Freely Filtered 022: Uric Acid faces the Music.
The uric acid is a mediator of CKD faces the music of two well done RCTs and fals on its face
Freely Filtered, a NephJC Podcast · NephJC
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Show Notes
The Filtrate:
Joel Topf
Swapnil Hiremath
Samira Farouk
And special guests:
Katalin Susztak, Professor of Medicine Perlman School of Medicine, University of Pennsylvania. @KSusztak
Show Notes:
CKD-FIX: Effects of Allopurinol on the Progression of Chronic Kidney Disease
PERL: Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes
Coverage at NephJC: Effects of Allopurinol on the Progression of Chronic Kidney Disease
Richard Johnson’s theory in pay-walled Nature Reviews Nephrology: Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
Richard Johnson’s theory in open access Nehrology Dialysis and Transplantation: Uric acid and chronic kidney disease: which is chasing which?
PERL: Preventing early renal loss
Iohexol, good for measuring GFR as well as causing contrast associated nephropathy?
Uric acid versus urate: The Crystallization of Monosodium Urate
WHO list of essential medications
Fixing the numbers, specifically phosphorous
Cost of allopurinol: $7/month but it is only $9 for 3 months
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial
Tipping point analysis - multiple imputation for stress test under missing not at random (MNAR) or a YouTube video if that’s your speed (sorry, I couldn’t find a TikTok on imputation stress tests).
Mendelian randomization study of urate and CKD by Ron Do and team
Fake systematic review by Johnson’s group showing Urate lowering prevented CKD
Hyperuricemia As a trigger of Immune Response in Hypertension and Chronic Kidney Disease by Claudio Ponticelli published the week after these two RCTs were published.
NEJM Editorial: Urate-Lowering Therapy and Chronic Kidney Disease Progression by Daniel Feig
‘WhatsApp®’ening in nephrology training
Arkana LIVE Pathology Sessions
NephJC Summer Book Club. Read Rana Awdish’s In Shock