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Show Notes
🧬 New insights from Nature Medicine!
Researchers reveal that obesity caused by MC4R deficiency — the most common monogenic form — is paradoxically linked to lower LDL-cholesterol, triglycerides, and blood pressure 💡. Despite severe obesity, these individuals show a "metabolically healthier" profile, likely due to altered central melanocortin signaling and reduced sympathetic tone 🧠💓.
These findings challenge traditional views on obesity and open doors for MC4R-targeted therapies to reduce cardiometabolic risk 🚀.
📖 Nature Medicine, 2025 — "Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk."