From Gut to Heart: Microbes, Metabolites & Myeloid Mayhem 🦠🧬🔥
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🧬 New Insights into Gut–Heart Axis 🫀💡
Groundbreaking research published in Nature shows that Imidazole propionate (ImP)—a metabolite produced by gut bacteria—drives atherosclerosis by hijacking immune pathways in myeloid cells via the I1R–mTORC1 axis 🔥🧫.
📈 Elevated ImP levels predicted subclinical atherosclerosis independently of cholesterol in two large cohorts (PESA & IGT).
💊 Blocking this pathway with AGN192403 prevented plaque buildup—offering a novel, cholesterol-independent therapeutic target.
📚 Time to rethink cardiovascular prevention beyond lipids?
#Cardiology #GutMicrobiome #Atherosclerosis #PrecisionMedicine #Inflammation #NatureMedicine