Episode #279: Dr. Anurag Singh: Urolithin A, the Aging Immune System, Biological Age Reversal and more…
LONGEVITY with Nathalie Niddam · Nathalie Niddam
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Show Notes
Are you protecting your immune system as you age?
In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system.
We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits.
Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow.
Go to TimelineNutrition.com/nat10 and/or use code Nat10 for a discount.
Thank you to our sponsors for making this episode possible:
Element Health: Use code Longevity when shopping at https://elementhealthsupply.com/discount/Longevity to save on your orders.
Siphox: Visit http://SiPhoxhealth.com/nat and save on your test.
Find more from Dr. Singh/Timeline:
Website: www.timelinenutrition.com
Instagram: @timeline_longevity
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What We Discuss:
09:04 The Role of the Immune System in Aging
12:10 Understanding Immune Exhaustion and Inflammation
15:12 Mitochondrial Health and Immune Function
18:06 Urolithin A: Sources and Production
12:05 Research Studies on Urolithin A and Cancer
30:01 Clinical Trials and Future Directions
31:17 Understanding the Immune System
33:54 The Mitoimmune Randomized Control Trial
38:31 Dosing and Effects of Urolithin A
40:22 Biological Age Reversal and Longevity
44:33 Combining Strategies for Enhanced Benefits
49:21 Future Research Directions in Cancer and Neurodegeneration
Studies Mentioned:
Mitochondrial Recycling Reverts Age-Associated Decline
Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
Mitopure Impact on Immune Aging: RCT