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πŸ’“ Genes, Gradients, and Game-Changers: FAQs on Hypertrophic Cardiomyopathy

πŸ’“ Genes, Gradients, and Game-Changers: FAQs on Hypertrophic Cardiomyopathy

Dr RR Baliga's "Got Knowledge Doc" Podkast

September 17, 20257m 6s

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Show Notes

🧠 Hypertrophic Cardiomyopathy β€” A Masterclass from Eugene Braunwald 🧬

πŸ“Œ Just published in NEJM (Aug 2025): a sweeping, state-of-the-art review on HCM β€” from Teare's first autopsy to myosin inhibitors, AI diagnostics, and gene therapy.

πŸ’₯ Clinical insights, historical depth, trial data (EXPLORER-HCM, SEQUOIA-HCM, VALOR-HCM), and future-facing advancesβ€”all distilled into one must-read.

πŸ“‰ SCD prevention, πŸ«€ LVOT obstruction, πŸ§ͺ MYBPC3/MYH7 mutations, 🧬 proteomics, and more.

πŸ”— Essential reading for cardiologists, geneticists, and translational scientists.

#HCM #Braunwald #NEJM #Cardiology #PrecisionMedicine #Mavacamten #Aficamten #GeneTherapy #MedicalEducation #SCDprevention