#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore
LONGEVITY with Nathalie Niddam
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Show Notes
Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.
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Episode Timestamps:
Welcome and episode introduction ... 00:00:00
Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55
Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27
Explaining and balancing AMPK and mTOR for performance ... 00:13:03
Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18
Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04
Assessing recovery capacity and individualizing protocols ... 00:26:02
Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57
Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00
Differentiating bodybuilder vs. longevity approaches ... 00:34:44
Integrating peptides and support molecules into routines ... 00:40:44
Ketone esters and mitochondrial peptide interventions ... 00:41:20
Cautions on stacking and combining interventions ... 00:54:04
Lessons learned from overdoing interventions ... 01:05:02
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