🧠 Precision, Prevention, Progress: Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 New in NEJM — The ALASCCA Trial 🧬
Low-dose aspirin (160 mg/day) reduced colorectal cancer recurrence in patients with PIK3CA, PIK3R1, or PTEN mutations 🎯
✅ 3-year recurrence: 7.7% (aspirin) vs 14–17% (placebo)
✅ Group A HR: 0.49 | Group B HR: 0.42
✅ NNT as low as 6 in stage III rectal cancer 💥
⚠️ Slight increase in adverse events
🧠 Editorial calls it a new standard of care:
🔬 Genotype early + 💊 Start aspirin early = 📉 Lower recurrence
📖 Read both the trial and editorial in NEJM, Sept 2025
#ColorectalCancer #PrecisionOncology #Aspirin #PIK3CA #NEJM #OncologyTrials #Genomics #AdjuvantTherapy #ALASCCA #ClinicalTrials