Mastering Nutrition

Niacin is vitamin B3. You use it to make NAD, the ultimate anti-aging molecule that repairs your DNA and lengthens your telomeres, and the most foundational molecule in our entire system of energy metabolism. It is especially important to protecting your mind, your skin, and your gut. You use it to release all your neurotransmitters. This is why depression sets in as the earliest sign of deficiency and why, when it gets bad enough, it leads to suicidality or schizophrenia-like psychosis. You use constantly it to repair the microscopic damage done to your skin every time you step out into the sunlight. This is why red, inflamed skin appears on the backs of your hands or on your face when you're deficient, but only if you get outdoors a lot. You use it to fuel the rapid turnover of cells in your intestines (the cells that absorb the nutrients in our food are replaced every 2-3 days!), and to repair those cells from the constant barrage of insults they face (think of everything those cells *don't* let in our body 💩and the fact that *they* need to stare all that stuff down!) This is why deficiency will give you diarrhea and make you deficient in lots of other nutrients. You use it for lots of other things too, like participating with riboflavin to make the methyl group of methylfolate and recycle glutathione, the master antioxidant of the cell. You use it to recycle vitamin K, to support detoxification in the liver, and to synthesize cholesterol, fatty acids, neurotransmitters and nucleotides. Who needs more? We all do! Why? Because just aging alone depletes niacin and getting sick or developing diseases as we age depletes it all the more. Niacin repairs damage, so the more damage we face the more we consume. In fact, this is why many people are taking supplements like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), to slow the onset of aging, or to age more gracefully. Some people are even injected NAD! But should we be? And what about the dark side of niacin? We all know the flush -- the redness and itching that accompanies high-dose niacin that people take to lower cholesterol. At high doses, niacin can even damage the liver. How? By sapping methyl groups. Sapping methyl groups can give you liver failure when it's *really* bad, but sapping them just a little can leave you feeling weak, emotionally stuck, or tied up in a mental funk. In this two-part podcast series, Alex Leaf and I tackle all of these questions. Click the link to listen to part 1, where we teach you what niacin is and why you need it. In part 2, two weeks from today, we'll cover how to get niacin in foods, blood tests, and supplements. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." In this episode, you will find all of the following and more: 00:37 Cliff Notes 11:35 The stories of Julie, John, and Jane 17:36 Symptoms of pellagra: the three Ds of dermatitis, dementia, and diarrhea, and the fourth D, death 24:00 Speculative signs and symptoms of suboptimal niacin status 24:59 Symptoms of excess niacin 26:43 Excess niacin will reduce the supply of methyl groups, which can lower creatine synthesis and affect neurotransmitters, and is probably what underlies niacin-induced liver damage. 30:31 Explaining the stories of Julie, John, and Jane in the context of niacin deficiency or toxicity 34:25 Chemical properties of niacin 37:03 How niacin and nicotinic acid derived their names 38:58 Chemical structures of nicotinic acid, nicotinamide, nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and nicotinamide adenine dinucleotide (NAD) 42:51 The biochemistry of niacin 43:05 The differences between NAD(H) and NADP(H) in metabolism 47:03 NAD is often broken down to form ADP-ribose. 48:10 How PARPs (including PARP1 and tankyrase) and sirtuins use NAD to protect us from DNA damage, repair DNA damage, lengthen telomeres, and regulate gene expression 54:27 ADP-ribosyltransferases (ARTs) 56:43 The NAD metabolites cyclic ADP-rib

I used to be addicted to melatonin. I couldn't sleep without taking a time-release melatonin every night. Well, it wasn't really an addiction. It was that my sleep just sucked, so I was stuck using melatonin because my body wasn't working right. I haven't needed melatonin to sleep for *years.* I regard it as a sign of the success of what I've done to fix my sleep that I don't need it anymore. Do you take melatonin? I'm not against it. I think everyone should have some melatonin on hand in their bedroom and their travel bag. But taking it every night cannot replicate the natural rhythm inside your body. Taking a dual action immediate- and time-release can get close, but it just ain't the same thing. So, use the melatonin when needed, but consider it part of the journey and not the destination. Until you're off the melatonin, you still have fixing to do. Tune in for the details! This episode is brought to you by Ancestral Supplements' Grass Fed Beef Brain. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and brain... all in the convenience of a capsule. For more information or to buy any of their products, go to https://AncestralSupplements.com This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 For more detail on the underlying science behind this episode, see part 4 of my Nutrition in Neuroscience series: https://chrismasterjohnphd.com/2019/02/01/nutrition-in-neuroscience-part-4/ Here's a good dual-action melatonin you could take when needed. Purchasing it with my link will earn me a small commission at no extra cost to you, which helps support the free work I put out: https://chrismasterjohnphd.com/amazon/dualactionmelatonin Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In order to sleep well, you need to get a good dose of tryptophan into your brain at any point during the day. The simplest way to do that is with natural, whole-food, high-glycemic carbohydrates like white potatoes and sweet potatoes. Tune in for how to make this work on a high-carb, low-carb or even keto diet, when to include a tryptophan supplement, and what to consider when timing the supplements or carbs. This episode is brought to you by Ancestral Supplements' Grass Fed Beef Brain. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and brain... all in the convenience of a capsule. For more information or to buy any of their products, go to https://AncestralSupplements.com This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here is the previous episode on carbs, tryptophan, and stress-resistance: https://chrismasterjohnphd.com/2019/01/22/carbs-serotonin-stress-resistance/ Here are some studies on carbs and protein affecting tryptophan transport and sleep: https://www.ncbi.nlm.nih.gov/pubmed/573061 https://www.ncbi.nlm.nih.gov/pubmed/21349213 https://www.ncbi.nlm.nih.gov/pubmed/17284739 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Could eating protein at night hurt your sleep? In this episode I discuss why it *might* hurt your sleep. Eating protein at the last meal of your day is important if you are trying to build muscle, but if you are trying to resolve sleeping problems then trying a lower-protein meal at night should be one of the tools in your kit. Tune in for the details! This episode is brought to you by Ancestral Supplements' Grass Fed Beef Brain. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and brain... all in the convenience of a capsule. For more information or to buy any of their products, go to https://AncestralSupplements.com This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 For more detail on the underlying science behind this episode, see part 4 of my Nutrition in Neuroscience series: https://chrismasterjohnphd.com/2019/02/01/nutrition-in-neuroscience-part-4/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In the last episode, I covered how and why I use alpha-GPC and ginkgo biloba supplements during periods where I need increased focused concentration. But could this hurt your sleep if you take them at night? Tune in for the details! This episode is brought to you by Ancestral Supplements' Grass Fed Beef Brain. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and brain... all in the convenience of a capsule. For more information or to buy any of their products, go to https://AncestralSupplements.com This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here's the last episode on using the cocktail for focused concentration: https://chrismasterjohnphd.com/2019/02/14/alpha-gpc-ginkgo-biloba-focused-concentration/ Here's the study mentioned in the episode that suggested better improvements in sleep quality when Alzheimer's patients took an acetylcholinesterase inhibitor in the morning instead of at night: https://www.ncbi.nlm.nih.gov/pubmed/23948729 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Riboflavin is the ultimate fat-burning nutrient. It makes even a bad MTHFR work right, and it keeps you looking young and beautiful forever. Here's everything you need to know about why you should manage your riboflavin status and how to do it. In this podcast I join with Alex Leaf of Examine.Com. I focus on what riboflavin is and what it does, while Alex focuses on riboflavin supplements. Going into this podcast I changed my mind about three important things: While I had always discussed riboflavin as relevant to methylation and MTHFR, I had kept it in the back seat in my methylation protocol. Half way through recording this podcast I realized that it really deserves a front seat in my MTHFR protocol. In fact, it may be the case that there's nothing wrong with the common MTHFR polymorphisms at all and that they only appear to hurt MTHFR activity because most of us aren't getting enough riboflavin. And why aren't we? Liver. Liver. We just have to eat liver. In Testing Nutritional Status: The Ultimate Cheat Sheet, I had included HDRI's erythrocyte glutathione reductase activity test as test for assessing riboflavin status. After doing the research for this podcast, I am now convinced that this test is only reliable as a marker of riboflavin status when the lab tests the enzyme activity with and without the addition of riboflavin, which HDRI doesn't do. I will be revising the cheat sheet soon to rely solely on LabCorp's whole blood riboflavin test for assessing riboflavin status. I have, for years, believed that riboflavin 5'-phosphate (aka, flavin mononucleotide or FMN) supplements are better than plain old riboflavin, especially for people who are hypothyroid or have low adrenal status, since these conditions impair the activation of riboflavin to it's 5'-phosphate form. After doing the research for this podcast I now believe that for healthy people it makes no difference and that for people with small intestinal pathologies, the cheaper, less fancy, plain old "riboflavin" is likely to be more effective. In this podcast we being by considering the fictional stories of people who seem to have little in common. We then explain their stories by looking at the signs and symptoms of riboflavin deficiency. We consider the science of what riboflavin is, how it is used by the body, what it does for us, how to have great riboflavin status, and how to become deficient. We round this out with an extensive discussion of riboflavin supplementation. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." In this episode, you will find all of the following and more: Riboflavin Show Notes 00:37 Introduction 01:46 Three things that I've changed my mind about while doing the research for this podcast 04:24 Cliff notes 14:13 Three stories of riboflavin deficiency 18:05 Signs and symptoms of riboflavin deficiency 21:31 Speculative symptoms of suboptimal riboflavin status 23:49 Chemical properties of riboflavin 27:22 Medical applications: infants with jaundice, eye surgery for keratoconus, and treatment of fungal keratitis 30:38 Chemical structure of riboflavin, flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD) 33:02 Riboflavin's roles in the body: energy metabolism, the antioxidant system, methylation, detoxification, and other nutrient interactions 34:03 Riboflavin's roles in energy metabolism 39:33 How the different macronutrients (carbohydrate, fat, and protein) affect the riboflavin requirement differently 46:05 Riboflavin's role in the antioxidant system 50:12 Riboflavin's roles in the methylation system 52:29 Riboflavin's interactions with other nutrients: vitamin B6, niacin, and iron 55:47 Riboflavin's roles in detoxification 57:44 Other riboflavin-dependent enzymes include NADPH oxidase, monoamine oxidase, and protein disulfide isomerase. 59:31 The physiology of riboflavin absorption 01:02:31 The physiology of riboflavin utilization and the importance of magnesium, ATP, thyroid hormone, adrenal hormones, a

Here's how and why I use alpha-GPC and ginkgo biloba supplements during periods where I need increased focused concentration. Tune in for the details! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 For a collection of my dopamine and choline resources, see https://chrismasterjohnphd.com/methylation where they are collected together with my methylation resources. Here is a science paper documenting the different plants that contain acetylcholinesterase inhibitors: https://www.ncbi.nlm.nih.gov/pubmed/17346955 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Here's how to make your own GABA, not in your basement, but in your brain. GABA helps relax you, helps you make faster and better decisions under pressure, and helps you face your fears with less of a harmful stress response. To make it ourselves we need glucose to enter the brain, then we need to use seven B vitamins, at least four minerals, and a robust supply of cellular energy to make the GABA, and we need salt, potassium, and energy to make it function properly. Tune in for how to get all these nutrients from food and make it happen. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are the recent episodes on GABA: GABA for Faster Decision Making https://chrismasterjohnphd.com/2019/01/24/gaba-faster-decision-making/ Facing your Fears with GABA https://chrismasterjohnphd.com/2019/01/29/face-fears-gaba/ Why You Might Need Carbs With Your GABA or Glycine https://chrismasterjohnphd.com/2019/02/05/7367/ How to Get GABA from Food https://chrismasterjohnphd.com/2019/02/07/get-gaba-food/Does GABA or Glycine Wake You Up? https://chrismasterjohnphd.com/2018/12/25/glycine-gaba-wake/Here are other episodes on the nutrients mentioned in this one: How to Monitor Your Thiamin Status: https://chrismasterjohnphd.com/2018/08/28/monitor-thiamin-vitamin-b1-status/ How to Monitor Your Vitamin B6 Status: https://chrismasterjohnphd.com/2018/11/13/manage-vitamin-b6-status/ Why You Need to Manage Your Iron Status and How to Do It: https://chrismasterjohnphd.com/2017/01/27/need-manage-iron-status How to Manage Your Copper Status: https://chrismasterjohnphd.com/2018/11/08/manage-copper-status-2 How to Manage Your Magnesium Status: https://chrismasterjohnphd.com/2018/08/23/manage-magnesium-status/ 3 Ways to Get Enough Potassium: https://chrismasterjohnphd.com/2018/07/19/3-ways-get-enough-potassium/ The Best Way to Supplement With Potassium: https://chrismasterjohnphd.com/2018/08/14/best-way-supplement-potassium/ For a comprehensive guide to managing nutritional status for all of these nutrients, making the information easier to find and use, get your copy of Testing Nutritional Status: The Ultimate Cheat Sheet at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 for $5 off, and save over 15%. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

GABA helps relax you, helps you make faster and better decisions under pressure, and helps you face your fears with less of a harmful stress response. Tune in to find out how to get it from FOOD! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Page 84 of this PDF has a table of the GABA content of foods: https://chrismasterjohnphd.com/gabathesis Here are the recent episodes on GABA: GABA for Faster Decision-Making https://chrismasterjohnphd.com/2019/01/24/gaba-faster-decision-making/ Face Your Fears With GABA https://chrismasterjohnphd.com/2019/01/29/face-fears-gaba/ Why You Might Need Carbs With Your GABA or Glycine https://chrismasterjohnphd.com/2019/02/05/7367/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Most people won't have adverse effects from taking GABA or glycine supplements, but some do. If you find that either of these cause anxiety from tanking your breathing or heart rate, a dose of high-glycemic carbs like white potatoes, sweet potatoes, or rice, could be the thing that helps. Tune in to find out why! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are the recent episodes on GABA: Face your Fears with GABA: https://chrismasterjohnphd.com/2019/01/29/face-fears-gaba/ Courage, Not Confidence, For Facing Fears: https://chrismasterjohnphd.com/2019/01/31/courage-not-confidence-facing-fears/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Part 4 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, "Neuroscience," pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the COGNITIVE FUNCTIONS! Mental and emotional health, cognitive performance, and sleep! Ads This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." In this episode, you will find all of the following and more: 00:39 Cliff Notes 12:08 Anatomy of the brain 16:41 The role of the basal ganglia in suppressing the investment of energy in any type of program until there is a worthwhile reason not to suppress it, and how dopamine acts as a signal of value in the basal ganglia via disinhibition 24:56 Why we can view Parkinson's as fundamentally not a problem with movement but as a problem with a perception of the value of investing energy in controlling movement 28:23 Tonic and phasic dopamine and the importance of COMT-mediated methylation for regulating the tonic level of dopamine 36:34 The importance of GABA in suppressing the programs that dopamine doesn't signal has value in order to make the dopamine signal of value meaningful 37:28 Overview of the autonomic nervous system; the sympathetic nervous system mediates the fight-or-flight response, and the parasympathetic nervous system mediates the rest-and-digest response. 41:11 The roles of acetylcholine and norepinephrine in the autonomic nervous system, and the importance of nitric oxide to the sexual functions of the autonomic nervous system 44:28 Sleep and circadian rhythms, the importance of vitamin A, morning sun exposure, and avoiding blue light at night 48:12 Melatonin synthesis, the importance of vitamin B6, BH4, oxidative stress, vitamin B5, methylation, and tryptophan uptake into the brain 51:10 Why you can't mimic your natural melatonin rhythm with melatonin supplements 52:55 Antidiuretic hormone, the importance of light hygiene for preventing you from getting up to pee in the middle of the night, and why salt might also help 56:14 Whether the timing of carbohydrate, protein, and choline supplements makes a difference for your daytime wakefulness, your nighttime sleepiness, your deep sleep, and your REM sleep 01:00:44 The possibility that glycine and magnesium could help get rid of conditioned fear responses 01:01:30 Thoughts on consciousness; are we a ghost in the machine, or are we just a machine? 01:06:25 The default mode network is fundamentally about our inward, introverted-directed processes, contrasted with the executive control network, which is fundamentally about our relationship to the outside world and our extraverted functions. 01:10:52 How activities that had nothing to do with people skills but allowed me to flex my extroverted muscles, like exploring the outside world on my own, helped me with my people skills 01:16:48 Nutrition cannot replace the cognitive work necessary to have a healthy mindset and life, but nutrition does make it easier to do the right thing for your mental health. Access the show notes, transcript, and comments here: https://chrismasterjohnphd.substack.com/p/056-nutrition-in-neuroscience-part Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

We often look to ourselves for confidence when facing up to our fears. This is wrong. Here I share a personal story about how the idea of "courage, not confidence," from Tim Ferriss's interview with the designer Deb Millman, helped me face up to a fear. And I didn't even have any GABA with me! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here is the book discussed in the episode. Purchasing it will earn me a small commission at no expense to you, which helps support the free content I put out: https://chrismasterjohnphd.com/amazon/tribeofmentors Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

The CMJ Masterpass is for those of you who really love me. 💙 The GINORMOUS earlybird discount is about to disappear! ⏰So check this out now if you're not a member yet to see if it's for you. (or sign up at https://chrismasterjohnphd.com/masterpass Here's a video tour of what it looks like inside the Masterpass. 🔷The Masterpass is an all-access pass to premium features on all my audio and video content including Chris Masterjohn Lite (short, practical tips), Mastering Nutrition (long, in-depth podcasts on a specific topic), or Masterclass With Masterjohn (nutritional biochemistry courses with lessons arranged in series) that help you get my content faster and get more out of it. 🔷 The Masterpass also gives you a once-a-month opportunity to get in on a small-group live digital Q&A. Here's what you get as premium features: ✅ Early access to content: you get episodes as soon as they are produced, usually weeks and sometimes months before they are released to the public. ✅ No ads standing in the way between you and my content. ✅ Transcripts! These are great if you like to read, or if you want to be more productive. For example, I would first listen to the episodes while I'm doing something else to scan for familiarity, then I'd go back later and keyword search the transcripts for the things I found most interesting so I could follow them up by taking notes or reviewing them in more detail. ✅ Specifically in Masterclass With Masterjohn, you get additional learning tools, such as videos you can keyword search (you literally type in a word and hit "enter" to watch it skip to each instance where I use that word) or put on a customized loop (with three clicks you start and end the loop wherever you want and it plays that section over and over again until you stop it). You also get transcripts with the slides, references, and further reading materials embedded exactly where they are relevant. Even the scientific papers are mostly one click to open up the full text. Here's what's going on with the Q&A sessions: 🔶We use Zoom, a video chatting software, in webinar mode. You can ask your question anonymously in text, but you can also ask it publicly, and you can even get "on stage" and share your mic, web cam, or screen with everyone. 🔶I can't promise that everyone will get in every month. I'm limiting the seating -- the first time around is this Friday, to 30 seats that are already sold out -- to ensure everyone included gets to ask a question and I have time to give them a good answer. Right now I am promising to open up one live Zoom session per month and you as a Masterpass holder get the opportunity to grab your seat on a first-come, first-served basis. Over time I will experiment with the frequency and size of the sessions to make sure I'm offering the best value I can. 🔶As a Masterpass holder, you'll get immediate access to the replay whether you had a seat in the session or not. 🔶Eventually they get published as an episode of Mastering Nutrition. So you can get a little mini-famous 🌟in these. 🤩 And now about that discount. This is for you --> 💰 Haha, seriously though. I created the "earlybird" discount for all the people most on fire to see this happen who signed up while the system was still being constructed. That discount is 50% off, not just right now, but on the recurring membership fee FOREVER, through the life of the program. Depending on whether you pay once a month or once a year, it saves you $60-90/year. Now, the CMJ Masterpass is virtually finished. All the content has been fully migrated. The only things I have left to do are finish getting up the search bars and some how-to video tours. I'll be finishing that up today. So the earlybird discount is about to disappear. It ends tomorrow, Thursday, January 31, at midnight eastern time. To lock in your last chance of a $60-90/year discount, use the link https://chrismasterjohnphd.com/masterpass That link has the 50% discount already activated and it will stay that way until the discount expires tomorrow night. Remember this isn't for everyone. I'm not asking you to sign up unless you really love my content and would just love to have more of it faster with all these features that help you get the most out of it. I love all of you either way. ❤️ If you're on the fence, check out this video to see what it looks like on the inside. Oh, and if it feels like a risk, it's not. I'm confident that if you love my content you will absolutely love the Masterpass, so I'm offering a 30-day money-back guarantee. If you didn't like it for any reason, let my support team know within 30 days and you get your money back. Hope to see you inside the Masterpass! 😊 Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Do you feel too stressed when trying to face your fears? That stress could tank your immune system. Believe it or not, a little GABA can help you tolerate the stress, and face your fears without hurting your immune function. Tune in for how 100 mg of GABA could help! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here's the study discussed in the episode: https://www.ncbi.nlm.nih.gov/pubmed/16971751 Here's a high-quality GABA supplement that uses the same dose as discussed in this episode. Purchasing it earns me a small commission at no extra cost to you, which helps support the free content I put out: https://chrismasterjohnphd.com/amazon/thorne/gaba Here's the higher-dose GABA supplement discussed in the last episode. Same deal on the commission. https://chrismasterjohnphd.com/amazon/pureencapsulations/gaba Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Part 3 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, "Neuroscience," pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the THE FIVE SENSES! This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 In this episode, you will find all of the following and more: 00:35 Cliff Notes 08:50 Exteroception and proprioception are mediated by mechanoreceptors. 11:32 Pain is mediated by nociceptors, which are unspecialized, low-sensitivity neurons. 13:10 Capsaicin activates the TRPV1 receptor, which is also activated by hot temperatures. 15:12 The use of topical capsaicin to relieve chronic pain 18:25 Interoception is our sense of the physiological state within the body. 20:20 Why anorexics crave spicy foods 22:17 Managing pain in the peripheral nervous system; acidity sensitizes pain receptors. 24:12 Managing the fatty acids that help resolve inflammation, particularly arachidonic acid and DHA, to help with peripheral sensitization to pain 25:59 Combining aspirin with fish oil, glycine, and bicarbonate to help with peripheral sensitization to pain 30:50 Central sensitization to pain occurs through an LTP-like process, which is mediated by NMDA receptors. 32:47 Overview of vision and the importance of vitamin A 38:21 The role of vitamin A in preventing night blindness and its very closely related role in setting your circadian rhythm 41:54 Overview of hearing 44:20 Nutrients important for hearing 45:44 Overview of smell 47:41 Overview of taste Access the show notes, transcript, and comments here: https://chrismasterjohnphd.substack.com/p/055-nutrition-in-neuroscience-part Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Need to make quick decisions under pressure? Tune in for how 800 mg of GABA could help! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here's the study discussed in the episode: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521208/ Here's a high-quality GABA supplement that uses a dose close to the one discussed in this episode. Purchasing it earns me a small commission at no extra cost to you, which helps support the free content I put out: https://chrismasterjohnphd.com/amazon/pureencapsulations/gaba Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

While collagen won't bonk your serotonin if you eat enough other protein, low-carbing too much might. Here's why at least one meal a day with natural high-glycemic carbs like white potatoes or sweet potatoes could help improve your stress-resistance. Tune in for more details and for what to do if low-carb is something you need to stick to. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, "Neuroscience," pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the NEUROTRANSMITTERS! Get all four episodes right now, ad-free, and with transcripts. Sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." In this episode, you will find all of the following and more: Nutrition in Neuroscience Show Notes 00:36 Cliff Notes 10:15 Overview of neurotransmitters 12:55 Glutamate is the primary excitatory neurotransmitter. 20:08 De novo glutamate in the central nervous system is overwhelmingly made from glucose. 22:55 Ketogenic diet for epilepsy 26:12 Glutamate metabolism 29:42 There are two classes of glutamate receptors: ionotropic and metabotropic. 30:45 There are three classes of metabotropic glutamate receptors, their actions are complex and variable, and they can be excitatory or inhibitory. 31:04 The ionotropic glutamate receptors include AMPA receptors, NMDA receptors, and kainite receptors, all of which have a depolarizing effect by allowing sodium and potassium to flow freely through them. 33:47 Four unique things about the NMDA receptor: magnesium is required to block its ion channel, it's important for coincidence detection, it allows calcium to come into the cell, and it has a glycine-binding site. 39:16 Long-term potentiation (LTP) and long-term depression (LTD) are important for forming memories, and glutamate receptors play an important role. 46:48 GABA and glycine are the two primary inhibitory neurotransmitters of the central nervous system. 50:04 GABA and presumably glycine can be stimulatory if there is more chloride on the inside of the neuron than the outside. 54:52 Evidence that GABA might cross the blood-brain barrier 57:43 GABA in foods 01:00:14 GABA metabolism in the nervous system 01:02:07 Glycine 01:08:01 Acetylcholine 01:13:49 The biogenic amines include histamine, serotonin, and the catecholamines (dopamine, norepinephrine, and epinephrine). 01:14:30 Synthesis of the catecholamines 01:16:45 Dopamine 01:20:07 Norepinephrine 01:22:31 Histamine 01:26:14 Serotonin 01:29:10 ATP and adenosine 01:32:37 Peptide neurotransmitters 01:32:59 Hypothalamic releasing hormones include thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH). 01:35:14 Melanocyte-stimulating hormone (MSH) 01:35:31 Oxytocin 01:36:18 Vasopressin 01:36:56 Synthesis of the neuropeptides Substance P, MSH, oxytocin, and vasopressin requires glycine, zinc, copper, and vitamin C. 01:40:23 Endocannabinoids and the importance of arachidonic acid, EPA, and DHA

Will collagen supplements bonk your serotonin and make you depressed or anxious? Tune in for my response to an article that Trudy Scott, author of The Anti-Anxiety Food Solution, wrote about this over at "Every Woman Over 29" blog. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links mentioned in this episode: Trudy Scott's article: https://www.everywomanover29.com/blog/collagen-gelatin-lower-serotonin-increase-anxiety-depression/ My episode on why collagen shouldn't replace other protein: https://chrismasterjohnphd.com/2018/11/06/do-you-supplement-with-collagen/ How GABA and glycine can sometimes have a stimulatory effect: https://chrismasterjohnphd.com/2018/12/25/glycine-gaba-wake/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Here are 5 ways to help resolve chronic pain: managing inflammation, reducing acidity, magnesium, glycine, and GABA. Tune in for more details! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links mentioned in this episode: 3 Ways to Clear Stubborn Inflammation: https://chrismasterjohnphd.com/2019/01/10/3-ways-clear-stubborn-inflammation/ Nutrition in Neuroscience has been started here: https://chrismasterjohnphd.com/2019/01/11/nutrition-neuroscience-part-1/ Part 3 of Nutrition in Neuroscience will be published on January 25 but is available now to members of the CMJ Masterpass. To get all four episodes of this series RIGHT NOW, ad-free, and with transcripts, sign up for the CMJ Masterpass. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Nutrition has a HUGE impact on your brain! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, "Neuroscience," pointing out along the way all the interesting connections to nutrition. Listen in for part 1 on the basic cellular functions of neurons! This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code "Chris" at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral To get all four episodes RIGHT NOW, ad-free, and with transcripts, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 In this episode, you will find all of the following and more: 00:37 Cliff Notes 14:55 The primary type of cell in the nervous system is the neuron. 16:32 Glial cells are the assistants of the nervous system. 17:22 Cells in the nervous system are polarized. 18:54 Mitochondria are typically only located at the synapse of neurons and in the middle of photoreceptors; creatine is important for transporting energy in a cell where ATP production is highly polarized. 26:43 Sources of creatine 28:13 Brief overview of how to support methylation 31:06 The polarization of astrocytes and the obligate need for glucose in the brain 37:33 Electrical signaling, resting membrane potential, depolarization, threshold potential, hyperpolarization, and the importance of sodium, potassium, and chloride 45:13 How to get enough sodium, chloride, and potassium in the diet 53:51 The sodium-potassium ATPase uses ATP to pump three sodium ions out of the cell and two potassium ions into the cell, so magnesium and all of the nutrients involved in energy metabolism are important. 58:44 How action potentials propagate 01:03:40 Myelin and the importance of cholesterol 01:06:53 Smith-Lemli-Opitz Syndrome is a rare genetic disorder of cholesterol synthesis that results in neurological problems that are corrected by dietary cholesterol. 01:09:32 Calcium acts as a second messenger in the nervous system, and the cytosolic calcium concentration has to be kept very low for this to work, which requires ATP energy. 01:14:22 Other roles of calcium in the nervous system 01:15:34 Sufficient dietary calcium and ATP energy are needed to support the second messenger roles of calcium. Access the show notes, transcript, and comments here: https://chrismasterjohnphd.substack.com/p/053-nutrition-in-neuroscience-part Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Here are 3 ways to clear stubborn inflammation: managing your fatty acids, taking a new supplement that jump-starts the resolution process, or going with the aspirin protocol from a few episodes ago. Tune in for the details! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links mentioned in this episode: The last episode on omega-6 and omega-3 fatty acids: https://chrismasterjohnphd.com/2019/01/08/omega-6-omega-3-fatty-acid-ratio-care/ The aspirin episode: https://chrismasterjohnphd.com/2019/01/01/aspirin-goes-best-bicarbonate-glycine/ Here are products mentioned in this episode. Purchasing them using these links earns me a small commission at no extra cost to you, which helps support the free work I provide: Arachidonic acid supplements: https://chrismasterjohnphd.com/aa Specialized pro-resolving mediators: https://chrismasterjohnphd.com/spm Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Should you care about your omega-6/omega-3 ratio? The short answer is, no, not unless you're vegan or eat a diet that doesn't contain liver, egg yolks, and fish. Nevertheless, blood testing for arachidonic acid, EPA, and DHA levels can be useful and can guide dietary choices to improve the levels of these fatty acids. Still, don't get caught up in the arachidonic acid-to-EPA ratio. And be mindful about how EPA behaves differently when you are or aren't taking aspirin. Tune in for the details! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links mentioned in this episode: How to avoid false data when using Cronometer to track your nutrient intake: https://chrismasterjohnphd.com/2018/07/24/track-vitamin-mineral-intake/ How anti-inflammatory drugs might lead to food intolerances: https://chrismasterjohnphd.com/2018/09/25/best-weapon-food-allergies-food-intolerances/ How anti-inflammatory drugs might contribute to chronic inflammation: https://chrismasterjohnphd.com/2019/01/01/aspirin-goes-best-bicarbonate-glycine/ The Quest test for AA, EPA, and DHA: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=91001 Testing Nutritional Status: The Ultimate Cheat Sheet, which puts this testing into the broader context of lab testing and gives protocols for using the testing: https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 for $5 off Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Ladies, do you gain a lot of weight around your period? Here's how daily supplementation with the right forms of magnesium and B6, as well as targeted use of a low-salt, high-potassium diet around your period with herbal diuretics and just the right dose of dark chocolate can help. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links mentioned in this episode: Briana Theroux's web site: https://brianatheroux.com Using the links below generates a small commission for me at no extra cost to you: Magnesium and B6 together (this could be taken twice a day): https://chrismasterjohnphd.com/amazon/mgandB6 Alternatively, you can take magnesium as glycinate or malate and B6 as pyridoxal 5'-phosphate (P5P) separately to yield 2-400 mg Mg and 40-50 mg P5P per day. If you like the taste, you could use this dandelion leaf and root tea: https://chrismasterjohnphd.com/amazon/dandelionleaftea If you don't like the taste of the tea, you could use these capsules: https://chrismasterjohnphd.com/amazon/dandelionleafcapsules Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Most over-the-counter anti-inflammatory drugs carry a risk of causing food intolerances and chronic, low-grade inflammation. Aspirin is an exception. But this is why it's best taken with bicarbonate and glycine. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Replacing most of your fat with MCT oil will help create a small caloric deficit that can assist in weight loss, but is it worth it? Tune in for my answer. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

GABA and glycine supplements should both have a calming effect, helping to reduce anxiety and make you sleep better. But some people have asked me, what if they do the opposite? What if they cause anxiety and wake you up at night? Tune in for my answer. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links to things mentioned in the episode: Testing Nutritional Status, The Ultimate Cheat Sheet is at https://chrismasterjohnphd.com/cheatsheet (use the code LITE5 to get $5 off) The specific comment addressed in this episode: https://chrismasterjohnphd.com/2018/10/11/dont-use-niacin-buffer-excess-methyl-groups/#comment-47351 For *many* resources on glycine: https://chrismasterjohnphd.com/methylation On GABA, 5 Ways to Help With Glutamate Sensitivity and Glutamate Dominance: https://chrismasterjohnphd.com/2018/06/14/5-ways-help-glutamate-sensitivity-glutamate-dominance/ 3 Ways to Get Enough Potassium: https://chrismasterjohnphd.com/2018/07/19/3-ways-get-enough-potassium/ The Best Way to Supplement With Potassium: https://chrismasterjohnphd.com/2018/08/14/best-way-supplement-potassium/ How to Manage Your Magnesium Status: https://chrismasterjohnphd.com/2018/08/23/manage-magnesium-status/ How to Manage Your Thiamin (Vitamin B1) Status: https://chrismasterjohnphd.com/2018/08/28/monitor-thiamin-vitamin-b1-status/ How to Manage Your Vitamin B6 Status: https://chrismasterjohnphd.com/2018/11/13/manage-vitamin-b6-status/ Why You Should Be Careful With Niacin and Nicotinamide Riboside: https://chrismasterjohnphd.com/2018/07/26/careful-niacin-nicotinamide-riboside/ DON'T Use Niacin to Buffer Excess Methyl Groups: https://chrismasterjohnphd.com/2018/10/11/dont-use-niacin-buffer-excess-methyl-groups/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Does methylfolate make you angry or depressed? Tune in to hear what I think is going on and what to do about it. This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here is a link to the liquid methylfolate supplement recommended in the episode: https://chrismasterjohnphd.com/liquidfolate Here are links to the original comment threads discussed in this episode: https://www.facebook.com/chrismasterjohn/videos/271674290121604/?comment_id=273676619921371&comment_tracking=%7B%22tn%22%3A%22R%22%7D https://chrismasterjohnphd.com/2018/10/02/what-everyone-should-be-doing-about-methylation/#comment-47229 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Here's a 7-step protocol to tackle histamine intolerance. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links to other episodes that were mentioned in this one. Copper: https://chrismasterjohnphd.com/2018/11/08/manage-copper-status-2/ Vitamin B6: https://chrismasterjohnphd.com/2018/11/13/manage-vitamin-b6-status/ Vitamin C: https://chrismasterjohnphd.com/2018/11/15/manage-vitamin-c-status/ Estrogen: https://chrismasterjohnphd.com/2018/12/04/migraines-menstrual-cycle-histamine/ Kidney and DAO: https://chrismasterjohnphd.com/2018/11/29/kidney-dao-supplements-histamine-intolerance/ Methylation: https://chrismasterjohnphd.com/methylation Selenium: https://chrismasterjohnphd.com/2018/11/20/manage-selenium-status/ Vitamin A: https://chrismasterjohnphd.com/2018/08/16/manage-vitamin-status/ Alcohol: https://chrismasterjohnphd.com/2018/12/11/alcohol-and-histamine/ https://chrismasterjohnphd.com/2018/12/13/is-alcohol-good-for-you/ Medications: https://chrismasterjohnphd.com/2018/12/06/taking-medications-cause-histamine-intolerance/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Is alcohol good for you? It's clear to me that 1) alcohol is a toxin and 2) it can help with having fun, which is good for you, but in this episode I consider whether some dose of alcohol might actually be fundamentally good for you. I discuss three ways this might work and what the optimal dose might be, as well as sharing a story of how I used alcohol to help clear up a fungal infection. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 This is the episode on alcohol and histamine that was mentioned: https://chrismasterjohnphd.com/2018/12/11/alcohol-and-histamine/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Could drinking alcohol be contributing to your allergies or histamine intolerance? When my allergies started going nuts in Greece this summer, I was drinking more alcohol. Alcohol impairs the clearance of histamine *and* competes with histamine to be cleared itself. So it could make your allergies worse or contribute to histamine intolerance if you have it. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Could your medications be contributing to your histamine intolerance? There are over 50 medications that could be culprits, so if you have symptoms of histamine intolerance and you are on any medications, tune in to this episode to find out if the ones you're taking could be a problem. Make sure to discuss any problems with your medication or changes to be made with your doctor! Please don't change your medications on the basis of this episode alone! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are the links to the introductory episodes on histamine intolerance: https://chrismasterjohnphd.com/2018/11/22/dietary-histamine-reliable-information/ https://chrismasterjohnphd.com/2018/11/27/test-histamine-intolerance/ https://chrismasterjohnphd.com/2018/11/29/kidney-dao-supplements-histamine-intolerance/ https://chrismasterjohnphd.com/2018/12/04/migraines-menstrual-cycle-histamine/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Ladies, let's talk about your cycle. Specifically, do you get migraines, other types of headaches, flushing, itching, or any other allergy-like symptoms that correlate with your menstrual cycle? If so, you could be experiencing temporary histamine intolerance caused by too much estrogen. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here is the link to the Histamine Block: https://chrismasterjohnphd.com/DAO Here is the link to the kidney extract: https://chrismasterjohnphd.com/kidney Here is the link to the last episode on using DAO supplements: https://chrismasterjohnphd.com/2018/11/29/kidney-dao-supplements-histamine-intolerance/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Got histamine intolerance? Here are two supplements that could help. Tune in to learn which ones to use! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here is the link to the Histamine Block: https://chrismasterjohnphd.com/DAO Here is the link to the kidney extract: https://chrismasterjohnphd.com/kidney Here is the link to the episode that lists the symptoms of histamine intolerance in more detail, and covers food sources of histamine: https://chrismasterjohnphd.com/2018/11/22/dietary-histamine-reliable-information/ Here are the links to the episodes on B6, copper, and vitamin C: https://chrismasterjohnphd.com/2018/11/08/manage-copper-status-2/ https://chrismasterjohnphd.com/2018/11/13/manage-vitamin-b6-status/ https://chrismasterjohnphd.com/2018/11/15/manage-vitamin-c-status/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Do you have histamine intolerance? It could be confused with an increased burden of mast cells, one of the main types of cells that release histamine. Tune in for two lab tests that can help you tell the difference. This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here is the link to the episode that lists the symptoms of histamine intolerance in more detail, and covers food sources of histamine: https://chrismasterjohnphd.com/2018/11/22/dietary-histamine-reliable-information/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Histamine! If you suffer from ANY of these symptoms -- diarrhea, headaches (including migraines), nasal congestion, asthma, wheezing, low or high blood pressure, heart palpitations (when your heart skips, flutters or beats irregularly), hives, itching, or flushing, you could be histamine intolerant. If you are, this means that, as much as your symptoms seem like allergies, it could be a reaction to histamine in foods, such as hard cheese, fish, shellfish, dried nuts and fruit, and fermented and aged products more generally. But can you trust the lists you find on the internet of which foods to avoid? In this episode I look at the data on histamine in foods -- and it's messier than you might think. Tune in to see which foods you should be most concerned with. This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Selenium makes you resilient to all kinds of stress, including the physical attacks of infections and toxins. It keeps your nails healthy, prevents the wear and tear on your tissues as you age, keeps your body from launching too much inflammation and releasing too much histamine, and appears to protect against several cancers. On the other hand, too much worsens the risk of diabetes and causes some of the same problems that "just enough" protects against. Because the soils vary so much in their selenium content, it's hard to judge what you're getting just from the foods you eat, and selenium is one mineral I think everyone should test at least once. Tune in for everything you need to know about how to manage your selenium status! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here's the methylation page mentioned in the episode: https://chrismasterjohnphd.com/methylation Here's a much more detailed page on selenium: https://chrismasterjohnphd.com/2017/02/18/why-you-should-manage-your-selenium-status-and-how-to-do-it/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Vitamin C protects against bleeding gums, makes your bones strong, helps keep you from getting sick, protects against the normal wear and tear on our tissues, helps us deal with alcohol, cigarette smoke, and toxins in our environment, and may even help support our ability to experience the emotional impact of physical intimacy. That last one is a little speculative, but it does make sense, because vitamin C is needed to make oxytocin, the so-called love hormone! Tune in for everything you need to know about how to manage your vitamin C status! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

In this episode, Hilda Librada Gore of the Wise Traditions podcast interviews me about the work of Weston Price, dental researcher extraordinaire and pioneer of nutritional anthropology. In the second half, we talk about how to condense what we've learned since Price's time about nutrition into some practical rules of thumb that can help us achieve the best diet to meet our nutritional needs. It originally appeared on the Wise Traditions podcast as episode 155 and 156. If you can be in Baltimore, MD this weekend, November 16-November 19, come to the Wise Traditions Conference! I'll be giving an all-day seminar on Monday the 19th about measuring and managing nutritional status. You can register for the conference on site and select my seminar as an add-on. Regardless of if you come to my seminar, you can get my "cheat sheet" for measuring and managing nutritional status at chrismasterjohnphd.com/cheatsheet and use the code MASTERINGNUTRITION to get $5 off your order. This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code "Chris" at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral Here's what you can expect to find in the podcast. PART 1 Dr. Weston A. Price, a Cleveland dentist and researcher from the late 1800s, has been called the "Isaac Newton of Nutrition." His research is just that pivotal to our understanding of the role diet plays in our health. Today, we take a deep dive into the research that Dr. Price conducted and how we can benefit from it. What foods did traditional peoples enjoy that helped them cultivate good health? What did they avoid? And what can we learn from their choices? On this podcast, Chris Masterjohn, a nutrition expert who has a PhD in Nutritional Sciences from the University of Connecticut, explains the foundational work of Dr. Price. In the 1930s, Dr. Price traveled the world in order to study isolated people groups, visiting sequestered villages in Switzerland, Polynesian South Sea Islanders, African tribal groups, Australian Aborigines, and more. He was interested in finding out how these groups resisted the tooth decay and deformations that he was seeing in his clinic in the United States. The world over, Dr. Price found that those on their traditional diets not only had beautiful straight teeth, free from decay, but they also enjoyed vibrant health and vitality. Chris discusses in detail how Dr. Price went about this work and how it can serve us in our pursuit of good health today. Highlights from the conversation include: Chris' own recent trip to Greece and how he made discoveries for himself the purpose of Dr. Price's research the wisdom and and history of traditional cultures the role nutrition plays in tooth decay the "displacing foods of modern commerce" the developmental effects of refined vs traditional foods how the width of the face is determined by more than just genetics the shocking story of the skulls Dr. Price found in Peru why our oral health and overall health are intrinsically linked how reversing tooth decay and healing cavities with diet is possible the difference between fat-soluble and water-soluble vitamins & which are so difficult to get Dr. Price's four main food categories for good health PART 2 We understand the beauty and benefit of diversity. We switch up our exercise routines. We diversify our investment portfolio. But did you know that it's a good idea to diversify our diets, as well? Today, Chris Masterjohn makes a strong case for why it's critical to do so for optimal health. Chris is a health expert and educator, with a PhD in Nutritional Sciences from the University of Connecticut. He explains in detail his rules of thumb for healthy eating. He give us practical ideas on how to translate the research of Dr. Weston A. Price from head knowledge to the dinner plate. Along the way, he tells stories about traditional people groups' dietary patterns; he warns us about the dangers of dietary extremes; and he gives us a window into the way he himself eats for op

Vitamin B6 protects against depression, anxiety, insomnia, age-related cognitive decline, hypoglycemia, kidney stones, and the morning sickness of pregnancy. Tune in for everything you need to know about how to manage your B6 status! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Copper! Copper is needed to prevent anemia, histamine intolerance, high cholesterol, and osteoporosis, probably helps with allergies, and is needed to make you feel good overall. There's a dark side to its toxicity, but more likely you need more copper than less. Tune in for everything you need to know about how to manage your copper status! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 These links are mentioned in the episode: Zinc for heavy metals: https://chrismasterjohnphd.com/2018/11/01/zinc-heavy-metals/ The methylation page: https://chrismasterjohnphd.com/methylation Here's a much more detailed page about copper: https://chrismasterjohnphd.com/2017/02/03/manage-copper-status/ Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Do you supplement with collagen? Collagen is great, and important, but you SHOULDN'T be counting it toward your protein intake. I've been seeing "collagen protein" bars around, and there's nothing inaccurate about calling them that, but it seems easily to be misled into thinking they provide all the protein we need at a meal. They don't. Many people have asked me why I talk about collagen and non-collagen protein separately, and this episode explains why. Listen in and let me know what you think! This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 These links are mentioned in the episode: The glycine database: https://chrismasterjohnphd.com/glycinedatabase The glycine podcast: https://chrismasterjohnphd.com/gycine The methylation page, where it all fits into context: https://chrismasterjohnphd.com/methylation Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Got heavy metals? If the elevation of heavy metals is modest (for example, less than twice the upper limit of the reference range), I think it is best to use zinc supplementation as a gentle approach to help detoxify. Here's how I recommend using zinc for heavy metals. My previous episode on how to supplement with zinc can be found here: https://chrismasterjohnphd.com/2018/10/25/how-to-supplement-with-zinc/ This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

There are plenty of zinc supplements out there, and while many are acceptable, I don't recommend using zinc oxide or zinc picolinate. People are often surprised that I recommend against picolinate. So, in this episode, I explain why. This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Wondering what the best way is to supplement with zinc? This episode covers what kind to take, what dose, when to take it, how often, with what foods or on an empty stomach, and of course how to know if you should be supplementing. My preferred zinc supplement for most people is Jarrow Zinc Balance. You can use one of these two links to generate a commission to support my work at no extra cost to you. Amazon: https://chrismasterjohnphd.com/amazon/jarrow/zincbalance Iherb: https://chrismasterjohnphd.com/iherb/jarrowzincbalance This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Zinc is needed for healthy skin, a robust immune system, sharp vision, stable blood sugar control, balanced and strong hormonal health, and far more. It's even needed for protection against the heavy metals that pollute our environment. Here's how to make sure you're getting enough -- but not too much! -- from managing your diet, to non-dietary causes of deficiency, to measuring and managing your zinc status with bloodwork. My methylation resources, mentioned in the episode, can be found here: https://chrismasterjohnphd.com/methylation My other zinc resources, mentioned in the episode, can be found here: https://chrismasterjohnphd.com/zincsearch This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Glutathione is a molecule you make from the protein in your diet that is incredibly important to protecting your liver, thyroid, and lungs. It's the master antioxidant of the cell, critical to detoxing and cleaning out your system, and plays an especially important role in preventing asthma. Here are seven natural ways to boost your glutathione status! This is the link to the glycine database that is mentioned in the episode: http://chrismasterjohnphd.com/glycinedatabase This is the link to the episode on magnesium status mentioned in the episode: https://chrismasterjohnphd.com/2018/08/23/manage-magnesium-status/ This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Do you have asthma? Do you know or love someone who does? Here's how to use supplemental glutathione (reduced, liposomal, and nebulized) to help with this condition. This is the link to the episode on nitric oxide, mentioned in this episode: https://chrismasterjohnphd.com/2018/01/11/nitric-oxide-genes-blood-pressure-asthma/ This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Many people use niacin supplements to reduce their methylation rate. Some use it regularly because they are "overmethylators" and some use it intermittently when they experience symptoms they associate with overmethylation. In this episode, I describe why I don't recommend using niacin in this way. Doing so is using niacin as a drug, not a nutrient. Our goal should be instead to supply glycine in nutritionally adequate amounts to make the methylation system run smoothly like a well-oiled machine. This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

A number of practitioners use whole blood histamine levels to classify people into undermethylators and overmethylators. I don't agree with using histamine levels to assess methylation status. Tune in to find out why. This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to ancestralsupplements.com. This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at https://chrismasterjohnphd.com/cheatsheet Use the code LITE5 to get $5 off. To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.