Left atrial appendage closure—promise meets proof, and proof meets pause.
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
Left atrial appendage closure—promise meets proof, and proof meets pause.
In The New England Journal of Medicine, two pivotal trials draw a nuanced arc:
CHAMPION-AF shows noninferior stroke prevention with less bleeding vs direct oral anticoagulants, while CLOSURE-AF tempers enthusiasm—failing noninferiority in older, high-risk patients with meaningful procedural risk.
The message is elegant and sobering: innovation must bow to evidence, and patient selection remains paramount.
In atrial fibrillation, the art lies not in closing the appendage—but in opening judgment.