From Sclerosis 🧱 to Stenosis 🚪 to Surgery 🔧
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🚨 Calcific Aortic Valve Stenosis (CAVS): Beyond Wear and Tear 🫀🪨
Once thought to be "degenerative," CAVS is now recognized as an active disease driven by oxidative stress ⚡, inflammation 🔥, and lipoprotein(a) 🧬. Despite its growing global burden, no drug therapy slows its progression.
🩺 Current management: Surgical (SAVR) or Transcatheter (TAVR) valve replacement.
💊 Emerging hope: PCSK9 inhibitors, Lp(a) lowering agents, SGLT2 inhibitors, soluble guanylate cyclase activators, and anti-inflammatory strategies.
📊 Modern tools: Aortic valve calcification on CT, PET imaging for microcalcification, and strain imaging for early detection.
🔑 Takeaway: CAVS is preventable in theory, but not yet in practice. Novel therapeutics may finally reshape its natural history.
#Cardiology #HeartValve #PrecisionMedicine #AorticStenosis