🫁💥 "Lung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots" 🧬🩸
Dr RR Baliga's "Got Knowledge Doc" Podkast
April 19, 20252m 43s
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Show Notes
🩸 Summary:
Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin β2⁺ extracellular vesicles (sEVs) 🧬 that bind platelet GPIb 🧲, triggering clot formation across the body.
These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection 🎯, offering safer, targeted therapeutic opportunities 💉.