Mutants, Mitochondria & Metformin 🔬🔋💊: Powering Down Clonal Haematopoiesis
Dr RR Baliga's "Got Knowledge Doc" Podkast
April 28, 20252m 59s
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Show Notes
🧬 Clonal haematopoiesis (CH)—especially with DNMT3A-R882 mutations—increases with age and raises leukemia risk.
💊 New studies reveal that metformin targets mutant blood stem cells by suppressing mitochondrial metabolism, sparing healthy cells.
📉 UK Biobank data shows lower CH prevalence in metformin users.
🔋 Targeting oxidative phosphorylation may offer a safe, preventative strategy against CH progression.