Evidence Based Medicine presented by InpharmD™

InpharmD's EBM podcast focuses on commonly asked drug information questions and the associated literature. This episode focuses on the use of ketamine for Sickle Cell Disease.

InpharmD's EBM podcast focuses on commonly asked drug information (DI) questions and the associated literature. Everyday, our queue gets tons of questions asked by health care providers all around the country. For this episode, we assess tirzepatide for obstructive sleep apnea and analyze the SURMOUNT-OSA clinical trials.

InpharmD's EBM podcast focuses on commonly asked drug information (DI) questions and the associated literature. Everyday, our queue gets tons of questions asked by health care providers all around the country. For this episode, we assess treatment options for excoriation disorder.

InpharmD's EBM podcast focuses on commonly asked DI questions. Every day, our queue gets tons of new questions asked from providers all around the country. Today's podcast focuses on the use of phenytoin to treat tacrolimus toxicity.

InpharmD's EBM podcast focuses on commonly asked drug information questions. Every day, our queue gets tons of new questions asked from providers all around the country. One question that's been garnering a lot of views from our users right now is which atypical antipsychotics are associated with the lowest and highest risk of QT prolongation.

Join InpharmD as we discuss the role of apixaban in peripheral artery disease.

Join InpharmD as we discuss the safety and efficacy of two FDA-approved RSV vaccines, Arexvy and Abrysvo.

Join us as we discuss the data surrounding newly approved antifungal agent, rezafungin. Interested in learning more? Join our CE on rezafungin on July 27th at 12:00 PM EST - open to all pharmacists!

Join InpharmD as we discuss the data on perioperative duloxetine (Cymbalta) during orthopedic surgery for pain reduction. Interested in the full data response? Read here!

Every month, InpharmD creates a continuing-education (CE) class on the most commonly asked drug information question and the related evidence. Our podcast offers a sneak peak into our CE as we briefly discuss the topic. Episode-2 looks at the safety and efficacy of lecanemab in the treatment of Alzheimer's dementia.

Join us as we discuss the evidence surrounding tirzepatide for weight loss in diabetic patient populations.

Many hospitals have been dealing with the recent oxytocin shortage. With this episode, we discuss possible alternatives and adjuncts to oxytocin, based on the evidence available.

Tune in as we discuss the PROVENT trial and the on-going TACKLE trial to determine whether or not Evusheld can increase cardiovascular events.

A randomized clinical trial conducted to assess time-restricted eating with calorie restriction as compared with daily calorie restriction alone for the effects on weight loss and metabolic risk factors in obese patients.

A regression analysis conducted in Israel showed that a fourth dose appeared to increase the protection against severe illness relative to three doses that were administered more than 4 months earlier. Further studies are needed before applying this to a larger population.

A multicenter, randomized, open label, non-inferiority trial conducted to test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections (UTI) with the current standard prophylaxis of daily low dose antibiotics.

A cohort study conducted to estimate the rate of breast cancer overdiagnosis in contemporary mammography practice accounting for the detection of nonprogressive cancer.

A prospective, double blind, superiority, randomized placebo-controlled trial conducted to confirm the rapid onset anti-suicidal benefits of ketamine in the short term and at six weeks.

A phase 3, double-blind, randomized, placebo-controlled trial conducted to show superiority of SER-109 in reducing the risk of C. difficile infection recurrence up to 8 weeks after treatment.

A retrospective study conducted to assess for any decrease in mortality associated with the use of the BNT162b2 (BioNTech, Pfizer vaccine) booster.

A double-blind, randomized, placebo-controlled trial conducted to evaluate the efficacy and safety of a 3-day course of remdesivir in high-risk, non-hospitalized patients with COVID-19.

A single-blind, multicenter, randomized, controlled trial conducted to evaluate the efficacy of financial incentives dependent on continuous smoking abstinence on smoking cessation and birth outcomes among pregnant smokers.

An open-label, randomized, parallel-group, adaptive design with blinded outcome adjudication trial conducted to compare the efficacy and safety of milvexian and enoxaparin in patients undergoing elective knee arthroplasty.

The first in-human, phase 1, randomized, double-blind, placebo-controlled study conducted to determine the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of molnupiravir in healthy subjects.

A double-blind, randomized, placebo-controlled trial conducted to assess the role of chlorthalidone for hypertension in advanced chronic kidney disease.

An investigator-initiated, multi-center, randomized, double-blind, superiority, placebo-controlled conducted to determine whether the combination of vasopressin and methylprednisolone administered during in-hospital cardiac arrest improves return of spontaneous circulation.

A randomized, adaptive, platform trial conducted to assess the efficacy of fluvoxamine versus placebo in preventing hospitalization (defined as either retention in a COVID-19 emergency setting or transfer to a tertiary hospital due to COVID-19).

A randomized, double-blind, placebo-controlled, phase 3 study, conducted to evaluate the efficacy and safety MDMA-assisted therapy for PTSD compared with placebo with therapy?

A randomized, double-blind, parallel-group, placebo-controlled, event-driven trial conducted to evaluate the effects of SGLT2 inhibition with empagliflozin on major heart failure outcomes in patients with heart failure and a preserved ejection fraction.

This week, InpharmD looks at two case reports discussing presentations of patients who developed Functional Neurological Disorder (FND) after receiving COVID-19 vaccination.

This week, we look at two different case reports: 1) Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination 2) Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination Tune in to learn more!

A cohort study conducted to determine whether there is a dose–response relationship between the intensity of exposure to the World Trade Center (WTC) site and the risk of hepatic steatosis (HS) in the WTC General Responder Cohort (GRC).

A prospective, multi-center, international cohort study conducted to evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD), Crohn's Disease, and Ulcerative Colitis.

A double-blind, placebo-controlled, cross-over study conducted to assess the impact of childhood trauma on responses to morphine and pain processing.

A study that use supervised machine learning to identify potential variables important to assessing risk of incident chronic heart disease (CHD), stroke, and heart failure (HF) in a hypothesis-free, data-driven manner.

A study conducted to investigate the acceptability and tolerability of an intra-oral device, designed to facilitate weight loss

Here we provide an overview of three case reports focusing on patients who developed rhino-orbital mucormycosis, a rare fungal infection, potentially from COVID-19.

A multicenter, randomized, open-label, parallel-group trial conducted to determine the effectiveness of continuous glucose monitoring (CGM) in adults with type 2 diabetes treated with basal insulin.

An international, randomized, double-blind, placebo-controlled trial conducted to evaluate the efficacy and safety of semaglutide, as compared with placebo, as an adjunct to lifestyle intervention for reducing body weight in overweight and obese adults without diabetes.

An investigator-initiated, multicenter, parallel-group, open-label, randomized clinical trial conducted to determine whether continuous infusion of hypertonic saline solution improves neurological outcomes at 6 months in patients with traumatic brain injury

A global, phase-3 trial conducted to evaluate the efficacy and safety of sacituzumab govitecan (Trodelvy) as compared with single-agent chemotherapy of the physician's choice in patients with relapsed or refractory metastatic triple-negative breast cancer. This trial led to the FDA's accelerated approval of Trodelvy for this indication.

A mutlicenter, randomized trial conducted to test whether dexmedetomidine leads to better short-term and long-term outcomes than propofol in mechanically ventilated adults with sepsis.

A randomized, multicenter, international, double-blind, placebo-controlled trial conducted to determine whether the addition of midodrine to standard care reduces the time to discontinuation of IV vasopressor use in otherwise resuscitated patients

A retrospective, multicenter, observational, database analysis conducted to quantify rates of organ-specific dysfunction in individuals with COVID-19 after discharge from hospital compared with a matched control group from the general population

A randomized, open-label, trial conducted to evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU).

A retrospective, observational, cohort study conducted to compare the rate of change in estimated glomerular filtration rate (eGFR) after hospital discharge between patients with and without COVID-19 who experienced in-hospital acute kidney injury (AKI)

A randomized study conducted to determine the effect of bamlanivimab monotherapy and combination therapy with bamlanivimab and etesevimab on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) viral load in mild to moderate COVID-19

A controlled, open-label trial conducted to report the results of the controlled, open-label Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial of dexamethasone in patients hospitalized with COVID-19.

A randomized multicenter, double-blind, parallel-group, placebo-controlled trial, conducted to investigate the effect of vitamin D3 administration on hospital length of stay and other relevant clinical outcomes and adverse events in hospitalized patients with moderate to severe COVID-19.

A randomized, multi-center, open-label, open-label, factorial clinical trial conducted to examine whether high-dose zinc and/or high-dose ascorbic acid reduce the severity or duration of symptoms compared with usual care among ambulatory patients with SARS-CoV-2 infection.