💊 Stroke. Minocycline. Meaningful Recovery.
Dr RR Baliga's "Got Knowledge Doc" Podkast
February 19, 20265m 20s
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Show Notes
Can we finally modulate post-stroke inflammation? 🧠
The EMPHASIS trial (Lancet 2026) randomized 1,724 patients with acute ischemic stroke to short-course oral minocycline within 72h.
Result: higher rates of excellent 90-day outcome (mRS 0–1 52.6% vs 47.4%; RR 1.11, p=0.0061) without safety concerns.
A cheap, generic drug showing signal in late neuroprotection.
Inflammation may not just follow stroke — it may shape recovery. 🔬