⏱️🩸 Timing is Brain: Early DOACs in Atrial Fibrillation
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer!
📊 5,441 patients from 4 RCTs
⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days
⚖️ No increased bleeding, even in moderate stroke severity
🚫 But patients with PH2 or very severe strokes were excluded
Individual Participant Data Meta-Analysis allowed detailed subgroup analysis and minimized bias
💡 Clinical Takeaway: In most mild-to-moderate strokes, don't delay—start DOACs early!
📄 #Stroke #AtrialFibrillation #CATALYST #DOAC #Neurology #Cardiology #MetaAnalysis #IPDMA #ClinicalTrials #PrecisionMedicine #StrokePrevention