Inflammation 🔥, Dopamine 💊, and Apathy 😐: A Neuroimmune Pathway in Brain Fog?
Dr RR Baliga's "Got Knowledge Doc" Podkast · MasterMedFacts
April 18, 20253m 30s
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Show Notes
Cancer cachexia isn't just weight loss—it's a hijacking of motivation 😔. Elevated IL-6 🔥 activates a brainstem-to-basal ganglia circuit 🧠 that suppresses dopamine 💊 in the nucleus accumbens, leading to effort-based apathy 💤.
Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway 💡.