Freely Filtered 051: Pip Tazo and Vanco: Nephrotoxin or Not so toxic

The Filtrate:

Joel Topf

Swapnil Hiremath

Nayan Arora

Priya Yenebere

Special Guests:

Todd Miano, PharmD, PhD @Miano81 Assistant Professor of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine.

Show Notes:

Early Pip/Tazo article showing nephrotoxicity. Covered by NephJC

Linazolid vs Vanco RCT showing excess AKI with Vanco. Yes Vance is a lot less toxic than it was in the Mississippi mud days but your attending telling you it is no longer nephrotoxic is wrong. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study and Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis.

Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine

Vancomycin-Associated Cast Nephropathy: Reality or Fantasy?

Molecular Epidemiology of SepsiS in the ICU (MESSI) prospective cohort. Learn about it her: A multibiomarker-based outcome risk stratification model for adult septic shock*

Cystatin C in acute kidney injury

Changing Definitions of Sepsis

Proposed new definitions of AKI incorporating biomarkers: Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference. A Consensus Statement in JAMA Network Open

Applications of propensity score methods in observational comparative effectiveness and safety research: where have we come and where should we go?

The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study

Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals

PulmCrit – Myth-busting the conditional nephrotoxicity of piperacillin-tazobactam by Josh Farkas

Sharp Objects on Good Reads

Bandon Dunes

The Ocean Course at Kiawah Island Golf Resort

Be Real follow me: BeRe.al/kidney_boy

SNL spoof of BeReal