🧬 Protein Restriction, Aging, and Longevity ⏳
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🧬 Protein Restriction, Aging, and Longevity ⏳
A remarkable new study in Cell shows that moderate protein restriction—especially when started in midlife—can reprogram aging biology across 41 organs, improving metabolic and cardiovascular health. 🫀⚙️
Using deep multi-organ proteomics in mice and human plasma validation, the authors demonstrate benefits mediated through ↓ IGF-1, ↓ mTOR, ↑ AMPK, and activation of brown adipose tissue. Importantly, the data also caution that extreme protein restriction may provoke inflammation, underscoring that moderation matters. ⚠️🎯
A powerful example of how nutrition shapes the biology of aging—organ by organ, pathway by pathway.
📖 Cell (2025)
#Aging #Longevity #ProteinRestriction #MetabolicHealth #CardiovascularHealth #Proteomics #PrecisionNutrition