Lower LDL-C earlier, protect longer—the artery remembers every LDL it has ever seen.
Dr RR Baliga's "Got Knowledge Doc" Podkast
March 29, 20265m 51s
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Show Notes
Evolocumab steps into primary prevention—quietly, convincingly. In JAMA, the VESALIUS-CV analysis shows that high-risk patients with diabetes without known atherosclerosis experienced a 31% relative reduction in first MACE (HR 0.69), with LDL-C lowered to ~52 mg/dL. The signal is clear: earlier, deeper lipid lowering matters. Yet questions remain—cost, long-term safety, and who benefits most. Are we ready to treat risk before disease declares itself? 🧠💉📉 #JAMA #Cardiology #Prevention