Intelligent Medicine | The Best of High Tech Medicine and Alternative Modalities

Embracing Winter: Strategies for Wellbeing with Dr. Kari Leibowitz, health psychologist and author of "How to Winter: Harness Your Mindset to Thrive on Cold, Dark, or Difficult Days." She explores how to push back against the notion of winter gloom and discusses the importance of mindset, cultural practices, and cognitive behavioral therapy in improving mental well-being during the winter months. Dr. Leibowitz shares insights from her experiences in Nordic countries and practical tips for maintaining a positive outlook, staying active, and embracing seasonal activities. She also covers the physiological and mental health benefits of practices such as cold water immersion and sauna use. This episode provides valuable advice for anyone looking to improve their winter wellness and overall resilience.

Dr. Hoffman continues his conversation with Dr. Kari Leibowitz, health psychologist and author of "How to Winter: Harness Your Mindset to Thrive on Cold, Dark, or Difficult Days," about winter survival strategies.

Unlocking Mitochondrial Health: Exploring Urolithin A and Mitochondria-Boosting Supplements with Dr. Brad Currier, a senior scientist and manager of clinical trials at Timeline, a Swiss biotech company known for their product MitoPure. The conversation delves into a unique compound, Urolithin A, which is derived from pomegranates and identified as a key activator of mitophagy—the cellular process of recycling and rejuvenating damaged mitochondria. Dr. Currier elaborates on the significant health benefits of Urolithin A, including improved muscle strength, enhanced immune function, and its potential cognitive and anti-aging effects. The episode also covers topics such as the role of exercise and dietary protein in maintaining muscle health, the future potential of supplementary compounds like creatine, and highlights the newly introduced MitoPure gummies designed for convenient daily intake. Additionally, the discussion extends to the implications of mitochondrial function in various tissues, including skin and hair health.

Dr. Hoffman continues his conversation with Dr. Brad Currier, a senior scientist and manager of clinical trials at Timeline, a Swiss biotech company known for their product MitoPure.

Applauding a long-overdue change to the broken Food Pyramid; Vitamin C enhances skin health, protects against environmental pollutants; FDA green lights testosterone replacement; Does CoQ10 protect against statin muscle damage? The story of America’s first vitamin pioneer; Millions of America’s seniors take 8 or more prescription drugs simultaneously.

MAHA derailed by federal policies that allow harmful chemicals to proliferate; 25 years later, a study that exonerated glyphosate has been retracted due to undue influence from Monsanto; Judge blocks W. Virginia artificial food dye and additive ban; New refined criteria would raise US obesity rate to nearly 70%; FDA approves electrical stimulation headset as safe and effective for home-use to treat depression; Accidental toxic fume releases on planes cause long-term disability, deaths, in passengers and crew. “Digital pacifier” screen time for toddlers found to hike risk for adolescent focus problems, anxiety; Is just a little red wine every day bad for you?

Nutritionist Leyla Muedin discusses the crucial importance of Omega-3 fats, particularly emphasizing their role in mental and heart health. She highlights a recent UK Biobank study demonstrating that higher Omega-3 levels are linked to a significantly lower risk of self-harm and suicidal ideation. Additionally, another study in the Journal of the American Heart Association reveals that elevated Omega-3 levels correlate with a reduced risk of atrial fibrillation (AFib). Leyla underscores the necessity of a balanced diet rich in Omega-3 sources like fatty fish and grass-fed meats, arguing that these nutrients are crucial for optimal mental and heart health.

Top stories of 2025Does the use of statins lead to muscle loss?I have mitral valve prolapse with regurgitation. Should I increase my supplement dosages?

Could you discuss GABA for insomnia and sleep support? Are there long-term health benefits?What impact does a cocktail of pharmaceutical drugs have on the microbiome?Can I take more than 2 daily doses of Dr. Ohira's probiotics?Which is the correct estrogen to take in HRT? Estriol or estradiol?In light of the recent EPA proposal to double permissible formaldehyde emissions, how does this jibe with MAHA?

Innovative Approaches to Parkinson's Disease with Dr. Heather Zwickey, Vice President of Research and Academic Excellence, Provost, and Professor of Immunology at the National University of Natural Medicine (NUNM), and author of "Eating Better for Parkinson’s: A Nutritional Starter Guide." She delves into innovative treatments for Parkinson's disease, including the role of diet, particularly a ketogenic diet, and the impact of the gut microbiome. Dr. Zwickey shares her inspiration from NBA player Brian Grant's experience with Parkinson's and discusses her small study on the feasibility of a ketogenic diet, showing promising results. She also details other potential treatments like supplements, exercise, particularly boxing and dancing, environmental factors, and even cannabis. Dr. Zwickey highlights the importance of personalized approaches due to varying individual responses to treatments.

Dr. Hoffman continues his conversation with Dr. Heather Zwickey, Vice President of Research and Academic Excellence, Provost, and Professor of Immunology at the National University of Natural Medicine (NUNM).

Understanding and Treating Complex Illnesses with Dr. Neil Nathan, author of “Toxic 2nd Edition: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness.” Dr. Nathan shares his expertise on the multifaceted nature of chronic illnesses, which often defy simple categorization and may be misdiagnosed as psychiatric issues. The discussion covers the impact of environmental toxins, electromagnetic fields, and infections like Lyme disease and long COVID. Dr. Nathan also highlights the importance of understanding inflammation's complex pathways and offers suggestions for both elimination of root causes and restoration of immune system functionality. The episode provides insights into new diagnostic tools and treatment methodologies for persistent and intrusive health issues.

Dr. Hoffman continues his conversation with Dr. Neil Nathan, author of “Toxic 2nd Edition: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness.”

The advent of artificial light is obliterating women’s moon-driven menstrual cycle rhythms; When the triple whammy of cataracts, glaucoma, and macular degeneration strikes; Why can systolic blood pressure spike erratically? Are wrist and finger wearables for blood pressure ready for prime time? Nearly half of drivers killed in crashes have THC in their blood; Drinking bottled water causes surge in plastic micro-particle intake; The common supplement that can supercharge cancer immunotherapy.

Examining the claim that cabbage family vegetables are bad for the thyroid; Walmart announces sweeping move to reformulate its products without synthetic dyes, sketchy additives; Under Congressional questioning, Google admits to censoring contrary narratives on YouTube during Covid; Children garner psychological benefits from grandparent time; J&J fined nearly $1 billion in landmark talc baby powder lawsuit; Humans are among the few animals who can’t make their own vitamin C—why that may be a good thing.

Nutritionist Leyla Muedin discusses the renaming of fatty liver disease to metabolic dysfunction-associated steatotic liver disease (M-A-S-L-D) to reduce stigma and improve diagnosis. Dr. Mary Ella's efforts at the University of Chicago Medicine highlight how this change aids in better patient identification and treatment. Leyla emphasizes lifestyle changes like a low-carb diet to manage and reverse the disease. The episode also covers the prevalence of fake extra virgin olive oil (EVOO) on the market, ways to identify authentic olive oil, and the importance of choosing quality over mass-produced options.

Consequences of weight loss with weight loss drugs...Enter myostatin inhibitor drugsMy latest HgbA1c is 5.9, and I'm doing everything right. What gives?I'm approaching 80. Could you discuss aging?

What are your thoughts on Alpha-ketoglutarate for healthy aging?A treatment for warts?Am I destined to develop diabetes given my strong family history of diabetes and high blood pressure?

Holiday Stress tops tax season stressWhat would Dr. Hoffman say?Is berberine truly efficacious?My doctor recommends I drink alcohol to reduce stress and improve circulation

What do you think of thiamine as a treatment for Parkinson's?Is there a natural thyroid medicine you recommend that is not pork-derived?Please discuss the COVID-19 vaccine and cardiology issuesCan you help my granddaughter with guttate psoriasis?

The Holiday Season in NYCPeanut allergies cause and effectWhich calcium supplements can I take if I'm allergic to cow protein?Can my husband take saw palmetto in lieu of his prostate medications?What do you think of traction to help bulging discs?What is your take on green powder supplements?

What do you think of serrapeptase for reducing coronary plaque?We were told to get a TDAP vaccine or we wouldn't be able to see our new grandchild for 8 weeks!Do I have lupus?Which supplements tend to reduce negative effects of X-rays?

RFK Jr. issues sharpest ultimatum yet to medical schools: “Start teaching nutrition now or face penalties!” Fast-food outlets continue to abound in teaching hospitals; Once serious causes of flank pain are ruled out, patients are often left to fend for themselves; Potatoes don’t increase risk of diabetes—unless you eat French fries; Deep-frying in seed oils can yield harmful byproducts—but so, too, when you substitute with lard; As doctors get more aggressive treating blood pressure, how to minimize medication side effects; New study shows beetroot juice can lower BP by 7 points.

For weight loss, complete avoidance of ultra-processed foods outperforms mere “healthy diet” comprising minimally-processed items; Research fraud undermines anti-dementia drug pipeline; Comprehensive lifestyle modification program scores against cognitive decline; Women’s brains especially vulnerable to Omega-3 deficiencies; Bible says “Lame shall walk again” and 21st century science may soon bring about this miracle; Breakthroughs in rheumatoid arthritis treatment.

Nutritionist Leyla Muedin details key aspects of supplement use and addresses frequently asked questions. Topics include the importance of targeted supplementation, the rationale behind personalized dosages, best practices for starting new supplements, and managing common issues like nausea and bright yellow urine. Leyla also explains why some supplements may cause gastrointestinal discomfort and provides guidance on how to adjust dosages for optimal results. Emphasis is placed on the benefits of pharmaceutical-grade supplements available on Fullscript and the necessity of regular blood tests to fine-tune supplementation.

For dark days, get some sun in your eyesThe misleading vegan diet twin studyA least favorite thing from one of our listeners

What are your thoughts on the efficacy of strontium for bone health?What to you think of HRT for bone health?I have aortic valve stenosis. Is there any alternative to surgery?I have dry eyes after cataract surgeryAre there any benefits to Deer Antler for increasing HGH?

Dr. Jeffrey Bland, founder and president of the Personalized Lifestyle Medicine Institute and Big Bold Health, discusses his significant influence on functional medicine and offers a deep dive into the history and benefits of fish oil, including its impact on cardiovascular health, inflammation, and immune system resilience. Dr. Bland elaborates on the necessity of balanced Omega-3 fatty acids, particularly EPA and DHA, and the unique benefits of cold-processed fish oils that retain natural nutrients. The conversation also touches on Big Bold Health's innovative approach to health through products like Omega-3 Rejuvenate and Himalayan Tartary Buckwheat, highlighting their roles in promoting immune health. The episode underscores the importance of sustainability and the dedication of farmers and fishermen in producing high-quality, health-supportive products.

Dr. Hoffman continues his conversation with Dr. Jeffrey Bland, founder and president of the Personalized Lifestyle Medicine Institute and Big Bold Health.

The MAHA Initiative and Health Advocacy with Jeffrey Rose, a certified master hypnotherapist and advocate for the MAHA (Make America Healthy Again) Initiative. Jeffrey Rose discusses his involvement with RFK Jr. and the MAHA movement, which aims to advance public health and freedom of choice in medicine. The conversation highlights various health reforms, including the benefits of starting school later for teenagers, the focus on chronic disease prevention, and the potential for bipartisan support in improving public health policies. Additionally, the discussion covers Rose's professional work in hypnotherapy, emphasizing its effectiveness in treating insomnia, addiction recovery, and weight loss.

Dr. Hoffman continues his conversation with Jeffrey Rose, a certified master hypnotherapist and advocate for the MAHA (Make America Healthy Again) Initiative.

Popular media leverage weak study to criticize RFK Jr.’s rethink of standard recommendations for saturated fat avoidance; Poor quality plant-based diets hike cardio risk; A listener complains his lp(a) is going up with age despite his healthy diet, lifestyle; Scientists pinpoint cocoa ingredient that slows aging; Berry proanthocyanidins preserve brain power; Tattooing may promote inflammation, undermine immunity.

Country singer Jellyroll dishes on his triple-digit weight loss odyssey; DGL for GERD—will it raise blood pressure? CBD curbs aggression in dogs; Hundreds of environmental chemicals may imbalance our microbiomes; ADHD isn’t just a malady—it may impart unrecognized superpowers; The evolutionary mismatch between our ancient genes and modern artificial environments; Could napping improve cognitive function? Heart attacks, lung problems soared after LA wildfires; HHS Secretary RFK Jr. focuses attention on inadequate testing, treatments for chronic Lyme Disease.

The Benefits of Matcha for Women in Menopause: Nutritionist Leyla Muedin discusses the potential benefits of matcha for women going through menopause. She explains how matcha, a finely ground green tea powder, offers higher concentrations of antioxidants, amino acids, and phytonutrients compared to regular green tea. These properties can help support cognitive function, mood stabilization, cardiovascular health, and weight management. The episode also touches on the importance of maintaining a healthy lifestyle, emphasizing an anti-inflammatory diet, regular exercise, restful sleep, and meaningful social connections. Leyla highlights how simple daily rituals, such as enjoying a cup of matcha, can provide emotional grounding and routine for women navigating menopause.

The benefits of sauna and sunlight during winter monthsApplied Behavioral Analysis in autism treatmentWhat are good supplements to take for HPV virus?

I was diagnosed with follicular lymphoma, but my symptoms may be caused by something else, per my oncologistI've been taking acidophilus and eating yogurt, but still have diarrhea for the last five months since taking a round of antibioticsThe consequences of antibiotic useMy carotid artery intima-media thickness shows higher than normal thickness. Should I be concerned?

Exploring the Benefits and Science of CBD and Canna Mimetics with Expert Maggie Frank, the national educator for CV Sciences, makers of PlusCBD Oil. She has a deep-dive into the latest updates on CBD (cannabidiol) products, their benefits, and distinctions from THC (tetrahydrocannabinol). Frank explains the endocannabinoid system and how phytocannabinoids like CBD can help achieve homeostasis in the body, aiding in stress management, inflammation, and gut health. They discuss the nuances of different cannabis plants, the current landscape of CBD research, and the misconceptions around THC use. Additionally, Maggie introduces some innovative CV Sciences products, including those that do not contain CBD but offer similar benefits through canna mimetics—natural compounds that mimic the effects of cannabinoids. Among these products are a focus-enhancing gummy and a metabolic support formulation called ReShape. They also touch upon upcoming legislation and how it impacts the hemp industry. The discussion highlights the broad-spectrum potential of CBD and related compounds in promoting overall health and addressing various conditions.

Dr. Hoffman continues his conversation with Maggie Frank, the national educator for CV Sciences, makers of PlusCBD Oil.

Examining the U.S. Healthcare System with Dr. Henry Buchwald: Challenges, Changes, and Solutions. Dr. Henry Buchwald, author of "Healthcare Upside Down: A Critical Examination of Policy and Practice," is an emeritus professor and pioneer in bariatric surgery. He discusses the significant changes and current flaws within the U.S. healthcare system, including the commodification of medicine, administrative bloat, and the decline of the doctor-patient relationship. He explores the high costs coupled with poor outcomes compared to other countries, and Dr. Buchwald's personal experience with the healthcare system. The discussion also touches on the role of new weight loss drugs, innovations in metabolic surgery, and the potential impact of artificial intelligence in medicine. Dr. Buchwald offers insights and potential solutions to improve the healthcare system, emphasizing the need for a return to patient-focused care. And check out Dr. Hoffman's book review HERE.

Dr Hoffman continues his conversation with Dr. Henry Buchwald, author of "Healthcare Upside Down: A Critical Examination of Policy and Practice."

Unmasking Hidden Sugars in 'Healthy' Drinks: Leyla Muedin, a registered dietitian nutritionist, examines the surprising amounts of sugar found in commonly perceived 'healthy' drinks. She discusses how beverages like energy drinks, fruit smoothies, and chai lattes can exceed the daily recommended sugar intake, based on a study by Ben's Natural Health. Leyla warns that even health-focused products and homemade drinks can contain high sugar levels, which can impact weight, blood sugar levels, and overall health. She emphasizes the importance of being an 'ingredient sleuth' and making informed choices.

Antioxidants and resistance training for treatment of sarcopeniaAnabolic resistance with advancing ageAre there any holistic medicine approaches to treating Lewy Body Syndrome?Is canned fish like sardines safe to eat?

What are your thoughts on the benefits of magnesium threonate?Is creatine helpful in building bone strength in osteoporosis?What are your thoughts on the REMS ultrasound to diagnose bone mineral density status?What should I do about my PSA, which appears to be trending upward? Are my diabetes meds causing erectile dysfunction?Does maltodextrin spike blood glucose tremendously?

Exploring the Microbiome and Longevity with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist. He details the pivotal role of the gut in chronic disease, referencing the ancient insights of Hippocrates, and explores the concept of postbiotics. The conversation touches on the influence of gut health on various organ systems, the importance of diversity in the gut microbiome, and how lifestyle choices like diet, exercise, and sleep contribute to healthy aging. They also tackle cutting-edge topics such as the implications of GLP-1 medications, anabolic resistance, and the potential benefits of rapamycin for longevity.

Dr. Hoffman continues his conversation with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist.

Exploring the World of Nutraceuticals and Herbal Medicine with Chris Killam, the Medicine Hunter, a renowned expert in herbal medicine, nutraceuticals, and sustainable botanical sourcing. Killam details his fascinating journey into the field, his extensive travel and research spanning over 45 countries, and his dedication to sustainable trade practices. The conversation delves into specific herbs and their health benefits, such as kava, maca, and adaptogens, as well as the impact of global climate change on botanical sourcing. They also explore the therapeutic potential of psychoactive plants, the safety concerns around herbal products, and the ongoing efforts to promote high-quality, standardized phytomedicines. Killam shares insights from his collaborations with various communities and highlights the importance of ethical trade and support for local economies.

Dr. Hoffman continues his conversation with Chris Killam, the Medicine Hunter, a renowned expert in herbal medicine, nutraceuticals, and sustainable botanical sourcing.

First shots fired in war against ultra-processed foods; What the big reveal of Trump’s MRI really shows; Is cruelty to horses really necessary to make estrogen? Early smartphone use linked to mental harms in kids; Nutritionist sues American Diabetes Association for forcing her to promote unhealthy artificial sweeteners; Halle Berry dings California Governor Newsom for vetoing menopause awareness bill.

Revolutionary study highlights anti-aging benefits of collagen supplementation; Creatine gummies flunk potency tests; Do small irregularities on an endoscopy dictate a lifetime prescription for acid-blockers? How exercise slows cancer and forestalls dementia; Pregnant women require frequent thyroid checks to avert autism; Fructose may stoke body-wide inflammation; What causes bleeding gums?

Nutritionist Leyla Muedin details a study on the effects of vitamins C and E supplementation in older women with sarcopenia. The study, published in the journal Medicine, found that combining 1000 mg of vitamin C and 335 mg of vitamin E with a 12-week resistance training program significantly improved muscle mass, strength, and certain blood parameters compared to a placebo group. The benefits were attributed to the alleviation of oxidative stress and inflammation. Leyla underscores the importance of adequate animal protein intake to optimize resistance training outcomes.