Explore Premuim Health

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

National Early Warning Score 2 (NEWS2)Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you for listening to this episode of "Health and Fitness" from the Nezpod Studios! Enjoy your night or the start of your day, spiced by our top-notch health and fitness/wellness updates coined from the best sources around the globe: made only for your utmost enjoyment and enlightenment… Click on subscribe to get more spicy episodes for free! See you again soon on the next episode of Health and fitness updates! Learn more about your ad choices. Visit megaphone.fm/adchoices

"...the 80 assessment is a fundamental tool used to provide a quick assessment for a patient who is critically ill it follows an order going through the potentially life-threatening problems giving priority to the most severe issues all right so the stands for Airway and what we're doing here is basically checking that there's no obstruction but also evaluating the likelihood that the patient will be able to maintain the airway if they deteriorate further there are several things you can do to assess the airway you can watch the patient and look for signs of an obstruction such as paradoxical chest or abdomen movements cyanosis which is a blue discoloration of the skin or use of accessory muscles you can also listen for sounds for example if the patient is talking that a fairly conclusive sign that the airway is obstructed however if you hear sounds extruder which is a high pitch sound mostly in inspiration or even a wheeze these sounds are indicative of a partial obstruction so what happens if you hear nothing you're either have to try and hear the breath sounds using a stethoscope or you'll have to try and feel for it the way you do this is by putting your hand or your ear next to the patient's nose or mouth and feeling for the air flow causes of an airway obstruction include the patient's tongue a foreign body swelling and even fluid it's such as vomiting or blood so what do we do about it well if it's obstructed the patient can rapidly deteriorating die or suffer hypoxic damage to organs such as the brain and heart so the first thing you do is you get help depending on the cause the patient may be moved into the recovery position so on this side you may perform movers like back slaps or the abdominal thrusts in order to help dislodge a foreign body it's patient ventilating and normal respiratory rate is between 12 and 20 breaths per minute hide and 25 is a marker that the patient may deteriorate quickly we would also look at the depth and the effort of the breathing are they using the accessory muscles is the chest expansion symmetrical is the trachea displaced or is the hyper resonance investigations include the use of a pulse oximeter so measuring the oxygen saturation generally we aim at for to 95% with a minimum of eighty eight percent however you need to be careful in COPD patients not to overdo the oxygen therapy because you can end up suppressing their breathing life-threatening causes of breathing issues include acute severe asthma pulmonary edema and tension pneumothorax the treatment again depends on the cause oxygen is given in most cases if no obstruction is present then non-invasive ventilation..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...stroke syndromes are collections of signs and symptoms resulting from Strokes in different regions of the brain or central nervous system in this video we will cover the stroke syndrome associated with Strokes in the territory of the and IT Supplies the medial and Superior frontal and parietal lobes as well as some other structures such as parts of the corpus callosum and basal ganglia it is made up of segments first arise connects both the left and right hemispheres this segment also gives off the medial lenticular striae arteries that Supply part of the caudate nucleus and the internal capsule the a to new segment extends from the anterior communicating artery up essentially segment A3 A4 and A5 at the proximal middle and distal segments of the pericoloso artery in and the findings very most commonly there is a contralateral weakness of the leg more so than the arm or the face this is due to the arrangement of the cortical neurons known as the motor homunculus which shows that the anterior cerebral artery supplies neurons involved mostly in the motor control of the contralateral leg sensory deficits are less common but when present are generally contralateral other findings can include abulia which is the absence of willpower or the inability to act decisively speech disturbances may also be present specifically another type is transcortical mixed Aphasia meaning there are severe deficits in speaking and comprehension but repetition is preserved as the anterior cerebral artery supplies the area of the brain associated with voluntary bladder control lesions here can result in urinary incontinence A syndrome of ipsilateral ataxia and contralateral lower limb paresis being described as a result of an anterior cerebral artery in fact if both anterior cerebral arteries are involved then they may be buying and frontal disinhibition symptoms which may include the presence of primitive reflexes such as grasping and sucking reflexes that are normally inhibited by amateur frontal lobe another example is personality changes..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...we will take a look at how Strokes are diagnosed and then how Strokes the treated and managed the diagnosis of a stroke is and with imaging techniques being used to Aid in that diagnosis a big part of stroke diagnosis and management is the early recognition and tools such as and Razia a used Fast involves facial drooping arm weakness and speech disturbances while T is for the time indicating the need for timely action the Razia score which stands for recognition of stroke in the emergency room is similar and involves looking for any loss of consciousness or seizure activity which counts against a stroke diagnosis as well as facial arm or leg weakness speech disturbances or visual disturbances it physical exam should also be done which will cover the NIH SS school including levels of consciousness motor function sensory function language and attention generally suspected stroke patients will undergo a CT of the head without contrast as coagulated blood will appear hyper-dense on these scans however ischemia may not be seen in the early stages there for a CT scan is done more commonly to rule out further investigations may involve an MRI of the head which is more sensitive for chronic hemorrhages and areas of ischemia usually appear hyper-intense on diffusion-weighted a Doppler ultrasound of the Carotid may be done and if the stroke was suspected to be caused by an aneurysm and angiogram may also be done as well as lab investigations including lipids and coagulation screens you may have heard the expression time is brain in the early stages ischemic stroke the aim is to restore cerebral blood flow as fast as possible as this results in fewer brain cells dying according to the nice guidelines patients with non disabling stroke or t.i. a should have early carotid Imaging and Urgent in data Rekha me as well as stenting if they have carotid stenosis in patients who have an acute ischemic stroke 150 to 300 milligrams of aspirin should be given orally or rectally if the patient is dysphasic this 150 to 300 milligram should be continued for two weeks following the stroke until long-term antithrombotic treatment has been prescribed in patients with an allergy to aspirin Clopidogrel may be used and a proton pump inhibitor should be added in patients with a history of dyspepsia in cases of venous sinus thrombosis anticoagulation..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...within the spinal cord, there are several different tracts grossly they are divided into ascending and descending tracts on the cross-section of the spinal cord these tracks make up the white matter named because of the whitish color that the myelin around the axon gives the gray matter is located centrally comprising the ventral and dorsal horns the ascending pathways are responsible for transporting information from the body these are sensory tracts we will color these tracks in blue and starting from the posterior column also known as the dorsal column we have the fasciculus Q8 and fasciculus gracilis these are responsible for fine touch or tactile sensation vibration and proprioception fasciculus gracilis lies medially to fasciculus CUNY waiters and the difference between the pathways is at signals from the lower limb generally below TC next travel in the fasciculus gracilis while signals from the Upper Limb generally T6 and above travel in the fasciculus CUNY aters you can remember this with the l in gracilis reminding you of legs or lower limbs these tracks run ipsilateral e through the spinal cord and decussate in the middle of the brain therefore a spinal cord injury will lead to loss of ipsilateral fine touch vibration and proprioceptive sensation next up we have the anterior spinal Salaam and the lateral spinothalamic Pathways the anterior spinal thalamic tract is responsible for crude touch and pressure while the lateral spinothalamic tract is responsible for pain and temperature in contrast to the dorsal column tracks the anthro a lateral Pathways decussate within the spinal cord and then travel up to the brain this means that a lesion of the spinal cord will generally cause a contralateral loss of crew touch pressure pain and temperature sensation this is not a 100% rule however I just nerves entering the anterolateral pathways typically a send one or two vertebral levels before they cross to the other side both the dorsal column and anthro lateral pathways are..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...the World Health Organization definition of stroke is rapidly developing clinical signs of focal or Global disturbance of cerebral function with symptoms lasting 24 hours or longer or leading to death with no apparent cause other than a vascular origin this means that patients with similar symptoms caused by other causes such as tumors subdural hematomas poisoning or trauma and not considered Strokes so the difference between a stroke and a TI a or a transient ischemic attack is that a TI a is a brief episode of neurological dysfunction typically less than one hour but up to 24 hours with a vascular cause and with no evidence of infarction meaning cell death on Imaging they were previously distinguished by the duration of the neurological symptoms but now a distinguished based on the absence of in fact evidence on it Jing and resolution of symptoms the two main types of stroke ischemic stroke or hemorrhagic stroke with around 80% being ischemic an ischemic stroke is caused by the blockage of blood flow while a hemorrhagic stroke is caused by a rupture and extravasation of blood in the brain or surrounding tissue also note that Strokes with ischemic areas have a risk for breeding there for ischemic stroke can undergo what is known as a hammer dragic transformation there are four main mechanisms for an ischemic stroke the first is thrombosis which is divided into large and small vessel disease large vessel disease involves the common and internal carotid 's the vertebral arteries and The Circle of Willis the main causes of thrombi here include atherosclerosis vasoconstriction dissection and vasculitis small vessel disease involves smaller she's of The Circle of Willis and arteries in the distal vertebral and battler arteries causes here include lightbulb highly gnosis which is a build-up of fatty hyelin matter secondary to hypertension and aging as well as micro after ohms which is small atherosclerosis plaques thrombi can also be caused by Sickle Cell red blood cells clumping together and thrombi may also generate emboli which are the second mechanism for ischemic stroke the emboli are entities that travel in the blood and can be part of a thrombus that has been broken off they can be fat they can be air or even cancer or clumps of bacteria most commonly the source of the embolus is the heart due to atrial fibrillation atrial or ventricular thrombi rheumatic heart disease recent myocardial infarction or even recent coronary artery bypass grafting emboli may also travel from sources..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...hypoalbuminemia is defined as a low level of albumin in the blood and the normal range is around 3.5 to five point five grams per deciliter I'll is the most abundant protein in human blood making up around half of all serum protein it plays a key role in maintaining oncotic pressure in the blood and since its hide therefore soluble in water albumin can transport lipophilic compounds such as hormones fatty acids and unconjugated bilirubin through the blood albumin also has in acting as a pH buffer Scavenging reactive oxygen species as well as binding some drugs and calcium hypoalbuminemia can be caused by an impact this is within the liver increased utilization by tissues problems in distribution or an increase in the loss of albumin this occurs in liver disease such as cirrhosis or chronic hepatitis weather is it decrease in the production of albumin as well as a distribution problem we're more album in leaks from the capillaries into the extracellular space kidney disease is another cause hypoalbuminemia is one of the features of nephrotic syndrome where patients are losing more than 3 grams per day of protein we take this few seconds off to inform you are valued loyal listener about the best from The Nest pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic health problems classic functional medicine Back to Basics health tips and special as doctors in the United States of America check out this health and wellness podcast shows explore Health talk weekly healthy lifestyle matters excellent Health digest healthy and free daily and last but not least weekly health and fitness Corner also check out nasty boy CC the truest story never told Fiction podcast for that real-life on-the-go experience with the 27 year old Golden Boy Who made our guest invite number one list he tells us about his story it's nasty boy CC the truest story never told go get a load of that happiness because happiness is healthy as we know it join us every week as we continue to provide you the best of health and fitness enjoy the show it can also occur in chronic kidney disease with a protein is not as quick but over a long period of time small consistent losses will lead to hypoalbuminemia malnutrition or malabsorption at other causes severe malnutrition can lead to conditions such as kwashiorkor syndrome but even mild malnutrition as is often seen in the elderly can also cause from anemia conditions affecting the absorption such as ulcerative colitis Crohn's disease and celiacs disease may also end up causing hypoalbuminemia out itself is a negative phase reactant meaning its level decreases with information cytokines like il-6 and tnf cause increased leakage from the capillaries increased and less Gene transcription of the album and Gene meaning less synthesis conditions like sepsis and septic shock particularly favorite the clinical findings are often known Civic and I linked it to the underlying cause the more common findings include weakness peripheral edema and swelling all the way up to a site he's thin hair and if they have an underlying liver disease in terms of the diagnosis when albumin levels are found to be low tests are performed to identify the cause which include liver function tests assessing for liver disease urine Vermin and protein levels to assess for nephrotic syndrome and to assess for a protein losing enteropathy we could look at levels of alpha-1 antitrypsin in the stool which if l suggest a protein leakage or increased permeability of the intestinal mucosa treatment focuses on finding and managing the underlying causes while infusions of a itself a performed in some situations such as major surgery rapidly progressing hepatorenal syndrome and certain cases of nephrotic syndrome..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...the ascending track to the spinal cord carries sensory information from the body up towards the central nervous system they are grossly divided into tracts that carry conscious sensation and unconscious Sensation will start with a conscious sensation the first that we will cover is the anterolateral system which is made up mostly by the anterior and lateral spinothalamic tract but it also features the spinal reticular and spinal technical tracks the anterior spinal thalamic tract is responsible for crude touch and pressure sensation while the lateral spinothalamic tract is responsible for pain and temperature generally the ascending Pathways have three neurons in the path compared to only two neurons in the descending Pathways the first order neuron in the anterolateral system comes from The receptors in the periphery and signups is with the second order neuron that has its cell body in the also Horn of the gray matter note that the first order neuron can Ascend one to two levels before sign up Ting on to the second order new run the second or the neuron then deficits to the other side of the spinal cord and it is at this point that they form the separate tracts the anterior and lateral spinothalamic tract these second-order neurons will carry the information up the spinal cord to the thalamus where they synapse to the third order on really they are located on the ventral posterolateral nucleus of the thalamus and from there the fibers will travel to the somatosensory cortex of the postcentral gyrus passing through the internal capsule note that the third order neurons do not decussate they travel to the ipsilateral cortex we said that the anterolateral system is made up mostly by the spinothalamic tract but there are also two others the spine reticular which is involved in the automatic response to pain and the spine a technical track which is involved in orienting the head and eyes to stimuli the other system involved in conscious sensation is the dorsal column medial lemniscus pathway named due to the fibers traveling in the dorsal column of the spinal cord and passing through the medial lemniscus in the brainstem the dorsal column medial lemniscus pathway is responsible for transmitting sensations of fine touch to touch discrimination vibration and proprioception slightly we take this few seconds our valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic health problems class..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...restless leg syndrome sometimes known as Willis ekblom disease is a common neurological condition characterized by an intense irresistible urge to move the legs on the surface this may tumnus however it can cause significant distress to patients and negatively affect multiple aspects of their lives the condition features unusual unpleasant Sensations described as crawling pitching and stretching of the deeper structures of the leg referred to as dysesthesia but importantly it does not typically feature pain or sensitivity to touch the sensations are usually worse in the evening and are often worst overnight typically when at rest interestingly these feelings are subsided by walking or moving there for patients feel a compulsion to move the legs giving the name restless leg we take this few seconds off to inform you are valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic classic functional medicine Back to Basics health tips and special updates from the best doctors in the United States of America check out this health and wellness podcast shows explore Health talk healthy lifestyle matters excellent Health digest healthy and free daily and last but not least weekly health and fitness Corner also check out nasty Boise see the truest story never told Fiction podcast for that real life on the go experience with the 27 year old Golden Boy Who made our guests in like number one list he tells us about his story as it happens in real time and in real life it's nasty boy CC the truest story never told go get a load of join us every week as we continue to provide you the best of health and fitness Wellness updates from around the globe enjoy the show in 80% of cases there are periodic leg moments during sleep which maybe twitching of periodic dorsiflexion of the foot this can last up to five seconds occurring approximately every 22 the second although the name States legs it can also affect the arms depending on severity this can mean A reduced quality of life including poor sleep leading to daytime somnolence which can affect concentration as well as performance in work or school restless leg syndrome is divided into primary and secondary where primary is mostly idiopathic meaning there is no apparent cause it is thought to be familial in many cases and tends to be inherited in an autosomal dominant pattern these patients are more likely to be affected earlier in life even as early as childhood it can demonstrate genetic anticipation which is where the age of onset gets younger through each generation secondary restless leg syndrome is the result of another underlying process examples could be pregnant Ian deficiency and end stage renal disease with 25 to 50 percent of patients on hemodialysis experiencing it it can even be due to some..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...jaundice is the yellow discoloration of the skin that is seen when bilirubin levels go above approximately 3 milligrams per deciliter but it can also be seen a particularly well in the sclera so first of all we need to know a little bit about bilirubin bilirubin is a breakdown product of him and is released from red blood cells when they are destroyed now bilirubin needs to get to the liver in order to be and the way it gets there is by initially being bound by albumin and then been transported to the liver via the blood it then gets taken up into the hepatic cells and is by the enzyme glucose urinal transfer is then secreted into the biliary system now this is the distinction between conjugated and unconjugated bilirubin the presence or absence of this glucose Iran sometimes this is referred to as soluble and insoluble bilirubin now direct and indirect bilirubin are often used as equivalence to conjugate it and unconjugated bilirubin but technically correct direct bilirubin includes conjugated bilirubin and Delta bilirubin which is the bilirubin bound to albumin that we mentioned earlier from there the conjugated bilirubin is present in the bayou and is secreted into the duodenum from the duodenum it travels through the small intestine up to the terminal ileum when most of the biological hepatic circulation but conjugated bilirubin is not reabsorbed it instead passes into the colon where the bacteria remove the gluco uronic acid that was added in the liver and forms urobilinogen which is colorless which is then oxidized into Starck or billion which gives feces it's brown color this is why in cases where the common bile duct is blocked you'll end up seeing pale stools right for anyone who's not been bored out of their mind by that bit will get into the causes of jaundice that you've probably heard split up into different categories these are pre hepatic hip-hop all post hypnotic jaundice which is also sometimes known as obstructive jaundice pre hepatic jaundice will have increased levels of unconjugated bilirubin because we are talking problem occurring before the bilirubin gets deliver these are going to be causes featuring excessive hemolysis so red blood cells being destroyed quicker than usual hemolytic anemia blood transfusions and hemolytic drugs hepatic causes are due to either having damaged hepato sites which is the case in hepatitis cirrhosis..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...stroke syndromes are collections of signs and symptoms resulting from Strokes in different regions of the brain or central nervous system in this video we will cover the stroke syndromes associated with Strokes in the territory of the posterior cerebral arteries they Supply the occipital lobe the inferior surface of the temporal lobes as well as some deeper structures such as the thalamus and the midbrain of the brainstem the posterior cerebral arteries arise from the distal end of the basilar artery which itself is formed from the vertebral arteries there is a connection with the anterior circulation via the posterior communicating artery our first syndrome is Alexia without a graph here which means the inability to read without the loss of writing here the affected regions are thus plenum of the corpus callosum and typically left occipital lobe the combination of these two areas being affected results in a pure word blindness meaning that the patient is able to write but is not able to read due to the involvement of the left occipital lobe contralateral homonymous hemianopia may also be present next is a similar syndrome the unilateral occipital stroke syndrome here as the name suggests the occipital lobe on one side side is affected and part of the inferior temporal lobe may also be involved in some instances the primary finding here is a contralateral homonymous hemianopia which may often be the only neurological deficit found we may see macular sparing due to the collateral blood supply to the macular region of the cortex in some instances and no Mia maybe present which is the inability to name in this case it's the inability T2 name colors and objects thirdly we have Anton syndrome also known as cortical blindness this occurs where there is an involvement of both occipital lobes either due to involvement of both posterior cerebral arteries or due to a lesion at the level of the distal basilar artery as a result there is visual loss however an interesting feature is that these patients may not be aware of the vision loss or we take this few our valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic health problems classic functional medicine Back to Basics health tips and special updates..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...portal hypertension refers to a higher than normal blood pressure in the portal system a normal range for this pressure is 5 to 10 millimeters of mercury portal hypertension can also be defined as a portal pressure more than 5 millimeters of mercury higher than the pressure in the inferior vena cava so the portal system refers to the portal vein which drains River and the main vessels that link to the portal vein and Superior mesenteric vein which comes from the small intestines the splenic vein which of course carries blood from the spleen the inferior mesenteric connects onto the splenic vein and carries blood from the large intestine but the gastric veins connect also on to the portal vein another thing to note is the umbilical vein which is normally obliterated and becomes the round ligament of the liver but if the pressure in the portal system gets high enough it can reopen varices are dilated veins that from an increased pressure in the portal system inside the liver you have structures known as sinusoids which are specialized capillaries within the liver the hepatocyte of the a separated from these sinusoids by a space known as the space of dese venous blood from the portal system mixes with arterial blood from the hepatic artery in the sign and then flows through into a central vein these Central veins collect together in the hepatic veins which takes blood into the inferior vena cava you can also see a which collects bile produced by the hepatocyte it's and takes it down towards the gallbladder the cell in red that you see inside the sinusoid is a cup for sale A specialized type of Mac the Scavenging and phagocytic activity the orange star shaped cells are important in Portal hypertension and cirrhosis these are hepatic stellate cells found in the space of these that are involved in fiberglass this and scaf formation in response to liver injury so what causes pressure in the portal system to increase the pathophysiology of portal hypertension ultimately comes down to blood being unable to pass smoothly from the portal circulation through the liver and into the inferior vena cava we typically divide the causes into pre hepatic intrahepatic post about it causes but remember that pre hepatic here means before the blood gets into the liver meaning causes in the portal vein itself well post hypnotic causes referred to causes after that two problems involving the inferior vena cava pre hepatic causes include portal vein thrombosis splenic vein thrombosis and arteriovenous malformation and splenomegaly intrahepatic causes include the most common cause cirrhosis which can come from alcohol abuse chronic viral hepatitis metabolic..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...Danish is a mnemonic to help you remember the cerebellar signs these are signs that indicate the presence of cerebellar lesions d stands for dysdiadochokinesia which is the inability to perform a rapid alternating movement such as flipping one hand against the palm of the other in a coordinated and controlled manner Desmet Rhea is a lack of coordination of movement involving the judgment of distance and this can be seen when asking the patient to reach a particular point with a finger a central Ataxia which literally means we take this few our valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic health problems classic functional medicine Back to Basics health tips and special updates from the best doctors in the United States of America check out this health and wellness podcast shows explore Health talk weekly healthy lifestyle matters excellent Health digest healthy and free daily and weekly health and fitness Corner also check out nasty boy CC the truest story never told Fiction podcast for that real-life on-the-go experience with the 27 year old Golden Boy Who made our he tells us about his story as it happens in real time and in real life it's nasty boy CC the truest story never told go get a load of that happiness because happiness is healthy as we know it join us every week continue to provide you the best of health and fitness Wellness updates from around the globe enjoy the show means without coordination and this can affect not only the legs but also the arms trunk and other muscles in the body the most common manifestation we think of in this instance is an unsteady gait it can also be highlighted in the upper limbs by asking the patient to abduct their arms out to the side and then pressing down again and then Letting Go you may then see rebounding with a limb rebounds up Beyond its original position n is for nystagmus which are involuntary uncontrollable I move it can be elicited by asking the patient to move their gaze to the extremities and can have various characteristics including the speed rotation and Direction meaning either 200 vertical beating as well as to the left or to the right I is for intention tremor which is a Tremor that is worsened or exaggerated by movement or when the need for precise movement increases s stands for speech which may be slurred inappropriate or slow while he h stands for hypotonia..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...stroke syndromes are collections of signs and symptoms resulting from Strokes in different regions of the brain or central nervous system in this video we will cover the stroke syndromes associated with Strokes in of the middle cerebral artery IT supplies in most of the temporal lobe the anterolateral frontal lobe and the parietal lobe the middle cerebral artery comes off the internal carotid and is divided into segments the segments are the M1 or the horizontal segment which is the most proximal part and gives off a lenticular striate a tree which are deeper penetrating arteries that Supply the basal ganglia and surrounding region the M2 segment known as the Sylvian segment is next which typically includes a bifurcation into the superior and inferior segments em three segments a cortical supplying the cortex our first syndrome results from a stroke affecting the middle cerebral artery Superior division which normally supplies the lateral frontal lobe I'm the superior parietal lobes in this syndrome findings include contralateral weakness of the upper Limbs and the lower Limbs and a weakness of the contralateral lower face with a greater effect seen on the face and the Upper Limb rather than the lower limb this is because of the motor homunculus where we see that the areas of the cortex responsible for the legs are supplied more so by the anterior and so a less affected in Middle cerebral artery Strokes also remember that it is the lower part of the face that is affected because this only receives unilateral from the facial nerve while the upper two-thirds receives bilateral Innovation there is also often a Hemi sensory loss on the contralateral side that may affect the face or leg if the stroke involves the dominant hemisphere which is usually the left side then an expressive Aphasia it may be seen as Broca's area is found on the dominant side and is responsible for the production of speech if the stroke is on the non-dominant side then we see a contralateral any neglect where the patient may be unaware or unresponsive to stimulate on one side which may include not being able to recognize their own limbs next we have the middle cerebral artery inferior division..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...following a stroke there are several complications to be aware of the patient may have brain edema or increased intracranial pressure which can have a detrimental effect on the outcome of that patient this occurs due to Cellular swelling breakdown of the blood-brain barrier leaking of cerebrospinal fluid from the ependymal lining as well as from cellular debris causing an increased osmolality in that affected region this then causes movement of water into the affected space symptoms include headache dizziness nausea and vomiting and you may have signs such as papilledema and a gradual loss of consciousness because of the increased pressure there is also a risk of obstructive hydrocephalus who Nation Mannitol was previously used to reduce intracranial pressure in these patients however a recent study has shown that this may even increase the in-hospital mortality other potential therapies include hyperventilation and diuretics and some sources also specify steroids although the evidence is contradictory surgery involving a craniotomy with a skull is temporarily lifted can also help to reduce the intracranial pressure ischemic Strokes can give rise to a hemorrhagic transformation especially after thrombolytic treatment in the case of hemorrhagic stroke secondary to a subarachnoid hemorrhage the maybe vasospasm following the initial bleed which can then generate infarction which is essentially a secondary stroke to counter this a calcium channel blocker such as numata peen may be given and in the acute setting the patient may be given a cute volume expansion and vasopressin has in an attempt to increase cerebral blood flow infections are another complication of stroke pneumonia can be due to post stroke paralysis with a patient is not able to move well and can suffer atelectasis which is a collapse of part along this generates an environment that Mike I'm growing leading to pneumonia additionally due to swallowing difficulty the patient may be more prone to aspiration and therefore aspiration pneumonia urinary tract infections are also common especially in patients who have an indwelling catheter placed this is because patients with stroke have an increased risk from suppression bladder dysfunction and of course the use of the catheter itself Additionally the fever and systemic inflammatory response associated with the urinary tract infection May impair stroke recovery..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...seizures are defined as a transient occurrence of signs and symptoms due to abnormally excessive or synchronous neuronal activity in the brain they are classified into several types the first thing to consider is where the seizure originated in the brain generalized seizures begin involving both hemispheres of the brain previously they were known as primary General seizures on the other hand focal seizures originate from an area on one hemisphere if seizures begin on one Hemisphere and then involve both they known as focal to bilateral seizures this was previously called secondarily generalized seizures the next factor is whether or not the patient keeps their awareness the seizure generalized seizures are automatically considered to affect awareness, therefore, this distinction only applies to focal seizures meaning you either have focal away previously known as simple partial or focal impaired awareness previously complex partial then we have motor or non-motor seizures motor implies the involvement of movement during The Siege generalized seizures May feature stiffening and jerking while focal seizures can have movements such as twitching jerking and stiffening too but they may also feature automatic movements like licking lips or rubbing hands in focal seizures initially one group of muscles may be affected but this abnormal movement can later spread or move to other muscle this occurs due to the abnormal neuronal activity in the brain also moving to a different area this is known as the Jacksonian March generalized non-motor seizures and mostly known as absence seizures were primarily individuals will have changes in awareness and stay focal know look to seizures typically have other symptoms that happen first previously known as an aura this could be changes in sensation in Emotion thinking or there are six main types of generalized seizure the most well-known is the tonic clonic seizure previously known as grand mal here the seizures present contraction of the limbs followed by limb extension and arching of the back usually lasting 10 to 30 seconds at this stage you may also hear what is known as the it cry which is a sound produced due to the contraction of the chest muscles following this the limbs May begin shaking and in total a tonic-clonic would last around two to three minutes atonic seizures as the name suggests present with increased tonicity meaning a sustained contraction similar to the start of the tonic-clonic..." Learn more about your ad choices. Visit megaphone.fm/adchoices

...the descending Pathways carry motor signals down the spinal cord and a generally divided into pyramidal or extrapyramidal tracts the pyramidal fibers travel through the medullary pyramids of the medulla oblongata which is why they are termed pyramidal these fibers originate in the cerebral cortex and are responsible for the voluntary control of the muscles of the body and the face there are two different tracks that make up the pyramidal tracts these are the corticospinal and corticobulbar tract the corticospinal tract responsible for the control of the body the cell bodies are found within the cerebral cortex with axons converging and passing through the internal capsule followed by the crus cerebri in the midbrain the pons and subsequently arriving into the medulla oblongata at this level around 75% the fibers will it to the other side of the spinal cord and continue down to sign ups with a lower motor neuron in the ventral horns at each level these fibers are known as the lateral corticospinal the other 25% of the fibers that remain on the ipsilateral side will continue as the anterior corticospinal tract and they will continue down ipsilateral e until the cervical and highest thoracic levels where they will decussate and sign ups with their motor neurons as for the corticobulbar tract this is the tract responsible for the voluntary control of the head the face and the neck similarly to the corticospinal tract they originated from the cerebral cortex and pass through the internal capsule however rather than descend into the spinal cord these neurons have their axons sign up sing to the lower motor neurons in the brain stem specifically on to the cranial nerve nuclei... Learn more about your ad choices. Visit megaphone.fm/adchoices

"...the definition of syncope is a reversible loss of consciousness that occurs due to an inadequate blood flow to the brain usually their fast onset short duration and a spontaneous recovery so first things first what's the difference between a transient loss of consciousness and sinker beep well a syncope is a form of transient loss of consciousness which can be divided into loss of consciousness due to head trauma or non-traumatic causes under which comes along with syncope do other non-traumatic causes of a transient loss of consciousness include epileptic seizures psychogenic causes and rear causes like the problem clinically with syncope is Discerning the really serious and by that I mean potentially lethal causes of syncope so the causes are divided into Exxon knurled mediated syncope orthostatic hypotension and cardiac causes under reflex mediated we have vasovagal syncope which can be due to author's death that happens when the patient experiences fear phobias such as seeing blood or even pain next we have situational underneath reflex mediated syncope which includes losing Consciousness after death coughing finally for reflux syncope we have carotid sinus syndrome which is where the Carotid baroreceptors react too strongly to detecting an increased pressure leading to an excessive drop in blood pressure and therefore syncope an example is when people put their Ties on too tightly we take this few seconds off to inform you are valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic classic functional medicine Back to Basics health tips and special updates from the best doctors in the United States of America check out this health and wellness podcast shows explore Health talk healthy lifestyle matters excellent Health digest healthy and free daily and last but not least weekly health and fitness Corner also check out nasty Boise see the truest story never told for that real life on the go experience with the 27 year old Golden Boy Who made our guest invite number one list he tells us about his story as it happens in real time and in real life it's nasty boy CC the truest story never told go get a load of that happiness because happiness is healthy as we know it join us every week as..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...stroke is characterized by having poor blood flow to part of the brain leading to cell death they are grossly divided into ischemic and hemorrhagic with around 15 to 20 percent of Strokes being hemorrhagic a hemorrhagic stroke results from the rupture of a blood vessel leading to bleeding compared ischemic stroke that have a sudden occlusion of a blood vessel within hemorrhagic Strokes there are two main types intracerebral meaning bleeding within the brain itself which can be intraparenchymal Hemorrhage weather is bleeding within the brain tissue or an intraventricular Hemorrhage where there is bleeding within the ventricular system of the brain around one intracerebral hemorrhage into the ventricles intracerebral Hemorrhage is most commonly caused by hypertension and age-related cerebral amyloid angiopathy which is where deposition of Lloyd Peter peptide in the vessels leads to a weaker vessel structure which is then therefore more likely to bleed the other main type is a subarachnoid with the bleed occurs between the arachnoid Mater and the Pia Mater subarachnoid hemorrhages can be due to trauma or can be spontaneous in 85% of cases in taneous subarachnoid hemorrhage is caused by rupture of a cerebral aneurysm with the most common locations being the anterior communicating artery in 35 percent of cases internal carotid artery in 30% and middle cerebral artery in 22% in 30% of cases there are multiple aneurysms the remaining maybe caused by rupture of an arteriovenous malformation coagulopathy or extension of an intraparenchymal bleed note that both of these types of hemorrhagic I considered intracranial bleeds however other types of intracranial bleeds such as epidural and subdural hemorrhages are not considered hemorrhagic stroke we take this few seconds off to inform you are valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic classic functional medicine Back to Basics health tips and special updates from the best doctors in the United States of America check out this health and wellness podcast shows explore Health talk healthy lifestyle matters excellent Health digest healthy and free daily and last but not least weekly health and fitness Corner also check out nasty Boise see the truest story never told Fiction podcast for that real life on the go experience with the 27 year old Golden boy..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"Hepatorenal syndrome is a life-threatening condition characterized by rapidly Progressive kidney failure that is seen in people with Advanced liver disease the prognosis is very Bleak and is usually fatal without the transplant there are two types type 1 has a median survival of two weeks and features a rapidly increasing creatinine level type 1 happens commonly in taneous bacterial peritonitis type 2 is a slightly more moderate form with a median survival of 10 weeks and a steadier creatinine here patients typically have a site that is resistant to DirectX approximately 18% of cirrhotic patients who have ascites will develop hepatorenal syndrome within one year so what exactly that makes this condition so bad the Hallmark is a renal basic constriction in the setting of vasodilation in splanchnic breasts those are the intestines spleen liver and pancreas the main branches of the aorta that make it up at the Celiac artery as well as the superior and inferior mesenteric arteries the underfill theory is that as liver disease progresses and portal hypertension follows possibly also generating ascites there is a splash so dilation because of release of vasodilatory mediators like nitric oxide and prostaglandins this vasodilation leads to more blood being directed into the splanchnic vessels which ends up draining into the portal circulation which causes the juxtaglomerular apparatus of the kidney to activate the renin-angiotensin-aldosterone system leading to vasoconstriction and in particular in the kidneys but the splanchnic vasculature is resistant to vasoconstriction due to the production of local vasodilators like nitric oxide and so remains vasodilate it the cycle leading to this vicious cycle of the renal vasoconstriction and splanchnic vasodilation ultimately leading to renal failure the activation of the renin-angiotensin-aldosterone is thought to be an important step in the formation of ascites in patients with cirrhosis to the extent that ascites and hepatorenal syndrome may be considered a splanchnic vasodilation determined the resistance of ascites to diuretics as is seen in type 2 hepatorenal syndrome as well as the onset of kidney vasoconstriction that leads to the initial onset of hepatorenal syndrome it is important to remember that having a cirrhotic patient with an AK I does not mean that the patient has HRS they may have the Aki for other reasons and so hepatorenal..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"diarrhea is defined as having stools that occur more than three times a day and a looser than usual specifically 200 grams 24 hours is considered diagnostic but as you can imagine trying to measure the weight of stools in everyone referring to diarrhea would be a mess literally so first off the call divide them into acute and chronic causes for start acute diarrhea is defined as lasting less than four weeks and is often caused by infections that they usually eat a viral or toxin-mediated typically they will resolve spontaneously I see cases lasting more than four weeks need to be divided into either organic or functional causes and the difference between them is that organic causes can be detected or Quantified through testing while functional causes cannot samples of organic causes include celiacs disease inflammatory bowel disease like ulcerative colitis or Crohn's disease we can also have bacterial and parasitic infections pain and of course intestinal neoplasms on the other hand functional causes of chronic diarrhea include irritable bowel syndrome lactose intolerance food alcohol how then can we begin to narrow down the causes when we encounter a patient with diarrhea let's first tackle how to distinguish functional from organic diarrhea firstly the duration of secondly the volume of organic diarrhea is usually larger than in functional next we look for the presence or absence of blood functional will never have blood while organic often does we can also ask about the naming organic doesn't have any specific pattern but may wake the patient up at night well functional is usually in the morning and will not wake the patient up this is also closely tied to stress where organic diarrhea doesn't have much Association to stress but functional diarrhea often coincides with we take this few seconds our valued loyal listener about the best health and fitness podcast shows from the Nez pod Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic classic functional medicine Back to Basics health tips and special updates from the best doctors in the United States of America check out this health and wellness podcast shows explore Health talk weekly healthy lifestyle matters excellent Health digest healthy and free daily and last but not least weekly Health and Fitness also check out nasty boy CC the truest story never told Fiction podcast for that real-life on-the-go experience with the 27 year old Golden Boy Who made our guest he tells us about his story as it happens in real time and in real life it's nasty boy CC the truest story never told go get a load of that happiness because happiness is healthy as we know it join us every week as we continue to provide you the best of health and fitness Wellness updates from around the globe enjoy the show" Learn more about your ad choices. Visit megaphone.fm/adchoices

a sudden deterioration in the function of the kidneys is known as an acute kidney injury sometimes also called acute renal failure to measure this reduction in kidney function glomerular filtration rate or GFR is normally used which is a measurement of how well the kidneys are filtering the blood the functional unit of the kidney that actually does this is the Nephron made up of the glomerulus which is a modified capillary and as blood passes through it the waste is filtered into the Bowman's capsule GFR is the volume filtered through the glomerulus into the Bowman's capsule and through the Nephron in a given unit of time the filtrate passes along through the proximal convoluted tubule Loop of henle distal convoluted tubule and the distal collecting duct undergoing secretion and reabsorptionas it travels ultimately it forms urine and collects into the renal pelvis and passes into the bladder through the ureter to directly measure this process is difficult we instead use creatinine clearance to estimate the GFR creatinine is a normal breakdown product of creatine released from muscle tissue and this is freely filtered by the glomerulus and is not reabsorbed so fits the kind of substance we need however creatinine is secreted into the filtrate by the peritubular capillaries so it does tend to overestimate the GFR slightly the cockcroft and Gault formula is a famous formula used to estimate the creatinine clearance and therefore GF are taking into account age Mass gender and the serum creatinine as it travels ultimately it forms urine and collects into the renal pelvis and passes into the bladder through the ureter to directly measure this process is difficult we instead use creatinine clearance to estimate the GFR creatinine is a normal breakdown product of creatine released from muscle tissue and this is freely filtered by the glomerulus and is not reabsorbed so fits the kind of substance we need however creatinine is secreted into the filtrate by the peritubular capillaries so it does tend to overestimate the GFR slightly the cockcroft and Gault formula is a famous formula used to estimate the creatinine clearance and therefore GF are taking into account age Mass gender and the serum creatinine Learn more about your ad choices. Visit megaphone.fm/adchoices

polycystic kidney disease is a condition characterized by the development of multiple cysts within the renal tubules of the kidney and is the most common hereditary renal disease the normal functional unit of the kidney is the nephron made up of a glomerulus and Bowman's capsule proximal convoluted tubule Loop of henle distal convoluted tubule and the collecting duct blood filters through the glomerulus forming filtrate which then passes through the tubules undergoing see and reabsorption eventually forming urine and passing into the ureter and bladder overall there are around 1 million of these nephrons in each kid in polycystic kidney disease these tubules develop into cysts which become filled with fluid and can range in size from being microscopic to several centimeters in size the process can start even in utero meaning in the womb as the tubules become cysts they cannot carry the normal filtering function therefore the number of functioning nephrons begins to decrease this is worsened by the fact that as the cysts grow they compress nearby nephrons also making them dysfunctional initially this may not be seen to have any clinical impact as the remaining number of nephrons may increase there to maintain the glomerular filtration rate but as the disease progresses and more nephrons are affected the remaining ones cannot make up the difference overall renal function then deteriorates eventually reaching end-stage renal disease by definition the presence of structural injury makes polycystic kidney disease a form of chronic kidney disease with end-stage renal disease being defined as needing renal replacement therapy like dialysis or transplant or a GF far below 15 ml per minute there are two main types of polycystic kidney disease both caused by genetics the first is autosomal dominant with two main types one coming from mutations in P KD 1 on a chromosome 16 which codes for the protein polycystic in this is affected in around 85% of cases and is involved in cell to cell or cell Matrix interaction cell cycle regulation and calcium transport the second coming from mutations in PKD to on chromosome for coding for Polly system to which codes for Learn more about your ad choices. Visit megaphone.fm/adchoices

Nephrotic syndrome is a collection of signs and symptoms that result from damage to the kidneys and is often confused with nephritic syndrome in fatigue syndrome there is a substantial amount of protein being lost through the kidneys in the urine defined as more than 3.5 grams per day this leads to hypoalbuminemia a low level of albumin in the blood as albumin is the most abundant protein normally in the blood these two are defining features in nephrotic syndrome nephritic syndrome is different in that there is less proteinuria but also the presence of hematuria and red blood cell or white blood cell casts in the urine hypertension and oliguria which is a reduced urine output typically between 80 and 400 ml per day the unit of the kidney is the nephron and normally in the glomerulus of the Nephron there is a specialized membrane that forms the filter made up of a fenestrated endothelium the Maryland basement membrane and the foot processes of podocytes which are cells that wrap around the capillary giving this additional filtration layer all together these structures normally act as a filter and prevent large molecules from passing through into the Bowman's capsule and renal tubules they have a net negative charge which may mean that they can repel other negatively charged molecules albumin is negatively charged in the fatigue syndrome there is sufficient injury to these structures to change the permeability and allow albumin and other molecules to pass into the urine leading to hypoalbuminemia the signs and symptoms linked to hypoalbuminemia which includes peripheral edema and fluid overload particularly in children this can be evident as facial swelling but can also occur in adults particularly around the eyes fluid overload can mean weight gain peripheral edema and even the development of ascites or pleural effusion which can manifest as shortness of breath known as this near the reduction in the blood levels of albumin causes the oncotic pressure of the blood 24 meaning fluid will more readily leak into the surrounding tissues causing edema this is sensed as hypovolemia because less fluid is in the vessels which then triggers the renin-angiotensin-aldosterone system causing retention of salt and water this is known as the underfill hypothesis while another is the Learn more about your ad choices. Visit megaphone.fm/adchoices

"...chronic kidney disease or chronic renal failure is a progressive irreversible condition characterized by either a reduction in kidney function or kidney damage as a result of any cause that a present for more than 3 months it is divided into stages based on the glomerular filtration rate which is a measure of how well the kidneys are functioning it shows the flow rate of filtrate through the glomerulus of the Nephron into the Bowman's capsule and ultimately through the renal tubules the stages are labeled 1 to 5 with 2 groups in stage 3 the definition of a reduced GFR is below 60 milliliters per minute but in groups 1 and 2 the GFR may actually be above 60 but there is evidence of kidney damage end-stage renal disease is classed as a GF are below 15 or the need for renal replacement therapy like dialysis or renal transplant kidney damage can be defined as signs of damage seen on Imaging or on testing such as a high albumin to creatinine ratio which is a measurement of the amount of protein lost in the urine in fact in combination with GFR these patients are divided into three food groups based on the albumin creatinine ratio with higher values indicating more damage and an increased likelihood of progression initially chronic kidney disease may not cause many problems and it is often asymptomatic however as it progresses it brings with it several significant complications these can include an elevated cardiovascular risk with patients are 5 to 10 times more likely to die from cardiovascular disease than end-stage renal disease the risk of stroke has been found to increase as the GFR lowers around seven percent for every 10 ml per minute lost this may also be the result of CKD contributing to hypertension as well as being caused by it this can be due to activation of the renin-angiotensin-aldosterone system and can also be because as the disease progresses the kidney is less able to excrete leading to retention and subsequent fluid overload signs of fluid overload could be dismissed near due to pulmonary edema or a fusion and peripheral edema or ascites anemia is also common which contributes to disappear and can come from a reduction in erythropoietin from the..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...nephritic syndrome is a collection of signs and symptoms that result from glomerulonephritis which is inflammation of the kidney specifically the glomerulus this could be remembered because it means inflammation rather than being a disease itself nephritic syndrome is the manifestation of an underlying disease that causes the inflammation and there are many of these causes it is easily confused with nephrotic syndrome which instead is a collection of signs and symptoms resulting from a high amount of protein being lost through the kidneys in the urine this leads to hypoalbuminemia meaning low levels of albumin in the blood these are the two defining features in nephrotic syndrome there is some overlap but nephritic syndrome is different in that the degree of proteinuria is lower and there is the dozens of hematuria meaning blood in the urine which could be microscopic or macroscopic red blood cell casts in the urine sterile / urea which is the presence of white blood cells without evidence of bacteria hypertension and oliguria which is a reduced urine output typically between 80 and 400 ml per day the functional unit of the kidney is the Nephron which includes the glomerulus and modified capillary surrounding this there are multiple layers which together form a filter these include a fenestrated endothelium the glomerular basement membrane and the foot processes of podocytes which are cells that wrap around the capillary in most cases of nephritic syndrome there is a trigger causing inflammation in this area overall featuring cellular proliferation complement activation recruitment of leukocytes and production of proteases and free radicals that ultimately lead to injury of the kidney this then leads to the characteristic features for example injury to the glomerular filtration membrane allows protein to leak into the urine though not as much as is seen in nephrotic syndrome red blood cells can also pass through causing hematuria and they can be dysmorphic with a camping sites in particular suggesting glomerular injury red blood cells can also Clump together within the tubules forming cylindrical structures called castes in fact this is considered suggestive of glomerulonephritis the injury and inflammation means white blood cells are recruited and can pass into the urine and as we said it's termed sterile pyuria because there..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...tricky to remember but this pneumonic will help you remember not only the names but also their positions the rest is made up of eight bones roughly in two rows of four the pneumonic starts as some lovers try positions s is for the scaphoid L flew name T4 triquetrum and P Pi is a form to remember the position you can use the letter P because the Paisa form is on the same side as the pinky the scaphoid and the lunate articulate with the and the radius is always on the same side as the thumb the second half of the pneumonic is that they can't handle which is for the trapezium trapezoid capitate and hamate the scaphoid is the most commonly injured bone of the wrist usually from a fall onto an outstretched hand and it is associated with pain in the anatomical snuffbox and with axial pressure applied on the thumb it is also famous for having a risk of a vast necrosis because it has a retrograde blood supply meaning blood flow from its distal end towards its proximal end this is mostly from the dorsal branch of the radial artery if the scaphoid is fractured blood might not be able to reach the proximal end giving avascular necrosis of the proximal part of the scaphoid at the metacarpals numbered 1 to 5 from the thumb which is easy to remember because each hand only has one thumb a famous fracture of the metacarpal is the boxer's fracture which is on the fifth metacarpal after striking with a closed fist this can lead to misalignment of the knuckle as the metacarpal makes up the now you then have the phalanges there are three in each finger called the proximal middle and distal phalange but only two in the thumb the proximal and distal phalanges we take this few seconds off to inform you are valued loyal listener about the best health and fitness podcast shows from the nest Studios join us as we give you the best of the best health and wellness updates you can rely on for the treatment of chronic health problems classic functional medicine Back to Basics health tips and special best doctors in the United States of America check out this health and wellness podcast shows explore Health talk weekly healthy lifestyle matters excellent Health digest healthy and free and last but not least weekly health and fitness Corner also check out nasty Boise see the truest story never told Fiction podcast for that real-life on the..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...tennis elbow and golfer's elbow a to similar conditions causing pain in the elbow and a medically know is lateral and medial epicondylitis respectively this means inflammation of the epicondyles which are bony protuberance has on the distal of the humerus the elbow is made up of the humerus articulated with the radius and ulna and allows for flexion and extension of the forearm however there are muscles that attach to the epicondyles that allow for wrist hand and finger movements like grasping and twisting and repetitive use of these muscles is thought to lead to micro attendance generating pain for this reason the conditions are known as enter Sapa these-- which means attachment point disease in act more recently it has been recommended that the conditions be referred to as tendinosis or epicondyle Alger rather than epicondylitis as histologically there is usually granulation tissue and a lack of traditional inflammatory cells suggesting that degeneration of the tendon maybe more an inflammation in the pathogenesis Motions like using handheld tools or even drawing are associated with the conditions and the names are slight misnomers is playing tennis can give you golfer's elbow and vice versa over all the movements causing the conditions do not necessarily need to be sports-related in some cases they can be triggered by a sudden contraction possibly from trauma elbow pain is the primary symptom in each lateral like this is 7 to 10 times more common and the pain is on the lateral or outer part of the elbow usually on the dominant hand it is generally worsened by extension of the wrist or fingers as the muscles responsible for these movements attached to the lateral epicondyle collectively known as the extensor tendons in particular the extensor carpi radialis brevis is commonly affected in lateral epicondylitis there is typically worsening of the pain with wrist extension against resistance when the is extended known as cozens test medial epicondylitis is less common but features pain on the medial or inner of the elbow it comes from tendinosis of the flexor and pronate attendance which originate from the medial epicondyle in particular the carpi radialis and the pronator teres and most commonly affected the pain is usually reproduced when the wrist is flexed and pronated against resistance well the is flexed called the reverse cozens test overall it is usually a gradual onset of pain that progressively get worse and can persist at night it also tends to be worsened by use of the forearm such as grasping and the pain may also be elicited by palpating several millimeters distal to the air condyles which corresponds with the location of the tendons people may also experience weaker grip strength the diagnosis is largely meaning no specific test or Imaging is required to make a diagnosis however Imaging like x-ray may be done to rule out arthritis of the elbow..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...Osgood-Schlatters disease also known as tibial tubercle apophysitis is a condition characterized by the anterior knee due to inflammation of the apophysis and apophysis is a normal developmental protuberance from a bone that provides an insertion site for tendons in this case the patellar tendon on to the tibial tubercle it primarily affects children and adolescents because by adulthood the apophysis will fuse with the rest of the tibia it is weaker than 10 and so is prone to injury Osgood-Schlatters disease is a stress or traction injury that occurs due to repetitive Force being applied through the strong patellar tendon on to the tibial tubercle typically from movements involving leg extension such as running or jumping but also during growth spurts the force can lead to small avulsion fractures of the tibial tubercle apophysis generating and pain and in rare cases a complete avulsion of the tibial tubercle knee pain is the most common symptom which is on the anterior portion of the knee just below the patella in most cases it is unilateral but both sides are affected in around 30 percent of cases in general it has an Insidious gradual onset with no trauma and may initially be episodic but go on to become continuous the tibial tubercle itself can be tender to touch and may have some Associated enlargement which can be felt as a prominent lump males in particular are up to seven times more likely to be affected..." Learn more about your ad choices. Visit megaphone.fm/adchoices