True Life Story" he gives some insight into what his first steroid cycle consisted of, and when he started it. The first thing of note is that he discovered steroid use before the 1967 Mr. Universe competition while researching about the training methods of the East Germans and the Soviets. There were rumors that they were using performance enhancing drugs to get superior results from their weightlifters, shot-putters, and swimmers and he soon found out that steroids were the drugs that they were using. Arnold goes on to touch on how he went to a doctor to ask for a prescription of anabolic steroids. He simply asked: Can you let me try it? The doctor agreed, and he was then prescribed an injection every two weeks and pills to take in between. Keep in mind, this was Arnold's first steroid cycle ever. His dosages may have titrated up in subsequent cycles, and he probably experimented with different anabolics at some point at least once or twice. The more muscle you gain, the higher your requirements will become for increasingly high amounts of calories, training volume, and drug use to support additional hypertrophy above and beyond what you have already achieved. While Arnold didn't state exactly what he was prescribed, we get some useful insight into the administration practice of each compound (oral and injectable) and what type of drugs would probably fall into these two categories at that time when considering all of the other information from other interviews we have compiled over the years. At this point, we know he was using one injectable compound and one oral compound. Arnold Schwarzenegger's Interview About Dianabol Use In another interview Arnold more or less implies that he used 3 Dianabol per day. It is well-known in the community that Arnold was big on using Dianabol back in the day. https://youtu.be/szGZ0bMxcTg?t=7 Obviously he's not actually straight up saying "this was what my cycle was", but we can put two and two together based on his prescription for pills and an injection from a doctor, Arnold talking about Dianabol himself, and the widespread information that's passed through the grapevine reinforcing his Dianabol use. It all culminates to paint a pretty convincing picture that Dianabol was the oral steroid in question that Arnold used. What the injectable compound was is mainly what is debated about. After doing some digging, I uncovered some pretty convincing information suggesting that the injectable compound was Primobolan. Steve Davis Outlines Golden Era Steroid Cycles In 2012, Ric Drasin interviewed Steve Davis to discuss steroid cycles from the golden era. Both men trained at Gold's Gym with Arnold in the 70's and had personal insight into what golden era stacks consisted of, as they literally took the same stacks themselves. After prompting the topic of what golden era bodybuilders were using, Steve goes on to touch on what most guys were using: Steve: You know, in my era, it was 3 Dianabol a day and a shot a week. Ric: That's exactly right. Steve: And we heard that certain Austrians were taking 4 Dianabol a day and a shot a week. Ric: Yeah. https://youtu.be/31-kQbjtxDc?t=453 I'm sure both Steve and Ric actually had this conversation with Arnold at some point to confirm this, as they trained with him and bodybuilders were supposedly pretty open about their use back then. The standard protocol going around then was 3 Dianabol a day, and 1 shot of Primobolan per week. While some of the protocols definitely differed from person to person (e.g. Robby Robinson and Danny Padilla using Deca-only cycles), for the most part it seems like the majority of guys that trained with Arnold in Gold's Gym in the 70's were doing the same thing. Now, the question is are they underplaying their use to not undervalue their training intensity and diet adherence? Perhaps. It is very common for "open" individuals to talk about their

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Gorilla Mind Smooth is the most potent and comprehensive stimulant-free Nootropic formula on the market. If you don't already know what Nootropics are, they are a category of compounds that can improve cognitive function. This can extend into many different specific benefits, but the main draw of Nootropics is their impact on productivity, concentration, creativity and information retention. Gorilla Mind Smooth is our stimulant-free version of Gorilla Mind that provides a smoother, much less extreme level of energy, but still maximizes mental clarity, memory, creativity and focus. Regardless if you're currently using stimulant-based products (coffee, energy drinks, pre-workouts, etc.), cycling off of stimulants, or just never use stimulants, Gorilla Mind Smooth is the most potent Nootropic formula you can add into your life to enhance cognitive function. https://youtu.be/Hcj8CinGG6s Reviews These are some of the reviews we've received from customers using Gorilla Mind Smooth: Gorilla Mind Smooth Supplement Facts Per Full Daily Dose: L-Tyrosine - 1000 mg Organic Lion's Mane Mushroom (Hericium Erinaceus) (standardized to 25% β-glucans) - 1000 mg DMAE (Dimethylaminoethanol) - 750 mg Alpha GPC 50% (L-alpha-glycerylphosphorylcholine) - 600 mg Kanna (Sceletium Tortuosum) - 500 mg Bacopa Monnieri (standardized to 45% Bacosides) - 400 mg L-Theanine - 200 mg Bioperine® (Black Pepper Fruit Extract) (standardized to 95% Piperine) - 10 mg Huperzine A (Huperzia serrata leaf standardized extract) - 400 mcg The original Gorilla Mind Smooth formula had PEA, Hordenine and Teacrine in it. Originally, I was trying to chase a stimulant-free energy boost in Smooth, which is why I had those ingredients in it. However, over the past year I've started to really lean towards reformulating Smooth to create an entirely Nootropic comprised formula that is 100% geared towards maxing out cognitive function, rather than chase a relatively weak level of energy that we already destroy with Gorilla Mind Rush. Anyone buying Gorilla Mind that is using it for the laser focus and massive boost in energy and productivity is buying RUSH anyways, not SMOOTH. Instead of wasting precious capsule space with things that achieve a subpar level of energy, I decided that space would be far better utilized with other Nootropics. This is what led to me creating the current Gorilla Mind Smooth formula, which now has 1000 mg of Lion's Mane mushroom and 500 mg of Kanna in it. These compounds are far more conducive to enhancing the SMOOTH formula by supporting actual brain health, creativity, mental clarity and memory formation. If you want ridiculous amounts of energy and drive, get RUSH. For those who want a true stimulant-free Nootropic formula, SMOOTH is even better now and I highly recommend you give it a try. Gorilla Mind Smooth Vs. Other Nootropics On The Market This is the most maxed out stim-free Nootropic formula on the market. The full daily dose is 6 capsules. Even a half dose (3 capsules) is still far more potent than the majority of other Nootropic formulas out there at their max dosages. I formulated Gorilla Mind Smooth the exact same way I formulate any other product. I put in exactly what I would buy myself if I were shopping for each Nootropic separately. If you thought the pre-workout market was bad for underdosed products, your jaw will drop when you see some of the top selling Nootropic formulas. This industry is even worse because it is so niche and new. Preying on unsuspecting customers with garbage formulas sprinkled with vitamins and completely useless dosages of Nootropics is even more common in this industry. Because Nootropics are relatively new and uncharted waters for many, the prices get pretty aggressive on these watered down formulas as well that promise the world, and deliver nothing more than placebo. What's baffling to me is how many people eat up the marketing and blindly buy products priced at $60, $70, even $100 that probably cost $4-5 max to make. When the cost of bottles, lids, and labels costs more than the Nootropics in your formula, there's a f*cking problem. Fortunately, my audience is comprised of intelligent individuals who actually know how to spot value. It would be so easy to make a formula with a couple hundred milligrams of cheap choline that doesn't even cross the blood brain barrier, 100-200 mg of Bacopa Monnieri, throw a bit of caffeine in there for a kick, put some exotic sounding ayurvedic herbs in there, maybe sprinkle a couple low dosed Adaptogens in there, add a useless pinch of vitamins to make my label look more impressive and confusing, and then slap a label on it like every other company and then aggressively smash people with ads and market a high priced subscription model to the masses, or put it up on Amazon to compete with all the other loss leader cheap and ineffective Nootropics on there. The fact that the hypothetical piece of sh*t formula I just made up as an example of what not to do is a

Of the minority of men taking steroids who actually get blood tests, 99% of them get inaccurate assays. Most doctors don't realize the importance of high sensitivity testing when it comes to men in general, and even more so in steroid users. The difference between high sensitivity testing and what you have probably been getting in the past can be the entire reference range, or in some cases, it may even be detecting metabolites or analogs of other hormones. This is not limited to just testosterone either. Measuring Estradiol via Roche ECLIA (Electrochemiluminescence Immunoassay) instead of liquid chromatography with tandem mass spectrometry (LC/MS-MS) has similar limitations, as do other hormone tests with insufficient analytical sensitivity. https://youtu.be/8mw-jZpmrsQ The Most Accurate Total Testosterone Blood Test The gold standard for accurately measuring total testosterone levels is high-performance liquid chromatography with tandem mass spectrometry (LC/MS-MS). Recent studies have shown that the current assays used in total testosterone testing lack the required sensitivity to produce accurate results when working with very low concentrations. This can be especially problematic when trying to accurately measure total testosterone levels in severely testosterone deficient men, normal or testosterone deficient women, and children. In addition, these tests have proven via my own personal tests to detect synthetic anabolic androgenic steroids as testosterone. This issue can be corrected by newer methods based on mass spectrometry. The Most Accurate Free Testosterone Blood Test The gold standard for accurately measuring free testosterone levels is equilibrium dialysis. Equilibrium ultrafiltration is also sufficient. A comparison of results obtained via equilibrium dialysis and equilibrium ultrafiltration found that the two methods correlated closely (r = 0.97) [R]. Direct analog enzyme immunoassay (EIA) is inaccurate and has shown in my own personal tests to detect synthetic anabolic androgenic steroids as testosterone. My Blood Test Results Comparing ECLIA And EIA Vs. LC/MS-MS And Equilibrium Ultrafiltration This is an example that very clearly shows how important high sensitivity testing can be. I went in for a blood test during a Nandrolone-only experiment. I had no Testosterone in my system whatsoever. Expectedly, by assessing my Total Testosterone level via liquid chromatography with tandem mass spectrometry (LC/MS-MS) and my Free Testosterone level via equilibrium ultrafiltration, we can see that my Testosterone levels were crashed. Both the total and the free were lower than a healthy female. This is what you should see in your blood work if you’re on just Nandrolone. The only Testosterone being produced in my body was indirectly via the trace amounts of androgens produced in my adrenal cortex, which is why the value wasn't completely bottomed out at 0. I've mentioned many times the importance of getting high sensitivity testing done for hormone levels and how Nandrolone will register as Testosterone in primitive garbage blood tests. This is another great example of this. In addition to high sensitivity testing, I had the same blood tested using electrochemiluminescence immunoassay (ECLIA) for my Total Testosterone level, and direct analog enzyme immunoassay (EIA) for my Free Testosterone level. These were the test results using the exact same blood sample with the terrible default assays that doctors will use to determine how to treat you, and that labs will give you in the majority of your blood work panels. According to ECLIA and EIA, I had a normal Total Testosterone and Free Testosterone level. This just one example of why getting accurate hormone testing is critical. My Testosterone levels were actually in the gutter, but ECLIA and EIA couldn't even tell the difference between Testosterone and 19-nortestosterone in my blood. Where To Order Accurate Blood Tests Most labs offer total testosterone (LC/MS-MS), and some offer free testosterone (equilibrium ultrafiltration). However, very few self-pay labs offer free testosterone (equilibrium dialysis). Of the ones that do offer it, it is extremely expensive and it does not come in a package with a total testosterone test. If your doctor will write you a requisition for it, great. If not, just get equilibrium ultrafiltration. Personally, I drive to the US just so I can get LC/MS-MS and equilibrium ultrafiltration testing done. This is the exact test I order every time to accurately check my testosterone levels: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS Learn more about your ad choices. Visit megaphone.fm/adchoices

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https://youtu.be/i7erwHTh8OM Contrary to popular belief, more is not better when it comes to exogenous GH use for fat loss. There is a ceiling on lipolysis, and the highest GH dose for maximizing fat loss per administration is much lower than most people think. As you can see here in the following study assessing the pharmacokinetics and acute lipolytic actions of GH, there were significant dose-response effects when comparing the incremental area under the curve of both free fatty acids and blood 3-hydroxy-butyrate following 0, 1, and 3 mcg/kg GH, whereas there were no differences between the responses following 3 and 6 mcg/kg GH [R]. These dosages were administered intravenously. 1 mg of Somatropin corresponds to 3 IU (International Units) of Somatropin [R]. So, this means that for someone who weighs 100 kg, lipolysis is maxed out at about 300 mcg of Somatropin, which is 0.9 IU’s of pharma grade GH IV. We need to math out the corresponding subcutaneous dose based on the bioavailability and bioactivity comparison data we have on humans administered HGH. Obviously IV dosages are not representative of what dosages would be via the far more realistic and tolerable method of administration (subcutaneous). In one study, the mean estimated availability of subcutaneous injected HGH was shown to be 63% of that of HGH administered I.V. after correcting for differences in the GH dose [R]. Another study found the availability of subcutaneous injected HGH to be about 70% of that of HGH administered I.V. [R]. So, for a 100 kg man, fat loss benefits would be maxed out around 1.35 IU of GH per administration subcutaneously. There is a refractory period cells need before another pulse of exogenous GH can even be useful in a lipolysis context, which I will delve into further in a future article. Learn more about your ad choices. Visit megaphone.fm/adchoices

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

RU58841 vs. Finasteride. As of now RU58841 is the most commonly used topical anti-androgen used for hair loss prevention, and Finasteride is the most commonly used 5α-Reductase inhibitor for hair loss prevention. Which is better for hair loss prevention? This is a common question I get asked and a dedicated post is long overdue. https://youtu.be/p39W1nBhxYE Study Comparing RU58841 Vs. Finasteride Head To Head While there are tons of anecdotal reviews comparing Finasteride to RU58841, there is very little scientific data for us to refer to. There is some though that is worth delving into. In this study, Finasteride was stacked up against RU58841 to see which would be more effective for hair loss prevention, and how much each would impact systemic hormone levels [R]. RU58841 was applied either in a 5% solution, a 0.5% solution, or just a vehicle with no RU58841 in it for 6 months to the bald scalp of 10 stump-tailed macaques. The 5% solution was applied to 4 of the 10 bald stump-tailed macaques, the 0.5% solution was applied to 3 of the 10 bald stump-tailed macaques, and the vehicle with no RU58841 was applied to the last 3 of the 10 bald stump-tailed macaques. The common dosing protocol for RU58841 is typically a 5% solution applied to androgenic alopecia affected areas, so this study was right in line with what we would want to see. Oral Finasteride was given in a dose of 1 mg/kg/day for 6 months to 10 bald stump-tailed macaques. An oral placebo was also given to 10 bald stump-tailed macaques. Male stump-tailed macaques weigh on average between 9.7–10.2 kg, so that would equate to a Finasteride dosage of roughly 10 mg orally per day. This dosage greatly exceeds the point of diminishing returns with Finasteride use, so this is also a great way for us to compare the efficacy of a standard dose of RU58841 to a maxed out dose of Finasteride. The stump-tailed macaque has shown to be a suitable biological model for human androgenetic alopecia as it possesses hereditary balding characteristics similar in many respects to that of androgenetic alopecia in humans [R]. Results Skin biopsies for micromorphometric analysis (folliculogram) were taken at 0 and 6 months for Finasteride treated macaques and at 0 and 4 months for RU58841 treated macaques. The amount of anagen follicles (hairs in the active growth phase) and vellus follicles (short, thin, and barely noticeable hairs) enlarged to terminal size were compared to those in pre-treatment stages. Anagen follicles increased an average of 88% with Finasteride. Anagen follicles increased an average of 103% with 5% strength RU58841. The growth of vellus follicles to terminal size (thick, strong, pigmented hairs that have fully matured) was 12% with Finasteride. The growth of vellus follicles to terminal size was 26% with 5% strength RU58841. The 0.5% strength RU58841 solution induced almost no effect. Expectedly, the Finasteride placebo induced no effect. The 5% strength RU58841 solution induced the most hair growth after only 2 months of treatment. RU58841 was given less time to work and still significantly outperformed Finasteride in this study. Although Finasteride significantly reduced DHT levels, DHT remaining and produced by Type I 5α-reductase isoenzyme still contributed to hair follicle miniaturization. Because Testosterone and DHT both bind to the androgen receptor, a locally sufficient dose of an "AR blocker" (topical anti-androgen) appears to suppress Testosterone and DHT induced follicular regression more effectively than 5α-reductase inhibition. Systemic Effects Plasma RU58841 and metabolites (10-20 ng/ml) were detected in 2 of the stump-tailed macaques that were applied the 5% strength RU58841 solution at the 3 month mark of treatment. Only 1 of the stump-tailed macaques had detectable plasma RU58841 and metabolites at at the 6 month mark of treatment. RU58841 had no significant impact on serum DHT or Testosterone levels at any point. Finasteride decreased serum DHT levels by about 70%, and Testosterone levels increased as a result of the 5α-reductase blockade. If Estrogen levels were assessed in the Finasteride treated group, their Estrogen levels would have showed significant elevation as well as a result of increased aromatization. My Concluding Thoughts On This Study This study shows that RU58841 can go systemic when topically applied, although there is no effect on endogenous androgen levels. First of all, I do believe that RU58841 can go systemic, in fact, I think it is an inevitable outcome. However, the degree to which it goes systemic and if the amount that goes systemic will cause anti-androgenic side effects will be based on several factors. These factors include but are not limited to endogenous androgen production, sex hormone metabolism, androgen receptor density and expression, scalp skin porosity, the dosage used, if there are open wounds on the scalp or not, the vehicle used, frequency of administration, and more. Does this ensure side eff

This article will be a continually updated log for my injectable SARMs cycle and review of injectable LGD-4033 (Magnalone). Rather than publish a separate article for each update, I will come back and update this article accordingly with any blood work or new findings. For those that are just here find out where to buy injectable SARMs, these are the only companies I currently use for my own personal research: Swiss Chems – 11% off coupon code “DC11” The Goal Of This Experiment In my log introduction I outlined the goal of this experiment. https://youtu.be/F3L7xhE6tlM My goal of this experiment was to truly evaluate how anabolic injectable SARMs are without any interfering factors. To be more specific, I wanted to find out if injectable LGD-4033 could "replace" a TRT dose of Testosterone entirely in a muscle growth/retention context. If injectable SARMs could replicate the same muscle building potential as traditionally used anabolic steroids with a fraction of the androgenic activity, the potential applications would be endless. LGD-4033 is purported to have a 500:1 anabolic to androgenic ratio. The following graph illustrates the data derived from the preclinical studies which exhibits how much LGD-4033 stimulated muscle growth relative to prostate growth in comparison to Testosterone. LGD-4033 Selectivity For Muscle To Prostate Compared To Testosterone LGD-4033 stacked up against Testosterone very well in the preclinical models with a greater than 500x tissue selectivity of muscle to prostate. As LGD-4033 is so tissue selective, individuals who are extremely prone to the androgenic side effects of Testosterone may be able to utilize LGD-4033 as a way to build supraphysiological amounts of muscle mass, or retain it, with a relative absence of those same side effects. How I Determined Exactly How Anabolic Injectable LGD-4033 Is By Utilizing Exogenous Estradiol Most guys using injectable SARMs are using them alongside a Testosterone base at minimum. To truly evaluate the efficacy of injectable LGD-4033 in an anabolism context, all other androgens would need to be removed from the equation. As I just finished a Nandrolone monotherapy experiment prior to starting LGD-4033, my endogenous androgen production was completely shutdown. Estrogen is what has shown to be neuroprotective and not Testosterone (and potentially cardioprotective as well). Estrogen also supports several other functions in the body that would be inhibited if I were to forgo Estrogen replacement during this experiment. These include but are not limited to muscle growth and fat loss. I needed to isolate LGD-4033 and keep myself shut down to accurately assess how anabolic it is, so adding an exogenous aromatizing compound was not an option. The most common solution to insufficient Estrogen would be a Testosterone base, DHEA, HCG, or an aromatizing anabolic steroid like Dianabol or Trestolone to act as a makeshift "Test base". None of these were viable options as they would add anabolic and androgenic activity to my body and skew my findings. The only option was to utilize exogenous Estradiol at a physiologic dose. This is because exogenous Estradiol would prevent my natural Testosterone production from turning back on (endogenous Testosterone production would also skew my findings), it would activate Estrogen receptors sufficiently to bandaid the issue of insufficient aromatization to fulfill physiologic functions, and it would not elevate androgenic activity in the body at all. In theory, by maintaining a physiologic level of Estrogen in the body I could largely avert the inhibition of anabolic pathways and assess exactly how anabolic LGD-4033 is with no factors interfering. The only potential drawback here is that aromatase is what normally regulates Estrogen production endogenously, and by bypassing this process entirely I could very well be missing out on some downstream anabolic pathways that would otherwise be fulfilled by Testosterone aromatizing into Estrogen. Just one of these being the IGF-1 pathway. The experiment is not perfect, but it is the closest I am going to get to it. Prior to my Nandrolone experiment I was maintaining my physique on 100 mg of Testosterone per week, and I was able to retain the same level of muscle mass and strength during my Nandrolone experiment with no other factors changed. If injectable LGD-4033 proved capable of maintaining my physique with no factors changed in my diet or training, then I would know that it is at least as anabolic as Testosterone and Nandrolone, but with a fraction of the androgenic activity. Oral SARMs Vs. Injectable SARMs Oral SARMs have shown to have a handful of common side effects in a clinical setting, with numerous other side effects cropping up when utilized in a performance enhancing context at higher dosages. The main side effects that are consistently seen both clinically as well as anecdotally with oral SARMs are: Negative Effect On Lipid Profile Natural Testosterone Suppr

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There's been a growing amount of hype around the "Deca only cycle". While it is most commonly referred to as the Deca only cycle, it is actually based on the compound Nandrolone being used on its own. The decanoate ester being abbreviated as "Deca" has just become synonymous nowadays in the bodybuilding community with Nandrolone itself. Seeing the potential merits of Nandrolone as a makeshift hormone replacement therapy alternative to Testosterone, I stopped using Testosterone and instead started using Nandrolone on its own with exogenous Estradiol for 3 months and paid over $1000 for an elaborate blood panel to assess how it affected my health markers. https://youtu.be/kLScNddgkks How Nandrolone Could Potentially Be A Superior HRT Alternative To Testosterone The primitive thought process is that Nandrolone used in conjunction with Testosterone will lead to horrible side effects, but Nandrolone used on its own will just result in all of the benefits of steroids with a near absence of the androgenic or estrogenic side effects associated with Testosterone use. In reality, it's a lot more nuanced than that. The reason why I found this experiment worth pursuing is the lack of androgenicity of Nandrolone in the body. Nandrolone 5α-reduces in tissues that express 5α-reductase to the much less androgenic metabolite Dihydronandrolone (DHN). Nandrolone is basically the only anabolic steroid that is going to maintain 100% anabolic activity of the Nandrolone in muscle tissue where you want it, but also be converted into a much less androgenic metabolite with a lower binding affinity in certain areas of the body where you wouldn't want Nandrolone to bind. The two areas of concern for most individuals being hair follicles and skin. By converting to DHN in these areas, Nandrolone (and by extension DHN) causes less hair loss and acne than Testosterone (and by extension DHT). In addition, some men are genetically predisposed to high levels of aromatization and estrogen receptor expression and can't even use TRT doses of Testosterone without experiencing estrogenic side effects. Nandrolone is not a potent substrate for aromatase, and mainly converts to a weaker estrogen called Estrone (Estradiol is about 10-fold more potent than Estrone). Nandrolone is also mildly estrogenic on its own via its ability to act as an estrogen receptor alpha (ERα) agonist [R]. Overall, Nandrolone is much less androgenic and estrogenic than Testosterone, and may provide symptom relief in those seeking a viable hormone replacement therapy alternative. In this context, Nandrolone may also have great potential as an efficacious alternative to Testosterone as an anabolic agent for some individuals who are prone to androgenic and/or estrogenic side effects. The Neurotoxicity And Cardiotoxicity Of Nandrolone Based on the limited data available, Nandrolone has shown to be more deleterious to cardiovascular and neurological health than testosterone. https://www.youtube.com/watch?v=Gv_v0mJy6Bg By extrapolating the data, we start to get a clearer picture as to why this likely is. Nandrolone is mildly estrogenic on its own, and it does not aromatize nearly enough to create as much Estradiol as Testosterone does. Comparing the effect of testosterone with that of 19-nortestosterone (Nandrolone) and Stanozolol (Winstrol) on neurotoxicity we can clearly see that Estrogen is what protects neurons in the brain, not Testosterone itself. In this study, a physiologic dosage of Testosterone was neuroprotective [R]. Testosterone only amplified neurotoxicity at supraphysiological dosages. The neuroprotective effect of a physiologic dosage of Testosterone was completely eliminated when the aromatase inhibitor Anastrozole (Arimidex) was co-administered, suggesting that the intrinsic toxicity of Testosterone as an androgen is only counterbalanced by its aromatization into 17β-estradiol. As opposed to testosterone, Nandrolone does not appear to aromatize sufficiently into estrogen. As you would expect, Nandrolone was neurotoxic at every single dose evaluated regardless of Arimidex being co-administered or not. If Nandrolone was inherently able to provide enough estrogen receptor alpha (ERα) activation to balance out its androgenicity without even requiring aromatization (it acts as an estrogen on its own to some extent), we would see a neuroprotective effect at equivalent dosages to a physiologic concentration of Testosterone when no AI is used, but that does not appear to be the case either. The anti-androgen flutamide attenuated the neurotoxicity of all three androgens, thus further reinforcing that physiologic dosages of androgens without a sufficient amount of opposing estrogens, or supraphysiological dosages of androgens may facilitate neuronal death. I suspect that the same applies for the inherent cardiotoxicity of Nandrolone as well. Just because you can get your Estradiol levels up to 15 pg/mL with a gram of Deca only, that ratio of androgens to estrogen in the b

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Testosterone is not neuroprotective, estrogen is. A common myth circulating in the bodybuilding and TRT community is that testosterone is inherently neuroprotective and is unique from all other anabolic steroids in that regard. The reason why testosterone is neuroprotective is simply because it aromatizes at a rate that provides a sufficient amount of estradiol to balance out the androgenicity in the body. Data in rodent models using cortical cells suggests this very convincingly by showing how the aromatase inhibitor Anastrozole (Arimidex) completely eliminated the neuroprotective effects of testosterone [R]. https://youtu.be/Gv_v0mJy6Bg Are Synthetic Anabolic Steroids More Dangerous Than Testosterone? There have been tons of studies published suggesting how much worse synthetic anabolic steroids are in contrast to testosterone for cardiovascular disease, neurotoxicity, and a myriad of other deleterious outcomes. I believe that a significant amount of this data is exaggerated based on the fact that exogenous estrogen is never co-administered in these studies. At the end of the day, testosterone is the safest androgen at physiologic dosages. However, I theorize that many synthetic anabolic steroids are not as dangerous as we are led to believe. My theory is that some compounds are not inherently significantly more dangerous than testosterone, rather, it is their lack of aromatization, 5-alpha reduction, or differing affinity for off-target receptors that makes them more dangerous. The effect on estrogen receptors and how potent of a substrate an anabolic steroid is for aromatase is the main factor that impacts how viable a hormone is for consideration in a monotherapy context. DHT derivatives cannot be converted by the enzyme aromatase into an estrogen like estradiol. Nandrolone (19-nortestosterone) and its derivatives (19-nors) each have their own individual affinity (or lack thereof) for estrogen receptors and interaction with aromatase, often resulting in subpar estrogen levels (exceptions to this exist such as Trestolone/MENT). Basically, I believe that some steroids may show to be significantly more cardiotoxic and neurotoxic in the data because they are always used on their own with an insufficient amount of estrogen to balance out the androgenicity in the body. The Importance Of Sufficient Estrogen Levels Healthy estrogen levels are needed for libido, erection quality, vasodilation, cardiovascular health, brain health, bone health and several other critical functions. In women the risk of cardiovascular disease spikes significantly after menopause. It isn't a coincidence that the majority of women who develop heart disease have it occur after their estrogen production has dropped to sub-male levels. If you don't have a sufficient amount of estrogen relative to androgen levels in the body, cardiotoxicity and neurotoxicity levels will be significantly higher than they would be if healthy estrogen levels were sustained. From a bodybuilding perspective, estrogen is needed to optimize muscle growth, fat loss, as well as IGF-1 and growth factor production/cellular signaling. This is why heavily aromatizing steroids may indirectly result in greater growth potential and are often classified as "bulking" compounds. Anecdotally, many bodybuilders report that the most they've ever grown was during off-season mass building phases when their estrogen levels were through the roof. The Point Of A Testosterone Base Testosterone is not tissue selective and is actually a poor muscle builder milligram for milligram when compared to other synthetic anabolic steroids developed in the years following its discovery. When it comes to nitrogen retention, on paper it is not superior to many anabolic steroids. However, it aromatizes into estradiol at a very tightly regulated rate, it is bioidentical, and our body knows exactly what to do with it. In addition, our body knows how much testosterone to bind up with SHBG, how much to free up and make available to tissues, as well as how much DHT to 5-alpha reduce to antagonize estrogen receptor activation should it get out of control. From a bodybuilding perspective, testosterone is subpar in many aspects. However, in an overall health, longevity AND bodybuilding context, testosterone cannot be beat at therapeutic dosages. By using a testosterone base or a source of sufficient estrogen the shortcomings of other anabolic agents can be attenuated to some extent, hence why testosterone is the base of most steroid cycles. The Balancing Act Of Testosterone, DHT and Estrogen Steroidogenesis in the body is carried out like a massive orchestra to regulate countless functions. It's far more elaborate than simply testosterone, estrogen and DHT production. Even at a snapshot view, the balancing act of androgens and estrogens in the body is tightly regulated and is carried out to ensure health remains optimized. This balancing act gets more and more dysfunctional with age, poor lifestyle, poor

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Kevin Levrone is among professional bodybuilders like Dorian Yates who have opened up about their steroid cycles and dosages. In an interview with Muscular Development Kevin Levrone outlined his first and second steroid cycles with specific details, which gives us great insight into what kind of compounds and dosages he used to build his physique up.… Learn more about your ad choices. Visit megaphone.fm/adchoices

As more and more IFBB pros and past Mr. Olympia winners like Dorian Yates start to open up over social media about their steroid use, we have started to get incredibly detailed insight into things like their genetic response to their first steroid cycle.… Learn more about your ad choices. Visit megaphone.fm/adchoices

After reviewing the molecular weight of some of the most promising SARMs developed, I theorized that they could potentially be prepared in a topical solution for hair loss prevention. As you probably already know, Selective Androgen Receptor Modulators (SARMs) are a class of androgen receptor ligands that bind to androgen receptors and exert tissue selective anabolic effects with a relative lack of androgenicity when compared to traditional anabolic steroids.… Learn more about your ad choices. Visit megaphone.fm/adchoices

There's a misconception that Finasteride is a reliable source of remedy for hair loss prevention caused by the intake of all anabolic steroids. For anyone who has reviewed the downstream mechanisms of Finasteride in the body, it is clear that this is not true.… Learn more about your ad choices. Visit megaphone.fm/adchoices

It’s theorized in the bodybuilding community that the reason Flex Wheeler and other top Olympia caliber bodybuilders are able to build such incredible physiques is due to Myostatin deficiency. Other popular theories circulate around that include ideas as vastly different as androgen receptor sensitivity is higher in top bodybuilders, to the complete opposite side of the spectrum where some believe that training past a certain pain threshold is what separates champions from the rest and that genetics are just a small factor in determining bodybuilding success.… Learn more about your ad choices. Visit megaphone.fm/adchoices

Many health authorities state that natural Testosterone levels decrease by 1% per year. This figure is incorrect, and is not based on bioavailable Testosterone. Once men enter their 30's and start to get closer to being middle-aged, their endogenous Testosterone production starts to steadily decline.… Learn more about your ad choices. Visit megaphone.fm/adchoices

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One of the most common obstacles guys run into during a cutting phase is plateauing in fat loss when they are eating less than 2000 calories per day, which is what I consider to be an unsustainable amount of calories for the majority of men.… Learn more about your ad choices. Visit megaphone.fm/adchoices

There is a lot of speculation around whether or not Chris Hemsworth's transformation for Thor was natural, or if he did a steroid cycle during his prep for the film in 2009. Chris Hemsworth purportedly gained between 20-25 pounds of muscle in 6 months to prepare for his role of Thor [R].… Learn more about your ad choices. Visit megaphone.fm/adchoices

After clinical data started circulating in the bodybuilding community showing that Trenbolone administration caused beta amyloid plaque accumulation in rat brains, more and more attention has been given to the potential neurodegenerative effects it may have in humans, and how Trenbolone may cause the progression of Alzheimer's disease.… Learn more about your ad choices. Visit megaphone.fm/adchoices

When I first started getting into bodybuilding and learning about pharmacology, a strategy I would see commonly advised on forums and by industry gurus was switching compounds at week 6 or week 8 to avoid androgen receptor downregulation and circumvent a plateau on a steroid cycle.… Learn more about your ad choices. Visit megaphone.fm/adchoices

I've been asked a few times about topical Estrogen cream for hair loss prevention. BiEstro-Care cream and Estrogel in particular. BiEstro-Care is a is a combination of 1 mg of natural Estriol USP and 0.25 mg of natural Estradiol USP per pump.… Learn more about your ad choices. Visit megaphone.fm/adchoices

Never do a quad injection. There are other shot locations that are far better and I'm going to elaborate on why in this article. When you first get into this stuff and you're trying to learn about proper administration technique the main shot locations you'll see recommended are glutes, quads, and maybe delts.… Learn more about your ad choices. Visit megaphone.fm/adchoices

It is theorized in the community that MK-677 can cause brain damage via chronically elevating ghrelin levels in the body. Does this crossover to human use, and has it been observed to date? Well, there have in fact been links established between chronic ghrelin exposure and negative mental outcomes.… Learn more about your ad choices. Visit megaphone.fm/adchoices

Lactobacillus Reuteri ATCC PTA 6475 is a strain that was hyped up in the community after an article was published called “Probiotic ‘glow of health': it's more than skin deep” [R]. In the article, you can see that the mice that were fed with this probiotic strain experienced significantly better hair growth, and also exhibited a much more favorable ratio of anagen to telogen hair cycle stages.… Learn more about your ad choices. Visit megaphone.fm/adchoices

After I made my first oral castor oil for hair loss post a couple of months ago, I received hundreds of DM's, private messages, YouTube comments, emails and tweets asking me to post an update. Well, here it is. After trying oral castor oil for hair loss for 2 months, I have concluded that it is an effective growth promoter, and is far more potent than topical castor oil.… Learn more about your ad choices. Visit megaphone.fm/adchoices

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Gorilla Mode Pre-Workout is the most potent and comprehensive pre-workout on the market in ALL aspects. Pump, strength, endurance, cognitive enhancement, and overall performance. Gorilla Mode Supplement Facts Per Full Daily Dose: L-Citrulline – 9000 mg Creatine Monohydrate – 5000 mg GlycerPump (65% Glycerol Powder) – 3000 mg Betaine Anhydrous – 2500 mg L-Tyrosine – 1500 mg Agmatine Sulfate – 1000 mg Kanna (Sceletium tortuosum) – 500 mg Caffeine Anhydrous – 350 mg N-Phenethyl Dimethylamine Citrate – 350 mg BioPerine® (Black Pepper Fruit Extract) (standardized to 95% Piperine) – 10 mg Huperzine A – 400 mcg Gorilla Mode Vs. … Learn more about your ad choices. Visit megaphone.fm/adchoices

Despite the fact that muscle bellies will mostly determine what shape your shoulders (or any muscle group) take on as they get bigger, there are some things you can do to maximize your genetics and encourage the development of capped 3D delts.… Learn more about your ad choices. Visit megaphone.fm/adchoices

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I finally got around to trying CB-03-01. I had heard varying opinions on its therapeutic promise in the community, but at the end of the day I had to do a CB-03-01 review myself to see if this compound is superior to other alternatives we already have at our disposal.… Learn more about your ad choices. Visit megaphone.fm/adchoices