Mitochondria, Mistakes, 🧬 InflammAgeing
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🔬 Exciting new insights from Nature (2025)!
When mitochondria run low on the right building blocks (deoxyribonucleotides), they mistakenly weave ribonucleotides into their DNA 🧬. The result? Fragile mitochondrial DNA gets expelled, setting off the cGAS–STING pathway and fueling inflammation 🔥—a key feature of ageing and senescence.
🧪 In MGME1-deficient mice, this process drives renal inflammation, while supplementation with deoxyribonucleosides 💊 can calm the storm.
✨ A major step in understanding "inflammageing" and potential interventions for age-related diseases.
#Mitochondria #DNA #Ageing #Inflammation #NaturePaper