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Show Notes
🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF!
Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️🔥
#HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism