In Our Time

Melvyn Bragg and guests discuss mutation in genetics and evolution. When lying mortally ill with cancer, the British geneticist J.B.S. Haldane penned the following lines: Cancer's a Funny Thing:I wish I had the voice of HomerTo sing of rectal carcinoma,Which kills a lot more chaps, in fact,Than were bumped off when Troy was sacked...Haldane knew better than most that many cancers, and many other diseases, are caused by genetic mutation. A mutation is an error in reproduction between one generation and the next as the copying mechanism that allows you to inherit your parent’s genes goes awry. Mutations are almost always bad news for the organism that suffers them and yet mutation is also a giver of life. Without it there would be no natural selection, no evolution and, arguably, no life on this planet. It’s not unreasonable to see life itself as a mutation and to understand this may also hold the key to aging and disease. It is, in the Darwinian view of life, the raw material of evolution.With Steve Jones, Professor of Genetics in the Galton Laboratory, University College London; Adrian Woolfson, lectures in Medicine at Cambridge University; Linda Partridge, Weldon Professor of Biometry at University College LondonTags

Melvyn Bragg and guests discuss the Fibonacci Sequence. Named after a 13th century Italian Mathematician, Leonardo of Pisa who was known as Fibonacci, each number in the sequence is created by adding the previous two together. It starts 1 1 2 3 5 8 13 21 and goes on forever. It may sound like a piece of mathematical arcania but in the 19th century it began to crop up time and again among the structures of the natural world, from the spirals on a pinecone to the petals on a sunflower.The Fibonacci sequence is also the mathematical first cousin of the Golden Ratio – a number that has haunted human culture for thousands of years. For some, the Golden ratio is the essence of beauty found in the proportions of the Parthenon and the paintings of Leonardo Da Vinci. With Marcus du Sautoy, Professor of Mathematics at the University of Oxford; Jackie Stedall, Junior Research Fellow in History of Mathematics at Queen’s College, Oxford; Ron Knott, Visiting Fellow in the Department of Mathematics at the University of Surrey

Melvyn Bragg and guests discuss one of the greatest long poems in the English language – The Prelude. Begun in Northern Germany during the terrible winter of 1798 by a young and dreadfully homesick William Wordsworth, The Prelude was to be his masterpiece - an epic retelling of his own life and the foundation stone of English Romanticism. In language of aching beauty wordsworth expressed thoughts about memory, identity, nature and experience familiar to anybody who has walked alone among the hills. With Rosemary Ashton, Quain Professor of English Language and Literature at University College London; Stephen Gill, University Professor of English Literature and Fellow of Lincoln College, Oxford; Emma Mason, Senior Lecturer in English at the University of Warwick.

Melvyn Bragg discusses the discovery of Oxygen by Joseph Priestley and Antoine Lavoisier. In the late 18th century Chemistry was the prince of the sciences – vital to the economy, it shaped how Europeans fought each other, ate with each other, what they built and the medicine they took. And then, in 1772, the British chemist, Joseph Priestley, stood in front of the Royal Society and reported on his latest discovery: “this air is of exalted nature…A candle burned in this air with an amazing strength of flame; and a bit of red hot wood crackled and burned with a prodigious rapidity. But to complete the proof of the superior quality of this air, I introduced a mouse into it; and in a quantity in which, had it been common air, it would have died in about a quarter of an hour; it lived at two different times, a whole hour, and was taken out quite vigorous.” For the British dissenting preacher, Joseph Priestley, and the French aristocrat, Antoine Lavoisier, Chemistry was full of possibilities and they pursued them for scientific and political ends. But they came to blows over oxygen because they both claimed to have discovered it, provoking a scientific controversy that rattled through the laboratories of France and England until well after their deaths. To understand their disagreement is to understand something about the nature of scientific discovery itself. With Simon Schaffer, Professor in History and Philosophy of Science at the University of Cambridge; Jenny Uglow, Honorary Visiting Professor at the University of Warwick; Hasok Chang, Reader in Philosophy of Science at University College London.

Melvyn Bragg and guests discuss the Persian Islamic philosopher, Avicenna. In the city of Hamadan in Iran, right in the centre, there is a vast mausoleum dedicated to an Iranian national hero. Built in 1952, exactly 915 years after his death, it’s a great conical tower with twelve supporting columns. It’s dedicated not to a warrior or a king but to a philosopher and physician. His name is Ali Al Husayn Ibn-Sina, but he is also known as Avicenna and he is arguably the most important philosopher in the history of Islam. In a colourful career Avicenna proved the existence of god, amalgamated all known medical knowledge into one big book and established a mind body dualism 600 years before Descartes and still found time to overindulge in wine and sex. With Peter Adamson, Reader in Philosophy at King's College London; Amira Bennison, Senior Lecturer in Middle Eastern and Islamic Studies at the University of Cambridge; Nader El-Bizri, Affiliated Lecturer in the History and Philosophy of Science at the University of Cambridge.

Melvyn Bragg and guests discuss morality by taking a long hard look at the idea of guilt. The 18th century politician and philosopher Edmund Burke was once moved to comment: “Guilt was never a rational thing; it distorts all the faculties of the human mind, it perverts them, it leaves a man no longer in the free use of his reason, it puts him into confusion.”Guilt is a legal category but also a psychological state and a moral idea. Over the centuries theologians, philosophers and psychologists have tried to determine how it relates to morality, reason and the workings of the mind? The answers seem to cut deeply into our understanding of what it is to be human.With Stephen Mulhall, Fellow and Tutor in Philosophy at New College, Oxford; Miranda Fricker, Senior Lecturer in Philosophy at Birkbeck, University of London; Oliver Davies, Professor of Christian Doctrine at King’s College London

Melvyn Bragg and guests discuss the 18th century obsession with taste. In the mid 18th century the social commentator, George Coleman, decried the great fashion of his time: “Taste is at present the darling idol of the polite world…The fine ladies and gentlemen dress with Taste; the architects, whether Gothic or Chinese, build with Taste; the painters paint with Taste; critics read with Taste; and in short, fiddlers, players, singers, dancers, and mechanics themselves, are all the sons and daughters of Taste. Yet in this amazing super-abundancy of Taste, few can say what it really is, or what the word itself signifies.”From the pens of philosophers to the interior decor of the middle classes, the idea of good and bad taste shaped decisions about dress, wallpaper, furniture, architecture, literature and much more. The period saw an explosion in the taste industries - the origins of Chippendale furniture, Wedgwood pottery and Christie's auction house - and a similar growth in magazines and journals devoted to the new aesthetic, moral and social guidelines. But taste was also a battle ground that pitched old money against new, the city against the country and men against women. With Amanda Vickery, Reader in History at Royal Holloway, University of London; John Mullan, Professor of English at University College London; Jeremy Black, Professor of History at the University of Exeter

Melvyn Bragg discusses the myths, tales and legends of the Arabian Nights.Once upon a time a wealthy merchant grew hot in the sun and sat down under a tree. Having eaten a date, he threw aside the stone, and immediately there appeared before him a Genie of enormous height who, holding a drawn sword in his hand, approached him, and said, “rise that I may kill thee”. This is from The Arabian Nights, a collection of miraculous tales including Ali Baba and the Forty Thieves and Sinbad the Sailor. Forged in the medieval Arab world, it became so popular in Europe that the 18th century Gothic writer Horace Walpole declared “Read Sinbad the Sailor’s Voyages and you will grow sick of Aeneas”.Its origins are Indian and Persian but it was championed initially by an 18th century Frenchman, Antoine Galland. Celebrated for its fabulous stories, it is a patchwork of sex, violence, magic, adventure, and cruelty – a far cry from the children’s book that it has become. With Robert Irwin, Senior Research Associate at the School of Oriental and African Studies, University of London; Marina Warner, Professor in the Department of Literature, Film and Theatre Studies at the University of Essex; Gerard van Gelder, Laudian Professor of Arabic at the University of Oxford.

Melvyn Bragg and guests discuss the Divine Right of Kings. In Shakespeare’s Macbeth, the character Malcolm describes the magical healing powers of the king: “How he solicits heaven, Himself best knows; but strangely-visited people, All swoln and ulcerous, pitiful to the eye, The mere despair of surgery, he cures; Hanging a golden stamp about their necks, Put on with holy prayers...”The idea that a monarch could heal with his touch flowed from the idea that a king was sacred, appointed by God and above the judgement of earthly powers. It was called the Divine Right of Kings. The idea resided deep in the culture of 17th century Britain affecting the pomp of the Stuart Kings, the writings of Milton and Shakespeare and the political works of John Locke. It is a story that involves witches, regicide, scrofula, Macbeth, miraculous portraits and some of the greatest poetry in the English language. With Justin Champion, Professor of the History of Early Modern Ideas at Royal Holloway, University of London; Tom Healy, Professor of Renaissance Studies at Birkbeck College, University of London; Clare Jackson, Lecturer and Director of Studies in History at Trinity Hall, Cambridge

Melvyn Bragg and guests discuss Antimatter, a type of particle predicted by the British physicist, Paul Dirac. Dirac once declared that “The laws of nature should be expressed in beautiful equations”. True to his word, he is responsible for one of the most beautiful. Formulated in 1928, it describes the behaviour of electrons and is called the Dirac equation. But the Dirac equation is strange. For every question it gives two answers – one positive and one negative. From this its author concluded that for every electron there is an equal and opposite twin. He called this twin the anti-electron and so the concept of antimatter was born.Despite its popularity with Science Fiction writers, antimatter is relatively mundane in physics – we have created antimatter in the laboratory and we even use it in our hospitals. But one fundamental question remains – why isn’t there more antimatter in the universe. Answering that question will involve developing new physics and may take us closer to understanding events at the origin of the universe. With Val Gibson, Reader in High Energy Physics at the University of Cambridge; Frank Close, Professor of Physics at Exeter College, University of Oxford; Ruth Gregory, Professor of Mathematics and Physics at the University of Durham

Melvyn Bragg and guests discuss the Greek philosopher Socrates, acknowledged as one of the founders of Western philosophy. Born in 469 BC into the golden age of the city of Athens, he has profoundly influenced philosophy ever since. In fact, his impact is so profound that all the thinkers who went before are simply known as pre-Socratic.In person Socrates was deliberately irritating, he was funny and he was rude; he didn’t like democracy very much and spent quite a lot of time in shoe shops. He claimed he was on a mission from God to educate his fellow Athenians but has left us nothing in his own hand because he refused to write anything down. With Angie Hobbs, Associate Professor of Philosophy at Warwick University; David Sedley, Laurence Professor of Ancient Philosophy at Cambridge University; Paul Millett, Senior Lecturer in Classics at the University of Cambridge.

Melvyn Bragg and guests discuss the literary sensation caused by Gustave Flaubert's novel Madame Bovary. In January 1857 a man called Ernest Pinard stood up in a crowded courtroom and declared, “Art that observes no rule is no longer art; it is like a woman who disrobes completely. To impose the one rule of public decency on art is not to subjugate it but to honour it”. Pinard was no grumbling hack, he was the imperial prosecutor of France, and facing him across the courtroom was the writer Gustave Flaubert. Flaubert’s work had been declared “an affront to decent comportment and religious morality”. It was a novel called Madame Bovary.The story of an adulterous housewife called Emma, Madame Bovary, is a vital staging post in the development of realism. The arguments in court involved a heady brew of art, morality, sex and marriage and ensured the fame of the novel and its author. With Andy Martin, Lecturer in French at the University of Cambridge; Mary Orr, Professor of French at the University of Southampton; Robert Gildea, Professor of Modern History at the University of Oxford

Melvyn Bragg and guests discuss the Pilgrim Fathers and their 1620 voyage to the New World on the Mayflower. Every year on the fourth Thursday in November, Americans go home to their families and sit down to a meal. It’s called Thanksgiving and it echoes a meal that took place nearly 400 years ago, when a group of religious exiles from Lincolnshire sat down, after a brutal winter, to celebrate their first harvest in the New World. They celebrated it in company with the American Indians who had helped them to survive.These settlers are called the Pilgrim Fathers. They were not the first and certainly not the largest of the early settlements but their Plymouth colony has retained a hold on the American imagination which the larger, older, violent and money-driven settlement of Jamestown has not.With Kathleen Burk, Professor of Modern and Contemporary History at University College London; Harry Bennett, Reader in History and Head of Humanities at the University of Plymouth; Tim Lockley, Associate Professor of History at the University of Warwick

Melvyn Bragg and guests discuss the Permian-Triassic boundary. 250 million years ago, in the Permian period of geological time, the most ferocious predators on earth were the Gorgonopsians. Up to ten feet in length, they had dog-like heads and huge sabre-like teeth. Mammals in appearance, their eyes were set in the side of their heads like reptiles. They looked like a cross between a lion and giant monitor lizard and were so ugly that they are named after the gorgons from Greek mythology – creatures that turned everything that saw them to stone. Fortunately, you’ll never meet a gorgonopsian or any of their descendants because they went extinct at the end of the Permian period. And they weren’t alone. Up to 95% of all life died with them. It’s the greatest mass extinction the world has ever known and it marks what is called the Permian-Triassic boundary. But what caused this catastrophic juncture in life, what evidence do we have for what happened and what do events like this tell us about the pattern and process of evolution itself?With Richard Corfield, Senior Lecturer in Earth Sciences at the Open University; Mike Benton, Professor of Vertebrate Palaeontology in the Department of Earth Sciences at the University of Bristol; Jane Francis, Professor of Palaeoclimatology at the University of Leeds

Melvyn Bragg looks at an unexpected philosophical subject - the philosophy of common sense. In the first century BC the Roman statesman Marcus Tullius Cicero claimed “There is no statement so absurd that no philosopher will make it”. Indeed, in the history of Western thought, philosophers have rarely been credited with having much common sense. In the 17th century Francis Bacon made a similar point when he wrote “Philosophers make imaginary laws for imaginary commonwealths, and their discourses are as the stars, which give little light because they are so high”. Samuel Johnson picked up the theme with characteristic pugnacity in 1751 declaring that “the public would suffer less present inconvenience from the banishment of philosophers than from the extinction of any common trade.” Philosophers, it seems, are as distinct from the common man as philosophy is from common sense.But as Samuel Johnson scribbled his pithy knockdown in the Rambler magazine, the greatest philosophers in Britain were locked in a dispute about the very thing he denied them: Common Sense. It was a dispute about the nature of knowledge and the individuality of man, from which we derive the idea of common sense today. The chief antagonists were a minister of the Scottish Church, Thomas Reid, and the bon-viveur darling of the Edinburg chattering classes, David Hume. It's a journey that also takes in Rene Descartes, Immanuel Kant, John Locke and some of the most profound questions about human knowledge we are capable of asking.With A C Grayling, Professor of Philosophy at Birkbeck, University of London; Melissa Lane, Senior University Lecturer in History at Cambridge University; Alexander Broadie, Professor of Logic and Rhetoric at the University of Glasgow.

Melvyn Bragg and guests discuss Renaissance Astrology. In Act I Scene II of King Lear, the ne’er do well Edmund steps forward and rails at the weakness and cynicism of his fellow men:This is the excellent foppery of the world, that,when we are sick in fortune, - often the surfeitof our own behaviour, - we make guilty of ourdisasters the sun, the moon, and the stars: asif we were villains by necessity.The focus of his attack is astrology and the credulity of those who fall for its charms. But the idea that earthly life was ordained in the heavens was essential to the Renaissance understanding of the world. The movements of the heavens influenced many things from the practice of medicine to major political decisions. Every renaissance court had its astrologer including Elizabeth Ist and the mysterious Dr. John Dee who chose the most propitious date for her coronation. But astrologers also worked in the universities and on the streets, reading horoscopes, predicting crop failures and rivalling priests and doctors as pillars of the local community. But why did astrological ideas flourish in the period, how did astrologers interpret and influence the course of events and what new ideas eventually brought the astrological edifice tumbling down? With Peter Forshaw, Lecturer in Renaissance Philosophies at Birkbeck, University of London; Lauren Kassell, Lecturer in the History and Philosophy of Science at the University of Cambridge; and Jonathan Sawday, Professor of English Studies at the University of Strathclyde.

Melvyn Bragg and guests discuss the war poet Siegfried Sassoon. In 1916 the Military Cross was awarded to a captain in the Royal Welch Fusiliers for "conspicuous gallantry during a raid on the enemy's trenches". The citation noted that he had braved "rifle and bomb fire" and that "owing to his courage and determination, all the killed and wounded were brought in". The hero in question was the poet, Siegfried Sassoon. And yet a year later, and at great personal risk, Sassoon publicly denounced the conduct of the war in which he had fought so well.Although famous for his bitter, satirical verses and his denunciation of the conduct of the war which landed him in Craiglockhart mental hospital there is much more to this man of contradictions. A mentor to Wilfred Owen, arch enemy of T.S. Eliot and the Modernist movement, his life included a string of homosexual affairs, a failed marriage, a religious conversion and several tumultuous arguments with literary friends. Notably Robert Graves. He was also an obsessive diarist and writer of autobiography and he continued to write poetry until his death, from cancer, in 1967. But how significant a poet is Siegfried Sassoon, what version of Englishness did this half-Jewish, homosexual cricket lover invent for himself and how do you explain the mind of a man who bitterly opposed the First World War, yet fought in it with an almost insane ferocity?With Jean Moorcroft Wilson, Lecturer in English at Birkbeck, University of London and a biographer of Sassoon; Fran Brearton, Reader in English and Assistant Director of the Seamus Heaney Centre for Poetry at the University of Belfast; Max Egremont, a biographer of Siegfried Sassoon

Melvyn Bragg and guests discuss the philosophical ideas of William Ockham including Ockham's Razor. In the small village of Ockham, near Woking in Surrey, stands a church. Made of grey stone, it has a pitched roof and an unassuming church tower but parts of it date back to the 13th century. This means they would have been standing when the village witnessed the birth of one of the greatest philosophers in Medieval Europe. His name was William and he became known as William of Ockham.William of Ockham’s ideas on human freedom and the nature of reality influenced Thomas Hobbes and helped fuel the Reformation. During a turbulent career he managed to offend the Chancellor of Oxford University, disagree with his own ecclesiastical order and get excommunicated by the Pope. He also declared that the authority of rulers derives from the people they govern and was one of the first people so to do. Ockham’s razor is the idea that philosophical arguments should be kept as simple as possible, something that Ockham himself practised severely on the theories of his predecessors. But why is William of Ockham significant in the history of philosophy, how did his turbulent life fit within the political dramas of his time and to what extent do we see his ideas in the work of later thinkers such as Thomas Hobbes and even Martin Luther?With Sir Anthony Kenny, philosopher and former Master of Balliol College, Oxford; Marilyn Adams, Regius Professor of Divinity at Oxford University; Richard Cross, Professor of Medieval Theology at Oriel College, Oxford

Melvyn Bragg and guests discuss the Siege of Orléans, when Joan of Arc came to the rescue of France and routed the English army with the help of God. The perfidious English then burnt her as a heretic in Rouen marketplace. At least that's the story we're told but the truth involves the murky world of French court politics, labyrinthine dynastic claims, mass religious hysteria and English military and political incompetenceLooking back on the events that followed, the Duke of Bedford wrote to King Henry VI and declared “all things prospered for you till the time of the siege of Orleans, taken in hand God knoweth by what advice”.But what happened at the siege of Orleans, did Joan of Arc really rescue the city and how significant was the battle in changing the course of the 100 Years' War and the subsequent histories of England and France?With Anne Curry, Professor of Medieval History at the University of Southampton; Malcolm Vale, Fellow and Tutor in History at St John’s College, Oxford; Matthew Bennett, Senior Lecturer at the Royal Military Academy, Sandhurst.

Melvyn Bragg and guests discuss mysterious phenomena called Gravitational Waves in contemporary physics. The rather un-poetically named star SN 2006gy is roughly 150 times the size of our sun. Last week it went supernova, creating the brightest stellar explosion ever recorded. But among the vast swathes of dust, gas and visible matter ejected into space, perhaps the most significant consequences were invisible – emanating out from the star like the ripples from a pebble thrown into a pond. They are called Gravitational Waves, predicted by Einstein and much discussed since, their existence has never actually been proved but now scientists may be on the verge of measuring them directly. To do so would give us a whole new way of seeing the cosmos. But what are gravitational waves, why are scientists trying to measure them and, if they succeed, what would a gravitational picture of the universe look like?With Jim Al-Khalili, Professor of Physics at the University of Surrey; Carolin Crawford, Royal Society Research Fellow at the Institute of Astronomy, Cambridge; Sheila Rowan, Professor in Experimental Physics in the Department of Physics and Astronomy at the University of Glasgow

Melvyn Bragg and guests discuss Victorian Pessimism. On 1 September 1851 the poet Matthew Arnold was on his honeymoon. Catching a ferry from Dover to Calais, he sat down and worked on a poem that would become emblematic of the fears and anxieties of a generation of Victorians. It is called Dover Beach and it finishes like this: “Ah, love, let us be true To one another! for the world, which seemsTo lie before us like a land of dreams,So various, so beautiful, so new,Hath really neither joy, nor love, nor light,Nor certitude, nor peace, nor help for pain;And we are here as on a darkling plainSwept with confused alarms of struggle and flight,Where ignorant armies clash by night”.From Matthew Arnold’s poem Dover Beach to the malign universe of Thomas Hardy’s novels, an age famed for its forthright sense of progress and Christian belief was also riddled with anxieties about faith, morality and the future of the human race. They were even worried that the sun would soon go out. But to what extent was this pessimism spread across all areas of Victorian life? What events and ideas were driving it on and were any of their concerns about race, religion, class and culture borne out as the 19th century drew to a close? With Dinah Birch, Professor of English at the University of Liverpool; Rosemary Ashton, Quain Professor of English Language and Literature at University College London; Peter Mandler, University Lecturer and Fellow in History at Gonville and Caius College, Cambridge.

Melvyn Bragg discusses the Dutch Jewish Philosopher Spinoza. For the radical thinkers of the Enlightenment, he was the first man to have lived and died as a true atheist. For others, including Samuel Taylor Coleridge, he provides perhaps the most profound conception of God to be found in Western philosophy. He was bold enough to defy the thinking of his time, yet too modest to accept the fame of public office and he died, along with Socrates and Seneca, one of the three great deaths in philosophy. Baruch Spinoza can claim influence on both the Enlightenment thinkers of the 18th century and great minds of the 19th, notably Hegel, and his ideas were so radical that they could only be fully published after his death. But what were the ideas that caused such controversy in Spinoza’s lifetime, how did they influence the generations after, and can Spinoza really be seen as the first philosopher of the rational Enlightenment?With Jonathan Rée, historian and philosopher and Visiting Professor at Roehampton University; Sarah Hutton, Professor of English at the University of Wales, Aberystwyth; John Cottingham, Professor of Philosophy at the University of Reading.

Melvyn Bragg and guests discuss Greek and Roman love poetry, from the Greek poet Sappho and her erotic descriptions of romance on Lesbos, to the love-hate poems of the Roman writer Catullus. The source of many of the images and metaphors of love that have survived in literature through the centuries. We begin with the words of Sappho, known as the Tenth Muse and one of the great love poets of Ancient Greece: “Love, bittersweet and inescapable, creeps up on me and grabs me once again”Such heartfelt imploring by Sappho and other writers led poetry away from the great epics of Homer and towards a very personal expression of emotion. These outpourings would have been sung at intimate gatherings, accompanied by the lyre and plenty of wine. The style fell out of fashion only to be revived first in Alexandria in the third Century BC and again by the Roman poets starting in the 50s BC. Catullus and his peers developed the form, employing powerful metaphors of war and slavery to express their devotion to their Beloved – as well as the ill treatment they invariably received at her hands!So why did Greek poetry move away from heroic narratives and turn to love in the 6th Century BC? How did the Romans transform the genre? And what effect did the sexual politics of the day have on the form? With Nick Lowe, Senior Lecturer in Classics at Royal Holloway, University of London; Edith Hall, Professor of Classics and Drama at Royal Holloway, University of London; Maria Wyke, Professor of Latin at University College London.

Melvyn Bragg and guests discuss symmetry. Found in Nature - from snowflakes to butterflies - and in art in the music of Bach and the poems of Pushkin, symmetry is both aesthetically pleasing and an essential tool to understanding our physical world. The Greek philosopher Aristotle described symmetry as one of the greatest forms of beauty to be found in the mathematical sciences, while the French poet Paul Valery went further, declaring; “The universe is built on a plan, the profound symmetry of which is somehow present in the inner structure of our intellect”.The story of symmetry tracks an extraordinary shift from its role as an aesthetic model - found in the tiles in the Alhambra and Bach's compositions - to becoming a key tool to understanding how the physical world works. It provides a major breakthrough in mathematics with the development of group theory in the 19th century. And it is the unexpected breakdown of symmetry at sub-atomic level that is so tantalising for contemporary quantum physicists.So why is symmetry so prevalent and appealing in both art and nature? How does symmetry enable us to grapple with monstrous numbers? And how might symmetry contribute to the elusive Theory of Everything?With Fay Dowker, Reader in Theoretical Physics at Imperial College, London; Marcus du Sautoy, Professor of Mathematics at the University of Oxford; Ian Stewart, Professor of Mathematics at the University of Warwick.

Melvyn Bragg discusses the Opium Wars, a series of conflicts in the 19th Century which had a profound effect on British Chinese relations for generations. Thomas De Quincey describes the pleasures of opium like this: “Thou hast the keys of Paradise, O just, subtle and mighty opium”. The Chinese had banned opium in its various forms several times, citing concern for public morals, but private British traders continued to smuggle large quantities of opium into China from India. In this way, the opium trade became a way of balancing a trade deficit brought about by Britain's own addiction...to Indian tea.The Chinese protested against the flouting of the ban, even writing to Queen Victoria. But the British continued to trade, leading to a crackdown by Lin Tse-Hsu, a man appointed to be China's Opium Drugs Czar. He confiscated opium from the British traders and destroyed it. The British military response was severe, leading to the Nanking Treaty which opened up several of China's ports to foreign trade and gave Britain Hong Kong. The peace didn't last long and a Second Opium War followed. The Chinese fared little better in this conflict, which ended with another humiliating treaty.So what were the main causes of the Opium Wars? What were the consequences for the Qing dynasty? And how did the punitive treaties affect future relations with Britain?With Yangwen Zheng, Lecturer in Modern Chinese History at the University of Manchester; Lars Laamann, Research Fellow in Chinese History at the School of Oriental and African Studies (SOAS), University of London; Xun Zhou, Research Fellow in History at SOAS, University of London

Melvyn Bragg and guests discuss the 7th century saint, Hilda, or Hild as she would have been known then, wielded great religious and political influence in a volatile era. The monasteries she led in the north of England were known for their literacy and learning and produced great future leaders, including 5 bishops. The remains of a later abbey still stand in Whitby on the site of the powerful monastery she headed there. We gain most of our knowledge of Hilda's life from The Venerable Bede who wrote that she was 66 years in the world, living 33 years in the secular life and 33 dedicated to God. She was baptised alongside the king of Northumbria and with her royal connections, she was a formidable character. Bede writes: “Her prudence was so great that not only indifferent persons but even kings and princes asked and received her advice”. Hild and her Abbey at Whitby hosted the Synod which decided when Easter would be celebrated, following a dispute between different traditions. Her achievements are all the more impressive when we consider that Christianity was still in its infancy in Northumbria. So what contribution did she make to establishing Christianity in the north of England? How unusual was it for a woman to be such an important figure in the Church at the time? How did her double monastery of both men and women operate on a day-to-day basis? And how did she manage to convert a farmhand into England's first vernacular poet?With John Blair, Fellow in History at The Queen's College, Oxford; Rosemary Cramp, Emeritus Professor in Archaeology at Durham University; Sarah Foot, Professor of Early Medieval History at Sheffield University.

Melvyn Bragg and guests discuss the history of anaesthetics, from laughing gas in the 1790s to the discovery of “blessed chloroform”. Remembering his unsuccessful stint at Edinburgh Medical school Charles Darwin described the horrors of surgery before anaesthetics : "I attended the operating theatre and saw two very bad operations... but I rushed away before they were completed. Nor did I ever attend again, for hardly any inducement would have been strong enough to make me do so; this being long before the blessed days of chloroform. The two cases fairly haunted me for many a long year."The suffering Darwin witnessed is almost unimaginable. In the 19th Century, a simple fracture often led to amputation carried out on a conscious patient, whose senses would be dulled only by brandy or perhaps some morphine. Many patients died of shock.The properties of gases like nitrous oxide or “laughing gas” held out hope. The chemist Humphrey Davy in the 1790s described it as “highly pleasurable, thrilling”. He also noticed his toothache disappeared. But he failed to apply his observations and it wasn't until the 1840s that there was a major breakthrough in anaesthetics, when an enterprising dentist in Boston managed to anaesthetize a patient with ether. It became known as the “Yankee Dodge”. Ether had its drawbacks and the search for a suitable alternative continued until chloroform was tried in 1847, winning many admirers including Queen Victoria, the first English royal to use it. So why did it take so long for inhaled gases to advance from providing merely recreational highs to providing an essential tool of humane surgery? What role did the development of the atomic bomb play in the development of anaesthetics? And how have society's changing attitudes to pain informed the debate?With David Wilkinson, Consultant Anaesthetist at St Bartholomew’s Hospital in London and President of the History of Anaesthesia Society; Stephanie Snow, Research Associate at the Centre for the History of Science, Technology & Medicine at the University of Manchester; Anne Hardy, Professor in the History of Modern Medicine at University College London

Melvyn Bragg and guests discuss the original Iron Chancellor, Otto Von Bismarck. One of Europe's leading statesmen in the 19th Century he is credited with unifying Germany under the military might of his home state of Prussia. An enthusiastic expansionist, Bismarck undertook a war against Denmark that has become a by-word for incomprehensible conflict. The British Prime Minister, Lord Palmerston, said: “The Schleswig-Holstein question is so complicated, only three men in Europe have ever understood it. One was Prince Albert, who is dead. The second was a German professor who became mad. I am the third and I have forgotten all about it.”After vanquishing Austria and France, Bismark led the new industrialising Germany, managing to remain in power for a further two decades. Bismarck said: “The art of statesmanship is to steer a course on the stream of time” and he founded one of Europe's first welfare states but he was also known for his ruthless tactics, ignoring democratic institutions, dabbling in dirty politics, leaking to the press and bribing journalists. Was the unification of Germany a carefully planned campaign or a series of unpredictable events that Bismarck made the most of? Did his encouragement of militaristic nationalism bear fruit in Nazi Germany, and what is his legacy today in contemporary Germany?With Richard J Evans, Professor of Modern History at the University of Cambridge; Christopher Clark, Reader in Modern European History at the University of Cambridge; and Katharine Lerman, Senior Lecturer in Modern European History at London Metropolitan University

Melvyn Bragg and guests discuss the great 18th Century fashion for epistolary literature. From its first appearance in the 17th Century with writers like Aphra Behn, epistolary fiction, fiction in the form of letters, reached its heyday in the 18th Century with works like Clarissa by Samuel Richardson. At over a million words, it's a contender for the longest English novel. It inspired impassioned followers such as Denis Diderot who described reading Richardson's novels like this: “In the space of a few hours I had been through a host of situations which the longest life can scarcely provide in its whole course. I had heard the genuine language of the passions; I had seen the secret springs of self-interest and self-love operating in a hundred different ways: I had become privy to a multitude of incidents and I felt I had gained in experience.”This sense of the reader gaining a privileged peek into the psychology of the protagonists was a key device of the epistolary form and essential to the development of the novel. Its emphasis on moral instruction also propelled the genre into literary respectability. These novels were a publishing sensation. Philosophers like Rousseau and Montesquieu took up the style, using it to convey their ideas on morality and society.So why was letter writing so important to 18th Century authors? How did this style aid the development of the novel? And why did epistolary literature fall out of favour?With John Mullan, Professor of English at University College London; Karen O’Brien, Professor in English at the University of Warwick; and Brean Hammond, Professor of Modern English Literature at the University of Nottingham.

Melvyn Bragg and guests discuss the history of microbiology. We have more microbes in our bodies than we have human cells. We fear them as the cause of disease, yet are reliant on them for processes as diverse as water purification, pharmaceuticals, bread-making and brewing. In the future, we may look to them to save the planet from environmental hazards as scientists exploit their ability to clean up pollution. For microbes are the great recyclers on the earth, processing everything – plants, animals and us. Without microbes life would grind to a halt. How did we first discover these invisible masters of the universe? The development of microscopes in the 17th Century played a key part, but for a while science seemed stuck in this purely observational role. It is only when Louis Pasteur and Robert Koch began to manipulate microbes in the lab two hundred years later that stunning advances were made. These breakthroughs led to an understanding of how microbes transform matter, spread disease and also prevent it with the development of antibiotics and vaccines.With John Dupré, Professor of Philosophy of Science at Exeter University; Anne Glover, Professor of Molecular and Cell Biology at Aberdeen University; and Andrew Mendelsohn, Senior Lecturer in the History of Science and Medicine at Imperial College, University of London

Melvyn Bragg and guests discuss the history of optics. From telescopes to microscopes, from star-gazing to the intimacies of a magnified flea. As Galileo turned his telescope to the heavens in the early 1600s, Kepler began to formulate a theory of optics. The new and improving instruments went hand in hand with radical new ideas about how we see and what we see. Spectacles allowed scholars to study long into the evening (and into old age), while giant telescopes, up to 100 feet long, led to the discovery of planets and attempts to map the universe. The craze for optical trickery swept Europe with enthusiastic amateurs often providing valuable discoveries. But this new view of the world through a lens raised questions too – how much can you rely on the senses, on what you see? The further into space you can spy, the larger and more unmanageable the universe becomes. At the same time, the microscope was utterly transforming the world close at hand.So how did these developments inform ideas of knowledge? If new methods of scientific observation support an empirical approach, what does this mean for divine, innate reason?With Simon Schaffer, Professor in History and Philosophy of Science at the University of Cambridge; Jim Bennett, Director of the Museum of the History of Science and Fellow of Linacre College at the University of Oxford; Emily Winterburn, Curator of Astronomy at the National Maritime Museum

Melvyn Bragg will be discussing Joseph Conrad’s Heart of Darkness. Written in 1899, Heart of Darkness is a fascinating fin de siecle critique of colonialism and man's greed. Conrad draws on his own adventures for the plot. The story's main narrator is Marlow, a merchant seaman who pilots a steamship upriver in what is largely assumed to be the Belgian Congo. He finds the scramble for Africa well underway, with Europeans desperately competing to make their fortunes from ivory. Marlow's journey takes him into the interior of this mysterious silent continent. After a dangerous passage he finally arrives at the company's most remote trading station. It is reigned over by Kurtz, a white man who seems to have become a kind of God figure to the local people. Marlow is fascinated by him, preferring his messianic ravings to the petty treachery and mercenarism of the other white traders. On the journey back, Kurtz dies, whispering “the horror, the horror”.The interpretation of these words has perplexed readers ever since and the book has prompted a diverse range of readings from the psychoanalytical, that sees the novella as a metaphor for the journey into the subconscious, to feminist readings that examine how Conrad excludes female characters and focuses on the male consciousness. Conrad wrote; “My task is, above all, to make you see”. So did he intend this novella to provoke a discussion of the immorality and rapacity at the centre of colonialism? Was he questioning the hero's welcome given to those famous explorers who came back from “civilising” Africa, as they saw it? Or was he, as the Nigerian writer Chinua Achebe put it, “guilty of preposterous and perverse arrogance in reducing Africa to the role of props for the break-up of one petty European mind?” With Susan Jones, Fellow and Tutor in English at St Hilda's College, Oxford; Robert Hampson, Professor of Modern Literature at Royal Holloway, University of London; Laurence Davies, Honorary Senior Research Fellow in English at Glasgow University and Visiting Professor of Comparative Literature at Dartmouth College, New Hampshire

Melvyn Bragg and guests discuss one of the most important philosophers of the 20th century, Karl Popper whose ideas about science and politics robustly challenged the accepted ideas of the day. He strongly resisted the prevailing empiricist consensus that scientists' theories could be proved true.Popper wrote: “The more we learn about the world and the deeper our learning, the more conscious, specific and articulate will be our knowledge of what we do not know, our knowledge of our ignorance”. He believed that even when a scientific principle had been successfully and repeatedly tested, it was not necessarily true. Instead it had simply not proved false, yet! This became known as the theory of falsification.He called for a clear demarcation between good science, in which theories are constantly challenged, and what he called “pseudo sciences” which couldn't be tested. His debunking of such ideologies led some to describe him as the “murderer of Freud and Marx”. He went on to apply his ideas to politics, advocating an Open Society. His ideas influenced a wide range of politicians, from those close to Margaret Thatcher, to thinkers in the Eastern Communist bloc and South America.So how did Karl Popper change our approach to the philosophy of science? How have scientists and philosophers made use of his ideas? And how are his theories viewed today? Are we any closer to proving scientific principles are “true”?With John Worrall, Professor of Philosophy of Science at the London School of Economics; Anthony O'Hear, Weston Professor of Philosophy at Buckingham University; Nancy Cartwright, Professor of Philosophy at the LSE and the University of California

Melvyn Bragg and guests discuss Genghis Khan. Born Temujin in the 12th Century, he was cast out by his tribe when just a child and left to struggle for survival on the harsh Steppes of what is now Mongolia. From these beginnings he went on to become Genghis Khan, leader of the greatest continuous land-based empire the world has ever seen. His conquered territories stretched from the Caspian Sea to the borders of Manchuria, from the Siberian forest to what is now Afghanistan.He was a charismatic commander and a shrewd military tactician. He was swift to promote those who served him well, ignoring race or creed, but vengeful to those who crossed him, killing every inhabitant of resistant towns, even the cats and dogs. Generally regarded as barbarians by their enemies, the Mongol armies were in fact disciplined and effective.So how did Genghis create such an impressive fighting force? How did he draw together such diverse peoples to create a wealthy and successful Empire? And what was his legacy for the territories he conquered?With Peter Jackson, Professor of Medieval History at Keele University; Naomi Standen, Lecturer in Chinese History at Newcastle University;George Lane, Lecturer in History at the School of Oriental and African Studies

Melvyn Bragg and guests discuss the Greek mathematician Archimedes. Reputed to have shouted “Eureka!” as he leapt from his bath having discovered the principles of floating bodies. Whatever the truth of the myths surrounding the man, he was certainly one of the world’s great mathematicians. The practical application of his work in pulleys and levers created formidable weapons such as catapults and ship tilting systems, allowing his home city in Sicily to defend itself against the Romans. “Give me a place to stand and I will move the earth”, he declared.But despite these triumphs, his true love remained maths for maths sake. Plutarch writes: “He placed his whole affection and ambition in those purer speculations where there can be no reference to the vulgar needs of life.” His most important breakthroughs came in the field of geometry with his work on the areas and volumes of curved objects.So how did this Greek mathematician in the third century BC arrive at a calculation of Pi? Did he really create a Death Ray to fight off invading ships? And what does a recently discovered manuscript reveal about his methods?With Jackie Stedall, Junior Research Fellow in the History of Mathematics at Queen's College, Oxford; Serafina Cuomo, Reader in the History of Science at Imperial College London; George Phillips, Honorary Reader in Mathematics at St Andrews University

Melvyn Bragg and guests discuss the Jesuits, a Catholic religious order of priests who became known as “the school masters of Europe”. Founded in the 16th century by the soldier Ignatius Loyola, they became a major force throughout the world, from China to South America. “Give us a boy and we will return you a man, a citizen of his country and a child of God”, they declared. By the 17th century there were more than 500 schools established across Europe. Their ideas about a standardised curriculum and teaching became the basis for many education systems today.They were also among the greatest patrons of art in early modern Europe, using murals and theatre to get their message across. To their enemies they were a sinister collective whose influence reached into the courts of kings. Their wealth and their adaptability to local customs abroad provoked suspicion, prompting their eventual suppression in the late 18th century. They were re-established in 1814 and now have more than twenty thousand members.So why was education so important to the Jesuit movement? How much influence did they really have in the courts and colonies of Europe? And were they really at the heart of conspiracies to murder kings?With Nigel Aston, Reader in Early Modern History at the University of Leicester; Simon Ditchfield, Reader in History at the University of York; Dame Olwen Hufton, Emeritus Fellow of Merton College, Oxford.

Melvyn Bragg and guests discuss the planet Mars. Named after the Roman god of war, Mars has been a source of continual fascination. It is one of our nearest neighbours in space, though it takes about a year to get there. It is very inhospitable with high winds racing across extremely cold deserts. But it is spectacular, with the highest volcano in the solar system and a giant chasm that dwarfs the Grand Canyon.For centuries there has been fierce debate about whether there is life on Mars and from the 19th century it was even thought there might be a system of canals on the planet. This insatiable curiosity has been fuelled by writers like HG Wells and CS Lewis and countless sci-fi films about little green men.So what do we know about Mars – its conditions, now and in the past? What is the evidence that there might be water and thus life on Mars? And when might we expect man to walk on its surface?With John Zarnecki, Professor of Space Science at the Open University and a team leader on the ExoMars mission; Colin Pillinger, Professor of Planetary Sciences at the Open University and leader of the Beagle 2 expedition to Mars; Monica Grady, Professor of Planetary and Space Sciences at the Open University and an expert on Martian meteorites.

Melvyn Bragg and guests discuss the life and work of the Argentinian master of the short story, Jorge Luis Borges. Borges is one of the greatest writers of the 20th Century, best known for his intriguing short stories that play with philosophical ideas, such as identity, reality and language. His work, which includes poetry, essays, and reviews of imaginary books, has had great influence on magical realism and literary theory. He viewed the realist novel as over-rated and deluded, revelling instead in fable and imaginary worlds. He declared "people think life is the thing but I prefer reading".Translation formed an important part of his work, writing a Spanish language version of an Oscar Wilde story when aged around 9. He went on to introduce other key writers such as Faulkner and Kafka to Latin America, liberally making changes to the original work which went far beyond what was, strictly speaking, translation.He lived most of his life in obscurity, finding recognition only in his sixties when he was awarded the International Publishers' Prize which he shared with Samuel Beckett. By this point he was blind but continued to write, composing poetry in his head and reciting from memory.So how has Borges' work informed ideas about our experience of the world through language? How much was his writing shaped by his travel abroad and an unrequited love? And how has his legacy inspired the next generation of great Latin American authors such as Gabriel Garcia Marquez and Mario Vargas Llosa?With Edwin Williamson, Professor of Spanish Studies at Oxford University; Efraín Kristal, Professor of Comparative Literature at University of California, Los Angeles; Evelyn Fishburn, Professor Emeritus at London Metropolitan University and Honorary Senior Research Fellow at University College London.

Melvyn Bragg and guests discuss the siege of Constantinople in 1453. When Sultan Mehmet the Second rode into the city of Constantinople on a white horse in 1453, it marked the end of a thousand years of the Byzantine Empire. After holding out for 53 days, the city had fallen. And as one contemporary witness described it: “The blood flowed in the city like rainwater in the gutters after a sudden storm”. It was the end of the classical world and the crowning of an Ottoman Empire that would last until 1922.Constantinople was a city worth fighting for – its position as a bridge between Europe and Asia and its triangular shape with a deep water port made it ideal both for trade and defence. It was also rumoured to harbour great wealth. Whoever conquered it would reap rewards both material and political. Earlier attempts to capture the city had largely failed – so why did the Ottomans succeed this time? What difference did the advances in weaponry such as cannons make in the outcome of the battle? And what effect did the fall of Constantinople have on the rest of the Christian world?With Roger Crowley, author and historian; Judith Herrin, Professor of Late Antique and Byzantine Studies at King's College London; Colin Imber, formerly Reader in Turkish at Manchester University.

Melvyn Bragg and guests discuss hell and its representation in literature and the visual arts, through the ages from Ancient Egypt to modern Christianity. Why do certain religions have a Satan figure and others don’t? And why did hell shift from the underworld to here on earth in 20th Century representations?A fiery vault beneath the earth or as Sartre put it, other people - it seems our ideas of hell are inevitably shaped by religious and cultural forces. For Homer and Virgil it’s a place you can visit and return from, often a wiser person for it. With Christianity it’s a one way journey and a just punishment for a sinful, unrepentant life. Writers and painters like Dante and Hieronymus Bosch gave free rein to their imaginations, depicting a complex hierarchical world filled with the writhing bodies of tormented sinners. In the 20th century hell can be found on earth in portrayals of war and the Holocaust but also in the mind, particularly in the works of TS Eliot and Primo Levi. So what is the purpose of hell and why is it found mainly in religions concerned with salvation? Why has hell proved so inspirational for artists through the ages, perhaps more so than heaven? And why do some ideas of hell require a Satan figure while others don't?With Martin Palmer, Director of the International Consultancy on Religion, Education and Culture; Margaret Kean, Tutor and Fellow in English at St Hilda’s College, Oxford; Neil MacGregor, Director of the British Museum.

Melvyn Bragg and guests discuss the contribution Indian mathematicians have made to our understanding of the subject. Mathematics from the Indian subcontinent has provided foundations for much of our modern thinking on the subject. They were thought to be the first to use zero as a number. Our modern numerals have their roots there too. And mathematicians in the area that is now India, Pakistan and Bangladesh were grappling with concepts such as infinity centuries before Europe got to grips with it. There’s even a suggestion that Indian mathematicians discovered Pythagoras’ theorem before Pythagoras. Some of these advances have their basis in early religious texts which describe the geometry necessary for building falcon-shaped altars of precise dimensions. Astronomical calculations used to decide the dates of religious festivals also encouraged these mathematical developments. So how were these advances passed on to the rest of the world? And why was the contribution of mathematicians from this area ignored by Europe for centuries?With George Gheverghese Joseph, Honorary Reader in Mathematics Education at Manchester University; Colva Roney-Dougal, Lecturer in Pure Mathematics at the University of St Andrews; Dennis Almeida, Lecturer in Mathematics Education at Exeter University and the Open University.

Melvyn Bragg and guests discuss Anarchism and why its political ideas became synonymous with chaos and disorder. Pierre Joseph Proudhon famously declared “property is theft”. And perhaps more surprisingly that “Anarchy is order”. Speaking in 1840, he was the first self-proclaimed anarchist. Anarchy comes from the Greek word “anarchos”, meaning “without rulers”, and the movement draws on the ideas of philosophers like William Godwin and John Locke. It is also prominent in Taoism, Buddhism and other religions. In Christianity, for example, St Paul said there is no authority except God. The anarchist rejection of a ruling class inspired communist thinkers too. Peter Kropotkin, a Russian prince and leading anarcho-communist, led this rousing cry in 1897: “Either the State for ever, crushing individual and local life... Or the destruction of States and new life starting again.. on the principles of the lively initiative of the individual and groups and that of free agreement. The choice lies with you!” In the Spanish Civil War, anarchists embarked on the largest experiment to date in organising society along anarchist principles. Although it ultimately failed, it was not without successes along the way.So why has anarchism become synonymous with chaos and disorder? What factors came together to make the 19th century and early 20th century the high point for its ideas? How has its philosophy influenced other movements from The Diggers and Ranters to communism, feminism and eco-warriors?With John Keane, Professor of Politics at Westminster University; Ruth Kinna, Senior Lecturer in Politics at Loughborough University; Peter Marshall, philosopher and historian.

Melvyn Bragg and guests discuss the speed of light. Scientists and thinkers have been fascinated with the speed of light for millennia. Aristotle wrongly contended that the speed of light was infinite, but it was the 17th Century before serious attempts were made to measure its actual velocity – we now know that it’s 186,000 miles per second. Then in 1905 Einstein’s Special Theory of Relativity predicted that nothing can travel faster than the speed of light. This then has dramatic effects on the nature of space and time. It’s been thought the speed of light is a constant in Nature, a kind of cosmic speed limit, now the scientists aren’t so sure. With John Barrow, Professor of Mathematical Sciences and Gresham Professor of Astronomy at Cambridge University; Iwan Morus, Senior Lecturer in the History of Science at The University of Wales, Aberystwyth; Jocelyn Bell Burnell, Visiting Professor of Astrophysics at Oxford University.

Melvyn Bragg and guests discuss altruism. The term altruism was coined by the 19th century sociologist Auguste Comte and is derived from the Latin “alteri” or "the others”. It describes an unselfish attention to the needs of others. Comte declared that man had a moral duty to “serve humanity, whose we are entirely.” The idea of altruism is central to the main religions: Jesus declared “you shall love your neighbour as yourself” and Mohammed said “none of you truly believes until he wishes for his brother what he wishes for himself”. Buddhism too advocates “seeking for others the happiness one desires for oneself.”Philosophers throughout time have debated whether such benevolence towards others is rooted in our natural inclinations or is a virtue we must impose on our nature through duty, religious or otherwise. Then in 1859 Darwin’s ideas about competition and natural selection exploded onto the scene. His theories outlined in the Origin of Species painted a world “red in tooth and claw” as every organism struggles for ascendancy.So how does this square with altruism? If both mankind and the natural world are selfishly seeking to promote their own survival and advancement, how can we explain being kind to others, sometimes at our own expense? How have philosophical ideas about altruism responded to evolutionary theory? And paradoxically, is it possible that altruism can, in fact, be selfish?With Miranda Fricker, Senior Lecturer in the School of Philosophy at Birkbeck, University of London; Richard Dawkins, evolutionary biologist and the Charles Simonyi Professor of the Public Understanding of Science at Oxford University; John Dupré, Professor of Philosophy of Science at Exeter University and director of Egenis, the ESRC Centre for Genomics in Society.

Melvyn Bragg and guests discuss the Peasants’ Revolt of 1381. “When Adam delved and Eve span, who was then the Gentleman?" these are the opening words of a rousing sermon, said to be by John Ball, which fires a broadside at the deeply hierarchical nature of fourteenth century England. Ball, along with Wat Tyler, was one of the principal leaders of the Peasants’ Revolt – his sermon ends: "I exhort you to consider that now the time is come, appointed to us by God, in which ye may (if ye will) cast off the yoke of bondage, and recover liberty". The subsequent events of June 1381 represent a pivotal and thrilling moment in England’s history, characterised by murder and mayhem, beheadings and betrayal, a boy-King and his absent uncle, and a general riot of destruction and death. By most interpretations, the course of this sensational story threatened to undermine the very fabric of government as an awareness of deep injustice was awakened in the general populace.But who were the rebels and how close did they really come to upending the status quo? And just how exaggerated are claims that the Peasants’ Revolt laid the foundations of the long-standing English tradition of radical egalitarianism? With Miri Rubin, Professor of Early Modern History at Queen Mary, University of London; Caroline Barron, Professorial Research Fellow at Royal Holloway, University of London; Alastair Dunn, author of The Peasants’ Revolt - England’s Failed Revolution of 1381.

Melvyn Bragg and guests discuss the life and work of Alexander Pope. His enemies – who were numerous - described him as a hunchbacked toad, twisted in body, twisted in mind, but Alexander Pope is without doubt one of the greatest poets of the English language. His acerbic wit and biting satire were the scourge of politicians, fellow writers and most especially the critics. He was the first Englishman to make a living from his pen, free from the shackles of patronage and flattery. Indeed, his sharp tongue meant he couldn’t go out walking without his Great Dane and a pair of loaded pistols. He was a ferocious businessman too, striking tough deals with his publishers, ensuring he kept control of his work and was well-rewarded for it. So how did Pope manage to transform himself from a crippled outsider into a major cultural and moral authority? How did he shape our ideas about what a “modern author” is? Does his work still have resonances today or is it too firmly embedded in the politics, cultural life and rivalries of the period?With John Mullan, Professor of English at University College London; Jim McLaverty, Professor of English at Keele University; Valerie Rumbold, Reader in English Literature at Birmingham University.

Melvyn Bragg and guests discuss the Poincaré Conjecture. The great French mathematician Henri Poincaré declared: “The scientist does not study mathematics because it is useful; he studies it because he delights in it, and he delights in it because it is beautiful. If nature were not beautiful, it would not be worth knowing and life would not be worth living. And it is because simplicity, because grandeur, is beautiful that we preferably seek simple facts, sublime facts, and that we delight now to follow the majestic course of the stars.” Poincaré’s ground-breaking work in the 19th and early 20th century has indeed led us to the stars and the consideration of the shape of the universe itself. He is known as the father of topology – the study of the properties of shapes and how they can be deformed. His famous Conjecture in this field has been causing mathematicians sleepless nights ever since. He is also credited as the Father of Chaos Theory.So how did this great polymath change the way we understand the world and indeed the universe? Why did his conjecture remain unproved for almost a century? And has it finally been cracked?With June Barrow-Green, Lecturer in the History of Mathematics at the Open University; Ian Stewart, Professor of Mathematics at the University of Warwick; Marcus du Sautoy, Professor of Mathematics at the University of Oxford.

Melvyn Bragg and guests discuss the French encyclopédie, the European Enlightenment in book form. One of its editors, D’Alembert, described its mission as giving an overview of knowledge, as if gazing down on a vast labyrinth of all the branches of human ideas, observing where they separate or unite and even catching sight of the secret routes between them. It was a project that attracted some of the greatest thinkers of the Enlightenment - Voltaire, Rousseau and Diderot - striving to bring together all that was known of the world in one comprehensive encyclopaedia. No subject was too great or too small, so while Voltaire wrote of “fantasie” and “elegance”, Diderot rolled up his sleeves and got to grips with jam-making.The resulting Encyclopédie was a bestseller - running to 28 volumes over more than 20 years, amidst censorship, bans, betrayals and reprieves. It even got them excited on this side of the Channel, with subscribers including Oliver Goldsmith, Samuel Johnson and Charles Burney. So what drove these men to such lengths that they were prepared to risk ridicule, prison, even exile? How did the Encyclopédie embody the values of the Enlightenment? And what was its legacy – did it really fuel the French Revolution? With Judith Hawley, Senior Lecturer in English at Royal Holloway, University of London; Caroline Warman, Fellow and Tutor in French at Jesus College, Oxford; David Wootton, Anniversary Professor of History at the University of York.

Melvyn Bragg and guests discuss the Needham Question; why Europe and not China developed modern technology. What do these things have in common? Fireworks, wood-block printing, canal lock-gates, kites, the wheelbarrow, chain suspension bridges and the magnetic compass. The answer is that they were all invented in China, a country that, right through the Middle Ages, maintained a cultural and technological sophistication that made foreign dignitaries flock to its imperial courts for trade and favour. But then, around 1700, the flow of ingenuity began to dry up and even reverse as Europe bore the fruits of the scientific revolution back across the globe. Why did Modern Science develop in Europe when China seemed so much better placed to achieve it? This is called the Needham Question, after Joseph Needham, the 20th century British Sinologist who did more, perhaps, than anyone else to try and explain it.But did Joseph Needham give a satisfactory answer to the question that bears his name? Why did China’s early technological brilliance not lead to the development of modern science and how did momentous inventions like gunpowder and printing enter Chinese society with barely a ripple and yet revolutionise the warring states of Europe? With Chris Cullen, Director of the Needham Research Institute in Cambridge; Tim Barrett, Professor of East Asian History at SOAS; Frances Wood, Head of Chinese Collections at the British Library.

Melvyn Bragg and guests discuss the Diet of Worms, an event that helped trigger the European Reformation. Nestled on a bend of the River Rhine, in the South West corner of Germany, is the City of Worms. It’s one of the oldest cities in central Europe; it still has its early city walls, its 11th century Romanesque cathedral and a 500-year-old printing industry, but in its centre is a statue of the monk, heretic and founder of the Protestant Reformation, Martin Luther. In 1521 Luther came to Worms to explain his attacks on the Catholic Church to the Holy Roman Emperor, Charles V, and the gathered dignitaries of the German lands. What happened at that meeting, called the Diet of Worms, tore countries apart, set nation against nation, felled kings and plunged dynasties into suicidal bouts of infighting. But why did Martin Luther risk execution to go to the Diet, what was at stake for the big players of medieval Europe and how did events at the Diet of Worms irrevocably change the history of Europe? With Diarmaid MacCulloch, Professor of the History of the Church at Oxford University; David Bagchi, Lecturer in the History of Christian Thought at the University of Hull; Reverend Dr Charlotte Methuen, Lecturer in Reformation History at the University of Oxford.