Hypertension: Old Foe 🥊, Novel Therapies 🛡️, Brighter Outcomes 🌈
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 Hypertension remains the world's #1 killer — yet fewer than 1 in 4 patients achieve control.
💊 Exciting innovations are reshaping the field:
✔️ Aprocitentan (endothelin receptor antagonist) – first new class in decades
✔️ siRNA (zilebesiran) – 6-monthly dosing, tackling adherence
✔️ Aldosterone synthase inhibitors – overcoming "aldosterone escape"
✔️ Non-steroidal MRAs & neprilysin inhibitors – precision targeting with broader benefits
✔️ Single-pill & quadpill combos – simplifying therapy, boosting adherence
🌍 Together, these therapies + smarter management could transform outcomes in resistant and uncontrolled hypertension.