📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention: A New Era in CAD Prediction
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 New Insights on Heart Attack Risk! 🧬❤️
A must-read from Circulation: Genomic and Precision Medicine—Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥
📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn't just academic—it's actionable. Add in hsCRP and Lp(a), and we're entering a new era of CAD risk stratification.
🔍 From base to full model:
➡️ R²: 0.021 → 0.053
➡️ C-statistic: 0.65 → 0.73
➡️ PAR: 84.3%
Let's embrace the fusion of clinical + genetic + biomarker data to better prevent cardiovascular disease. 🧠💡 #Cardiology #Genomics #PrecisionMedicine #CAD #PRS #RiskPrediction #Circulation #HeartHealth #FutureOfMedicine #Biomarkers #PreventionIsPower