What cofactors are needed to synthesize and recycle BH4? | Masterjohn Q&A Files #319
Mastering Nutrition · Chris Masterjohn, PhD
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Show Notes
Question: What cofactors are needed to synthesize and recycle BH4? Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR). This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:
https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis
In that batch of free episodes you will also find the answers to these questions:
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Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
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How Much Iron Can We Absorb At Once?
If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up:
https://chrismasterjohnphd.substack.com/qanda
Learn more about the Masterpass here:
https://chrismasterjohnphd.substack.com/about
This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:
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Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
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How Much Iron Can We Absorb At Once?
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What nutrients are important for long-term PPI use?
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For how long does transferrin saturation respond to recent iron-rich food?
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Muscle spasms: creatine, creatinine, sodium, and potassium.
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Hematologists ignore iron saturation.
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How to detox arsenic?
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Could folic acid supplements impair BH4 recycling?
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How to increase butyrate?
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More on hematologists and transferrin saturation.
Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february
Access the show notes, transcript, and comments here.
Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.