Faster. Colder. Smarter: REUP and the New Era of DCD Heart Transplantation
Dr RR Baliga's "Got Knowledge Doc" Podkast
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Show Notes
🫀 Rethinking DCD Heart Transplantation
A new JAMA Original Investigation reports encouraging early outcomes using rapid recovery with extended ultraoxygenated preservation (REUP) for donation after circulatory death (DCD) heart transplantation—without donor heart reanimation or machine perfusion.
🔬 In a 24-patient case series, REUP achieved 96% 30-day survival, low primary graft dysfunction (4%), and minimal early rejection, even with older donors and prolonged ischemic times.
⚖️ By avoiding reanimation, REUP may reduce ethical concerns, cost, and logistical complexity, while expanding the usable donor pool.
🌍 A potentially scalable, globally relevant step forward in transplant medicine.
Sometimes progress is not about doing more—but about doing just enough, better.