Mastering Nutrition

Question: If undercarboxylated osteocalcin has health benefits, and vitamin K2 decreases it, what does that mean for K2 supplementation? Short Answer: Vitamin K2 helps secure osteocalcin in bone matrix, where it is decarboxylated and released as an endocrine hormone in response to certain stimuli. When released, it acts to optimize insulin secretion, insulin sensitivity, fuel use during exercise, and male testosterone. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-phosphatidylcholine In that batch of free episodes you will also find the answers to these questions: Phosphatidylcholine and TMAO What to Do About Twitching If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Inositol, What Is It Good For? If I am at risk of heart disease, and phosphatidylcholine raises my TMAO, should I stop the supplement? Maragen Calcium Could slow methylation cause high selenium levels? My current thoughts on cholesterol and heart disease If I already have oxidative stress, what ducks should I have in a row before supplementing with iron? Is it safe to take eight milligrams of zinc daily without copper? What to do about developing sensitivities to an increasingly broad range of foods? What else to do about hemochromatosis besides phlebotomy? If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS? What to do about chronically elevated amylase and lipase? What to do about a non-drinker having very high GGT and occasionally high ALT? What are the most common vitamin and mineral deficiencies? What are the best supplements, vitamins, and minerals for OCD and depression? What is the connection between low pyruvate and high ketones? Is high LDL a concern if the carotid IMT and coronary calcium scan are clear? An algorithm to fix twitching Do I trust food allergy tests? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-december Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Finally, the long-awaited results of my self-experiments conducted from September through January are released! First, make sure you get my MTHFR Protocol, my free 7-page quick guide to optimizing and personalizing your methylation status, here: https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation The primary abnormalities in my metabolism during this pre-biotin period were 1) 15 minutes of paradoxical rise in ketones after eating rice, 2) paradoxical rise in lactate during fasting that is suppressed by my meals, and 3) a massively outsized lactate response to alcohol. The first two were provoked by an 18-hour fast and the last by undereating prior to the alcohol. These support a deficiency in the biotin-dependent, manganese-dependent, oxalate-poisoned enzyme pyruvate carboxylase. This is long, and if your time is limited, you may want to skip to "The Bottom Line" in this link: https://chrismasterjohnphd.substack.com/p/self-experiments-in-the-biochemically However, there are some major reasons to commit some time to reading the whole report: It serves as a crash course on the most relevant biochemistry of glucose, ketones, lactate, and ethanol across contexts that include general health, diabetes, infancy, and pregnancy. It includes a literature review of all of the relevant "normal" data. For example, what usually happens to lactate during fasting? What is the normal response of ketones to a glucose tolerance test at the 15-minute mark? How high should you expect your lactate to go up when you drink vodka, bourbon, or beer? I have laid out a model of self-experimentation that you can borrow from for your own experiments. There are many thought-provoking nuggets in here. For example: Is it possible that two pounds of extra body fat prevents peripheral neuropathy in me and perhaps others? I make the case that it may. Has your fasting glucose gone up on low-carb? See why mine went down after doing repeated glucose tolerance tests on myself (which I don't recommend at home!) And, learn why I can fast my way to a glucose of 70 or eat my way to a glucose of 70 and I would choose eating my way there every time. The full written version with linked references is found here: https://chrismasterjohnphd.substack.com/p/self-experiments-in-the-biochemically And don't forget to get my MTHFR Protocol, my free 7-page quick guide to optimizing and personalizing your methylation status, here: https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

I have a free gift for you. That is my MTHFR Protocol, a 7-page quick guide to optimizing and personalizing your methylation status using foods and supplements. My MTHFR Protocol is free to anyone who subscribes to my Substack, whether free or paid. Use this link to get your copy: https://chrismasterjohnphd.substack.com/p/mthfr-protocol I hope you enjoy your free gift and find it useful. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

For nearly 20 years, I have strongly suspected that I have a genetic disorder in synthesizing or recycling something that is absent or poorly available from plant foods, is very rich in organ meats, and is not present in any of the supplements I was taking when I was a vegan. After six months of research, testing, and self-experimenting, I now believe what I have been looking for is a mix of moderate genetic defects in biotin recycling, possibly combined with poor cellular uptake of biotin, and definitely combined with a defect in burning long-chain fatty acids for energy. The treatments for this, which I will be testing one at a time, will be high-dose biotin, high-dose riboflavin, possibly high-dose L-carnitine and glycine, and, if needed, an otherwise low-fat diet supplemented with C8-specific MCT oil. This episode covers the content of the first of two articles I have written up on Substack. First, I have a free gift for you: my MTHFR Protocol. This 7-page quick guide to optimizing your MTHFR status using foods and supplements is freely available to all subscribers to my Substack. Subscribe now and you will immediately get it emailed to you in the welcome email. You can subscribe here: https://chrismasterjohnphd.substack.com/p/mthfr-protocol The content of this episode can be found in the written version, with live links, here: https://chrismasterjohnphd.substack.com/p/getting-to-the-bottom-of-my-health The second article that will be covered in the next episode is about my self-experiments between September 2022 and June 2023 in the "biochemically unoptimized state" and can be found here: https://chrismasterjohnphd.substack.com/p/self-experiments-in-the-biochemically Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: If I'm at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement? Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. There are thousands of things that should be given equal weight as potential contributors to heart disease, but TMAO gets the most attention because the Cleveland Clinic has an incredible PR machine to spread their research, which serves to bolster their financial interest in marketing the test. That said, it is not a universal necessity to supplement with phosphatidylcholine. If you are concerned about your TMAO, you can try substituting trimethylglycine (TMG), and ultimately judge the value of each supplement by whether it is helping you in a demonstrable way. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-phosphatidylcholine In that batch of free episodes you will also find the answers to these questions: Vitamin K2 and Undercarboxylated Osteocalcin What to Do About Twitching If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Inositol, What Is It Good For? If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation? Maragen Calcium Could slow methylation cause high selenium levels? My current thoughts on cholesterol and heart disease If I already have oxidative stress, what ducks should I have in a row before supplementing with iron? Is it safe to take eight milligrams of zinc daily without copper? What to do about developing sensitivities to an increasingly broad range of foods? What else to do about hemochromatosis besides phlebotomy? If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS? What to do about chronically elevated amylase and lipase? What to do about a non-drinker having very high GGT and occasionally high ALT? What are the most common vitamin and mineral deficiencies? What are the best supplements, vitamins, and minerals for OCD and depression? What is the connection between low pyruvate and high ketones? Is high LDL a concern if the carotid IMT and coronary calcium scan are clear? An algorithm to fix twitching Do I trust food allergy tests? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-december Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: How do I get my ceruloplasmin up if copper doesn't raise it? Short Answer: Usually ceruloplasmin raises with copper, which may be important to protect copper from causing oxidative stress. If it does not raise in parallel, the usual suspects to look at are vitamin A and thyroid hormone. However, in this person's case, his own evidence from self-experiments suggest that he needs antioxidants to lower his transferrin saturation. Lowering his transferrin saturation may be the key to raising his ceruloplasmin. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Brain Fog on Calcium, Vitamin D, or K2 Low Blood Sugar on Vegan Keto If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Brain Fog on Calcium, Vitamin D, or K2 Low Blood Sugar on Vegan Keto How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

This analysis of the recent study by the Hazen group at Cleveland Clinic published in Nature Medicine claiming erythritol contributes to cardiovascular disease shows the following: Why elevated plasma erythritol is likely to reflect thiamin deficiency and NADPH depletion from insulin resistance, inflammation, and oxidative stress Why the in vitro and mouse study blood clotting likely reflects osmotic stress with no relevance to the use of erythritol as a sweetener. Why I strongly suspect the Hazen group is hiding data, specifically the data that they obviously had a chance to collect and would have clinched their case but appears nowhere in their paper. Why even though I do not use erythritol as a sweetener, were I ever to think about doing so, the new Nature Medicine paper would play no role in my decision. Read the analysis in written form, fully referenced, here: https://chrismasterjohnphd.substack.com/p/erythritol-and-blood-clotting Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: How do I fix low blood sugar on vegan keto? Short Answer: Consider how important it is for your ketones to be elevated. Most likely you need to eat more protein, which will lower your ketones. I would aim for a minimum of 0.8 grams per kilogram of ideal bodyweight and consider using 1.2 grams per kilogram of ideal bodyweight. If this does not work, consider all of the nutrients involved in energy metabolism — all of the B vitamins, iron, copper, sulfur, magnesium, potassium — but especially biotin and B6 for their disproportionate role in gluconeogenesis. If the protein you need to normalize your blood sugar does reduce your ketones to a level that are not giving you the benefits you are looking for, you could consider raising them with exogenous ketones. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Brain Fog on Calcium, Vitamin D, or K2 Raising Ceruloplasmin When Copper Won't Do It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Brain Fog on Calcium, Vitamin D, or K2 How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? How do I get my ceruloplasmin up if copper doesn't raise it? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Question: Why would vitamin D, vitamin K2, and calcium give me brain fog? Short Answer: Most likely by decreasing serum phosphorus. The solution is to balance these nutrients with vitamin A and phosphorus. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Low Blood Sugar on Vegan Keto Raising Ceruloplasmin When Copper Won't Do It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Low Blood Sugar on Vegan Keto How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? How do I get my ceruloplasmin up if copper doesn't raise it? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: Plasma zinc is the single most important marker of zinc status. Urine zinc may decline faster in deficiency. Hair zinc increases with supplementation but does not decrease in deficiency. Plasma zinc is decreased by inflammation, oxidative stress, the ovulatory and luteal phases of the menstrual cycle, probably pregnancy and oral contraceptive use, and any kind of stress that leads to an adrenal output. If plasma zinc declines despite supplementation, corroborate that this reflects zinc status by showing normal hair zinc and low urine zinc. Use symptoms as the ultimate arbiter of whether zinc supplementation is helping. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Glutathione Intolerance: Getting to the Bottom of It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ammonia, hydrogen sulfide, sulfite, and propionyl CoA, or it could be microbial metabolites of glutathione produced in the gut. The full answer contains seven hypothesis-driven tests that can be done at home to determine the cause. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of interest and industry funding. There are plausible mechanisms by which they may hurt mitochondrial function and promote soft tissue calcification. Dietary sulfur appears to lower cholesterol. While Lester Morrison showed 1500 milligrams per day of chondroitin sulfate could reduce cardiac events 7-fold, this has a theoretical potential to hurt the microbiome. My preferred way of getting sulfur is 1.2-1.8 grams per kilogram bodyweight of total non-collagen protein, with an emphasis on animal protein. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Glutathione Intolerance: Getting to the Bottom of It Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-cognitive-health-mct In that batch of free episodes you will also find the answers to these questions: Does whey protein hurt the kidneys or otherwise hurt our health Why would someone not tolerate methyl donors even if they need them? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Why isn't my ferritin as high as diabetics when my transferrin saturation is higher? Why are vitamins A and E needed alongside D and K? Sunflower lecithin versus phosphatidylcholine supplements How do I reduce congestion while consuming dairy? Could eggs be raising triglycerides by curing fatty liver? Why would homocysteine ever be high when you can just use it to make glutathione? Why did my eye start twitching after sweating more than usual this weekend? Why do I now think A and D should be in roughly 1:1 ratios? Would MK-7 be enough to take with D or do I need MK-4? Why does water make me hungry? What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2? Is it safe to take zinc carnosine long term? Why did I recommend only using high-dose zinc for COVID protection for one year? Why did I recommend limiting quercetin phytosome to three months? Why take MK-4 when it has such a short half-life? How to make bowel movements more regular? Could freeze dried animal beef supplements cause gut infections? Do I recommend food sensitivity testing? What are the nutritional causes of restless leg syndrome? What do I think of drinking deuterium-depleted water for COVID severity? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-september Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: The main problem with too much protein, particularly animal protein, is that acidity may hurt the bones and increase the risk of calcium oxalate kidney stones, but this can be obviated by balancing it with organic acids, which have bicarbonate-sparing effects that are alkalinizing. The best index of the organic acid content of foods is the potassium content. This balance can be achieved with 750 to 1500 milligrams of potassium for every 100 grams of protein. This is not specific to whey protein. Other than allergies, none of the claimed harms of whey protein are convincing. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-cognitive-health-mct In that batch of free episodes you will also find the answers to these questions: Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline? Why would someone not tolerate methyl donors even if they need them? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Why isn't my ferritin as high as diabetics when my transferrin saturation is higher? Why are vitamins A and E needed alongside D and K? Sunflower lecithin versus phosphatidylcholine supplements How do I reduce congestion while consuming dairy? Could eggs be raising triglycerides by curing fatty liver? Why would homocysteine ever be high when you can just use it to make glutathione? Why did my eye start twitching after sweating more than usual this weekend? Why do I now think A and D should be in roughly 1:1 ratios? Would MK-7 be enough to take with D or do I need MK-4? Why does water make me hungry? What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2? Is it safe to take zinc carnosine long term? Why did I recommend only using high-dose zinc for COVID protection for one year? Why did I recommend limiting quercetin phytosome to three months? Why take MK-4 when it has such a short half-life? How to make bowel movements more regular? Could freeze dried animal beef supplements cause gut infections? Do I recommend food sensitivity testing? What are the nutritional causes of restless leg syndrome? What do I think of drinking deuterium-depleted water for COVID severity? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-september Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

High-dose biotin supplements can cause a multitude of false lab tests, masking recent heart attacks, pregnancies, or allergies, giving false signals about tumors, and far more. In this episode, I lay out for you the nature, scope, and magnitude of the problem, and develop actionable strategies you can use to protect your lab tests from generating false information as a result of this phenomenon. You can find the written and fully referenced version of this episode here: https://chrismasterjohnphd.substack.com/p/biotin-causes-false-lab-tests The written version also contains some figures that help you visualize the mechanistic information. If you find this episode valuable, please head over to the written version on Substack using the above link to like it, share it, and comment on it. This will encourage the Substack algorithm to get it in front of more people. In High Protein? You Need More Biotin, I made the case that 30 micrograms per day is not enough for adults, and that many people need 150-300 micrograms per day, depending on how much protein they eat. My simple food-based recommendations for getting enough biotin are found in my Cliff Notes (free for Masterpass members here). To learn more about the Masterpass, click here. Stay Immune Through the Winter My new 7-page quick guide on how to not get sick this winter, Staying Immune Through the Winter, is free for everyone. All you need is a free or paid subscription to my Substack. Head here to check your subscription status and to make sure you get the guide: Staying Immune Through the Winter Join the Next Live Q&A Have a question for me? Ask it at the next Q&A! Learn more here. Join the Masterpass Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button: Join the Masterpass Learn more about the Masterpass here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in people who do not experience cognitive decline. Cognitive decline does appear to be driven by decreases in brain energy metabolism, but these are not best described as a specific impairment in glucose handling. MCT oil can be modestly beneficial and a ketogenic diet can probably be somewhat more beneficial in people who have cognitive decline from any type. There is no evidence to support using it as a preventative. For prevention, I believe we should focus on aerobic fitness, nutrients required for healthy energy metabolism and antioxidant defense, and maintaining metabolic health with a healthy body composition and a healthy physical activity routine that includes the proper spread of a portfolio of different types of exercise. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-cognitive-health-mct In that batch of free episodes you will also find the answers to these questions: Does whey protein hurt the kidneys or otherwise hurt our health Why would someone not tolerate methyl donors even if they need them? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Why isn't my ferritin as high as diabetics when my transferrin saturation is higher? Why are vitamins A and E needed alongside D and K? Sunflower lecithin versus phosphatidylcholine supplements How do I reduce congestion while consuming dairy? Could eggs be raising triglycerides by curing fatty liver? Why would homocysteine ever be high when you can just use it to make glutathione? Why did my eye start twitching after sweating more than usual this weekend? Why do I now think A and D should be in roughly 1:1 ratios? Would MK-7 be enough to take with D or do I need MK-4? Why does water make me hungry? What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2? Is it safe to take zinc carnosine long term? Why did I recommend only using high-dose zinc for COVID protection for one year? Why did I recommend limiting quercetin phytosome to three months? Why take MK-4 when it has such a short half-life? How to make bowel movements more regular? Could freeze dried animal beef supplements cause gut infections? Do I recommend food sensitivity testing? What are the nutritional causes of restless leg syndrome? What do I think of drinking deuterium-depleted water for COVID severity? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-september Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: If it can't be explained by the dose of salt, it may be that the salt is not being absorbed orally. Glucose, starch, or simply a meal consumed alongside the salted water may help with this. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: Protein and Longevity How to Increase or Decrease SHBG? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Get my new 7-page quick guide on how to not get sick for free when you sign up to my Substack: https://chrismasterjohnphd.substack.com/p/staying-immune-through-the-winter Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: Protein and Longevity Why is an IV more hydrating than salted water? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

I am done with my work on COVID vaccines, at least until I finish my Vitamins and Minerals 101 Book, so I am now making my scientific review on the likely causes of COVID vaccine side effects public. This is an excerpt of pages 19-52 of my Healing From COVID Vaccine Side Effects guide (free to Masterpass members here). You can read the written version on Substack using this link, which contains 139 of the 221 references. It does not contain the protocol, but rather the scientific review used to judge the mechanisms most likely underlying the side effects. Since I am no longer working on this, I hope it proves useful to anyone doing further work on the topic. This was originally published on August 10, 2022. The science described is not intended to be comprehensive. Rather, emphasis is placed on what is likely to provide insights into the mechanisms of side effects. Please visit the Substack version to like it, comment on it, and share it: COVID Vaccine Side Effects: What Causes Them? Join the Next Live Q&A Have a question for me? Ask it at the next Q&A! Learn more here. Join the Masterpass Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Learn more about the Masterpass here. Take a Look at the Store At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements, MASA chips. Find more affiliates here. For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I've learned in over 15 years of studying nutrition science. For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick. For $10, you can purchase Healing From COVID Vaccine Side Effects for yourself or a loved one if dealing with this issue. It also contains an extensive well-referenced scientific review, so you can also use this just to learn more about my research into the COVID vaccines. For $15, you can pre-order a single format of my Vitamins and Minerals 101 book, my complete guide to nutrition, which I am currently working full-time on finishing. For $25, you can pre-order a digital bundle of my Vitamins and Minerals 101 book. For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork. For $35, you can pre-order a complete bundle of my Vitamins and Minerals 101 book. For $250-$1499.99, you can work one-on-one with me. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of protein or calories might otherwise provide, and a high protein intake supports bone mass, muscle mass, and the detoxification of carcinogens, all of which are important to longevity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: How to Increase or Decrease SHBG? Why is an IV more hydrating than salted water? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite of an apple. It requires the preponderance of signaling. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal? What is my favorite web site for finding enzymatic cofactors? Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don't at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: What to do about persistent SIBO? Are there toxicity concerns for intravenous B vitamins? Should zinc be taken apart from oral rehydration salts? Why would magnesium cause erratic heartbeat, bad dreams, and tinnitus? How do you know if you have low stomach acid? What is a good sweetener to replace granulated sugar? Do I need to eat foods with calcium every day? What bread do I eat? Should you take vitamin D for COVID prevention if you have a history of hypercalcemia? What to do about extreme CFS, depression, anxiety, and brain fog when nothing seems to work. Why balance K2 with vitamin E rather than K1? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: What to do about persistent SIBO? Are there toxicity concerns for intravenous B vitamins? Should zinc be taken apart from oral rehydration salts? Why would magnesium cause erratic heartbeat, bad dreams, and tinnitus? How do you know if you have low stomach acid? What is a good sweetener to replace granulated sugar? Do I need to eat foods with calcium every day? What bread do I eat? Should you take vitamin D for COVID prevention if you have a history of hypercalcemia? What to do about extreme CFS, depression, anxiety, and brain fog when nothing seems to work. Why balance K2 with vitamin E rather than K1? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made from organic corn from small New England farms. The corn is nixtimalized, which frees the niacin, makes it more digestible, and eliminates 97-100% of the mycotoxins (based on studies with aflatoxin). Then they are fried in grass-fed beef tallow! They are full-bodied and feel nourishing, and they are the perfect saltiness. That is, I do not feel like a company has tagged me as eating a low-salt diet just because I want a healthy chip. The bulk of your diet should be unprocessed and minimally processed foods, but there is an important place for health snacks! Get your MASA chips today at https://chrismasterjohnphd.com/masa and use the code MASTERJOHN for 10% off. I will get a small commission at no extra cost to you. You will rarely ever find me promoting a chip, but this is one I endorse! Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Nick Hiebert and I debate the value of ancestral health as a framework for approaching health in the modern era. For my summary of and reflections on the debate, as well as time stamps, relevant links, and a transcript, head to: https://chrismasterjohnphd.substack.com/p/the-ancestral-health-debate If you found this valuable, please like, share, and comment on the Substack version to get it before more eyeballs. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this interview, Mathew Crawford walks me through his slide presentation of data showing that, at some point between 2020 and 2021, the 2016-2019 data from the US Military's health database was altered in a way that hides the explosion of poorly-defined illness among troops that happened in 2021 as the COVID vaccines were rolled out. For the video with the slides, a more complete summary, and a transcript, head over to Substack with this link: https://chrismasterjohnphd.substack.com/p/mathew-crawford-fraud-in-the-militarys If you find this valuable, please like, share, and comment on the Substack video to help me promote this before more eyeballs by leveraging the Substack algorithm. Please need to see this! Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, "Neuroscience," pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the NEUROTRANSMITTERS! 0:00:37 Cliff Notes 0:04:15 Overview of neurotransmitters 0:06:55 Glutamate is the primary excitatory neurotransmitter. 0:14:08 De novo glutamate in the central nervous system is overwhelmingly made from glucose. 0:16:55 Ketogenic diet for epilepsy 0:20:12 Glutamate metabolism 0:23:42 There are two classes of glutamate receptors: ionotropic and metabotropic. 0:24:45 There are three classes of metabotropic glutamate receptors, their actions are complex and variable, and they can be excitatory or inhibitory. 0:25:05 The ionotropic glutamate receptors include AMPA receptors, NMDA receptors, and kainite receptors, all of which have a depolarizing effect by allowing sodium and potassium to flow freely through them. 0:27:47 Four unique things about the NMDA receptor: magnesium is required to block its ion channel, it's important for coincidence detection, it allows calcium to come into the cell, and it has a glycine-binding site. 0:33:16 Long-term potentiation (LTP) and long-term depression (LTD) are important for forming memories, and glutamate receptors play an important role. 0:40:48 GABA and glycine are the two primary inhibitory neurotransmitters of the central nervous system. 0:44:04 GABA and presumably glycine can be stimulatory if there is more chloride on the inside of the neuron than the outside. 0:48:53 Evidence that GABA might cross the blood-brain barrier 0:51:44 GABA in foods 0:54:14 GABA metabolism in the nervous system 0:56:08 Glycine 1:02:02 Acetylcholine 1:07:50 The biogenic amines include histamine, serotonin, and the catecholamines (dopamine, norepinephrine, and epinephrine). 1:08:30 Synthesis of the catecholamines 1:10:46 Dopamine 1:14:08 Norepinephrine 1:16:32 Histamine 1:20:15 Serotonin 1:23:10 ATP and adenosine 1:26:38 Peptide neurotransmitters 1:27:00 Hypothalamic releasing hormones include thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH). 1:29:15 Melanocyte-stimulating hormone (MSH) 1:29:32 Oxytocin 1:30:18 Vasopressin 1:30:57 Synthesis of the neuropeptides Substance P, MSH, oxytocin, and vasopressin requires glycine, zinc, copper, and vitamin C. 1:34:24 Endocannabinoids and the importance of arachidonic acid, EPA, and DHA Nutrition in Neuroscience Related Content Chris Masterjohn Lite: Could Oxaloacetate Supplements Help With Glutamate Sensitivity? Chris Masterjohn Lite: 5 Ways to Help With Glutamate Sensitivity and Glutamate Dominance Chris Masterjohn Lite: Does Glycine or GABA Wake You Up? Chris Masterjohn Lite: Carbs or Keto for Sleep? Chris Masterjohn Lite: How to Manage Your Magnesium Status Mastering Nutrition: Why You Need Glycine -- A Panel Discussion Balancing Methionine and Glycine in Foods: The Database Chris Masterjohn Lite: Get Better Sleep With Glycine Start Here for Methylation has glycine and choline resources, and covers the methylation process used in the synthesis and degradation of biogenic amines. Mastering Nutrition: Methylate Your Way to Mental Health With Dopamine The Pursuit of Happiness: How Nutrient-Dense Animal Fats Promote Mental and Emotional Health, covers the endocannibinoids. Testing Nutritional Status: The Ultimate Cheat Sheet is a comprehensive guide for testing nutritional status for all the nutrients discussed in this episode, and more. Use the code MASTERINGNUTRITION for $5 OFF. Nutrition in Neuroscience Research The textbook, Neuroscience. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. on the use of GABA for fear of heights and to alter anxiety- and focus-related brain waves. γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial on use of GABA to improve decision-making under pressure. Desarrollo de un pan de masa madre rico en GABA y péptidos IECA contains a table on the GABA content of foods on page 84 of the PDF. Acetylcholinesterase inhibitor from plants on the different plants containing natural acetylcholinesterase inhibitors. A Mass Spectrometry-Based Method to Screen for α-Amidated Peptides on the neuropeptides that require glycine, vitamin C, copper, and zinc for their biological activity. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase also on the neuropeptides that require glycine, vitamin C, copper, and zinc for their biological activity. Access the show notes, transcr

This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in severe COVID and may reflect the rapid onset of a somewhat cancer-reminiscent state where vitamins A and D and other myeloid differentiation factors run out. The written version with references and links to research is available here: https://chrismasterjohnphd.substack.com/p/a-new-paradigm-for-severe-covid If you find this valuable, please like, share, and comment on the Substack article to help boost it within the Substack algorithm and get more people to read it. Vitamins A and D should be properly balanced with each other, and with vitamins E and K. My COVID-specific recommendations for this balance are in the COVID Guide, and recommendations for balancing them in various different contexts are included in the Vitamins and Minerals 101 Cliff Notes, both of which are freely available to paid Substack subscribers. These also contain general (Cliff Notes) or COVID-specific (COVID Guide) information for managing all the other nutrients mentioned. I will be updating the COVID guide next time to include tryptophan and N-acetylcysteine whenever arginine is used, but other than that this new paradigm does not alter the protocol. It does, however, move much more emphasis to A and D, and bring A onto much more equal footing with D. Disclaimer I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional. Paid Subscriptions, Coming Guides, the Book My current plan is to wrap up a vaccine side effect protocol and my general work on the vaccines into a COVID Vaccine Guide that will be free to those who have pre-ordered my book, Masterpass members, and paid Substack subscribers. I will then do one final update to the COVID guide, also free to everyone I just mentioned. Paid Substack subscribers and Masterpass members will also have access to all paid-only Substack posts, which are the posts that feed into the creation of the vaccine side effect protocol. Most of these will be available for 48 hours to everyone. You can become a paid Substack subscriber here, which earns you 50% off the fee on Masterpass membership if you choose to join. The book can be pre-ordered here. As soon as these two guides are finished I will return full-time to finishing the book and will send everyone who pre-ordered an ETA as soon as I am ready. Take a Look at the Store At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here. For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I've learned in over 15 years of studying nutrition science. For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick (free if you become a paid subscriber to my Substack). For $15, you can pre-order a single format of my Vitamins and Minerals 101 book, my complete guide to nutrition, to be finished as soon as my work on COVID vaccines is done. For $25, you can pre-order a digital bundle of my Vitamins and Minerals 101 book. For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork. For $35, you can pre-order a complete bundle of my Vitamins and Minerals 101 book. For a recurring $15/month or $120/year, you can join the CMJ Masterpass, with monthly access to live Zoom Q&A sessions with me, and huge discounts on my consulting, my informational products, and the health and wellness products from other companies that I value most. Paid Substack subscribers get 50% off the membership fee. For $250-$1499.99, you can work one-on-one with me. In any amount at all, you can make a donation to support my work on COVID vaccines during this time when our freedom of speech, bodily autonomy, and right to earn a living are all under attack. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short answer: You should be able to see changes on imaging within a few weeks if your approach is working well, but ultimately this is entirely dependent on how negative your "delta fatty liver = (fat in) - ((fat out) + (fat burned))" equation is. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the April 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How to balance vitamins E and K What prenatal vitamin do I recommend? Why does my smoothie make my hands cold? What type of choline to use? Is there an interaction between glycine and aspirin? What supplements can be used in the fasting state? How to manage protein intake within a small eating window on an intermittent fasting regimen? Looking at a study on calcium alpha-ketoglutarate supplementation. Should I take vitamin D for COVID if I easily get hypercalcemia from it? What to do about nausea in pregnancy? Brief questions on restless legs, exercise during fasting, puffy eyes, and health effects of spicy foods. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/ask-me-anything-april-13-2022 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of "biological vitamin D activity" from them. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the April 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How to balance vitamins E and K What prenatal vitamin do I recommend? Why does my smoothie make my hands cold? What type of choline to use? Is there an interaction between glycine and aspirin? What supplements can be used in the fasting state? How to manage protein intake within a small eating window on an intermittent fasting regimen? Looking at a study on calcium alpha-ketoglutarate supplementation. Should I take vitamin D for COVID if I easily get hypercalcemia from it? What to do about nausea in pregnancy? Brief questions on restless legs, exercise during fasting, puffy eyes, and health effects of spicy foods. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/ask-me-anything-april-13-2022 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Rising Food Prices Part 4: Can Regenerative Agriculture Solve the Food Crisis? This is the 4th in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving landscape of food availability, and what we should do about it. Allen Williams joins me to talk about conventional, organic, and regenerative agriculture, and how fuel and fertilizer inputs differ between them, and why regenerative agriculture offers the best resilience in the face of what looks like an emerging food crisis. Allen Williams is a 6th generation family farmer and founding partner of Grass Fed Insights, LLC, Understanding Ag, LLC and the Soil Health Academy. He has consulted with more than 4000 farmers and ranchers in the U.S., Canada, Mexico, South America, and other countries, on operations ranging from a few acres to over 1 million acres. Allen pioneered many of the early regenerative grazing protocols and forage finishing techniques and now teaches those practices and principles to farmers globally. He is a "recovering academic", having served 15 years on the faculty at Louisiana Tech University and Mississippi State University. He holds a B.S. and M.S. in Animal Science from Clemson University and a Ph.D. in Livestock Genetics from LSU. He has authored more than 400 scientific and popular press articles, and is an invited speaker at regional, national, and international conferences and symposia. Allen and his colleagues specialize in whole farm & ranch planning based on the concept of regenerative agriculture. Their approach creates significant "value add" and prepares the landowner for multiple enterprise/revenue stream opportunities that stack enterprises and acres. This approach allows for enhanced profitability and/or investment value. They routinely conduct workshops and seminars across the U.S., Canada, and Mexico. Find regenerative agriculture at https://regenified.com/ This is a work in progress. Until it is completed, use https://localharvest.org, https://eatwild.com, and https://soilhealthacademy.org/shop-regen-foods/ Follow Allen's work at https://understandingag.com/ Learn about soil at https://soilhealthacademy.org/ Find more research on the topic at https://www.ecdysis.bio/ If you are interested in investment opportunities in regenerative agriculture, inquire with Allen using the Understanding Ag contact form: https://understandingag.com/connect-with-us/ This series started from a Substack post I wrote, The Emerging Food Crisis: https://chrismasterjohnphd.substack.com/p/the-emerging-food-crisis Over the next month, as part of this series, I will conduct interviews and panel discussions on my podcast in an effort to better understand the issue and what to do about it. Relying primarily on interviews will allow me to better understand the issue while staying focused on finishing my vaccine research so I can ultimately return to finishing my book. I will eventually be concluding my work on the vaccines with a COVID Vaccine Guide, which I will distribute for free to paid Substack subscribers, those who have pre-ordered my Vitamins and Minerals 101 book, and members of the CMJ Masterpass. Articles in this series that lay out actionable foundations of my future protocol for vaccine side effects will be for paid Substack subscribers and Masterpass members. However, most of them will available for free for the first 48 hours, and all of them will be readable with a free trial. Paid Substack subscribers get immediate access to my COVID Guide, and are entitled to 50% off a membership to the Masterpass as well. You can subscribe or upgrade your subscription here: https://chrismasterjohnphd.substack.com/subscribe You can pre-order the book here: https://chrismasterjohnphd.com/book And you can join the Masterpass here: https://themasterpass.chrismasterjohnphd.com/sales-page Masterpass members get to watch these interviews live, and also have monthly access to a live Q&A with me. The next Q&A session is Wednesday, May 18, 12:00 PM Eastern. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Tony Greer joins me to talk about how lockdowns, politics, and the commodity trade contribute to rising food prices. Tony Greer is partly responsible for my awareness of the emerging food crisis as I had initially learned of Doomberg from him last year. He has been a macro trader for over thirty years, is a regular on the Real Vision Daily Briefing, and is editor of the Morning Navigator. Tony brings us unique insights as a trader who saw the rise in commodity prices early. Will the rotation out of tech stocks into commodities continue? What role does this trade have in amplifying food prices itself? Can we use technical signals from the market to gauge the likelihood this problem will get much worse, and to be able to spot light at the end of the tunnel when it finally emerges? Tony surprised me by suggesting the most important signal to look for as "light at the end of the tunnel" ushering in a reprieve from rising food prices is not so much a technical indicator from the charts or from economic data but rather a sustainable 180-degree reversal in the political hostility to the energy markets. He suggests food prices would take another 7 or more years to calm down once this reversal is sustained. None of this is financial advice and you must make your own decisions at your own risk. However, we conclude with some thoughts Tony has on how to keep savings safe in an environment like this. You can join his newsletter at https://tgmacro.com/ and follow him on Twitter at https://twitter.com/TgMacro This series started from a Substack post I wrote, The Emerging Food Crisis: https://chrismasterjohnphd.substack.com/p/the-emerging-food-crisis Over the next month, as part of this series, I will conduct interviews and panel discussions on my podcast in an effort to better understand the issue and what to do about it. Relying primarily on interviews will allow me to better understand the issue while staying focused on finishing my vaccine research so I can ultimately return to finishing my book. I will eventually be concluding my work on the vaccines with a COVID Vaccine Guide, which I will distribute for free to paid Substack subscribers, those who have pre-ordered my Vitamins and Minerals 101 book, and members of the CMJ Masterpass. Articles in this series that lay out actionable foundations of my future protocol for vaccine side effects will be for paid Substack subscribers and Masterpass members. However, most of them will available for free for the first 48 hours, and all of them will be readable with a free trial. Paid Substack subscribers get immediate access to my COVID Guide, and are entitled to 50% off a membership to the Masterpass as well. You can subscribe or upgrade your subscription here: https://chrismasterjohnphd.substack.com/subscribe You can pre-order the book here: https://chrismasterjohnphd.com/book And you can join the Masterpass here: https://themasterpass.chrismasterjohnphd.com/sales-page Masterpass members get to watch these interviews live, and also have monthly access to a live Q&A with me. The next Q&A session is Wednesday, April 13, 6:00 PM Eastern. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

With Dr. Michael Howell, PhD. This is the second in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving landscape of food availability, and what we should do about it. Michael Howell, PhD joins me to discuss whether "money printing" and the liquidity cycle might be playing a role in rising food prices. Howell has a PhD in Economics and specializes in analyzing global central bank activities, liquidity trends, and capital flow data across 80 economies. He is CEO of CrossBorder Capital, which he founded in 1996. He developed the quantitative liquidity research methodology while he was Research Director at Salomon Bros. from 1986. He was subsequently appointed Head of Research at Baring Securities in 1992, and was top-ranked "Emerging Market Strategist" by institutional investors for the three years prior to setting up CrossBorder Capital. Michael has worked in financial markets since 1981 and is a regular international conference speaker. He is a qualified US Supervisory Analyst. You can buy his book, Capital Wars: The Rise of Global Liquidity, here. You can follow his company, Cross Border Capital, on Twitter here. This series started from a Substack post I wrote, The Emerging Food Crisis: https://chrismasterjohnphd.substack.com/p/the-emerging-food-crisis Over the next month, as part of this series, I will conduct interviews and panel discussions on my podcast in an effort to better understand the issue and what to do about it. Relying primarily on interviews will allow me to better understand the issue while staying focused on finishing my vaccine research so I can ultimately return to finishing my book. I will eventually be concluding my work on the vaccines with a COVID Vaccine Guide, which I will distribute for free to paid Substack subscribers, those who have pre-ordered my Vitamins and Minerals 101 book, and members of the CMJ Masterpass. Articles in this series that lay out actionable foundations of my future protocol for vaccine side effects will be for paid Substack subscribers and Masterpass members. However, most of them will available for free for the first 48 hours, and all of them will be readable with a free trial. Paid Substack subscribers get immediate access to my COVID Guide, and are entitled to 50% off a membership to the Masterpass as well. You can subscribe or upgrade your subscription here: https://chrismasterjohnphd.substack.com/subscribe You can pre-order the book here: https://chrismasterjohnphd.com/book And you can join the Masterpass here: https://themasterpass.chrismasterjohnphd.com/sales-page Masterpass members get to watch these interviews live, and also have monthly access to a live Q&A with me. The next Q&A session is Wednesday, April 13, 6:00 PM Eastern. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

This is the first in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving landscape of food availability, and what we should do about it. Josh Young and Tracy Schuchart are here to talk about why oil and fertilizer are in short supply and why their prices have been steadily rising. Josh Young is Chief Investment Officer and Founder of Bison Interests, which invests in the publicly traded oil and gas markets. Follow him on Twitter at https://twitter.com/Josh_Young_1 Tracy Shuchart is Partner and Global Macro Energy and Materials Strategist at Intelligence Quarterly. Follow her on Twitter at https://twitter.com/chigrl This series started from a Substack post I wrote, The Emerging Food Crisis: https://chrismasterjohnphd.substack.com/p/the-emerging-food-crisis Over the next month, as part of this series, I will conduct interviews and panel discussions on my podcast in an effort to better understand the issue and what to do about it. Relying primarily on interviews will allow me to better understand the issue while staying focused on finishing my vaccine research so I can ultimately return to finishing my book. I will eventually be concluding my work on the vaccines with a COVID Vaccine Guide, which I will distribute for free to paid Substack subscribers, those who have pre-ordered my Vitamins and Minerals 101 book, and members of the CMJ Masterpass. Articles in this series that lay out actionable foundations of my future protocol for vaccine side effects will be for paid Substack subscribers and Masterpass members. However, most of them will available for free for the first 48 hours, and all of them will be readable with a free trial. Paid Substack subscribers get immediate access to my COVID Guide, and are entitled to 50% off a membership to the Masterpass as well. You can subscribe or upgrade your subscription here: https://chrismasterjohnphd.substack.com/subscribe Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

The spike protein pokes holes in cell membranes at concentrations much lower than those achieved with vaccination, contributing to COVID-like illness and mitochondrial damage. But is the J&J immune? This is not medical advice. This podcast was originally published in written form as a Substack article, fully referenced, found here: https://chrismasterjohnphd.substack.com/p/the-spike-protein-as-a-pore-forming This is the first in a series of posts in which I will outline the potential mechanisms of spike protein toxicity and vaccine side effects and brainstorm actionable steps vaccinees can take to protect against these effects or heal from them. I will eventually be concluding my work on the vaccines with a COVID Vaccine Guide, which I will distribute for free to paid Substack subscribers, those who have pre-ordered my Vitamins and Minerals 101 book, and members of the CMJ Masterpass. Articles in this series that lay out actionable foundations of my future protocol for vaccine side effects will be for paid Substack subscribers and Masterpass members. However, most of them will available for free for the first 48 hours, and all of them will be readable with a free trial. Paid Substack subscribers get immediate access to my COVID Guide, and are entitled to 50% off a membership to the Masterpass as well. You can subscribe or upgrade your subscription here: https://chrismasterjohnphd.substack.com/subscribe Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

My tentative view on what is causing it and what to do about it. This is NOT caused primarily by the conflict in Ukraine and a sudden peaceful solution to the conflict will not avert it. The written version with links to sources can be found here: https://chrismasterjohnphd.substack.com/p/the-emerging-food-crisis Please Show The Substack Post Some Love Please hit up the Substack post and let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable. Subscribe or Upgrade I will eventually be concluding my work on the vaccines with a COVID Vaccine Guide, which I will distribute for free to paid Substack subscribers, those who have pre-ordered my Vitamins and Minerals 101 book, and members of the CMJ Masterpass. Articles in this series that lay out actionable foundations of my future protocol for vaccine side effects will be for paid Substack subscribers and Masterpass members. However, most of them will available for free for the first 48 hours, and all of them will be readable with a free trial. Paid Substack subscribers get immediate access to my COVID Guide, and are entitled to 50% off a membership to the Masterpass as well. You can subscribe or upgrade your subscription here: https://chrismasterjohnphd.substack.com/subscribe Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

https://chrismasterjohnphd.com/paradox Please subscribe to my Substack at https://chrismasterjohnphd.substack.com Subscription is completely free but if you take the option to pay $5 a month or $30 per year, you will get access to exclusive content, as well as my COVID guide for free and 50% off my Masterpass membership program. Please like, comment on, and share the Substack version of this post. This will help spread it far and wide, as subscriber engagement drives the Substack algorithm. Engagements from paid subscribers count the most, but engagements from free subscribers come in the highest numbers and are the foundation for spreading the content. This episode covers how a negative PCR test can serve as a marker for systemic inflammation and spike protein toxicity, creating a widely exploited statistical anomaly to make misleading claims about hospitalization. I consider this the absolute most important topic of our decade: the core anomaly in COVID data that is exploited worldwide to claim the vaccines are protecting against hospitalization among those who get COVID, yet which is at complete odds with the CDC data showing the majority of people hospitalized for COVID-like illness are vaccinated and that the vast majority of them test negative. "COVID-like illness" refers to the signs and symptoms of COVID, regardless of the results of a PCR test. While the clinical fate of PCR-negative COVID-like illness is completely unclear, we cannot just ignore it. In fact, recent evidence suggests that as much as 69% of PCR-negative COVID-like illness might be genuine COVID. Zooming out to capture the total COVID-like illlness, the "Hospitalization Paradox" refers to the fact that the vaccines do not protect against it at all. When the vaccines have high efficacy against a negative test, all they do is make ill people test negative. In contexts where they have sub-par efficacy against a negative test — the Johnson and Johnson trial, after 3 months of being vaccinated with no booster, and in the face of increasingly vaccine-resistant variants like delta and omicron — suddenly they appear to have efficacy against hospitalization, but only among vaccinated people who test positive. The vaccinated people who test negative, by contrast, wind up in the hospital with PCR-negative COVID-like illness. In this very extensively documented article, I argue that this can be explained by the negative test, during the waning phase, becoming a marker of vaccine-induced systemic inflammation and the persistence of spike protein in the body, contributing to acute and cumulative spike protein toxicity and possibly spike-induced autoimmunity. Read the article here: https://chrismasterjohnphd.com/paradox Please subscribe to my Substack at https://chrismasterjohnphd.substack.com Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

I'm recording from "Youtube Jail," where I'll be until Monday morning. Two more strikes and I'm out. Please help our community stay connected by joining my email list at https://chrismasterjohnphd.com/uncensored Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

The pandemic that no one dare speak of: 79% of people hospitalized for COVID-like illness test negative for COVID. The vaccines protect against testing positive among those hospitalized, but not against winding up in the hospital with the symptoms. And deaths? We have no idea. What the heck is going on? Read the written and referenced analysis here: The Pandemic of PCR-Negative COVID-Like Illness Help Me Fight Censorship and Stay Connected With Me Please join my email list ASAP at https://chrismasterjohnphd.com/uncensored Here's why: YouTube took down my interview of Jessica Rose after it started going viral and hit 35,305 views. They gave me a warning. Then they took down my livestream of the Washington, DC Defeat the Mandates Rally. That earned me a strike. I'm currently in "YouTube Jail" until Monday morning. Two more strikes and I'm out. Instagram has threatened me with account deletion, accused me of causing people physical harm by discussing research on arginine, banned you from tagging me, and is "like suppressing me" by preventing a percentage of people from liking my posts. Please stand for free expression by joining my email list, ensuring we stay connected. I will immediately send you an email of the most important alternative platforms to follow me on and how to join me in the fight against censorship. Join now at https://chrismasterjohnphd.com/uncensored Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this episode, Chris Masterjohn interviews Angela McArdle on strategies to defeat the mandates. McArdle is the current chair of the Los Angeles Libertarian Party and is spearheading an effort to amend the New York City charter to prohibit the mayor from making mandates. We discuss the ethics of mandates, steelmanning the case in favor of them, and then justifying our opposition to them. We discuss strategies to defeat them, as well as strategies for employees to keep their jobs when faced with them. Angela has worked as a paralegal and legal aid for over eleven years. Angela currently works in litigation and also has a private practice where she provides self help legal services to low income clients. The bulk of Angela's practices focuses on real estate and constitutional law. She was a key organizer for the Los Angeles 2013 protest against a ban on feeding in public rights of way, which was a major obstacle to feeding the homeless. Angela received her Bachelor's Degree in Organizational Leadership from Biola University in 2009 and a Paralegal Certificate from UCLA Extension in 2013. Angela is also trained as a craniosacral therapist through the Upledger Institute. She believes strongly in the sanctity of personal choice and allowing people to govern their own lives. Important Links Visit her web site at https://angelamcardle.com and follow her on twitter @angela4LNCChair Time Stamps 00:45 George Washington's smallpox mandate 02:45 McArdle's background in law and natural health 09:05 Test negative case control studies are a scam, same with RCTs without inert placebos 13:38 The ethics of mandates 25:22 Amending the city's charter 30:33 Changing the hearts and minds of the people 38:10 Voting with your feet: to move, or to stay and fight? 46:07 Connecting with people on an emotional level; city council meetings; changing the hearts and minds of reporters 49:46 The role of protests and rallies 56:52 Restaurant sit-ins 1:05:10 Call banking businesses 1:07:54 Perceptions of the sit-ins 1:11:16 Different ways individuals can get involved 1:12:26 Persuading the police 1:17:02 What to do if your job is threatened 1:23:12 If we don't stop this now, what's the end game? Help Me Fight Censorship and Stay Connected With Me Please join my email list ASAP at https://chrismasterjohnphd.com/uncensored Here's why: YouTube took down my interview of Jessica Rose after it started going viral and hit 35,305 views. Instagram has threatened me with account deletion, accused me of causing people physical harm by discussing research on arginine, banned you from tagging me, and is "like suppressing me" by preventing a percentage of people from liking my posts. Please stand for free expression by joining my email list, ensuring we stay connected. I will immediately send you an email of the most important alternative platforms to follow me on and how to join me in the fight against censorship. Join now at https://chrismasterjohnphd.com/uncensored Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this episode, I have Dr. Dmitry Kats, MPH, PhD. He has a PhD in epidemiology from the University of North Carolina at Chapel Hill. Many people have asked me what I think of his Niatonin protocol for COVID. And as you'll see in this interview that has since evolved into the Niacur protocol, which now has the dosing regimen of just niacin and curcumin, having abandoned the melatonin from the original protocol. You will find in this 3.5-hour conversation all about the justification for that protocol, how it evolved over time, where it came from, and you will get a really interesting look into the fascinating mind of Dr. Kats. Important Links Follow Dr. Kats on Telegram here: https://t.me/NiaCur During this critical time where our freedom of health and freedom of speech is in imminent danger, and where tens of thousands of people are facing imminent job losses as the result of medical mandates, I am devoting my analytical skills full time toward the battle for health freedom. This includes working directly with lawyers in lawsuits over mandates, lockdowns, and the current standard of care, scientifically analyzing the safety, efficacy, and risks of mandated medical treatments and their alternatives as well as ways to mitigate their harms, publishing my findings in scientific journals and sharing them with you. It is my firm conviction that this is the most important gift I can offer the world right now, and I view this as a needed public service. I would be extremely grateful if you could support me during this time. At https://chrismasterjohnphd.com/support, you can purchase one of my information products in amounts ranging from $3 to $30, or take advantage of my consulting services for more. You can also make a purchase using one of my affiliate links to buy something you would have bought anyway at no extra cost to you. Finally, at https://chrismasterjohnphd.com/donate, you can make a donation in any amount. In a world increasingly dominated by censorship, we may have censored certain words in this video in order to protect the show and keep our community connected. To make sure we stay together as a community, please join my newsletter at chrismasterjohnphd.com/newsletter, where I can guarantee that I'll never deplatform myself. This interview was recorded during a Live Zoom recording, where members of the CMJ Masterpass sat in and submitted comments and questions in the live chat. If you would like to sit in on future interviews I conduct with the chance to contribute questions, sign up for the Masterpass at https://chrismasterjohnphd.com/masterpass and use the code INTERVIEW for 10% off the membership fee for as long as you remain a member. Masterpass members also have access to a transcript and to the uncensored video and audio. Don't forget to like, share, and subscribe as well. Thank you for your support! Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this episode, I have a fascinating 3-hour conversation with Dr. Jessica Rose about all things related to C-word juices, ranging from interpreting the adverse event reporting system to the future of mandatory prophylactic gene therapy. If you follow Dr. Rose on her web site or YouTube channel, she is first and foremost an analyst of the adverse event reporting system. If you follow her substack, her bio is simple: "I am a dissident." Her academic bio emphasizes her expertise in biology and immunology: Dr. Jessica Rose is a Canadian researcher with a Bachelor's degree in Applied Mathematics and a Master's degree in Immunology from Memorial University of Newfoundland. She also holds a PhD in Computational Biology from Bar Ilan University and 2 post-doctoral degrees: one in Molecular Biology from the Hebrew University of Jerusalem and one in Biochemistry from the Technion Institute of Technology. She was also accepted for a 2-month program as a senior researcher at the Weizmann Institute prior to completion of her latest post doctoral degree at the Technion. Important Links Her CV is rich in published work on infectious diseases: https://i-do-not-consent.netlify.app/media/Curriculum%20Vitae%20June%202021.pdf She plays advisory roles in the Canadian organization Take Back Our Freedoms: https://takingbackourfreedoms.ca/about-us/ She is also involved with Geert Vanden Bossche's Voice for Science and Solidarity: https://www.voiceforscienceandsolidarity.org/authors/jessica-rose The three most important ways to keep up with her work are her web site, substack, and YouTube channel: https://i-do-not-consent.netlify.app/ https://jessicar.substack.com/ https://www.youtube.com/user/74jessicarose This is her currently withdrawn paper on myocarditis: https://61b87bfde22db9000824d656--i-do-not-consent.netlify.app/media/A%20Report%20on%20Myocarditis%20Adverse%20Events%20in%20the%20U.S.%20Vaccine%20AdverseEvents%20Reporting%20System%20%28VAERS%29%20in%20Association%20with%20COVID19%20Injectable%20Biological%20Products.pdf This is her critical appraisal of the adverse event reporting system as a pharmacovigilence tool: https://i-do-not-consent.netlify.app/media/Pharmacovigilance%20VAERS%20paper%20FINAL_OCT_1_2021.pdf Time Stamps 07:25 The interview starts 08:27 Her academic background 25:09 How she started analyzing adverse effect reporting system data 31:14 Were the mandates a surprise or expected? 31:34 Raw milk persecution, Rawsome raids, National Animal Identification System, swine flu microchips and forced quarantining laws 38:45 Interpreting the adverse event reporting system: how do we think about underreporting, overreporting, stimulated reporting, and causality? 52:08 Total adverse events are continuing to accumulate at the same rate even though the rollout is tapering, breakthrough infections, female reproduction issues 56:38 John Su misrepresents the data on 5-11-year-olds at CDC meeting 01:03:02 Hiding the children injected illegally 1:08:52 Severe adverse events in 5-11-year-olds 1:15:37 Back when 50 deaths would take a product off the market 1:18:04 We should be more cautious, not less cautious, when the data is poor quality 1:21:00 Hiding the all-cause mortality data 1:26:51 Can you get the C-word twice? And what does it mean, exactly, to get the C-word? 1:48:37 Widespread low-level inflammation throughout the population 1:53:14 Can the spike protein be written to the human genome? 1:57:31 Why is the risk/reward ratio so much worse for kids? 2:03:57 The effect of the juices on viral evolution in the era of omicron 2:12:18 Do we have an epidemic of hospitalizations for PCR-negative C-word-like illness in fully juiced people? 2:16:13 The saga of the retracted paper 2:20:14 Most myocarditis is severe by standard definition 2:27:13 Two approaches to language in peer-reviewed papers: raw honesty vs deference to the narrative. 2:32:58 What is a juice, and are these injections technically juices? 2:42:48 The importance of precision 2:45:20 The potential future of widespread or even mandatory prophylactic gene therapy 2:50:00 Why risk-reward is the wrong way to thing about the juice 2:56:36 Blood transfusions and shedding 3:01:57 Her advice as a concerned citizen of the human species to us as we enter into a world wherein we are rapidly losing our freedoms. During this critical time where our freedom of health and freedom of speech is in imminent danger, and where tens of thousands of people are facing imminent job losses as the result of medical mandates, I am devoting my analytical skills full time toward the battle for health freedom. This includes working directly with lawyers in lawsuits over mandates, lockdowns, and the current standard of care, scientifically analyzing the safety, efficacy, and risks of mandated medical treatments and their alternatives as well as ways to mitigate their harms, publishing my findings in scientific journals and sharing them with you. It is my firm conviction that this is the most

In this episode, I interview Law Professor Jorge Contreras about the past, present, and future of biotech companies patenting the human genome. Jorge L. Contreras received his law degree from Harvard and teaches intellectual property, science policy, antitrust law and genetics law at the University of Utah. His scholarship has appeared in Science, Nature, NYU Law Review, Georgetown Law Journal, Harvard Journal of Law and Technology, and other leading journals. He has been featured on NPR, PRI and BBC radio, and his opinions have been cited by news outlets including the New York Times, Wall Street Journal, Economist, and Washington Post. He is the author of The Genome Defense: Inside the Epic Legal Battle to Control Who Owns Your DNA. You can buy the book, find out more about it, see primary documents relating to the legal battle, get further reading suggestions, or participate in discussions at https://genomedefense.org. 04:48 How many naturally occurring human gene patents are currently on the books? 09:04 What does it mean, in a practical sense, for a human gene to be patented? 16:36 When did the patenting of human genes start? 28:29 The global race to find the "breast cancer gene," first private company to patent a natural human gene 39:13 The legal battle to overturn the patenting of human genes 48:32 The solicitor general's bizarre cDNA vs gDNA compromise wins the day; Big Diagnostics hurt; Big Pharma survives 1:06:51 Do patents help or hurt innovation? 1:10:53 The C-word virus's genome would have been patented, but wasn't because of the 2013 Supreme Court decision; why the juices but not the virus can be patented 1:16:30 His role in the Open C-Word Pledge 1:23:16 Thinking about the future of widespread or even mandatory prophylactic gene therapy 1:33:31 What if a small number of companies race to engineer us into Microsoft-style or Apple-style operating systems and related ecosystems using prophylactic gene therapy? 1:38:41 Efforts to overturn the 2013 Supreme Court decision: all eyes on Congress for the next couple of years During this critical time where our freedom of health and freedom of speech is in imminent danger, and where tens of thousands of people are facing imminent job losses as the result of medical mandates, I am devoting my analytical skills full time toward the battle for health freedom. This includes working directly with lawyers in lawsuits over mandates, lockdowns, and the current standard of care, scientifically analyzing the safety, efficacy, and risks of mandated medical treatments and their alternatives as well as ways to mitigate their harms, publishing my findings in scientific journals and sharing them with you. It is my firm conviction that this is the most important gift I can offer the world right now, and I view this as a needed public service. I would be extremely grateful if you could support me during this time. At https://chrismasterjohnphd.com/support, you can purchase one of my information products in amounts ranging from $3 to $30, or take advantage of my consulting services for more. You can also make a purchase using one of my affiliate links to buy something you would have bought anyway at no extra cost to you. Finally, at https://chrismasterjohnphd.com/donate, you can make a donation in any amount. In a world increasingly dominated by censorship, we may have censored certain words in this video in order to protect the show and keep our community connected. To make sure we stay together as a community, please join my newsletter at chrismasterjohnphd.com/newsletter, where I can guarantee that I'll never deplatform myself. This interview was recorded during a Live Zoom recording, where members of the CMJ Masterpass sat in and submitted comments and questions in the live chat. If you would like to sit in on future interviews I conduct with the chance to contribute questions, sign up for the Masterpass at https://chrismasterjohnphd.com/masterpass and use the code INTERVIEW for 10% off the membership fee for as long as you remain a member. Masterpass members also have access to a transcript and to the uncensored video and audio. Don't forget to like, share, and subscribe as well. Thank you for your support! Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this episode, I interview Tess Lawrie about Iver Mixin', public health corruption, and C-word juices. Tess is a medical doctor with expertise in research analysis and has served as an external consultant for groups at Cochrane and the World Health Organization. She holds an MBBCh and PhD. She is the Director of the Evidence-based Medicine Consultancy Ltd, and CEO of EbMCsquared CiC, an independent, a not for profit, health-focused think tank, based in Bath, in the United Kingdom. She is also the founder of the British Ivermectin Recommendation Development initiative (now called BiRD International) and a co-founder of the new World Council for Health. If you haven't yet heard of it, The World Council for Health is a coalition of more than 80 international health advocacy organisations in more than 30 countries. Important Links The World Council for Health at https://worldcouncilforhealth.org/ Her research on pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=lawrie-ta In the interview, we talk about updates to her meta-analysis: https://pubmed.ncbi.nlm.nih.gov/34469921/ And Andrew Hill's: https://pubmed.ncbi.nlm.nih.gov/34410284/ Timestamps 01:15 Tess's Bio 04:33 The interview begins 05:27 How she went from Ob/Gyn to research analysis, serving as a consultant for Cochrane and the WHO 08:54 How she got involved in the "horse drug" 14:43 Political and financial obstruction of ivermectin research 23:37 Why her meta-analysis and Andrew Hill's came to radically different conclusions 31:11 Why focusing exclusively on randomized controlled trials is nonsense 35:32 Public health manipulating preferences instead of acknowledging and serving them 37:05 Mortality in "horse drug" studies versus juice studies 40:34 How regulatory agencies are failing to represent us 45:32 The course of the viral illness 47:03 What she did when she had the C-word 52:06 What she does for prevention 55:42 "Horse drug" as a prophylactic? 1:01:25 Her take on the C-word juices 01:07:21 Interpreting the adverse efffect data: Underreported or overreported? Causal? 01:17:05 Rapid fire questions: HCQ, juice mandates, liability shields, masks, lockdowns 01:20:51 Introducing the World Council for Health During this critical time where our freedom of health and freedom of speech is in imminent danger, and where tens of thousands of people are facing imminent job losses as the result of medical mandates, I am devoting my analytical skills full time toward the battle for health freedom. This includes working directly with lawyers in lawsuits over mandates, lockdowns, and the current standard of care, scientifically analyzing the safety, efficacy, and risks of mandated medical treatments and their alternatives as well as ways to mitigate their harms, publishing my findings in scientific journals and sharing them with you. It is my firm conviction that this is the most important gift I can offer the world right now, and I view this as a needed public service. I would be extremely grateful if you could support me during this time. At https://chrismasterjohnphd.com/support, you can purchase one of my information products in amounts ranging from $3 to $30, or take advantage of my consulting services for more. You can also make a purchase using one of my affiliate links to buy something you would have bought anyway at no extra cost to you. Finally, at https://chrismasterjohnphd.com/donate, you can make a donation in any amount. In a world increasingly dominated by censorship, we may have censored certain words in this video in order to protect the show and keep our community connected. For the uncensored version, please see the link in the description. For uncensored material in general, head to chrismasterjohnphd.com/uncensored. To make sure we stay together as a community, please join my newsletter at chrismasterjohnphd.com/newsletter, where I can guarantee that I'll never deplatform myself. This interview was recorded during a Live Zoom recording, where members of the CMJ Masterpass sat in and submitted comments and questions in the live chat. If you would like to sit in on future interviews I conduct with the chance to contribute questions, sign up for the Masterpass at https://chrismasterjohnphd.com/masterpass and use the code INTERVIEW for 10% off the membership fee for as long as you remain a member. Don't forget to like, share, and subscribe as well. Thank you for your support! Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this episode, I interview Stephanie Seneff, PhD, on her hypothesis about glyphosate, deuterium, and the C-word. Stephanie Seneff is a senior research scientist at MIT, where she has had continuous affiliation for more than five decades. After receiving four degrees from MIT (B.S.. in Biophysics, M.S., E.E., and Ph.D. in Electrical Engineering and Computer Science), she has conducted research in packet-switched networks, computational modeling of the human auditory system, natural language processing, spoken dialogue systems, and second language learning. Currently a Senior Research Scientist (MIT's highest research rank) at the Computer Science and Artificial Intelligence Laboratory, she has supervised 21 Master's and 14 Ph.D. students. For over a decade, since 2008, she has directed her attention towards the role of nutrition and environmental toxicants on human disease, with a special emphasis on the herbicide glyphosate and the mineral sulfur. Here are the slides for the presentation she gave on this topic: https://people.csail.mit.edu/seneff/2021/WAPF_2021_Part1.pdf https://people.csail.mit.edu/seneff/2021/WAPF_2021_Part2.pdf Here is her book: https://stephanieseneff.net/book/ Here is her web site: https://stephanieseneff.net/ Here is how to access the uncensored version, the transcript, and where to find this on YouTube or on social: https://chrismasterjohnphd.com/covid-19/2021/12/10/stephanie-seneff During this critical time where our freedom of health and freedom of speech is in imminent danger, and where tens of thousands of people are facing imminent job losses as the result of medical mandates, I am devoting my analytical skills full time toward the battle for health freedom. This includes working directly with lawyers in lawsuits over mandates, lockdowns, and the current standard of care, scientifically analyzing the safety, efficacy, and risks of mandated medical treatments and their alternatives as well as ways to mitigate their harms, publishing my findings in scientific journals and sharing them with you. It is my firm conviction that this is the most important gift I can offer the world right now, and I view this as a needed public service. I would be extremely grateful if you could support me during this time. At https://chrismasterjohnphd.com/support, you can purchase one of my information products in amounts ranging from $3 to $30, or take advantage of my consulting services for more. You can also make a purchase using one of my affiliate links to buy something you would have bought anyway at no extra cost to you. Finally, at https://chrismasterjohnphd.com/donate, you can make a donation in any amount. In a world increasingly dominated by censorship, we may have censored certain words in this video in order to protect the show and keep our community connected. For the uncensored version, please see the link in the description. For uncensored material in general, head to chrismasterjohnphd.com/uncensored. To make sure we stay together as a community, please join my newsletter at chrismasterjohnphd.com/newsletter, where I can guarantee that I'll never deplatform myself. This interview was recorded during a Live Zoom recording, where members of the CMJ Masterpass sat in and submitted comments and questions in the live chat. If you would like to sit in on future interviews I conduct with the chance to contribute questions, sign up for the Masterpass at https://chrismasterjohnphd.com/masterpass and use the code INTERVIEW for 10% off the membership fee for as long as you remain a member. Don't forget to like, share, and subscribe as well. Thank you for your support! 00:00:31 Stephanie's bio 00:03:51 Her hypothesis in brief 00:08:25 Her path from virology to computer science and back to virology 00:14:20 Our common interest in educational video games 00:20:29 Evidence linking glyphosate to the C-word 00:21:37 Glyphosate and biofuels 00:26:47 Evidence that glyphosate substitutes for glycine in protein synthesis and industry's argument against this 00:40:37 The specific role of glyphosate in the C-word, interfering with lung surfactants 00:47:58 Selenomethionine as an example of non-toxic irregular amino acids that substitute for regular amino acids in protein synthesis 00:53:41 Vaping 00:57:14 NAD derivatives and the cells' deuterium depletion machines 00:58:02 G6PDH as the primary deuterium depletion machine 00:59:41 Glutathione, mucus fluidity, nitrosoglutathione, bronchodilation 01:03:26 Surfactants, hyaluronic acid gels, lipoxygenase, and the virus as deuterium depletion agents; deuterium and viral stabilization 01:14:54 Prion proteins 01:19:44 The spike protein as a prion protein 01:21:47 Spike protein toxicity depends on location and context, and may depend on glyphosate 01:27:42 Clotting, and platelets as deuterium-depletion and mitochondria-providing agents 01:32:40 C-word harms may depend on glyphosate status 01:34:15 Practical strategy around deuterium depletion and glyphosate avoida

In this interview with Dr. David Brownstein, best known for his use of iodine and nebulized hydrogen peroxide, we discuss his treatment of patients during the pandemic. Here is Brownstein's protocol and publication of his early results: https://cf5e727d-d02d-4d71-89ff-9fe2d3ad957f.filesusr.com/ugd/adf864_cc5004cfa84a46d3b1a0338d4308c42c.pdf Dr. David Brownstein is a Board-Certified family physician and is one of the foremost practitioners of holistic medicine. He is the Medical Director of the Center for Holistic Medicine in West Bloomfield, MI. Dr. Brownstein has lectured internationally to physicians and others about his success in using natural hormones and nutritional therapies in his practice. He is a graduate of the University of Michigan and Wayne State University School of Medicine. Dr. Brownstein is a member of the American Academy of Family Physicians and the American College for the Advancement in Medicine. He is the father of two beautiful girls, Hailey and Jessica, and has been happily married to his wife, Allison, for over 25 years. During this critical time where our freedom of health and freedom of speech is in imminent danger, and where tens of thousands of people are facing imminent job losses as the result of medical mandates, I am devoting my analytical skills full time toward the battle for health freedom. This includes working directly with lawyers in lawsuits over mandates, lockdowns, and the current standard of care, scientifically analyzing the safety, efficacy, and risks of mandated medical treatments and their alternatives as well as ways to mitigate their harms, publishing my findings in scientific journals and sharing them with you. It is my firm conviction that this is the most important gift I can offer the world right now, and I view this as a needed public service. I would be extremely grateful if you could support me during this time. At https://chrismasterjohnphd.com/support, you can purchase one of my information products in amounts ranging from $3 to $30, or take advantage of my consulting services for more. You can also make a purchase using one of my affiliate links to buy something you would have bought anyway at no extra cost to you. Finally, at https://chrismasterjohnphd.com/donate, you can make a donation in any amount. Don't forget to like, share, and subscribe as well. Thank you for your support! Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

If you live near or in NYC, sign up for notifications about my local anti-mandate activities at https://chrismasterjohnphd.com/mandate Visit New York Freedom Rally's new web site at https://newyorkfreedomrally.org In case I get deplatformed, please sign up to my Occasional Newsletter, my Telegram, and the Masterpass Free Forum here: https://chrismasterjohnphd.com/newsletter https://t.me/chrismasterjohnphd https://chrismasterjohnphd.com/freeforum For the present time, I am taking time off from finishing the book to devote my analytical skills to critical questions around C risks, V safety and efficacy, and the full spectrum of V alternatives, due to the imminent massive job loss occurring as a result of V mandates. If you would like to support me doing this work you can also make a donation in any amount at https://chrismasterjohnphd.com/donate or support my work in many other ways listed at https://chrismasterjohnphd.com/support. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.