🫀 Sense. 🧠 Signal. 🛡️ Scar. A Heart–Brain–Immune Loop in Myocardial Infarction
Dr RR Baliga's "Got Knowledge Doc" Podkast
Audio is streamed directly from the publisher (traffic.libsyn.com) as published in their RSS feed. Play Podcasts does not host this file. Rights-holders can request removal through the copyright & takedown page.
Show Notes
🫀🧠🛡️ Sense. Signal. Scar.
A striking Cell study reframes myocardial infarction as a systems disease, not a heart-only event. Using single-cell and spatial transcriptomics in murine MI, the authors identify a triple-node heart–brain–immune loop: TRPV1-positive vagal sensory neurons (injury sensing) → hypothalamic paraventricular nucleus AT1aR neurons (central integration) → superior cervical ganglion IL-1β signaling (sympathetic–immune effector arm).
Intervening at any node improved ejection fraction, reduced infarct size, and normalized autonomic balance—pointing to neuroimmune modulation as a new therapeutic frontier beyond myocardium-centric care.
📌 Key takeaway: Treat the circuit, not just the scar.
📖 Yadav et al., Cell (2026)